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Patients and Family Resources

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Resources in Evidence Repository and Individual Compendia

Key Resources

Bottom Line: Assessment in the emergency department for patients with head injury  (2014)

Bottom Line: Assessment in the emergency department for patients with head injury

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National Institute for Health and Care Excellence (NICE), National Clincial Guideline Centre

National Institute for Health and Care Excellence (NICE), National Clincial G...

A NICE pathway brings together all NICE guidance, quality standards and materials to support implementation on a specific topic area. The pathways are interactive and designed to be used online.

A NICE pathway brings together all NICE guidance, quality standards and materials to support implementation on a specific topic area. The pathways are interactive and designed to be used online.

Bottom Line Recommendations: Severe Head Injury (2022)

Bottom Line Recommendations: Severe Head Injury (2022)

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Dr. Susan Beno and Dr. Joe Nemeth

Dr. Susan Beno and Dr. Joe Nemeth

Bottom line recommendations for severe head injury. Uploaded to the website on November 15, 2022. 

Bottom line recommendations for severe head injury. Uploaded to the website on November 15, 2022. 

Algorithme Pediatrique pour Choc Septique Severe  (2018)

Algorithme Pediatrique pour Choc Septique Severe

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PedsPac de TREKK sur le Choc Septique

PedsPac de TREKK sur le Choc Septique

This point of care algorithm is to guide initial management of pediatric sepsis in the Emergency Department. This algorithm is intended for use on patients greater than 28 days of age. Published online: April 2019, v 2.2.

This point of care algorithm is to guide initial management of pediatric sepsis in the Emergency Department. This algorithm is intended for use on patients greater than 28 days of age. Published online: April 2019, v 2.2.

Feuille D’ordonnances Pré-Rédigées pour Choc Septique Severe  (2020)

Feuille D’ordonnances Pré-Rédigées pour Choc Septique Severe

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PedsPac de TREKK sur le Choc Septique

PedsPac de TREKK sur le Choc Septique

This order set is for management of severe sepsis in the ED and is adaptable to your hospitals form policy. This document is intended for use on patients greater than 28 days of age. Published online: Feb 2020, v 1.2.

This order set is for management of severe sepsis in the ED and is adaptable to your hospitals form policy. This document is intended for use on patients greater than 28 days of age. Published online: Feb 2020, v 1.2.

Carte de signes vitaux pour Choc Septique Severe  (2018)

Carte de signes vitaux pour Choc Septique Severe

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PedsPac de TREKK sur le Choc Septique

PedsPac de TREKK sur le Choc Septique

This pocket card outlines pediatric heart rate and pediatric respiratory rate guidelines and was reviewed in October 2018. Posted online April 2019, version 2.0.

This pocket card outlines pediatric heart rate and pediatric respiratory rate guidelines and was reviewed in October 2018. Posted online April 2019, version 2.0.

Clinical management of patients with moderate to severe COVID-19 - Interim guidance  (2020)

Clinical management of patients with moderate to severe COVID-19 - Interim guidance

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Government of Canada

Government of Canada

Recommendations de Base: Traumatisme Cranien Severe (2022)

Recommendations de Base: Traumatisme Cranien Severe (2022)

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Dr. Susan Beno and Dr. Joe Nemeth

Dr. Susan Beno and Dr. Joe Nemeth

Bottom line recommendations for the treatment and management of severe head injury - French. Version 3.0 published online November 15, 2022.

Bottom line recommendations for the treatment and management of severe head injury - French. Version 3.0 published online November 15, 2022.

Bottom Line Recommenation: Optimal pain relief for pediatric MSK injury.  (2015)

Bottom Line Recommenation: Optimal pain relief for pediatric MSK injury.

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Korownyk C, Young J, Michael Allan G

Korownyk C, Young J, Michael Allan G

Evidence suggests that ibuprofen provides better single-agent relief than acetaminophen or codeine, and is at least equivalent to both acetaminophen with codeine and morphine for acute injury pain, with fewer adverse events.

Evidence suggests that ibuprofen provides better single-agent relief than acetaminophen or codeine, and is at least equivalent to both acetaminophen with codeine and morphine for acute injury pain, with fewer adverse events.

Clinical guidelines

Clinical Practice Guideline: Australian and New Zealand guideline for mild to moderate head injuries in children  (2021)

Clinical Practice Guideline: Australian and New Zealand guideline for mild to moderate head injuries in children

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Babl FE, Tavender E, Dalziel S. On behalf of the Guideline Working Group for the Paediatric Research in Emergency Departments International Collaborative (PR...

Babl FE, Tavender E, Dalziel S. On behalf of the Guideline Working Group for ...

Children frequently present with head injuries to acute care settings. Led by PREDICT (Paediatric Research in Emergency Departments International Collaborative), a multidisciplinary working group developed the first Australian and New Zealand guideline for mild to moderate head injuries in children. Addressing 33 key clinical questions, it contains 71 recommendations, and an imaging/observation algorithm. The Guideline provides evidence-based, locally applicable, practical clinical guidance for the care of children with mild to moderate head injuries presenting to acute care settings.

Children frequently present with head injuries to acute care settings. Led by PREDICT (Paediatric Research in Emergency Departments International Collaborative), a multidisciplinary working group developed the first Australian and New Zealand guideline for mild to moderate head injuries in children. Addressing 33 key clinical questions, it contains 71 recommendations, and an imaging/observation algorithm. The Guideline provides evidence-based, locally applicable, practical clinical guidance for the care of children with mild to moderate head injuries presenting to acute care settings.

Clinical Practice Guideline: Management of the paediatric patient with acute head trauma  (2018)

Clinical Practice Guideline: Management of the paediatric patient with acute head trauma

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Farrell CA, Canadian Paediatric Society Acute Care Committee

Farrell CA, Canadian Paediatric Society Acute Care Committee

The purpose of this statement is to describe issues related to head trauma in infants, children and youth, including clinical manifestations, initial management priorities, guidelines for imaging, and subsequent observation and treatment.

The purpose of this statement is to describe issues related to head trauma in infants, children and youth, including clinical manifestations, initial management priorities, guidelines for imaging, and subsequent observation and treatment.

Clinical Practice Guideline: Multidisciplinary guidelines on the identification, investigation and management of suspected abusive head trauma  (2008)

Clinical Practice Guideline: Multidisciplinary guidelines on the identification, investigation and management of suspected abusive head trauma

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Canadian Paediatric Society

Canadian Paediatric Society

The Multidisciplinary Guidelines on the Identification, Investigation and Management of Suspected Abusive Head Trauma have been prepared in order to provide community organizations with assistance in developing local protocols for managing cases of Abusive Head Trauma. The guidelines are intended to be generic enough that large or small communities can use them to help develop a resoinse appropriate to their specific circumstances.

The Multidisciplinary Guidelines on the Identification, Investigation and Management of Suspected Abusive Head Trauma have been prepared in order to provide community organizations with assistance in developing local protocols for managing cases of Abusive Head Trauma. The guidelines are intended to be generic enough that large or small communities can use them to help develop a resoinse appropriate to their specific circumstances.

Clinical Practice Guideline: Head injury: assessment and early management  (2019)

Clinical Practice Guideline: Head injury: assessment and early management

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National Institute for Health and Care Excellence (NICE), National Clincial Guideline Centre

National Institute for Health and Care Excellence (NICE), National Clincial G...

This guideline covers the assessment and early management of head injury in children, young people and adults. It promotes effective clinical assessment so that people receive the right care for the severity of their head injury, including referral directly to specialist care if needed.

This guideline covers the assessment and early management of head injury in children, young people and adults. It promotes effective clinical assessment so that people receive the right care for the severity of their head injury, including referral directly to specialist care if needed.

Clinical Practice Guideline: Italian guidelines on the assessment and management of pediatric head injury in the emergency department.  (2018)

Clinical Practice Guideline: Italian guidelines on the assessment and management of pediatric head injury in the emergency department.

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Da Dalt L, Parri N, Amigoni A, Nocerino A, Selmin F, Manara R, et al.

Da Dalt L, Parri N, Amigoni A, Nocerino A, Selmin F, Manara R, et al.

We aim to formulate evidence-based recommendations to assist physicians decision-making in the assessment and management of children younger than 16 years presenting to the emergency department (ED) following a blunt head trauma with no suspicion of non-accidental injury.

We aim to formulate evidence-based recommendations to assist physicians decision-making in the assessment and management of children younger than 16 years presenting to the emergency department (ED) following a blunt head trauma with no suspicion of non-accidental injury.

Clinical Practice Guideline: Management of Pediatric Severe Traumatic Brain Injury: 2019 Consensus and Guidelines-Based Algorithm for First and Second Tier Therapies.  (2019)

Clinical Practice Guideline: Management of Pediatric Severe Traumatic Brain Injury: 2019 Consensus and Guidelines-Based Algorithm for First and Second Tier Therapies.

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ochanek PM, Tasker RC, Bell MJ, Adelson PD, Carney N, Vavilala MS, et al

ochanek PM, Tasker RC, Bell MJ, Adelson PD, Carney N, Vavilala MS, et al

To produce a treatment algorithm for the ICU management of infants, children, and adolescents with severe traumatic brain injury.

To produce a treatment algorithm for the ICU management of infants, children, and adolescents with severe traumatic brain injury.

Clinical Practice Guideline: The management of pediatric severe traumatic brain injury: Italian Guidelines.  (2021)

Clinical Practice Guideline: The management of pediatric severe traumatic brain injury: Italian Guidelines.

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Bussolin L, Falconi M, Leo MC, Parri N, DE Masi S, Rosati A, et al

Bussolin L, Falconi M, Leo MC, Parri N, DE Masi S, Rosati A, et al

The aim of the work was to update the "Guidelines for the Management of Severe Traumatic Brain Injury" published in 2012, to reflect the new available evidence, and develop the Italian national guideline for the management of severe pediatric head injuries to reduce variation in practice and ensure optimal care to patients.

The aim of the work was to update the "Guidelines for the Management of Severe Traumatic Brain Injury" published in 2012, to reflect the new available evidence, and develop the Italian national guideline for the management of severe pediatric head injuries to reduce variation in practice and ensure optimal care to patients.

Clinical Practice Guideline: Management of Pediatric Supracondylar Humerus Fractures with Vascular Injury  (2016)

Clinical Practice Guideline: Management of Pediatric Supracondylar Humerus Fractures with Vascular Injury

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Sanders JO, Heggeness MH, Murray JN, Pezold RC, Sevarino KS

Sanders JO, Heggeness MH, Murray JN, Pezold RC, Sevarino KS

Evidence-based information, in conjunction with the clinical expertise of physicians, was used to develop the criteria to improve patient care and obtain the best outcomes while considering the subtleties and distinctions necessary in making clinical decisions for pediatric supracondylar humerus fractures with vascular injury.

Evidence-based information, in conjunction with the clinical expertise of physicians, was used to develop the criteria to improve patient care and obtain the best outcomes while considering the subtleties and distinctions necessary in making clinical decisions for pediatric supracondylar humerus fractures with vascular injury.

Guidelines: Centers for Disease Control and Prevention Guideline on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children  (2018)

Guidelines: Centers for Disease Control and Prevention Guideline on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children

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Lumba-Brown A, Yeates KO, Sarmiento K, et al.

Lumba-Brown A, Yeates KO, Sarmiento K, et al.

Based on a previous systematic review of the literature, this guideline includes 19 sets of recommendations on diagnosis, prognosis, and management/treatment of pediatric mTBI. Each recommendation was assigned a level of obligation (ie, must, should, or may) based on confidence in the evidence.

Based on a previous systematic review of the literature, this guideline includes 19 sets of recommendations on diagnosis, prognosis, and management/treatment of pediatric mTBI. Each recommendation was assigned a level of obligation (ie, must, should, or may) based on confidence in the evidence.

Clinical Practice Guideline: Centers for Disease Control and Prevention Guideline on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children.  (2018)

Clinical Practice Guideline: Centers for Disease Control and Prevention Guideline on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children.

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Lumba-Brown A, Yeates KO, Sarmiento K, Breiding MJ, Haegerich TM, Gioia GA, et al.

Lumba-Brown A, Yeates KO, Sarmiento K, Breiding MJ, Haegerich TM, Gioia GA, e...

Mild traumatic brain injury (mTBI), or concussion, in children is a rapidly growing public health concern because epidemiologic data indicate a marked increase in the number of emergency department visits for mTBI over the past decade. However, no evidence-based clinical guidelines have been developed to date for diagnosing and managing pediatric mTBI in the United States.

Mild traumatic brain injury (mTBI), or concussion, in children is a rapidly growing public health concern because epidemiologic data indicate a marked increase in the number of emergency department visits for mTBI over the past decade. However, no evidence-based clinical guidelines have been developed to date for diagnosing and managing pediatric mTBI in the United States.

Summaries of systematic reviews

Cochrane Summary: Intravenous immunoglobulins for treating patients with severe sepsis and septic shock (2013)

Cochrane Summary: Intravenous immunoglobulins for treating patients with severe sepsis and septic shock (2013)

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Alejandria Marissa MLMA, D.; Dans Leonila, F.; Mantaring, I. I. I. Jacinto Blas

Alejandria Marissa MLMA, D.; Dans Leonila, F.; Mantaring, I. I. I. Jacinto Blas

Objective: For this updated Cochrane review, we searched the medical literature databases to January 2012. We included 43 randomized controlled trials (RCTs); 25 were RCTs of polyclonal intravenous immunoglobulins (IVIGs) with 17 in adults (1958 participants) and eight in newborn infants (3831 participants) including a large polyclonal IVIG trial on infants with sepsis that was published in 2011. The remaining 18 trials (a total of 13,413 participants) were of monoclonal antibodies. Published: 2013.

Objective: For this updated Cochrane review, we searched the medical literature databases to January 2012. We included 43 randomized controlled trials (RCTs); 25 were RCTs of polyclonal intravenous immunoglobulins (IVIGs) with 17 in adults (1958 participants) and eight in newborn infants (3831 participants) including a large polyclonal IVIG trial on infants with sepsis that was published in 2011. The remaining 18 trials (a total of 13,413 participants) were of monoclonal antibodies. Published: 2013.

Cochrane Summary: Human recombinant activated protein C for severe sepsis and septic shock in adult and paediatric patients (2012)

Cochrane Summary: Human recombinant activated protein C for severe sepsis and septic shock in adult and paediatric patients (2012)

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Mart-Carvajal Arturo JS, Ivan; Gluud, Christian; Lathyris, Dimitrios; Cardona Andrs, Felipe

Mart-Carvajal Arturo JS, Ivan; Gluud, Christian; Lathyris, Dimitrios; Cardona...

Objective: In this updated Cochrane review we searched the databases until June 2012. We included six randomized clinical trials which involved 6781 people (6307 adult and 474 paediatric participants) with either a high or low risk of death. All trials had high risk of bias and were sponsored by the pharmaceutical industry (Eli Lilly). moreover, there is an increased risk of bleeding associated with its use. Published: 2012.

Objective: In this updated Cochrane review we searched the databases until June 2012. We included six randomized clinical trials which involved 6781 people (6307 adult and 474 paediatric participants) with either a high or low risk of death. All trials had high risk of bias and were sponsored by the pharmaceutical industry (Eli Lilly). moreover, there is an increased risk of bleeding associated with its use. Published: 2012.

Cochrane Summary: Role of ketamine for management of acute severe asthma in children (2012)

Cochrane Summary: Role of ketamine for management of acute severe asthma in children (2012)

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Jat, KR, Chawla, D,

Jat, KR, Chawla, D,

Children frequently visit theemergencydepartment foracuteexacerbation of asthma. Some of these children fail to respond tostandard treatment(corticosteroids and bronchodilators) with increasedmorbidity. Ketamine has bronchodilatory properties and may be useful foracuteexacerbation of asthma. We evaluated theefficacyof ketamine for management of severeacuteasthma in children who had not responded to standardtherapy. We found, through systematic search, only onestudywhere investigators assessed the usefulness of ketamine for management of severeacuteasthma in children. While this singlestudysuggested that there is a lack of evidence for usefulness of ketamine inacuteexacerbation of asthma in children, more trials are needed regarding the use of ketamine inacuteasthma before more specific recommendations can be made.

Children frequently visit theemergencydepartment foracuteexacerbation of asthma. Some of these children fail to respond tostandard treatment(corticosteroids and bronchodilators) with increasedmorbidity. Ketamine has bronchodilatory properties and may be useful foracuteexacerbation of asthma. We evaluated theefficacyof ketamine for management of severeacuteasthma in children who had not responded to standardtherapy. We found, through systematic search, only onestudywhere investigators assessed the usefulness of ketamine for management of severeacuteasthma in children. While this singlestudysuggested that there is a lack of evidence for usefulness of ketamine inacuteexacerbation of asthma in children, more trials are needed regarding the use of ketamine inacuteasthma before more specific recommendations can be made.

Overviews of systematic reviews

Treatment of severe blunt pancreatic lesions in children  (2014)

Treatment of severe blunt pancreatic lesions in children

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Haugaard MV, Wettergren A, Hillings JG, Gluud C, Penninga L,

Haugaard MV, Wettergren A, Hillings JG, Gluud C, Penninga L,

This review shows that strategies regarding non-operative versus operative treatment of severe blunt pancreatic trauma in children are not based on randomised clinical trials.

This review shows that strategies regarding non-operative versus operative treatment of severe blunt pancreatic trauma in children are not based on randomised clinical trials.

Systematic reviews

Systematic Review: Hypothermia for traumatic head injury  (2017)

Systematic Review: Hypothermia for traumatic head injury

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Sydenham E, Roberts I, Alderson P

Sydenham E, Roberts I, Alderson P

To estimate the effect of mild hypothermia for traumaticheadinjury on mortality and long-term functional outcome complications.

To estimate the effect of mild hypothermia for traumaticheadinjury on mortality and long-term functional outcome complications.

Review: Addressing Key Clinical Care and Clinical Research Needs in Severe Pediatric Traumatic Brain Injury: Perspectives From a Focused International Conference.  (2021)

Review: Addressing Key Clinical Care and Clinical Research Needs in Severe Pediatric Traumatic Brain Injury: Perspectives From a Focused International Conference.

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Nacoti M, Fazzi F, Biroli F, Zangari R, Barbui T, Kochanek PM, Collaborative Pediatric TBI Working Group

Nacoti M, Fazzi F, Biroli F, Zangari R, Barbui T, Kochanek PM, Collaborative ...

We explore the clinical and research unmet needs focusing on severe pediatric TBI to identify best practices in pathways of care and optimize both inpatient and outpatient management of children following TBI.

We explore the clinical and research unmet needs focusing on severe pediatric TBI to identify best practices in pathways of care and optimize both inpatient and outpatient management of children following TBI.

Review: Emergency Department Implementation of the Brain Trauma Foundation's Pediatric Severe Brain Injury Guideline Recommendations.  (2020)

Review: Emergency Department Implementation of the Brain Trauma Foundation's Pediatric Severe Brain Injury Guideline Recommendations.

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Lumba-Brown A, Totten A, Kochanek PM.

Lumba-Brown A, Totten A, Kochanek PM.

Provides new and updated recommendations applicable to the emergency department management of children with severe traumatic brain injury. Practice-changing takeaways include specific recommendations for administration of 3% hypertonic saline, administration of seizure prophylaxis, and avoiding hyperventilation.

Provides new and updated recommendations applicable to the emergency department management of children with severe traumatic brain injury. Practice-changing takeaways include specific recommendations for administration of 3% hypertonic saline, administration of seizure prophylaxis, and avoiding hyperventilation.

Cochrane Systematic Review: Interventions for treating head lice

Cochrane Systematic Review: Interventions for treating head lice

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Dodd CS

Dodd CS

OBJECTIVES: The aim of this review was to assess the effects of interventions for head lice.

OBJECTIVES: The aim of this review was to assess the effects of interventions for head lice.

Systematic Review: Retinal haemorrhages and related findings in abusive and non-abusive head trauma: a systematic review  (2013)

Systematic Review: Retinal haemorrhages and related findings in abusive and non-abusive head trauma: a systematic review

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Maguire SA, Watts PO, Shaw AD, Holden S, Taylor RH, Watkins WJ, Mann MK, Tempest V, Kemp AM

Maguire SA, Watts PO, Shaw AD, Holden S, Taylor RH, Watkins WJ, Mann MK, Temp...

Aim: To report the retinal signs that distinguish abusive head trauma (AHT) from non-abusive head trauma (nAHT).

Aim: To report the retinal signs that distinguish abusive head trauma (AHT) from non-abusive head trauma (nAHT).

Systematic Review: Clinical and radiographic characteristics associated with abusive and nonabusive head trauma: a systematic review  (2012)

Systematic Review: Clinical and radiographic characteristics associated with abusive and nonabusive head trauma: a systematic review

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Piteau SJ, Ward MG, Barrowman NJ, Plint AC

Piteau SJ, Ward MG, Barrowman NJ, Plint AC

Objective: To systematically review the literature to determine which clinical and radiographic characteristics are associated with abusive head trauma (AHT) and nonabusive head trauma (nAHT) in children.

Objective: To systematically review the literature to determine which clinical and radiographic characteristics are associated with abusive head trauma (AHT) and nonabusive head trauma (nAHT) in children.

Systematic Review: Neuroimaging: what neuroradiological features distinguish abusive from non-abusive head trauma?  (2011)

Systematic Review: Neuroimaging: what neuroradiological features distinguish abusive from non-abusive head trauma?

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Kemp AM, Jaspan T, Griffiths J, Stoodley N, Mann MK, Tempest V, Maguire SA

Kemp AM, Jaspan T, Griffiths J, Stoodley N, Mann MK, Tempest V, Maguire SA

Objective: To identify the evidence base behind the neuroradiological features that differentiate abusive head trauma (AHT) from non-abusive head trauma (nAHT).

Objective: To identify the evidence base behind the neuroradiological features that differentiate abusive head trauma (AHT) from non-abusive head trauma (nAHT).

Systematic Review: Helmets for preventing head and facial injuries in bicyclists  (2000)

Systematic Review: Helmets for preventing head and facial injuries in bicyclists

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Thompson DC, Rivara FP, Thompson R

Thompson DC, Rivara FP, Thompson R

To determine whether bicycle helmets reducehead, brain and facial injury for bicyclists of all ages involved in a bicycle crash or fall.

To determine whether bicycle helmets reducehead, brain and facial injury for bicyclists of all ages involved in a bicycle crash or fall.

Review: Emergency Medicine Myths: Computed Tomography of the Head Prior to Lumbar Puncture in Adults with Suspected Bacterial Meningitis - Due Diligence or Antiquated Practice?  (2017)

Review: Emergency Medicine Myths: Computed Tomography of the Head Prior to Lumbar Puncture in Adults with Suspected Bacterial Meningitis - Due Diligence or Antiquated Practice?

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April MD, Long B, Koyfman A

April MD, Long B, Koyfman A

Objective: To review the evidence regarding the utility of obtaining head CT prior to lumbar puncture in adults with suspected bacterial meningitis.

Objective: To review the evidence regarding the utility of obtaining head CT prior to lumbar puncture in adults with suspected bacterial meningitis.

Review: Pediatric Head Trauma: A Review and Update.  (2019)

Review: Pediatric Head Trauma: A Review and Update.

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Gelineau-Morel RN, Zinkus TP, Le Pichon JB.

Gelineau-Morel RN, Zinkus TP, Le Pichon JB.

There is still a considerable amount of confusion when it comes to managing concussions. An excessive number of head computed tomographic scans are being obtained for concussions, resulting in unnecessary exposure to ionizing radiation. Clinicians should be aware of the most recent guidelines for the management of concussion, including the need for imaging, and should be able to differentiate mild from moderate and severe traumatic brain injury.

There is still a considerable amount of confusion when it comes to managing concussions. An excessive number of head computed tomographic scans are being obtained for concussions, resulting in unnecessary exposure to ionizing radiation. Clinicians should be aware of the most recent guidelines for the management of concussion, including the need for imaging, and should be able to differentiate mild from moderate and severe traumatic brain injury.

Review: Monitoring and measurement of intracranial pressure in pediatric head trauma.  (2020)

Review: Monitoring and measurement of intracranial pressure in pediatric head trauma.

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Pedersen SH, Lilja-Cyron A, Astrand R, Juhler M.

Pedersen SH, Lilja-Cyron A, Astrand R, Juhler M.

Monitoring of intracranial pressure (ICP) is an important and integrated part of the treatment algorithm for children with severe traumatic brain injury (TBI). Guidelines often recommend ICP monitoring with a treatment threshold of 20 mmHg. This focused review discusses; (1) different ICP technologies and how ICP should be monitored in pediatric patients with severe TBI, (2) existing evidence behind guideline recommendations, and (3) how we could move forward to increase knowledge about normal ICP in children to support treatment decisions.

Monitoring of intracranial pressure (ICP) is an important and integrated part of the treatment algorithm for children with severe traumatic brain injury (TBI). Guidelines often recommend ICP monitoring with a treatment threshold of 20 mmHg. This focused review discusses; (1) different ICP technologies and how ICP should be monitored in pediatric patients with severe TBI, (2) existing evidence behind guideline recommendations, and (3) how we could move forward to increase knowledge about normal ICP in children to support treatment decisions.

Cochrane Systematic Review: Oral antibiotics versus parenteral antibiotics for severe pneumonia in children

Cochrane Systematic Review: Oral antibiotics versus parenteral antibiotics for severe pneumonia in children

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Rojas MX, Granados C.

Rojas MX, Granados C.

Objectives: To determine the equivalence in effectiveness and safety of oral antibiotic compared to parenteral antibiotic therapies in the treatment of severe pneumonia in children between three months and five years of age.

Objectives: To determine the equivalence in effectiveness and safety of oral antibiotic compared to parenteral antibiotic therapies in the treatment of severe pneumonia in children between three months and five years of age.

Cochrane Systematic Review: Short-course versus long-course antibiotic therapy for non-severe community-acquired pneumonia in children aged 2 months to 59 months

Cochrane Systematic Review: Short-course versus long-course antibiotic therapy for non-severe community-acquired pneumonia in children aged 2 months to 59 months

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Kozyrskyj A, Klassen TP, Moffatt M, Harvey K.

Kozyrskyj A, Klassen TP, Moffatt M, Harvey K.

Objectives: To determine the effectiveness of a short course of antibiotics (less than seven days) in comparison to a long course of antibiotics (seven days or greater) for the treatment of AOM in children.

Objectives: To determine the effectiveness of a short course of antibiotics (less than seven days) in comparison to a long course of antibiotics (seven days or greater) for the treatment of AOM in children.

Cochrane Systematic Review: Intravenous aminophylline for acute severe asthma in children over two years receiving inhaled bronchodilators

Cochrane Systematic Review: Intravenous aminophylline for acute severe asthma in children over two years receiving inhaled bronchodilators

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Mitra A, Bassler D, Goodman K, Lasserson TJ, Ducharme FM.

Mitra A, Bassler D, Goodman K, Lasserson TJ, Ducharme FM.

Objectives: To determine if the addition of intravenous aminophylline produces a beneficial effect in children with acute severe asthma receiving conventional therapy.

Objectives: To determine if the addition of intravenous aminophylline produces a beneficial effect in children with acute severe asthma receiving conventional therapy.

Cochrane Systematic Review: Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients

Cochrane Systematic Review: Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients

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Mart-Carvajal AJ, Sol I, Gluud C, Lathyris D, Cardona AF

Mart-Carvajal AJ, Sol I, Gluud C, Lathyris D, Cardona AF

OBJECTIVES: We assessed the benefits and harms of APC for patients with severe sepsis or septic shock.

OBJECTIVES: We assessed the benefits and harms of APC for patients with severe sepsis or septic shock.

Cochrane Systematic Review: Artemisinin derivatives for treating severe malaria

Cochrane Systematic Review: Artemisinin derivatives for treating severe malaria

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McIntosh HM, Olliaro P

McIntosh HM, Olliaro P

OBJECTIVES: The objective of this review was to assess the effects of artemisinin drugs for severe and complicated falciparum malaria in adults and children.

OBJECTIVES: The objective of this review was to assess the effects of artemisinin drugs for severe and complicated falciparum malaria in adults and children.

Cochrane Systematic Review: Intramuscular arteether for treating severe malaria

Cochrane Systematic Review: Intramuscular arteether for treating severe malaria

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Afolabi BB, Okoromah CN

Afolabi BB, Okoromah CN

OBJECTIVES: To compare intramuscular arteether with other antimalarial drugs to treat severe malaria.

OBJECTIVES: To compare intramuscular arteether with other antimalarial drugs to treat severe malaria.

Cochrane Systematic Review: High first dose quinine regimen for treating severe malaria

Cochrane Systematic Review: High first dose quinine regimen for treating severe malaria

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Lesi A, Meremikwu M

Lesi A, Meremikwu M

OBJECTIVES: To assess the clinical outcomes and adverse events of a high first (loading) dose regimen of quinine compared with a uniform (no loading) dose regimen in people with severe malaria.

OBJECTIVES: To assess the clinical outcomes and adverse events of a high first (loading) dose regimen of quinine compared with a uniform (no loading) dose regimen in people with severe malaria.

Cochrane Systematic Review: Artesunate versus quinine for treating severe malaria

Cochrane Systematic Review: Artesunate versus quinine for treating severe malaria

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Sinclair D, Donegan S, Isba R, Lalloo DG

Sinclair D, Donegan S, Isba R, Lalloo DG

OBJECTIVES: To compare artesunate with quinine for treating severe malaria.

OBJECTIVES: To compare artesunate with quinine for treating severe malaria.

Cochrane Systematic Review: Modes of administration of antibiotics for symptomatic severe urinary tract infections

Cochrane Systematic Review: Modes of administration of antibiotics for symptomatic severe urinary tract infections

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Pohl A

Pohl A

OBJECTIVES: To assess whether the mode of administration of antibiotic therapy for severe UTI has an effect on cure rate, reinfection rate and kidney scarring.

OBJECTIVES: To assess whether the mode of administration of antibiotic therapy for severe UTI has an effect on cure rate, reinfection rate and kidney scarring.

Cochrane Systematic Review: Corticosteroids for treating severe sepsis and septic shock

Cochrane Systematic Review: Corticosteroids for treating severe sepsis and septic shock

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Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, Kupfer Y. Corticosteroids for treating severe sepsis and septic shock. Cochrane Database Syst Rev. 20...

Annane D, Bellissant E, Bollaert PE, Briegel J, Keh D, Kupfer Y. Corticoster...

OBJECTIVES: To examine the effects of corticosteroids on death at one month in patients with severe sepsis and septic shock.

OBJECTIVES: To examine the effects of corticosteroids on death at one month in patients with severe sepsis and septic shock.

Cochrane Systematic Review: Intranasal corticosteroids for nasal airway obstruction in children with moderate to severe adenoidal hypertrophy  (2008)

Cochrane Systematic Review: Intranasal corticosteroids for nasal airway obstruction in children with moderate to severe adenoidal hypertrophy

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Zhang L, Mendoza-Sassi RA, Csar JA, Chadha NK

Zhang L, Mendoza-Sassi RA, Csar JA, Chadha NK

OBJECTIVES: To assess the effectiveness of intranasal corticosteroids for improving nasal airway obstruction in children with moderate to severe adenoidal hypertrophy.

OBJECTIVES: To assess the effectiveness of intranasal corticosteroids for improving nasal airway obstruction in children with moderate to severe adenoidal hypertrophy.

Cochrane Systematic Review: Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock (2013)

Cochrane Systematic Review: Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock (2013)

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Alejandria Marissa MLMA, D.; Dans Leonila, F.; Mantaring, I. I. I. Jacinto Blas

Alejandria Marissa MLMA, D.; Dans Leonila, F.; Mantaring, I. I. I. Jacinto Blas

Objectives: To estimate the effects of IVIG as adjunctive therapy in patients with bacterial sepsis or septic shock on mortality, bacteriological failure rates, and duration of stay in hospital. Published: 2013.

Objectives: To estimate the effects of IVIG as adjunctive therapy in patients with bacterial sepsis or septic shock on mortality, bacteriological failure rates, and duration of stay in hospital. Published: 2013.

Cochrane Systematic Review: Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients (2012)

Cochrane Systematic Review: Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients (2012)

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Mart-Carvajal Arturo JS, Ivan; Gluud, Christian; Lathyris, Dimitrios; Cardona Andrs, Felipe

Mart-Carvajal Arturo JS, Ivan; Gluud, Christian; Lathyris, Dimitrios; Cardona...

Background: Sepsis is a common and frequently fatal condition. Human recombinant activated protein C (APC) has been introduced to reduce the high risk of death associated with severe sepsis or septic shock. This systematic review is an update of a Cochrane review originally published in 2007.Objectives: We assessed the benefits and harms of APC for patients with severe sepsis or septic shock. Published: 2012.

Background: Sepsis is a common and frequently fatal condition. Human recombinant activated protein C (APC) has been introduced to reduce the high risk of death associated with severe sepsis or septic shock. This systematic review is an update of a Cochrane review originally published in 2007.Objectives: We assessed the benefits and harms of APC for patients with severe sepsis or septic shock. Published: 2012.

Systematic Review: Early goal-directed therapy in severe sepsis and septic shock: a contemporary review of the literature (2008)

Systematic Review: Early goal-directed therapy in severe sepsis and septic shock: a contemporary review of the literature (2008)

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Rivers EPC, V.; Whitmill, M.

Rivers EPC, V.; Whitmill, M.

Objective: Aggressive approaches to acute diseases such as acute myocardial infarction, trauma, and stroke have improved outcomes. Early goal-directed therapy for severe sepsis and septic shock represents a similar approach. An analysis of the literature assessing external validity and generalizability of this intervention is lacking. Published: 2008.

Objective: Aggressive approaches to acute diseases such as acute myocardial infarction, trauma, and stroke have improved outcomes. Early goal-directed therapy for severe sepsis and septic shock represents a similar approach. An analysis of the literature assessing external validity and generalizability of this intervention is lacking. Published: 2008.

Review: Risk multipliers for severe food anaphylaxis  (2015)

Review: Risk multipliers for severe food anaphylaxis

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Smith PK, Hourihane JO, Lieberman P

Smith PK, Hourihane JO, Lieberman P

This paper reviews the factors that contribute to the risk of severe anaphylactic events and provides a framework for the ongoing management of patients at risk of severe food allergy.

This paper reviews the factors that contribute to the risk of severe anaphylactic events and provides a framework for the ongoing management of patients at risk of severe food allergy.

Review: Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of data from The European Anaphylaxis Registry.  (2018)

Review: Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of data from The European Anaphylaxis Registry.

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Worm M, Francuzik W, Renaudin JM, et al.

Worm M, Francuzik W, Renaudin JM, et al.

To identify and prioritize factors associated with an increased risk of developing severe anaphylaxis.

To identify and prioritize factors associated with an increased risk of developing severe anaphylaxis.

Systematic review: Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2: a systematic review.  (2020)

Systematic review: Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2: a systematic review.

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Abrams JY, Godfred-Cato SE, Oster ME, et al.

Abrams JY, Godfred-Cato SE, Oster ME, et al.

Objective: To develop a more comprehensive description of multisystem inflammatory syndrome in children (MIS-C), a novel syndrome linked to severe acute respiratory syndrome coronavirus 2, by conducting a systematic analysis of studies from different settings that used various inclusion criteria.

Objective: To develop a more comprehensive description of multisystem inflammatory syndrome in children (MIS-C), a novel syndrome linked to severe acute respiratory syndrome coronavirus 2, by conducting a systematic analysis of studies from different settings that used various inclusion criteria.

Application of bench studies at the bedside to improve outcomes in the management of severe diabetic ketoacidosis in children-a narrative review.  (2021)

Application of bench studies at the bedside to improve outcomes in the management of severe diabetic ketoacidosis in children-a narrative review.

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Ravikumar N, Bansal A.

Ravikumar N, Bansal A.

In this review, we address a few key issues and the challenges faced in the management of severe diabetic ketoacidosis (DKA) in children, highlighting the existing standard of care, supported by evidence and bench studies.

In this review, we address a few key issues and the challenges faced in the management of severe diabetic ketoacidosis (DKA) in children, highlighting the existing standard of care, supported by evidence and bench studies.

Cochrane Systematic Review: Aerosolized prostacyclin for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)

Cochrane Systematic Review: Aerosolized prostacyclin for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)

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Afshari A, Brok J, Mller AM, Wetterslev J

Afshari A, Brok J, Mller AM, Wetterslev J

OBJECTIVES: To systematically assess the benefits and harms of aerosolized prostacyclin in critically ill patients with ALI and ARDS.

OBJECTIVES: To systematically assess the benefits and harms of aerosolized prostacyclin in critically ill patients with ALI and ARDS.

Cochrane Systematic Review: High-frequency ventilation versus conventional ventilation for treatment of acute lung injury and acute respiratory distress syndrome

Cochrane Systematic Review: High-frequency ventilation versus conventional ventilation for treatment of acute lung injury and acute respiratory distress syndrome

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Sud S, Sud M, Friedrich JO, Wunsch H, Meade MO, Ferguson ND, Adhikari NK

Sud S, Sud M, Friedrich JO, Wunsch H, Meade MO, Ferguson ND, Adhikari NK

OBJECTIVES: To determine clinical and physiological effects of high frequency oscillation (HFO) in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) compared to conventional ventilation.

OBJECTIVES: To determine clinical and physiological effects of high frequency oscillation (HFO) in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) compared to conventional ventilation.

Cochrane Systematic Review: Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) and acute lung injury in children and adults

Cochrane Systematic Review: Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) and acute lung injury in children and adults

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Afshari A, Brok J, Mller AM, Wetterslev J. Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) and acute lung injury in children and adults....

Afshari A, Brok J, Mller AM, Wetterslev J. Inhaled nitric oxide for acute re...

OBJECTIVES: To systematically assess the benefits and harms of INO in critically ill patients with AHRF.

OBJECTIVES: To systematically assess the benefits and harms of INO in critically ill patients with AHRF.

Cochrane Systematic Review: Antifibrinolytic drugs for acute traumatic injury

Cochrane Systematic Review: Antifibrinolytic drugs for acute traumatic injury

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Roberts I, Shakur H, Ker K, Coats T; CRASH-2 Trial collaborators

Roberts I, Shakur H, Ker K, Coats T; CRASH-2 Trial collaborators

OBJECTIVES: To quantify the effects of antifibrinolytic drugs on mortality, vascular occlusive events, surgical intervention and receipt of blood transfusion after acute traumatic injury.

OBJECTIVES: To quantify the effects of antifibrinolytic drugs on mortality, vascular occlusive events, surgical intervention and receipt of blood transfusion after acute traumatic injury.

Cochrane Systematic Review: Bradykinin beta-2 receptor antagonists for acute traumatic brain injury

Cochrane Systematic Review: Bradykinin beta-2 receptor antagonists for acute traumatic brain injury

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Ker K, Blackhall K

Ker K, Blackhall K

OBJECTIVES: The objective was to assess the safety and effectiveness of beta-2 receptor antagonists for TBI.

OBJECTIVES: The objective was to assess the safety and effectiveness of beta-2 receptor antagonists for TBI.

Cochrane Systematic Review: Decompressive craniectomy for the treatment of refractory high intracranial pressure in traumatic brain injury

Cochrane Systematic Review: Decompressive craniectomy for the treatment of refractory high intracranial pressure in traumatic brain injury

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Sahuquillo J, Arikan F

Sahuquillo J, Arikan F

OBJECTIVES: To assess the effects of secondary decompressive craniectomy (DC) on outcome and quality of life in patients with severe TBI in whom conventional medical therapeutic measures have failed to control raised ICP.

OBJECTIVES: To assess the effects of secondary decompressive craniectomy (DC) on outcome and quality of life in patients with severe TBI in whom conventional medical therapeutic measures have failed to control raised ICP.

Cochrane Systematic Review: Excitatory amino acid inhibitors for traumatic brain injury

Cochrane Systematic Review: Excitatory amino acid inhibitors for traumatic brain injury

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Willis C, Lybrand S, Bellamy N

Willis C, Lybrand S, Bellamy N

OBJECTIVES: To assess systematically the efficacy of excitatory amino acid inhibitors on improving patient outcome following traumatic brain injury.

OBJECTIVES: To assess systematically the efficacy of excitatory amino acid inhibitors on improving patient outcome following traumatic brain injury.

Cochrane Systematic Review: Hyperventilation therapy for acute traumatic brain injury

Cochrane Systematic Review: Hyperventilation therapy for acute traumatic brain injury

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Schierhout G, Roberts I

Schierhout G, Roberts I

OBJECTIVES: To quantify the effect of hyperventilation on death and neurological disability following head injury.

OBJECTIVES: To quantify the effect of hyperventilation on death and neurological disability following head injury.

Cochrane Systematic Review: Pharmacological interventions for spasticity following spinal cord injury

Cochrane Systematic Review: Pharmacological interventions for spasticity following spinal cord injury

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Taricco M, Adone R, Pagliacci C, Telaro E

Taricco M, Adone R, Pagliacci C, Telaro E

OBJECTIVES: To assess the effectiveness and safety of Baclofen, Dantrolene, Tizanidine and any other drugs for the treatment of long term spasticity in SCI patients as well as the effectiveness and safety of different routes of administration of Baclofen.

OBJECTIVES: To assess the effectiveness and safety of Baclofen, Dantrolene, Tizanidine and any other drugs for the treatment of long term spasticity in SCI patients as well as the effectiveness and safety of different routes of administration of Baclofen.

Cochrane Systematic Review: Progesterone for acute traumatic brain injury

Cochrane Systematic Review: Progesterone for acute traumatic brain injury

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Ma J, Huang S, Qin S, You C

Ma J, Huang S, Qin S, You C

OBJECTIVES: To assess the effectiveness and safety of progesterone in people with acute TBI.

OBJECTIVES: To assess the effectiveness and safety of progesterone in people with acute TBI.

Cochrane Systematic Review: Steroids for acute spinal cord injury

Cochrane Systematic Review: Steroids for acute spinal cord injury

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Bracken MB

Bracken MB

OBJECTIVES: To review randomized trials of steroids for human acute spinal cord injury.

OBJECTIVES: To review randomized trials of steroids for human acute spinal cord injury.

Cochrane Systematic Review: Primary closure versus delayed closure for non bite traumatic wounds within 24 hours post injury

Cochrane Systematic Review: Primary closure versus delayed closure for non bite traumatic wounds within 24 hours post injury

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Eliya-Masamba MC, Banda GW

Eliya-Masamba MC, Banda GW

OBJECTIVES: To determine the effect on time to healing of primary closure versus delayed closure for non bite traumatic wounds presenting within 24 hours post injury. To explore the adverse effects of primary closure compared with delayed closure for non bite traumatic wounds presenting within 24 hours post injury.

OBJECTIVES: To determine the effect on time to healing of primary closure versus delayed closure for non bite traumatic wounds presenting within 24 hours post injury. To explore the adverse effects of primary closure compared with delayed closure for non bite traumatic wounds presenting within 24 hours post injury.

Systematic Review: Haemostatic drugs for traumatic brain injury  (2010)

Systematic Review: Haemostatic drugs for traumatic brain injury

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Perel P, Roberts I, Shakur H, Thinkhamrop B, Phuenpathom N, Yutthakasemsunt S

Perel P, Roberts I, Shakur H, Thinkhamrop B, Phuenpathom N, Yutthakasemsunt S

To assess the effects of haemostatic drugs on mortality, disability and thrombotic complications inpatientswith traumatic brain injury.

To assess the effects of haemostatic drugs on mortality, disability and thrombotic complications inpatientswith traumatic brain injury.

Systematic Review: Corticosteroids for acute traumatic brain injury  (2005)

Systematic Review: Corticosteroids for acute traumatic brain injury

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Alderson P, Roberts I

Alderson P, Roberts I

To quantify the effectiveness and safety of corticosteroids in the treatment ofacutetraumatic brain injury.

To quantify the effectiveness and safety of corticosteroids in the treatment ofacutetraumatic brain injury.

Systematic Review: What neuroimaging should be performed in children in whom inflicted brain injury (iBI) is suspected? A systematic review  (2009)

Systematic Review: What neuroimaging should be performed in children in whom inflicted brain injury (iBI) is suspected? A systematic review

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Kemp AM, Rajaram S, Mann M, Tempest V, Farewell D, Gawne-Cain ML, Jaspan T, Maguire S, Welsh Child Protection Systematic Review Group

Kemp AM, Rajaram S, Mann M, Tempest V, Farewell D, Gawne-Cain ML, Jaspan T, M...

Aim: To investigate the optimal neuroradiological investigation strategy to identify inflicted brain injury (iBI).

Aim: To investigate the optimal neuroradiological investigation strategy to identify inflicted brain injury (iBI).

Systematic Review: Which clinical features distinguish inflicted from non-inflicted brain injury? A systematic review  (2009)

Systematic Review: Which clinical features distinguish inflicted from non-inflicted brain injury? A systematic review

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Maguire S, Pickerd N, Farewell D, Mann M, Tempest V, Kemp AM

Maguire S, Pickerd N, Farewell D, Mann M, Tempest V, Kemp AM

Aim: A systematic review of the scientific literature to define clinical indicators distinguishing inflicted (iBI) from non-inflicted brain injury (niBI).

Aim: A systematic review of the scientific literature to define clinical indicators distinguishing inflicted (iBI) from non-inflicted brain injury (niBI).

Antifibrinolytic drugs for acute traumatic injury  (2015)

Antifibrinolytic drugs for acute traumatic injury

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Ker K, Roberts I, Shakur H, Coats TJ,

Ker K, Roberts I, Shakur H, Coats TJ,

Review to assess the effect of antifibrinolytic drugs in patients with acute traumatic injury.

Review to assess the effect of antifibrinolytic drugs in patients with acute traumatic injury.

Systematic Review: Perioperative Care for Pediatric Patients With Penetrating Brain Injury: A Review  (2018)

Systematic Review: Perioperative Care for Pediatric Patients With Penetrating Brain Injury: A Review

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Mikhael M, Frost E, Cristancho M

Mikhael M, Frost E, Cristancho M

We present an overview of PBI, its presenting features, epidemiology, and causes as well as an analysis of case series and the conclusions that may be drawn from those and other studies.

We present an overview of PBI, its presenting features, epidemiology, and causes as well as an analysis of case series and the conclusions that may be drawn from those and other studies.

Systematic Review: The ketamine effect on ICP in traumatic brain injury  (2014)

Systematic Review: The ketamine effect on ICP in traumatic brain injury

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Zeiler FA, Teitelbaum J, West M, Gillman LM

Zeiler FA, Teitelbaum J, West M, Gillman LM

Our goal was to perform a systematic review of the literature on the use of ketamine in traumatic brain injury (TBI) and its effects on intracranial pressure (ICP).

Our goal was to perform a systematic review of the literature on the use of ketamine in traumatic brain injury (TBI) and its effects on intracranial pressure (ICP).

Systematic Review: A systematic review and quality analysis of pediatric traumatic brain injury clinical practice guidelines.  (2018)

Systematic Review: A systematic review and quality analysis of pediatric traumatic brain injury clinical practice guidelines.

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Appenteng R, Nelp T, Abdelgadir J, Weledji N, Haglund M, Smith E, et al

Appenteng R, Nelp T, Abdelgadir J, Weledji N, Haglund M, Smith E, et al

To inform the creation of a pediatric TBI management guideline for a low and middle income country context, we assessed the quality of available clinical practice guidelines (CPGs) for the acute management pediatric TBI.

To inform the creation of a pediatric TBI management guideline for a low and middle income country context, we assessed the quality of available clinical practice guidelines (CPGs) for the acute management pediatric TBI.

Systematic review: A systematic review of sleep-wake disturbances in childhood traumatic brain injury: relationship with fatigue, depression, and quality of life  (2019)

Systematic review: A systematic review of sleep-wake disturbances in childhood traumatic brain injury: relationship with fatigue, depression, and quality of life

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Botchway EN, Godfrey C, Anderson V, Catroppa C.

Botchway EN, Godfrey C, Anderson V, Catroppa C.

Objective: To systematically appraise the literature on the prevalence, types, and predictors of sleep-wake disturbances (SWD), and on the relationship between SWD, fatigue, depression, and quality of life in children and adolescents with traumatic brain injury (TBI).

Objective: To systematically appraise the literature on the prevalence, types, and predictors of sleep-wake disturbances (SWD), and on the relationship between SWD, fatigue, depression, and quality of life in children and adolescents with traumatic brain injury (TBI).

Systematic review: Diagnosis and management of mild traumatic brain injury in children: a systematic review  (2018)

Systematic review: Diagnosis and management of mild traumatic brain injury in children: a systematic review

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Lumba-Brown A, Yeates KO, Sarmiento K, et al.

Lumba-Brown A, Yeates KO, Sarmiento K, et al.

Objective: To conduct a systematic review of the pediatric mTBI literature to serve as the foundation for an evidence-based guideline with clinical recommendations associated with the diagnosis and management of pediatric mTBI.

Objective: To conduct a systematic review of the pediatric mTBI literature to serve as the foundation for an evidence-based guideline with clinical recommendations associated with the diagnosis and management of pediatric mTBI.

Systematic review: Pediatric traumatic brain injury and antisocial behavior: are they linked? A systematic review  (2019)

Systematic review: Pediatric traumatic brain injury and antisocial behavior: are they linked? A systematic review

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Bellesi G, Barker ED, Brown L, Valmaggia L.

Bellesi G, Barker ED, Brown L, Valmaggia L.

This review aimed to explore systematically previous literature on the association between TBI before the age of 19 and severe behavioral problems such as violence, aggression and assault.

This review aimed to explore systematically previous literature on the association between TBI before the age of 19 and severe behavioral problems such as violence, aggression and assault.

Systematic review: Sleep disturbances after pediatric traumatic brain injury: a systematic review of prevalence, risk factors, and association with recovery  (2020)

Systematic review: Sleep disturbances after pediatric traumatic brain injury: a systematic review of prevalence, risk factors, and association with recovery

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Luther M, Poppert Cordts KM, Williams CN

Luther M, Poppert Cordts KM, Williams CN

Objectives: Sleep is vital for brain development and healing after injury, placing children with sleep-wake disturbances (SWD) after traumatic brain injury (TBI) at risk for worse outcomes. We conducted a systematic review to quantify SWD after pediatric TBI including prevalence, phenotypes, and risk factors. We also evaluated interventions for SWD and the association between SWD and other posttraumatic outcomes.

Objectives: Sleep is vital for brain development and healing after injury, placing children with sleep-wake disturbances (SWD) after traumatic brain injury (TBI) at risk for worse outcomes. We conducted a systematic review to quantify SWD after pediatric TBI including prevalence, phenotypes, and risk factors. We also evaluated interventions for SWD and the association between SWD and other posttraumatic outcomes.

Cochrane Systematic Review: Interventions to reduce body temperature to 35 C to 37 C in adults and children with traumatic brain injury  (2021)

Cochrane Systematic Review: Interventions to reduce body temperature to 35 C to 37 C in adults and children with traumatic brain injury

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Lewis SR, Baker PE, Andrews PJD, Cheng A, Deol K, Hammond N, Saxena M

Lewis SR, Baker PE, Andrews PJD, Cheng A, Deol K, Hammond N, Saxena M

To assess the effects of pharmacological interventions or physical interventions given with the intention of reducing body temperature to 35 C to 37.5 C in adults and children admitted to hospital after TBI.

To assess the effects of pharmacological interventions or physical interventions given with the intention of reducing body temperature to 35 C to 37.5 C in adults and children admitted to hospital after TBI.

Review: Approach to Pediatric Traumatic Brain Injury in the Emergency Department.  (2018)

Review: Approach to Pediatric Traumatic Brain Injury in the Emergency Department.

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Belisle S, Lim R, Hochstadter E, Sangha G.

Belisle S, Lim R, Hochstadter E, Sangha G.

We discuss the initial management of traumatic brain injury based on mild, moderate and severe presentations. Management strategies to address Intracranial Pressure and Cerebral perfusion pressure, the use of oxygenation and ventilation strategies, temperature, correction of metabolic abnormalities and seizure care are discussed.

We discuss the initial management of traumatic brain injury based on mild, moderate and severe presentations. Management strategies to address Intracranial Pressure and Cerebral perfusion pressure, the use of oxygenation and ventilation strategies, temperature, correction of metabolic abnormalities and seizure care are discussed.

Cochrane Systematic Review: Hypothermia for neuroprotection in children after cardiopulmonary arrest  (2013)

Cochrane Systematic Review: Hypothermia for neuroprotection in children after cardiopulmonary arrest

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Scholefield B, Duncan H, Davies P, Gao Smith F, Khan K, Perkins GD, Morris K

Scholefield B, Duncan H, Davies P, Gao Smith F, Khan K, Perkins GD, Morris K

OBJECTIVES: To assess the clinical effectiveness of therapeutic hypothermia after paediatric cardiopulmonary arrest.

OBJECTIVES: To assess the clinical effectiveness of therapeutic hypothermia after paediatric cardiopulmonary arrest.

Key studies

Key Study: Prospective validation and head-to-head comparison of 3 ankle rules in a pediatric population  (2009)

Key Study: Prospective validation and head-to-head comparison of 3 ankle rules in a pediatric population

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Gravel, J, Hedrei, P, Grimard, G & Gouin, S

Gravel, J, Hedrei, P, Grimard, G & Gouin, S

Objective: To determine the criterion validity of three rules for predicting clinically important ankle fractures in children.

Objective: To determine the criterion validity of three rules for predicting clinically important ankle fractures in children.

Key Study: Reducing Head CT Use for Children With Head Injuries in a Community Emergency Department  (2017)

Key Study: Reducing Head CT Use for Children With Head Injuries in a Community Emergency Department

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Jennings RM, Burtner JJ, Pellicer JF, Nair DK, Bradford MC, Shaffer M, Uspal NG, Tieder JS

Jennings RM, Burtner JJ, Pellicer JF, Nair DK, Bradford MC, Shaffer M, Uspal ...

Clinical decision rules have reduced use of computed tomography (CT) to evaluate minor pediatric head injury in pediatric emergency departments (EDs). CT use remains high in community EDs, where the majority of children seek medical care. We sought to reduce the rate of CT scans used to evaluate pediatric head injury from 29% to 20% in a community ED.

Clinical decision rules have reduced use of computed tomography (CT) to evaluate minor pediatric head injury in pediatric emergency departments (EDs). CT use remains high in community EDs, where the majority of children seek medical care. We sought to reduce the rate of CT scans used to evaluate pediatric head injury from 29% to 20% in a community ED.

Key Study: Comparison of PECARN, CATCH, and CHALICE rules for children with minor head injury: a prospective cohort study  (2014)

Key Study: Comparison of PECARN, CATCH, and CHALICE rules for children with minor head injury: a prospective cohort study

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Easter JS, Bakes K, Dhaliwal J, Miller M, Caruso E, Haukoos JS

Easter JS, Bakes K, Dhaliwal J, Miller M, Caruso E, Haukoos JS

Objective: To evaluate the diagnostic accuracy of clinical decision rules and physician judgment for identifying clinically important traumatic brain injuries in children with minor head injuries presenting to the emergency department.

Objective: To evaluate the diagnostic accuracy of clinical decision rules and physician judgment for identifying clinically important traumatic brain injuries in children with minor head injuries presenting to the emergency department.

Key Study: CATCH: a clinical decision rule for the use of computed tomography in children with minor head injury  (2010)

Key Study: CATCH: a clinical decision rule for the use of computed tomography in children with minor head injury

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Osmond MH, Klassen TP, Wells GA, Correll R, Jarvis A, Joubert G, Bailey B, Chauvin-Kimoff L, Pusic M, McConnell D, Nijssen-Jordan C, Silver N, Taylor B, Stie...

Osmond MH, Klassen TP, Wells GA, Correll R, Jarvis A, Joubert G, Bailey B, Ch...

There is controversy about which children with minorheadinjury need to undergo computed tomography (CT). We aimed to develop a highly sensitive clinical decision rule for the use of CT in children with minorheadinjury.

There is controversy about which children with minorheadinjury need to undergo computed tomography (CT). We aimed to develop a highly sensitive clinical decision rule for the use of CT in children with minorheadinjury.

Key study: Delayed presentations to emergency departments of children with head injury: A PREDICT Study  (2019)

Key study: Delayed presentations to emergency departments of children with head injury: A PREDICT Study

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Borland ML, Dalziel SR, Phillips N, et al.

Borland ML, Dalziel SR, Phillips N, et al.

Objective: Existing clinical decision rules guide management for head-injured children presenting 24 hours or sooner after injury, even though some may present greater than 24 hours afterward. We seek to determine the prevalence of traumatic brain injuries for patients presenting to emergency departments greater than 24 hours after injury and identify symptoms and signs to guide management.

Objective: Existing clinical decision rules guide management for head-injured children presenting 24 hours or sooner after injury, even though some may present greater than 24 hours afterward. We seek to determine the prevalence of traumatic brain injuries for patients presenting to emergency departments greater than 24 hours after injury and identify symptoms and signs to guide management.

Key study: Effect of cognitive and physical rest on persistent postconcussive symptoms following a pediatric head injury  (2020)

Key study: Effect of cognitive and physical rest on persistent postconcussive symptoms following a pediatric head injury

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Root JM, Sady MD, Gai J, Vaughan CG, Madati PJ

Root JM, Sady MD, Gai J, Vaughan CG, Madati PJ

To evaluate the effect of cognitive and physical rest on persistent postconcussive symptoms in a pediatric population.

To evaluate the effect of cognitive and physical rest on persistent postconcussive symptoms in a pediatric population.

Key study: Pediatric minor head injury imaging practices: results from an ESPR survey  (2020)

Key study: Pediatric minor head injury imaging practices: results from an ESPR survey

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Argyropoulou MI, Alexiou GA, Xydis VG, et al.

Argyropoulou MI, Alexiou GA, Xydis VG, et al.

Objective: Computed tomography (CT) for minor head injury exposes a large number of children to ionizing radiation, with an associated increased lifetime risk of malignancy. To study imaging practices for children with minor head injury and the level of awareness of radiologists of the current clinical decision rules for minor traumatic brain injury (TBI).

Objective: Computed tomography (CT) for minor head injury exposes a large number of children to ionizing radiation, with an associated increased lifetime risk of malignancy. To study imaging practices for children with minor head injury and the level of awareness of radiologists of the current clinical decision rules for minor traumatic brain injury (TBI).

Key study: Reduction of computed tomography use for pediatric closed head injury evaluation at a nonpediatric community emergency department  (2019)

Key study: Reduction of computed tomography use for pediatric closed head injury evaluation at a nonpediatric community emergency department

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Puffenbarger MS, Ahmad FA, Argent M, Gu H, Samson C, Quayle KS, Saito JM.

Puffenbarger MS, Ahmad FA, Argent M, Gu H, Samson C, Quayle KS, Saito JM.

The purpose of this study was to determine if implementation of a Pediatric Emergency Care Applied Research Network (PECARN)-based Closed Head Injury Assessment Tool could safely decrease computed tomography (CT) use for pediatric head injury evaluation at a nonpediatric community emergency department (ED).

The purpose of this study was to determine if implementation of a Pediatric Emergency Care Applied Research Network (PECARN)-based Closed Head Injury Assessment Tool could safely decrease computed tomography (CT) use for pediatric head injury evaluation at a nonpediatric community emergency department (ED).

Key Study: Acute care clinical indicators associated with discharge outcomes in children with severe traumatic brain injury  (2014)

Key Study: Acute care clinical indicators associated with discharge outcomes in children with severe traumatic brain injury

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Vavilala MS, Kernic MA, Wang J, Kannan N, Mink RB, Wainwright MS, Groner JI, Bell MJ, Giza CC, Zatzick DF, Ellenbogen RG, Boyle LN, Mitchell PH, Rivara FP

Vavilala MS, Kernic MA, Wang J, Kannan N, Mink RB, Wainwright MS, Groner JI, ...

The effect of the 2003 severe pediatric traumatic brain injury (TBI) guidelines on outcomes has not been examined. We aimed to develop a set ofacutecare guideline-influenced clinical indicators of adherence and tested the relationship between these indicators during the first 72 hours after hospital admission and discharge outcomes.

The effect of the 2003 severe pediatric traumatic brain injury (TBI) guidelines on outcomes has not been examined. We aimed to develop a set ofacutecare guideline-influenced clinical indicators of adherence and tested the relationship between these indicators during the first 72 hours after hospital admission and discharge outcomes.

Key Study: Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial  (2013)

Key Study: Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial

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Adelson PD, Wisniewski SR, Beca J, Brown SD, Bell M, Muizelaar JP, Okada P, Beers SR, Balasubramani GK, Hirtz D

Adelson PD, Wisniewski SR, Beca J, Brown SD, Bell M, Muizelaar JP, Okada P, B...

On the basis of mixed results from previous trials, we assessed whether therapeutic hypothermia for 48-72 h with slow rewarming improved mortality in children after brain injury.

On the basis of mixed results from previous trials, we assessed whether therapeutic hypothermia for 48-72 h with slow rewarming improved mortality in children after brain injury.

Key Study: Differences in medical therapy goals for children with severe traumatic brain injury-an international study  (2013)

Key Study: Differences in medical therapy goals for children with severe traumatic brain injury-an international study

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Bell MJ, Adelson PD, Hutchison JS, Kochanek PM, Tasker RC, Vavilala MS, Beers SR, Fabio A, Kelsey SF, Wisniewski SR

Bell MJ, Adelson PD, Hutchison JS, Kochanek PM, Tasker RC, Vavilala MS, Beers...

To describe the differences in goals for their usual practice for various medical therapies from a number of international centers for children with severe traumatic brain injury.

To describe the differences in goals for their usual practice for various medical therapies from a number of international centers for children with severe traumatic brain injury.

Key Study: Early resuscitation of children with moderate-to-severe traumatic brain injury  (2009)

Key Study: Early resuscitation of children with moderate-to-severe traumatic brain injury

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Zebrack M, Dandoy C, Hansen K, Scaife E, Mann NC, Bratton SL

Zebrack M, Dandoy C, Hansen K, Scaife E, Mann NC, Bratton SL

The purpose of this study was to identify the prevalence, monitoring, and treatment of hypotension and hypoxia during "early" (prehospital and emergency department) care and to evaluate their relationship to vital status and neurologic outcomes at hospital discharge.

The purpose of this study was to identify the prevalence, monitoring, and treatment of hypotension and hypoxia during "early" (prehospital and emergency department) care and to evaluate their relationship to vital status and neurologic outcomes at hospital discharge.

Key Study: Long-term outcomes and prognostic factors in pediatric patients with severe traumatic brain injury and elevated intracranial pressure  (2008)

Key Study: Long-term outcomes and prognostic factors in pediatric patients with severe traumatic brain injury and elevated intracranial pressure

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Jagannathan J, Okonkwo DO, Yeoh HK, Dumont AS, Saulle D, Haizlip J, Barth JT, Jane JA, Jane JA

Jagannathan J, Okonkwo DO, Yeoh HK, Dumont AS, Saulle D, Haizlip J, Barth JT,...

Themanagementstrategies and outcomes in pediatricpatientswith elevated intracranial pressure (ICP) following severe traumatic brain injury (TBI) are examined in this study.

Themanagementstrategies and outcomes in pediatricpatientswith elevated intracranial pressure (ICP) following severe traumatic brain injury (TBI) are examined in this study.

Key Study: Examining Emergency Department Treatment Processes in Severe Pediatric Traumatic Brain Injury  (2017)

Key Study: Examining Emergency Department Treatment Processes in Severe Pediatric Traumatic Brain Injury

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Ajdari A, Boyle LN, Kannan N, Rowhani-Rahbar A, Wang J, Mink R, Ries B, Wainwright M, Groner JI, Bell MJ, Giza C, Zatzick DF, Ellenbogen RG, Mitchell PH, Riv...

Ajdari A, Boyle LN, Kannan N, Rowhani-Rahbar A, Wang J, Mink R, Ries B, Wainw...

Our objectives were to examine the treatment process of acute pediatric TBI and the impact of non-value-added time (NVAT) on patient outcomes.

Our objectives were to examine the treatment process of acute pediatric TBI and the impact of non-value-added time (NVAT) on patient outcomes.

Key Study: Tripartite Stratification of the Glasgow Coma Scale in Children with Severe Traumatic Brain Injury and Mortality: An Analysis from a Multi-Center Comparative Effectiveness Study  (2017)

Key Study: Tripartite Stratification of the Glasgow Coma Scale in Children with Severe Traumatic Brain Injury and Mortality: An Analysis from a Multi-Center Comparative Effectiveness Study

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Murphy S, Thomas NJ, Gertz SJ, Beca J, Luther JF, Bell MJ, Wisniewski SR, Hartman AL, Tasker RC

Murphy S, Thomas NJ, Gertz SJ, Beca J, Luther JF, Bell MJ, Wisniewski SR, Har...

This study describes the distribution of GCS scores in the population, the relationship between injury characteristics with the GCS score, and the association between the tripartite stratification of the GCS on mortality in children with severe traumatic brain injury (TBI).

This study describes the distribution of GCS scores in the population, the relationship between injury characteristics with the GCS score, and the association between the tripartite stratification of the GCS on mortality in children with severe traumatic brain injury (TBI).

Key Study: Presenting characteristics associated with outcome in children with severe traumatic brain injury: a secondary analysis from a randomized, controlled trial of therapeutic hypothermia.  (2018)

Key Study: Presenting characteristics associated with outcome in children with severe traumatic brain injury: a secondary analysis from a randomized, controlled trial of therapeutic hypothermia.

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Rosario BL, Horvat CM, Wisniewski SR, Bell MJ, Panigrahy A, Zuccoli G, et al.

Rosario BL, Horvat CM, Wisniewski SR, Bell MJ, Panigrahy A, Zuccoli G, et al.

To identify injury patterns and characteristics associated with severe traumatic brain injury course and outcome, within a well-characterized cohort, which may help guide new research and treatment initiatives.

To identify injury patterns and characteristics associated with severe traumatic brain injury course and outcome, within a well-characterized cohort, which may help guide new research and treatment initiatives.

Key Study: The Pediatric Guideline Adherence and Outcomes (PEGASUS) programme in severe traumatic brain injury: a single-centre hybrid implementation and effectiveness study.  (2019)

Key Study: The Pediatric Guideline Adherence and Outcomes (PEGASUS) programme in severe traumatic brain injury: a single-centre hybrid implementation and effectiveness study.

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Vavilala MS, King MA, Yang JT, Erickson SL, Mills B, Grant RM, et al

Vavilala MS, King MA, Yang JT, Erickson SL, Mills B, Grant RM, et al

As far as we know, there are no tested in-hospital care programmes for paediatric traumatic brain injury. We aimed to assess implementation and effectiveness of the Pediatric Guideline Adherence and Outcomes (PEGASUS) programme in children with severe traumatic brain injury.

As far as we know, there are no tested in-hospital care programmes for paediatric traumatic brain injury. We aimed to assess implementation and effectiveness of the Pediatric Guideline Adherence and Outcomes (PEGASUS) programme in children with severe traumatic brain injury.

Key Study: Computed tomography practice standards for severe pediatric traumatic brain injury in the emergency department: a national survey.  (2020)

Key Study: Computed tomography practice standards for severe pediatric traumatic brain injury in the emergency department: a national survey.

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Yoo G, Leach A, Woods R, Holt T, Hansen G.

Yoo G, Leach A, Woods R, Holt T, Hansen G.

Acute medical management of traumatic brain injury (TBI) can be challenging outside of the resuscitation bay, specifically while obtaining a computed tomography (CT) scan of the brain. We sought out to determine the management practices of Canadian traumatologists for pediatric patients with severe TBI requiring CT in the emergency department.

Acute medical management of traumatic brain injury (TBI) can be challenging outside of the resuscitation bay, specifically while obtaining a computed tomography (CT) scan of the brain. We sought out to determine the management practices of Canadian traumatologists for pediatric patients with severe TBI requiring CT in the emergency department.

Key Study: Big for Small; Validating Brain Injury Guidelines in Pediatric Traumatic Brain Injury  (2017)

Key Study: Big for Small; Validating Brain Injury Guidelines in Pediatric Traumatic Brain Injury

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Azim A, Jehan FS, Rhee P, O'Keeffe T, Tang A, Vercruysse G, Kulvatunyou N, Latifi R, Joseph B

Azim A, Jehan FS, Rhee P, O'Keeffe T, Tang A, Vercruysse G, Kulvatunyou N, La...

The aim of this study was to evaluate the established BIG (BIG-1 category) for managing pediatric traumatic brain injury (TBI) patients with intracranial hemorrhage (ICH) without NC (no-NC).

The aim of this study was to evaluate the established BIG (BIG-1 category) for managing pediatric traumatic brain injury (TBI) patients with intracranial hemorrhage (ICH) without NC (no-NC).

Key Study: Validation of a clinical prediction rule for pediatric abusive head trauma  (2014)

Key Study: Validation of a clinical prediction rule for pediatric abusive head trauma

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Hymel KP, Armijo-Garcia V, Foster R, Frazier TN, Stoiko M, Christie LM, Harper NS, Weeks K, Carroll CL, Hyden P, Sirotnak A, Truemper E, Ornstein AE, Wang M

Hymel KP, Armijo-Garcia V, Foster R, Frazier TN, Stoiko M, Christie LM, Harpe...

To reduce missed cases of pediatric abusive head trauma (AHT), Pediatric Brain Injury Research Network investigators derived a 4-variable AHT clinical prediction rule (CPR) with sensitivity of .96. Our objective was to validate the screening performance of this AHT CPR in a new, equivalent patient population.

To reduce missed cases of pediatric abusive head trauma (AHT), Pediatric Brain Injury Research Network investigators derived a 4-variable AHT clinical prediction rule (CPR) with sensitivity of .96. Our objective was to validate the screening performance of this AHT CPR in a new, equivalent patient population.

Key Study: Clinical significance of scalp abnormalities in asymptomatic head-injured infants  (2001)

Key Study: Clinical significance of scalp abnormalities in asymptomatic head-injured infants

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Greenes DS, Schutzman SA

Greenes DS, Schutzman SA

Objectives: 1) To identify clinical features indicating a high risk of skull fracture (SF) and associated intracranial injury (ICI) in asymptomatichead-injured infants. 2) To develop a clinical decision rule to determine which asymptomatichead-injured infants requireheadimaging.

Objectives: 1) To identify clinical features indicating a high risk of skull fracture (SF) and associated intracranial injury (ICI) in asymptomatichead-injured infants. 2) To develop a clinical decision rule to determine which asymptomatichead-injured infants requireheadimaging.

Key Study: Prior opportunities to identify abuse in children with abusive head trauma  (2016)

Key Study: Prior opportunities to identify abuse in children with abusive head trauma

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Letson MM, Cooper JN, Deans KJ, Scribano PV, Makoroff KL, Feldman KW, Berger RP

Letson MM, Cooper JN, Deans KJ, Scribano PV, Makoroff KL, Feldman KW, Berger RP

Infants with minor abusive injuries are at risk for more serious abusive injury, including abusive head trauma (AHT). Our study objective was to determine if children with AHT had prior opportunities to detect abuse and to describe the opportunities.

Infants with minor abusive injuries are at risk for more serious abusive injury, including abusive head trauma (AHT). Our study objective was to determine if children with AHT had prior opportunities to detect abuse and to describe the opportunities.

Key Study: Abusive head trauma: recognition and the essential investigation  (2011)

Key Study: Abusive head trauma: recognition and the essential investigation

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Kemp AM

Kemp AM

This article describes the evidence base behind the associated historical, clinical and neuroradiological features of abusive head trauma and spinal injury in physical abuse and sets out an algorithm of essential investigations that should be performed in any infant or young child where abusive head trauma is suspected.

This article describes the evidence base behind the associated historical, clinical and neuroradiological features of abusive head trauma and spinal injury in physical abuse and sets out an algorithm of essential investigations that should be performed in any infant or young child where abusive head trauma is suspected.

Key Study: Analysis of missed cases of abusive head trauma  (1999)

Key Study: Analysis of missed cases of abusive head trauma

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Jenny C, Hymel KP, Ritzen A, Reinert SE, Hay TC

Jenny C, Hymel KP, Ritzen A, Reinert SE, Hay TC

Objectives: To determine how frequently AHT was previously missed by physicians in a group of abused children with head injuries and to determine factors associated with the unrecognized diagnosis.

Objectives: To determine how frequently AHT was previously missed by physicians in a group of abused children with head injuries and to determine factors associated with the unrecognized diagnosis.

Key Study: Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study  (2009)

Key Study: Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study

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Kuppermann N, Holmes JF, Dayan PS, Hoyle JD, Atabaki SM, Holubkov R, Nadel FM, Monroe D, Stanley RM, Borgialli DA, Badawy MK, Schunk JE, Quayle KS, Mahajan P...

Kuppermann N, Holmes JF, Dayan PS, Hoyle JD, Atabaki SM, Holubkov R, Nadel FM...

CT imaging ofhead-injured children has risks of radiation-induced malignancy. Our aim was to identify children at very low risk of clinically-important traumatic brain injuries (ciTBI) for whom CT might be unnecessary.

CT imaging ofhead-injured children has risks of radiation-induced malignancy. Our aim was to identify children at very low risk of clinically-important traumatic brain injuries (ciTBI) for whom CT might be unnecessary.

Key Study: Assessment of non-routine events and significant physiological disturbances during emergency department evaluation after pediatric head trauma.  (2021)

Key Study: Assessment of non-routine events and significant physiological disturbances during emergency department evaluation after pediatric head trauma.

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Alberto EC, Harvey AR, Amberson MJ, Zheng Y, Thenappan AA, Oluigbo C, et al

Alberto EC, Harvey AR, Amberson MJ, Zheng Y, Thenappan AA, Oluigbo C, et al

The purpose of this study was to determine the association of non-routine events (NREs) during the initial resuscitation phase with these physiological disturbances.

The purpose of this study was to determine the association of non-routine events (NREs) during the initial resuscitation phase with these physiological disturbances.

Key Study: Comparison of minor head trauma management in the emergency departments of a United States and Italian Children's hospital.  (2019)

Key Study: Comparison of minor head trauma management in the emergency departments of a United States and Italian Children's hospital.

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Stopa BM, Amoroso S, Ronfani L, Neri E, Barbi E, Lee LK.

Stopa BM, Amoroso S, Ronfani L, Neri E, Barbi E, Lee LK.

Pediatric head trauma management varies between emergency departments globally. Here we aim to compare the pediatric minor head trauma management between a US and Italian hospital.

Pediatric head trauma management varies between emergency departments globally. Here we aim to compare the pediatric minor head trauma management between a US and Italian hospital.

Key Study: A comparison of nebulized budesonide, intramuscular dexamethasone, and placebo for moderately severe croup  (1998)

Key Study: A comparison of nebulized budesonide, intramuscular dexamethasone, and placebo for moderately severe croup

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Johnson, DW, Jacobson, S, Edney, PC, Hadfield, P, Mundy, ME, Schuh, S,

Johnson, DW, Jacobson, S, Edney, PC, Hadfield, P, Mundy, ME, Schuh, S,

Objective: To study how budesonide compares with dexamethasone, the conventional therapy for croup, and whether either reduces the rate of hospitalization.

Objective: To study how budesonide compares with dexamethasone, the conventional therapy for croup, and whether either reduces the rate of hospitalization.

Key Study: Adjunctive corticosteroid therapy in pediatric severe sepsis: observations from the RESOLVE study (2011)

Key Study: Adjunctive corticosteroid therapy in pediatric severe sepsis: observations from the RESOLVE study (2011)

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Zimmerman JJW, M. D.

Zimmerman JJW, M. D.

Objective: To assess whether corticosteroids, used as adjunctive therapy for pediatric severe sepsis, is associated with improved outcomes. Published: 2011.

Objective: To assess whether corticosteroids, used as adjunctive therapy for pediatric severe sepsis, is associated with improved outcomes. Published: 2011.

Key Study: Emergency management of children with severe sepsis in the United Kingdom: the results of the Paediatric Intensive Care Society sepsis audit (2009)

Key Study: Emergency management of children with severe sepsis in the United Kingdom: the results of the Paediatric Intensive Care Society sepsis audit (2009)

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Inwald DPT, R. C.; Peters, M. J.; Nadel, S.

Inwald DPT, R. C.; Peters, M. J.; Nadel, S.

Objective: To audit current UK practice of the management of severe sepsis in children against the 2002 American College of Critical Care Medicine/Pediatric Advanced Life Support (ACCM-PALS) guideline. Published: 2009.

Objective: To audit current UK practice of the management of severe sepsis in children against the 2002 American College of Critical Care Medicine/Pediatric Advanced Life Support (ACCM-PALS) guideline. Published: 2009.

Key Study: Early goal-directed therapy in the treatment of severe sepsis and septic shock (2001)

Key Study: Early goal-directed therapy in the treatment of severe sepsis and septic shock (2001)

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Rivers EN, B.; Havstad, S.; Ressler, J.; Muzzin, A.; Knoblich, B.; Peterson, E.; Tomlanovich, M.

Rivers EN, B.; Havstad, S.; Ressler, J.; Muzzin, A.; Knoblich, B.; Peterson, ...

Background: Goal-directed therapy has been used for severe sepsis and septic shock in the intensive care unit. This approach involves adjustments of cardiac preload, afterload, and contractility to balance oxygen delivery with oxygen demand. The purpose of this study was to evaluate the efficacy of early goal-directed therapy before admission to the intensive care unit. Published: 2001.

Background: Goal-directed therapy has been used for severe sepsis and septic shock in the intensive care unit. This approach involves adjustments of cardiac preload, afterload, and contractility to balance oxygen delivery with oxygen demand. The purpose of this study was to evaluate the efficacy of early goal-directed therapy before admission to the intensive care unit. Published: 2001.

Key Study: Early coagulopathy is an independent predictor of mortality in children after severe trauma  (2013)

Key Study: Early coagulopathy is an independent predictor of mortality in children after severe trauma

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Whittaker B, Christiaans SC, Altice JL, Chen MK, Bartolucci AA, Morgan CJ, Kerby JD, Pittet JF

Whittaker B, Christiaans SC, Altice JL, Chen MK, Bartolucci AA, Morgan CJ, Ke...

To determine whether early coagulopathy affects the mortality associated with severe civilian pediatrictrauma,traumapatientsyounger than 18 years admitted to a pediatric intensive care unit from 2001 to 2010 were evaluated.

To determine whether early coagulopathy affects the mortality associated with severe civilian pediatrictrauma,traumapatientsyounger than 18 years admitted to a pediatric intensive care unit from 2001 to 2010 were evaluated.

Key Study: Disimpaction of children with severe constipation in 3-4 days in a suburban clinic using polyethylene glycol with electrolytes and sodium picosulphate  (2015)

Key Study: Disimpaction of children with severe constipation in 3-4 days in a suburban clinic using polyethylene glycol with electrolytes and sodium picosulphate

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Jordan-Ely J, Hutson JM, Southwell BR

Jordan-Ely J, Hutson JM, Southwell BR

The aim of this study was to assess the effectiveness of a high-dose oral protocol using polyethylene glycol with electrolytes (PEG + E) (Movicol Rx) combined with sodium picosulphate (SP) (Dulcolax SP Rx) in faecal impaction in children presenting to a suburban clinic.

The aim of this study was to assess the effectiveness of a high-dose oral protocol using polyethylene glycol with electrolytes (PEG + E) (Movicol Rx) combined with sodium picosulphate (SP) (Dulcolax SP Rx) in faecal impaction in children presenting to a suburban clinic.

Key Study: Development and implementation of a standardized pathway in the Pediatric Intensive Care Unit for children with severe traumatic brain injuries  (2016)

Key Study: Development and implementation of a standardized pathway in the Pediatric Intensive Care Unit for children with severe traumatic brain injuries

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Rakes L, King M, Johnston B, Chesnut R, Grant R, Vavilala M

Rakes L, King M, Johnston B, Chesnut R, Grant R, Vavilala M

The aim of this quality improvement project was to increase TBI guideline adherence by implementing a standard care pathway for PICU management of children with severe TBI.

The aim of this quality improvement project was to increase TBI guideline adherence by implementing a standard care pathway for PICU management of children with severe TBI.

Key Study: Predicting severe bacterial infections in well-appearing febrile neonates: laboratory markers accuracy and duration of fever  (2010)

Key Study: Predicting severe bacterial infections in well-appearing febrile neonates: laboratory markers accuracy and duration of fever

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Bressan S, Andreola B, Cattelan F, Zangardi T, Perilongo G, Da Dalt L

Bressan S, Andreola B, Cattelan F, Zangardi T, Perilongo G, Da Dalt L

The objective of this study was to assess the diagnostic accuracy of white blood cell count, absolute neutrophil count, and C-reactive protein in detecting severe bacterial infections in well-appearing neonates with early onset fever without source and in relation to fever duration.

The objective of this study was to assess the diagnostic accuracy of white blood cell count, absolute neutrophil count, and C-reactive protein in detecting severe bacterial infections in well-appearing neonates with early onset fever without source and in relation to fever duration.

Key study: How fast does oral dexamethasone work in mild to moderately severe croup? A randomized double-blinded clinical trial  (2012)

Key study: How fast does oral dexamethasone work in mild to moderately severe croup? A randomized double-blinded clinical trial

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Dobrovoljac M, Geelhoed GC

Dobrovoljac M, Geelhoed GC

Objective: For children with croup controversy remains over dosage and time to onset of action of oral steroids. The Cochrane Collaboration and other reviews have suggested 0.6 mg/kg dexamethasone be used (despite some evidence that 0.15 mg/kg is effective) with no expectation of benefit before 4-6 h. This randomized double-blinded clinical trial examines whether 0.15 mg/kg dexamethasone works by 30 min. Published: 2012.

Objective: For children with croup controversy remains over dosage and time to onset of action of oral steroids. The Cochrane Collaboration and other reviews have suggested 0.6 mg/kg dexamethasone be used (despite some evidence that 0.15 mg/kg is effective) with no expectation of benefit before 4-6 h. This randomized double-blinded clinical trial examines whether 0.15 mg/kg dexamethasone works by 30 min. Published: 2012.

Key study: A randomized comparison of dexamethasone 0.15 mg/kg versus 0.6 mg/kg for the treatment of moderate to severe croup  (2007)

Key study: A randomized comparison of dexamethasone 0.15 mg/kg versus 0.6 mg/kg for the treatment of moderate to severe croup

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Chub-Uppakarn S, Sangsupawanich P

Chub-Uppakarn S, Sangsupawanich P

Objective: The aim of this study was to investigate the effectiveness of dexamethasone 0.15 mg/kg single dose compared with the recommended dose of 0.6 mg/kg for treatment of hospitalized children with moderate to severe croup.

Objective: The aim of this study was to investigate the effectiveness of dexamethasone 0.15 mg/kg single dose compared with the recommended dose of 0.6 mg/kg for treatment of hospitalized children with moderate to severe croup.

Key study: Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single centers observational study.  (2020)

Key study: Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single centers observational study.

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Sun D, Li H, Lu X, et al.,

Sun D, Li H, Lu X, et al.,

Objective: To describe the clinical features of severe pediatric patients with COVID-19.

Objective: To describe the clinical features of severe pediatric patients with COVID-19.

Key Study: Nebulised hypertonic saline (3%) among children with mild to moderately severe bronchiolitis--a double blind randomized controlled trial  (2015)

Key Study: Nebulised hypertonic saline (3%) among children with mild to moderately severe bronchiolitis--a double blind randomized controlled trial

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Khanal A, Sharma A, Basnet S, Sharma PR, Gami FC

Khanal A, Sharma A, Basnet S, Sharma PR, Gami FC

Objective: To Assess the efficacy of nebulised hypertonic saline (HS) (3%) among children with mild to moderately severe bronchiolitis.

Objective: To Assess the efficacy of nebulised hypertonic saline (HS) (3%) among children with mild to moderately severe bronchiolitis.

Key study: Assessment of 135794 pediatric patients tested for severe scute respiratory syndrome coronavirus across the United States.  (2020)

Key study: Assessment of 135794 pediatric patients tested for severe scute respiratory syndrome coronavirus across the United States.

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Bailey LC, Razzaghi H, Burrows EK, et al.

Bailey LC, Razzaghi H, Burrows EK, et al.

Objective: To describe testing for SARS-CoV-2 and the epidemiology of infected patients.

Objective: To describe testing for SARS-CoV-2 and the epidemiology of infected patients.

Key study: Severe acute respiratory syndrome coronavirus 2 clinical syndromes and predictors of disease severity in hospitalized children and youth.  (2020)

Key study: Severe acute respiratory syndrome coronavirus 2 clinical syndromes and predictors of disease severity in hospitalized children and youth.

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Fernandes DM, Oliveira CR, Guerguis S, et al.

Fernandes DM, Oliveira CR, Guerguis S, et al.

Objective: To characterize the demographic and clinical features of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) syndromes and identify admission variables predictive of disease severity.

Objective: To characterize the demographic and clinical features of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) syndromes and identify admission variables predictive of disease severity.

Key study: Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome.  (2020)

Key study: Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome.

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Pereira MFB, Litvinov N, Farhat SCL, et al.

Pereira MFB, Litvinov N, Farhat SCL, et al.

Objectives: To assess the outcomes of pediatric patients with laboratory-confirmed coronavirus disease (COVID-19) with or without multisystem inflammatory syndrome in children (MIS-C).

Objectives: To assess the outcomes of pediatric patients with laboratory-confirmed coronavirus disease (COVID-19) with or without multisystem inflammatory syndrome in children (MIS-C).

Key Study: Child abuse and orthopaedic injury patterns:analysis at a level I pediatric trauma center  (2009)

Key Study: Child abuse and orthopaedic injury patterns:analysis at a level I pediatric trauma center

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Pandya NK, Baldwin K, Wolfgruber H, Christian CW, Drummond DS, Hosalkar HS

Pandya NK, Baldwin K, Wolfgruber H, Christian CW, Drummond DS, Hosalkar HS

The purpose of our study was to describe the patterns of orthopaedic injury for child abuse cases detected in the large urban area that our institution serves, and to compare the injury profiles of these victims of child abuse to that of general (accidental) trauma patients seen in the emergency room and/or hospitalized during the same time period.

The purpose of our study was to describe the patterns of orthopaedic injury for child abuse cases detected in the large urban area that our institution serves, and to compare the injury profiles of these victims of child abuse to that of general (accidental) trauma patients seen in the emergency room and/or hospitalized during the same time period.

Key Study: Epidemiology of Injury-Related Emergency Department Visits in the US Among Youth with Autism Spectrum Disorder  (2016)

Key Study: Epidemiology of Injury-Related Emergency Department Visits in the US Among Youth with Autism Spectrum Disorder

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Kalb LG, Vasa RA, Ballard ED, Woods S, Goldstein M, Wilcox HC

Kalb LG, Vasa RA, Ballard ED, Woods S, Goldstein M, Wilcox HC

This study aims to use nationally-representative emergency department data to characterize injury-related ED visits among youth with autism spectrum disorder.

This study aims to use nationally-representative emergency department data to characterize injury-related ED visits among youth with autism spectrum disorder.

Key Study: Injury treatment among children with autism or pervasive developmental disorder  (2008)

Key Study: Injury treatment among children with autism or pervasive developmental disorder

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McDermott S, Zhou L, Mann J

McDermott S, Zhou L, Mann J

This study examined the difference in the frequency and type of injury for children with autism and pervasive developmental disorder compared with typically developing peers.

This study examined the difference in the frequency and type of injury for children with autism and pervasive developmental disorder compared with typically developing peers.

Key Study: A clinical decision rule for the use of plain radiography in children after acute wrist injury: development and external validation of the Amsterdam Pediatric Wrist Rules  (2016)

Key Study: A clinical decision rule for the use of plain radiography in children after acute wrist injury: development and external validation of the Amsterdam Pediatric Wrist Rules

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Slaar A, Walenkamp MM, Bentohami A, Maas M, van Rijn RR, Steyerberg EW, Jager LC, Sosef NL, van Velde R, Ultee JM, Goslings JC, Schep NW

Slaar A, Walenkamp MM, Bentohami A, Maas M, van Rijn RR, Steyerberg EW, Jager...

The objective of this study was to develop and validate a clinica decision rule to decide whether radiography in children with wrist trauma is required.

The objective of this study was to develop and validate a clinica decision rule to decide whether radiography in children with wrist trauma is required.

Key Study: Investigating the Connection Between Traumatic Brain Injury and Posttraumatic Stress Symptoms in Adolescents  (2017)

Key Study: Investigating the Connection Between Traumatic Brain Injury and Posttraumatic Stress Symptoms in Adolescents

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Rhine T, Cassedy A, Yeates KO, Taylor HG, Kirkwood MW, Wade SL

Rhine T, Cassedy A, Yeates KO, Taylor HG, Kirkwood MW, Wade SL

To identify potentially modifiable individual and social-environmental correlates of posttraumatic stress symptoms (PTSS) among adolescents hospitalized for traumatic brain injury (TBI).

To identify potentially modifiable individual and social-environmental correlates of posttraumatic stress symptoms (PTSS) among adolescents hospitalized for traumatic brain injury (TBI).

Key study: Admission of pediatric concussion injury patients: is it necessary?  (2019)

Key study: Admission of pediatric concussion injury patients: is it necessary?

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Lindholm EB, DCruz R, Fajardo R, et al.

Lindholm EB, DCruz R, Fajardo R, et al.

The purpose of this study was to determine if pediatric patients evaluated in the emergency department (ED) for concussion with a negative head CT scan require routine hospital admission.

The purpose of this study was to determine if pediatric patients evaluated in the emergency department (ED) for concussion with a negative head CT scan require routine hospital admission.

Key study: Association of time since injury to the first clinic visit with recovery following concussion  (2020)

Key study: Association of time since injury to the first clinic visit with recovery following concussion

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Kontos AP, Jorgensen-Wagers K, Trbovich AM, et al.

Kontos AP, Jorgensen-Wagers K, Trbovich AM, et al.

To investigate the association of time since injury with initiation of clinical care on recovery time following concussion.

To investigate the association of time since injury with initiation of clinical care on recovery time following concussion.

Key study: Early versus delayed emergency department presentation following mild traumatic nrain injury and the presence of symptom at 1, 4 and 12 weeks in children  (2020)

Key study: Early versus delayed emergency department presentation following mild traumatic nrain injury and the presence of symptom at 1, 4 and 12 weeks in children

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Gravel J, Ledoux AA, Tang K, et al.

Gravel J, Ledoux AA, Tang K, et al.

We evaluated the association between timing of presentation and postconcussive symptoms (PCS) at 1, 4 and 12 weeks after injury.

We evaluated the association between timing of presentation and postconcussive symptoms (PCS) at 1, 4 and 12 weeks after injury.

Key study: MRI in mild pediatric traumatic brain injury: diagnostic overkill or useful tool?  (2018)

Key study: MRI in mild pediatric traumatic brain injury: diagnostic overkill or useful tool?

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Cohrs, G., Huhndorf, M., Niemczyk, N. et al.

Cohrs, G., Huhndorf, M., Niemczyk, N. et al.

Magnetic resonance imaging (MRI) is a sensitive imaging tool which lacks the burden of ionizing radiation. It is not established as primary diagnostic tool in traumatic brain injury (TBI). The purpose of this study was to evaluate the usefulness of MRI as initial imaging modality in the emergency management of mild pediatric TBI.

Magnetic resonance imaging (MRI) is a sensitive imaging tool which lacks the burden of ionizing radiation. It is not established as primary diagnostic tool in traumatic brain injury (TBI). The purpose of this study was to evaluate the usefulness of MRI as initial imaging modality in the emergency management of mild pediatric TBI.

Key study: Physical activity after mild traumatic brain injury: what are the relationships with fatigue and sleep quality?  (2019)

Key study: Physical activity after mild traumatic brain injury: what are the relationships with fatigue and sleep quality?

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van Markus-Doornbosch F, Peeters E, van der Pas S, Vlieland TV, Meesters J.

van Markus-Doornbosch F, Peeters E, van der Pas S, Vlieland TV, Meesters J.

To determine self-reported physical activity (PA) levels and relationships with fatigue and sleep quality in adolescents and young adults after mild traumatic brain injury (mTBI).

To determine self-reported physical activity (PA) levels and relationships with fatigue and sleep quality in adolescents and young adults after mild traumatic brain injury (mTBI).

Key study: Practice patterns in pharmacological and non-pharmacological therapies for children with mild traumatic brain injury: a survey of 15 canadian and United States centers  (2019)

Key study: Practice patterns in pharmacological and non-pharmacological therapies for children with mild traumatic brain injury: a survey of 15 canadian and United States centers

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Mannix R, Zemek R, Yeates KO, et al.

Mannix R, Zemek R, Yeates KO, et al.

Given the lack of evidence regarding effective pharmacological and non-pharmacological interventions for pediatric mild traumatic brain injury (mTBI) and the resultant lack of treatment recommendations reflected in consensus guidelines, variation in the management of pediatric mTBI is to be expected. We therefore surveyed practitioners across 15 centers in the United States and Canada who care for children with pediatric mTBI to evaluate common-practice variation in the management of pediatric mTBI.

Given the lack of evidence regarding effective pharmacological and non-pharmacological interventions for pediatric mild traumatic brain injury (mTBI) and the resultant lack of treatment recommendations reflected in consensus guidelines, variation in the management of pediatric mTBI is to be expected. We therefore surveyed practitioners across 15 centers in the United States and Canada who care for children with pediatric mTBI to evaluate common-practice variation in the management of pediatric mTBI.

Key study: Risk factors for prolonged symptoms of mild traumatic brain injury: a pediatric sports concussion clinic cohort  (2019)

Key study: Risk factors for prolonged symptoms of mild traumatic brain injury: a pediatric sports concussion clinic cohort

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Fehr SD, Nelson LD, Scharer KR, et al.

Fehr SD, Nelson LD, Scharer KR, et al.

To examine predictors of prolonged symptom duration from mild traumatic brain injury (mTBI) in a pediatric sports medicine specialty clinic cohort as these predictors may be distinct in this population.

To examine predictors of prolonged symptom duration from mild traumatic brain injury (mTBI) in a pediatric sports medicine specialty clinic cohort as these predictors may be distinct in this population.

Key Study: The use of Rotterdam CT score for prediction of outcomes in pediatric traumatic brain injury patients admitted to emergency service.  (2020)

Key Study: The use of Rotterdam CT score for prediction of outcomes in pediatric traumatic brain injury patients admitted to emergency service.

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Katar S, Aydin Ozturk P, Ozel M, Arac S, Evran S, Cevik S, et al.

Katar S, Aydin Ozturk P, Ozel M, Arac S, Evran S, Cevik S, et al.

In this study, we aimed to evaluate the use of the Rotterdam scale on pediatric trauma patients in our country and assess its relationship with lesion type, location and severity, trauma type, and need for surgery.

In this study, we aimed to evaluate the use of the Rotterdam scale on pediatric trauma patients in our country and assess its relationship with lesion type, location and severity, trauma type, and need for surgery.

Key Study: An Exploration of Emergency Department Visits for Home Unintentional Injuries Among Children With Autism Spectrum Disorder for Evidence to Modify Injury Prevention Guidelines  (2021)

Key Study: An Exploration of Emergency Department Visits for Home Unintentional Injuries Among Children With Autism Spectrum Disorder for Evidence to Modify Injury Prevention Guidelines

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Jones V, Ryan L, Rooker G, Debinski B, Parnham T, Mahoney P, et al.

Jones V, Ryan L, Rooker G, Debinski B, Parnham T, Mahoney P, et al.

Current childhood injury prevention guidance is anchored by a child's age. For example, children are considered at high risk for falls at ages 4 years and less, and guidance for prevention focuses on these ages. However, these guidelines may not be adequate for children with autism spectrum disorders (ASD). Analyses suggest that unintentional home injury prevention for children with ASD may require prevention guidance extended through older ages.

Current childhood injury prevention guidance is anchored by a child's age. For example, children are considered at high risk for falls at ages 4 years and less, and guidance for prevention focuses on these ages. However, these guidelines may not be adequate for children with autism spectrum disorders (ASD). Analyses suggest that unintentional home injury prevention for children with ASD may require prevention guidance extended through older ages.

Acute Kidney Injury in Critically Ill Children Admitted to the PICU for Diabetic Ketoacidosis. A Retrospective Study.  (2019)

Acute Kidney Injury in Critically Ill Children Admitted to the PICU for Diabetic Ketoacidosis. A Retrospective Study.

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Weissbach A, Zur N, Kaplan E, Kadmon G, Gendler Y, Nahum E.

Weissbach A, Zur N, Kaplan E, Kadmon G, Gendler Y, Nahum E.

Acute kidney injury in the critically ill pediatric population is associated with worse outcome. The aim of this study was to assess the prevalence, associated clinical variables, and outcomes of acute kidney injury in children admitted to the PICU with diabetic ketoacidosis.

Acute kidney injury in the critically ill pediatric population is associated with worse outcome. The aim of this study was to assess the prevalence, associated clinical variables, and outcomes of acute kidney injury in children admitted to the PICU with diabetic ketoacidosis.

Key Study: Are CT scans obtained at referring institutions justified prior to transfer to a pediatric trauma center?  (2014)

Key Study: Are CT scans obtained at referring institutions justified prior to transfer to a pediatric trauma center?

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Benedict LA, Paulus JK, Rideout L, Chwals WJ

Benedict LA, Paulus JK, Rideout L, Chwals WJ

To assess whether pediatrictraumapatientsinitially evaluated at referring institutions met Massachusetts statewidetraumafield triage criteria for stabilization and immediate transfer to a PediatricTraumaCenter (PTC) without pre-transfer CT imaging.

To assess whether pediatrictraumapatientsinitially evaluated at referring institutions met Massachusetts statewidetraumafield triage criteria for stabilization and immediate transfer to a PediatricTraumaCenter (PTC) without pre-transfer CT imaging.

Key Study: The emerging use of ketamine for anesthesia and sedation in traumatic brain injuries  (2013)

Key Study: The emerging use of ketamine for anesthesia and sedation in traumatic brain injuries

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Chang LC, Raty SR, Ortiz J, Bailard NS, Mathew SJ

Chang LC, Raty SR, Ortiz J, Bailard NS, Mathew SJ

This article reviews the current literature in regards to using ketamine inpatientswith traumatic brain injuries in different clinical settings associated with anesthesia, as well as reviews the potential mechanisms underlying the neuroprotective effects of ketamine.

This article reviews the current literature in regards to using ketamine inpatientswith traumatic brain injuries in different clinical settings associated with anesthesia, as well as reviews the potential mechanisms underlying the neuroprotective effects of ketamine.

Key Study: Ability of emergency ultrasonography to detect pediatric skull fractures: a prospective, observational study  (2013)

Key Study: Ability of emergency ultrasonography to detect pediatric skull fractures: a prospective, observational study

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Parri N, Crosby BJ, Glass C, Mannelli F, Sforzi I, Schiavone R, Ban KM

Parri N, Crosby BJ, Glass C, Mannelli F, Sforzi I, Schiavone R, Ban KM

Our objective was to determine if bedside ED ultrasound is an accurate diagnostic tool for identifying skull fractures when compared toheadCT.

Our objective was to determine if bedside ED ultrasound is an accurate diagnostic tool for identifying skull fractures when compared toheadCT.

Key Study: Reliability and validity of the Pediatric Intensity Level of Therapy (PILOT) scale: a measure of the use of intracranial pressure-directed therapies  (2006)

Key Study: Reliability and validity of the Pediatric Intensity Level of Therapy (PILOT) scale: a measure of the use of intracranial pressure-directed therapies

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Shore PM, Hand LL, Roy L, Trivedi P, Kochanek PM, Adelson PD

Shore PM, Hand LL, Roy L, Trivedi P, Kochanek PM, Adelson PD

To test the reliability and validity of the Pediatric Intensity Level of Therapy (PILOT) scale, a novel measure of overall therapeutic effort directed at controlling intracranial pressure (ICP) in the setting of severe (Glasgow Coma Scale of

To test the reliability and validity of the Pediatric Intensity Level of Therapy (PILOT) scale, a novel measure of overall therapeutic effort directed at controlling intracranial pressure (ICP) in the setting of severe (Glasgow Coma Scale of

Key Study: Prevalence and Impact of Admission Acute Traumatic Coagulopathy on Treatment Intensity, Resource Use, and Mortality: An Evaluation of 956 Severely Injured Children and Adolescents  (2017)

Key Study: Prevalence and Impact of Admission Acute Traumatic Coagulopathy on Treatment Intensity, Resource Use, and Mortality: An Evaluation of 956 Severely Injured Children and Adolescents

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Liras IN, Caplan HW, Stensballe J, Wade CE, Cox CS, Cotton BA

Liras IN, Caplan HW, Stensballe J, Wade CE, Cox CS, Cotton BA

The purpose of this study was to assess the prevalence and impact of arrival coagulopathy, determined by viscoelastic hemostatic testing, in severely injured children.

The purpose of this study was to assess the prevalence and impact of arrival coagulopathy, determined by viscoelastic hemostatic testing, in severely injured children.

Key Study: Intracranial pressure monitoring associated with increased mortality in pediatric brain injuries.  (2020)

Key Study: Intracranial pressure monitoring associated with increased mortality in pediatric brain injuries.

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Delaplain PT, Grigorian A, Lekawa M, Mallicote M, Joe V, Schubl SD, et al.

Delaplain PT, Grigorian A, Lekawa M, Mallicote M, Joe V, Schubl SD, et al.

Utilization of ICP monitors for pediatric patients is low and varies between centers. We hypothesized that in more severely injured patients (GCS 3-4), there would be a decreased mortality associated with invasive monitoring devices.

Utilization of ICP monitors for pediatric patients is low and varies between centers. We hypothesized that in more severely injured patients (GCS 3-4), there would be a decreased mortality associated with invasive monitoring devices.

Other

Intranasal Lorazepam for Treatment of Severe Agitation in a Pediatric Behavioral Health Patient in the Emergency Department  (2020)

Intranasal Lorazepam for Treatment of Severe Agitation in a Pediatric Behavioral Health Patient in the Emergency Department

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Bregstein, J. S., A. M. Wagh and D. S. Tsze

Bregstein, J. S., A. M. Wagh and D. S. Tsze

Conventional intramuscular sedatives versus ziprasidone for severe agitation in adolescents: case-control study  (2009)

Conventional intramuscular sedatives versus ziprasidone for severe agitation in adolescents: case-control study

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Jangro, W. C., H. Preval, R. Southard, S. G. Klotz and A. Francis

Jangro, W. C., H. Preval, R. Southard, S. G. Klotz and A. Francis

A prospective study of ketamine versus haloperidol for severe prehospital agitation  (2016)

A prospective study of ketamine versus haloperidol for severe prehospital agitation

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Cole, J. B., J. C. Moore, P. C. Nystrom, B. S. Orozco, S. J. Stellpflug, R. L. Kornas, B. J. Fryza, L. W. Steinberg, A. O'Brien-Lambert, P. Bache-Wiig, K. M....

Cole, J. B., J. C. Moore, P. C. Nystrom, B. S. Orozco, S. J. Stellpflug, R. L...

Ketamine reduces the need for intubation in patients with acute severe mental illness and agitation requiring transport to definitive care: An observational study  (2017)

Ketamine reduces the need for intubation in patients with acute severe mental illness and agitation requiring transport to definitive care: An observational study

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Parsch, C. S., A. Boonstra, D. Teubner, W. Emmerton, B. McKenny and D. Y. Ellis

Parsch, C. S., A. Boonstra, D. Teubner, W. Emmerton, B. McKenny and D. Y. Ellis

Psychiatric Outcomes of Patients With Severe Agitation Following Administration of Prehospital Ketamine  (2019)

Psychiatric Outcomes of Patients With Severe Agitation Following Administration of Prehospital Ketamine

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Lebin, J. A., A. R. Akhavan, D. S. Hippe, M. H. Gittinger, J. Pasic, A. M. McCoy and M. C. Vrablik

Lebin, J. A., A. R. Akhavan, D. S. Hippe, M. H. Gittinger, J. Pasic, A. M. Mc...

Emergency Medicine Cases Podcast: Pediatric Trauma  (2017)

Emergency Medicine Cases Podcast: Pediatric Trauma

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Dr. Sue Beno, Dr. Faud Alnaji

Dr. Sue Beno, Dr. Faud Alnaji

Management of the pediatric trauma patient is challenging regardless of where you work. In this EM Cases episode, two leading pediatric trauma experts, Dr. Sue Beno from Hospital for Sick Children in Toronto and Dr. Faud Alnaji from Children’s Hospital of Eastern Ontario in Ottawa answer such questions as: what are the most important physiologic and anatomic differences between children and adults that are key to managing the trauma patient? How much fluid should be given prior to blood products? What is the role of POCUS in abdominal trauma? Which patients require abdominal CT?

Management of the pediatric trauma patient is challenging regardless of where you work. In this EM Cases episode, two leading pediatric trauma experts, Dr. Sue Beno from Hospital for Sick Children in Toronto and Dr. Faud Alnaji from Children’s Hospital of Eastern Ontario in Ottawa answer such questions as: what are the most important physiologic and anatomic differences between children and adults that are key to managing the trauma patient? How much fluid should be given prior to blood products? What is the role of POCUS in abdominal trauma? Which patients require abdominal CT?

TREKK.ca Info Pages

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Brain Injury Awareness month

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Brain Injury Awareness Month 2019

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Predicting the duration of post-concussion symptoms

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Croup in children - a Canadian Medical Association Review

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New Podcast: Pediatric Physical Abuse Recognition and Management

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Croup Storybooks

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Posted: Aug 08, 2014  | Announcement  | Team: News and Events 


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New asthma video for parents

Posted: Mar 22, 2021  | Announcement  | Team: News and Events 


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Does a child's cough sound like a barking seal? Could be croup

Posted: May 01, 2015  | Announcement  | Team: News and Events 
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NEW Burns Bottom Line Recommendations

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