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Flow diagram for the management of children with suspected and confirmed acute otitis media
Le Saux N, Robinson JL, Canadian Paediatric Society, Infectious Diseases and Immunization Committee
Le Saux N, Robinson JL, Canadian Paediatric Society, Infectious Diseases and ...
Flow chart of criteria for management of children with suspected and confirmed acute otitis media based on symptoms of children over 6 months of age.
Flow chart of criteria for management of children with suspected and confirmed acute otitis media based on symptoms of children over 6 months of age.
Acute Otitis Media- Emergency Management in Children - Flowchart
Children's Health Queensland Hospital and Health Service
Children's Health Queensland Hospital and Health Service
Flowchart of emergency management in children for acute otitis media.
Flowchart of emergency management in children for acute otitis media.
Bottom Line Recommendations: Acute Otitis Media (2022)
Dr. Nicole Le Saux
Dr. Nicole Le Saux
Bottom line recommendations for the treatment of acute otitis media. Published online November (2022).
Bottom line recommendations for the treatment of acute otitis media. Published online November (2022).
Videos in clinical medicine. Diagnosing otitis media--otoscopy and cerumen removal
Shaikh N, Hoberman A, Kaleida PH, Ploof DL, Paradise JL
Shaikh N, Hoberman A, Kaleida PH, Ploof DL, Paradise JL
Video instructing how to diagnose otitis media with otoscopy and cerum removal.
Video instructing how to diagnose otitis media with otoscopy and cerum removal.
Bottom Line: Management of Acute Symptoms Algorithm
Ontario Neurotrauma Foundation
Ontario Neurotrauma Foundation
This document is intended to guide health care professionals in diagnosing and managing pediatric concussion. See Page 48 of this document for the Management of Acute Symptoms Algorithm (Tool 2.1).
This document is intended to guide health care professionals in diagnosing and managing pediatric concussion. See Page 48 of this document for the Management of Acute Symptoms Algorithm (Tool 2.1).
Bottom Line: Acute Concussion Evaluation (ACE): Physician/Clinician Office Version
Goia G, Collins M
Goia G, Collins M
The ACE is intended to provide an evidence-based clinical protocol to conduct an initial evaluation and diagnosis of patients (both children and adults) with known or suspected mild traumatic brain injury.
The ACE is intended to provide an evidence-based clinical protocol to conduct an initial evaluation and diagnosis of patients (both children and adults) with known or suspected mild traumatic brain injury.
Executive Summary: Evaluation and Management of Children and Adolescents With Acute Mental Health or Behavioral Problems. Part I: Common Clinical Challenges of Patients With Mental Health and/or Behavioral Emergencies
Chun TH, Mace SE, Katz ER, American Academy of Pediatrics Committee on Pediatric Emergency Medicine, American College of Emergency Physicians Pediatric Emerg...
Chun TH, Mace SE, Katz ER, American Academy of Pediatrics Committee on Pediat...
This executive summary is an overview of the common clinical challenges pediatric caregivers face when a child or adolescent presents with a psychiatric chief complaint or emergency.
This executive summary is an overview of the common clinical challenges pediatric caregivers face when a child or adolescent presents with a psychiatric chief complaint or emergency.
Executive Summary: Evaluation and Management of Children With Acute Mental Health or Behavioral Problems. Part II: Recognition of Clinically Challenging Mental Health Related Conditions Presenting With Medical or Uncertain Symptoms
Chun TH, Mace SE, Katz ER, American Academy of Pediatrics Committee on Pediatric Emergency Medicine, American College of Emergency Physicians Pediatric Emerg...
Chun TH, Mace SE, Katz ER, American Academy of Pediatrics Committee on Pediat...
This executive summary is an overview of the common clinical challenges pediatric caregivers face when a mental health condition may be an unclear or complicating factor in a non-mental health ED presentation.
This executive summary is an overview of the common clinical challenges pediatric caregivers face when a mental health condition may be an unclear or complicating factor in a non-mental health ED presentation.
Acute Procedural Pain: Paediatric Recommendations and Implementation Toolkits
The Canadian Association of Paediatric Health Centres, Knowledge Exchange Network
The Canadian Association of Paediatric Health Centres, Knowledge Exchange Net...
Objective: This overview is intended to summarize the systematic reviews of interventions studied to decrease paediatric pain that are currently available in the Cochrane Library. Given their unique physiology, research relevant to the management of newbo
Objective: This overview is intended to summarize the systematic reviews of interventions studied to decrease paediatric pain that are currently available in the Cochrane Library. Given their unique physiology, research relevant to the management of newbo
Recommandations de base: Otite moyenne aigue (2022)
Dr. Nicole Le Saux
Dr. Nicole Le Saux
French bottom line recommendations for the treatment of acute otitis media. Published online November, 2022.
French bottom line recommendations for the treatment of acute otitis media. Published online November, 2022.
Clinical Practice Guideline: Acute otitis media - Emergency management in children
Children's Health Queensland Hospital and Health Service
Children's Health Queensland Hospital and Health Service
Children's Health Queensland Statewide Paediatric Guideline for emergency management of acute otitis media in children.
Children's Health Queensland Statewide Paediatric Guideline for emergency management of acute otitis media in children.
Clinical Practice Guideline: Otitis media (acute): antimicrobial prescribing
National Institute for Health and Care Excellence (NICE) NICE Guideline
National Institute for Health and Care Excellence (NICE) NICE Guideline
Objective: This guideline sets out an antimicrobial prescribing strategy for acute otitis media (ear infection). aims to limit antibiotic use and reduce antimicrobial resistance.
Objective: This guideline sets out an antimicrobial prescribing strategy for acute otitis media (ear infection). aims to limit antibiotic use and reduce antimicrobial resistance.
Clinical Practice Guideline: The diagnosis and management of acute otitis media
Lieberthal AS, Carroll AE, Chonmaitree T, Ganiats TG, Hoberman A, Jackson MA, Joffe MD, Miller DT, Rosenfeld RM, Sevilla XD, Schwartz RH, Thomas PA, Tunkel DE
Lieberthal AS, Carroll AE, Chonmaitree T, Ganiats TG, Hoberman A, Jackson MA,...
Evidence-based clinical practice guideline from the American Academy of Pediatrics (AAP) and American Academy of Family Physicians.
Evidence-based clinical practice guideline from the American Academy of Pediatrics (AAP) and American Academy of Family Physicians.
Clinical Practice Guideline: Management of acute otitis media in children six months of age and older
Le Saux N, Robinson JL, Canadian Paediatric Society, Infectious Diseases and Immunization Committee
Le Saux N, Robinson JL, Canadian Paediatric Society, Infectious Diseases and ...
Canadian Paediatric Society position statement on the management of acute otitis media in children aged 6 months and older.
Canadian Paediatric Society position statement on the management of acute otitis media in children aged 6 months and older.
Clinical Practice Guideline: Acute Otitis Media
The Royal Children's Hospital Melbourne
The Royal Children's Hospital Melbourne
Guideline on the assessment and management of acute otitis media in children
Guideline on the assessment and management of acute otitis media in children
Clinical Practice Guideline: Diagnosis and management of Pediatric Acute Otitis Media (Ear Infection)
Intermountain Healthcare
Intermountain Healthcare
Objective: This CPM provides best-practice recommendations for diagnosis and management of acute otitis media (AOM), including guidance for appropriate use of antibiotics.
Objective: This CPM provides best-practice recommendations for diagnosis and management of acute otitis media (AOM), including guidance for appropriate use of antibiotics.
Clinical Practice Guideline: Danish guidelines on management of otitis media in preschool children
Heidemann CH, Lous J, Berg J, Christensen JJ, Hkonsen SJ, Jakobsen M, Johansen CJ, Nielsen LH, Hansen MP, Poulsen A, Schousboe LP, Skrubbeltrang C, Vind AB, ...
Heidemann CH, Lous J, Berg J, Christensen JJ, Hkonsen SJ, Jakobsen M, Johanse...
The Danish Health and Medicines Authority and the Danish Society of Otorhinolaryngology guidelines regarding the diagnostic criteria for acute otitis media and surgical treatment of recurrent AOM and chronic OME in preschool children.
The Danish Health and Medicines Authority and the Danish Society of Otorhinolaryngology guidelines regarding the diagnostic criteria for acute otitis media and surgical treatment of recurrent AOM and chronic OME in preschool children.
Clinical Practice Guideline: Management of otitis media with effusion in children. Socit franc aise dORL et de chirurgie cervico-faciale clinical practice guidelines
Blanc, F. et al.
Blanc, F. et al.
Objective: The Socit franaise dORL et de chirurgie cervico-faciale clinical practice guidelines concern the management of otitis media with effusion (OME) in children under the age of 12 years. They are based on extensive review of MEDLINE and Cochrane Library publications in English or French from 1996 to 2016 concerning the methods of diagnosis and assessment of otitis media with effusion, as well as the efficacy of tympanostomy tubes and medical and surgical treatments of OME.
Objective: The Socit franaise dORL et de chirurgie cervico-faciale clinical practice guidelines concern the management of otitis media with effusion (OME) in children under the age of 12 years. They are based on extensive review of MEDLINE and Cochrane Library publications in English or French from 1996 to 2016 concerning the methods of diagnosis and assessment of otitis media with effusion, as well as the efficacy of tympanostomy tubes and medical and surgical treatments of OME.
Clinical Practice Guideline: Resuscitation of blue baby and the use of prostaglandins
Linney M, Gnapragassam J, Wilson P, Rodd I
Linney M, Gnapragassam J, Wilson P, Rodd I
This document relates to the acute management of infants presenting acutely with collapse and/or cyanosis suggestive of congenital heart defect.
This document relates to the acute management of infants presenting acutely with collapse and/or cyanosis suggestive of congenital heart defect.
Clinical Practice Guideline: Management of the paediatric patient with acute head trauma
Farrell CA, Canadian Paediatric Society Acute Care Committee
Farrell CA, Canadian Paediatric Society Acute Care Committee
The purpose of this statement is to describe issues related to head trauma in infants, children and youth, including clinical manifestations, initial management priorities, guidelines for imaging, and subsequent observation and treatment.
The purpose of this statement is to describe issues related to head trauma in infants, children and youth, including clinical manifestations, initial management priorities, guidelines for imaging, and subsequent observation and treatment.
Clinical Practice Guideline: Evaluation and Management of Children and Adolescents With Acute Mental Health or Behavioral Problems. Part I: Common Clinical Challenges of Patients With Mental Health and/or Behavioral Emergencies
Chun TH, Mace SE, Katz ER, American Academy of Pediatrics Committee on Pediatric Emergency Medicine, American College of Emergency Physicians Pediatric Emerg...
Chun TH, Mace SE, Katz ER, American Academy of Pediatrics Committee on Pediat...
Part 1 of the report discusses the common clinical issues that may be encountered in caring for children and adolescents presenting to the emergency department or primary care setting with a mental health condition or emergency.
Part 1 of the report discusses the common clinical issues that may be encountered in caring for children and adolescents presenting to the emergency department or primary care setting with a mental health condition or emergency.
Clinical Practice Guideline: Evaluation and Management of Children With Acute Mental Health or Behavioral Problems. Part II: Recognition of Clinically Challenging Mental Health Related Conditions Presenting With Medical or Uncertain Symptoms
Chun TH, Mace SE, Katz ER, American Academy of Pediatrics Committee on Pediatric Emergency Medicine, American College of Emergency Physicians Pediatric Emerg...
Chun TH, Mace SE, Katz ER, American Academy of Pediatrics Committee on Pediat...
Part 2 of the report discusses the challenges a pediatric clinician may face when evaluating patients with a mental health condition, which may be contributing to or a complicating factor for a medical or indeterminate clinical presentation.
Part 2 of the report discusses the challenges a pediatric clinician may face when evaluating patients with a mental health condition, which may be contributing to or a complicating factor for a medical or indeterminate clinical presentation.
Acute management of croup in the emergency department
Ortiz-Alvarez O,
Ortiz-Alvarez O,
Acute management of croup in the emergency department.
Acute management of croup in the emergency department.
Clinical Practice Guideline: The recognition and assessment of acute pain in children
Royal College of Nursing
Royal College of Nursing
The guideline is aimed at a range of professional groups, patients and carers who may be involved in the assessment and management of childrens pain. The primary aims of this guideline are to: identify reliable and valid measures of pain intensity appropr
The guideline is aimed at a range of professional groups, patients and carers who may be involved in the assessment and management of childrens pain. The primary aims of this guideline are to: identify reliable and valid measures of pain intensity appropr
Clinical Practice Guideline: Pain-Less Practice: Techniques to Reduce Procedural Pain and Anxiety in Pediatric Acute Care
Olsen, K, Weinberg, E
Olsen, K, Weinberg, E
Purpose: This article introduces the concept of a PainLESS Practicean evidence-based, tiered approach to procedural pain and anxiety management in acute care
Purpose: This article introduces the concept of a PainLESS Practicean evidence-based, tiered approach to procedural pain and anxiety management in acute care
Managing acute pain in children presenting to the emergency department without opioids
Corrie E Chumpitazi1,Cindy Chang2,Zaza Atanelov3,Ann M Dietrich4,Samuel Hiu-Fung Lam5,Emily Rose6,Tim Ruttan7,Sam Shahid8,Michael J Stoner9,Carmen Sulton10,M...
Corrie E Chumpitazi1,Cindy Chang2,Zaza Atanelov3,Ann M Dietrich4,Samuel Hiu-F...
Implementing clinical pathways for acute behavioral health issues in pediatric medical settings
Feuer, V. and L. M. Prager
Feuer, V. and L. M. Prager
Clinical Practice Guideline: Guidelines of the French Society of Otorhinolaryngology (SFORL): Nonsteroidal anti-inflammatory drugs (NSAIDs) and pediatric ENT infections. Short version
Truffert, E. et al.
Truffert, E. et al.
Objective: To present the guidelines of the French Society of Otolaryngology-Head and Neck Surgery concerning the use of non-steroidal anti-inflammatory drugs (NSAIDs) in pediatric ENT infections.
Objective: To present the guidelines of the French Society of Otolaryngology-Head and Neck Surgery concerning the use of non-steroidal anti-inflammatory drugs (NSAIDs) in pediatric ENT infections.
Cochrane Summary: Influenza vaccine for preventing acute otitis media (middle ear infection)
Norhayati MN, Ho JJ, Azman MY
Norhayati MN, Ho JJ, Azman MY
Objective: To assess the effectiveness of influenza vaccine in reducing the occurrence of acute otitis media in infants and children.
Objective: To assess the effectiveness of influenza vaccine in reducing the occurrence of acute otitis media in infants and children.
Cochrane Summary: Antibiotics for otitis media with effusion ('glue ear') in children
Venekamp RP, Burton MJ, van Dongen TM, van der Heijden GJ, van Zon A, Schilder AG
Venekamp RP, Burton MJ, van Dongen TM, van der Heijden GJ, van Zon A, Schilde...
Objective: To assess the benefits and harms of oral antibiotics in children up to 18 years with OME.
Objective: To assess the benefits and harms of oral antibiotics in children up to 18 years with OME.
Cochrane Summary: Fluids for people with acute bacterial meningitis
Maconochie IK, Bhaumik S
Maconochie IK, Bhaumik S
Objective: To evaluate treatment of acute bacterial meningitis with differing volumes of initial fluid administration (up to 72 hours after first presentation) and the effects on death and neurological sequelae.
Objective: To evaluate treatment of acute bacterial meningitis with differing volumes of initial fluid administration (up to 72 hours after first presentation) and the effects on death and neurological sequelae.
Cochrane Summary: Systemic corticosteroids for improving symptoms in children with acute middle ear infection
Ranakusuma RW, Pitoyo Y, Safitri ED, Thorning S, Beller EM, Sastroasmoro S, Del Mar CB
Ranakusuma RW, Pitoyo Y, Safitri ED, Thorning S, Beller EM, Sastroasmoro S, D...
Objective: To assess the effects of systemic corticosteroids (oral or parenteral), with or without antibiotics, for AOM in children.
Objective: To assess the effects of systemic corticosteroids (oral or parenteral), with or without antibiotics, for AOM in children.
Cochrane Summary: Pain relievers for children with acute middle ear infection
Sjoukes A, Venekamp RP, van de Pol AC, Hay AD, Little P, Schilder AG, Damoiseaux RA
Sjoukes A, Venekamp RP, van de Pol AC, Hay AD, Little P, Schilder AG, Damoise...
Objective: Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM. Our secondary objective was to assess the effectiveness of NSAIDs compared with paracetamol in children with AOM.
Objective: Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM. Our secondary objective was to assess the effectiveness of NSAIDs compared with paracetamol in children with AOM.
Evidence Summary: Towards evidence based medicine for paediatricians. Question 3. Does the administration of glucagon improve the rate of radiological reduction in children with acute intestinal intussusception?
Cachat F, Ramseyer P,
Cachat F, Ramseyer P,
This summary examines the relationship between glucagon and the rate of radiological reduction for acute intestinal intussusception.
This summary examines the relationship between glucagon and the rate of radiological reduction for acute intestinal intussusception.
Evidence Summary: Are topical antibiotics an alternative to oral antibiotics for children with acute otitis media and ear discharge?
Venekamp RP, Prasad V, Hay AD
Venekamp RP, Prasad V, Hay AD
Objective: To review the evidence comparing efectiveness of topical antibiotics with oral antibiotics, placebo, or no treatment in children with AOM presenting with ear discharge caused by spontaneous perforation of the eardrum.
Objective: To review the evidence comparing efectiveness of topical antibiotics with oral antibiotics, placebo, or no treatment in children with AOM presenting with ear discharge caused by spontaneous perforation of the eardrum.
Cochrane Systematic Review: Decongestants and antihistamines for acute otitis media in children
Coleman C, Moore M.
Coleman C, Moore M.
Objectives: To determine the efficacy of decongestant and antihistamine therapy in children with AOM on outcomes of AOM resolution, symptom resolution, medication side effects, and complications of AOM.
Objectives: To determine the efficacy of decongestant and antihistamine therapy in children with AOM on outcomes of AOM resolution, symptom resolution, medication side effects, and complications of AOM.
Cochrane Systematic Review: Once or twice daily versus three times daily amoxicillin with or without clavulanate for the treatment of acute otitis media
Thanaviratananich S, Laopaiboon M, Vatanasapt P.
Thanaviratananich S, Laopaiboon M, Vatanasapt P.
Objectives: To compare the effectiveness of one or two daily doses with three or four daily doses of amoxicillin, with or without clavulanate, for the treatment of AOM in children; and to compare complication rates and adverse reactions.
Objectives: To compare the effectiveness of one or two daily doses with three or four daily doses of amoxicillin, with or without clavulanate, for the treatment of AOM in children; and to compare complication rates and adverse reactions.
Cochrane Systematic Review: Short-course antibiotics for acute otitis media
Kozyrskyj A, Klassen TP, Moffatt M, Harvey K.
Kozyrskyj A, Klassen TP, Moffatt M, Harvey K.
Objectives: To determine the effectiveness of a short course of antibiotics (less than seven days) in comparison to a long course of antibiotics (seven days or greater) for the treatment of AOM in children.
Objectives: To determine the effectiveness of a short course of antibiotics (less than seven days) in comparison to a long course of antibiotics (seven days or greater) for the treatment of AOM in children.
Cochrane Systematic Review: Topical analgesia for acute otitis media
Foxlee R, Johansson A, Wejfalk J, Dawkins J, Dooley L, Del Mar C.
Foxlee R, Johansson A, Wejfalk J, Dawkins J, Dooley L, Del Mar C.
Objectives: To assess the effectiveness of topical analgesia for AOM.
Objectives: To assess the effectiveness of topical analgesia for AOM.
Cochrane Systematic Review: Antibiotics for acute otitis media in children
Venekamp RP, Sanders SL, Glasziou PP, Del Mar CB, Rovers MM
Venekamp RP, Sanders SL, Glasziou PP, Del Mar CB, Rovers MM
Objective: To assess the effects of antibiotics for children with AOM.
Objective: To assess the effects of antibiotics for children with AOM.
Cochrane Systematic Review: Antibiotics for the prevention of acute and chronic suppurative otitis media in children
Leach AJ, Morris PS
Leach AJ, Morris PS
OBJECTIVES: To determine the effectiveness of long-term antibiotics (for longer than six weeks) in preventing any AOM, AOM with perforation and C
OBJECTIVES: To determine the effectiveness of long-term antibiotics (for longer than six weeks) in preventing any AOM, AOM with perforation and C
Systematic Review: A systematic review and meta-analysis of antimicrobial resistance in paediatric acute otitis media
Michael W. Mathera, Michael Drinnana, John D. Perryc, Steven Powellb, Janet A. Wilsonb, Jason Powella
Michael W. Mathera, Michael Drinnana, John D. Perryc, Steven Powellb, Janet A...
Objective: We present a comprehensive review and meta-analysis, of both the microbiology and antimicrobial resistance of AOM organisms to commonly used antimicrobial agents, with the aim of informing responsible antimicrobial stewardship.
Objective: We present a comprehensive review and meta-analysis, of both the microbiology and antimicrobial resistance of AOM organisms to commonly used antimicrobial agents, with the aim of informing responsible antimicrobial stewardship.
Cochrane Systematic Review: Systemic corticosteroids for acute otitis media in children
Ranakusuma RW, Pitoyo Y, Safitri ED, Thorning S, Beller EM, Sastroasmoro S, Del Mar CB
Ranakusuma RW, Pitoyo Y, Safitri ED, Thorning S, Beller EM, Sastroasmoro S, D...
Objective: To assess the effects of systemic corticosteroids (oral or parenteral), with or without antibiotics, for AOM in children.
Objective: To assess the effects of systemic corticosteroids (oral or parenteral), with or without antibiotics, for AOM in children.
Cochrane Systematic Review: Influenza vaccines for preventing acute otitis media in infants and children
Norhayati MN, Ho JJ, Azman MY
Norhayati MN, Ho JJ, Azman MY
Objective: To assess the effectiveness of influenza vaccine in reducing the occurrence of acute otitis media in infants and children.
Objective: To assess the effectiveness of influenza vaccine in reducing the occurrence of acute otitis media in infants and children.
Review: Antibiotic therapy for children with acute otitis media
Sakulchit T, Goldman RD
Sakulchit T, Goldman RD
Objective: Review of AOM and the evidence regarding use of antibiotics or watchful waiting to treat children at different levels of disease severity.
Objective: Review of AOM and the evidence regarding use of antibiotics or watchful waiting to treat children at different levels of disease severity.
Cochrane Systematic Review: Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children
Sjoukes A, Venekamp RP, van de Pol AC, Hay AD, Little P, Schilder AG, Damoiseaux RA
Sjoukes A, Venekamp RP, van de Pol AC, Hay AD, Little P, Schilder AG, Damoise...
Objective: Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM. Our secondary objective was to assess the effectiveness of NSAIDs compared with paracetamol in children with AOM.
Objective: Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM. Our secondary objective was to assess the effectiveness of NSAIDs compared with paracetamol in children with AOM.
Cochrane Review: Probiotics for preventing acute otitis media in children
Scott AM, Clark J, Julien B, Islam F, Roos K, Grimwood K, Little P, Del Mar CB
Scott AM, Clark J, Julien B, Islam F, Roos K, Grimwood K, Little P, Del Mar CB
Objective: To assess the effects of probiotics to prevent the occurrence and reduce the severity of acute otitis media in children.
Objective: To assess the effects of probiotics to prevent the occurrence and reduce the severity of acute otitis media in children.
Cochrane Review: Pneumococcal conjugate vaccines for preventing acute otitis media in children
de Svaux JLH, Venekamp RP, Lutje V, Hak E, Schilder AGM, Sanders EAM, Damoiseaux RAMJ de
de Svaux JLH, Venekamp RP, Lutje V, Hak E, Schilder AGM, Sanders EAM, Damoise...
Objective: To assess the effect of PCVs in preventing AOM in children up to 12 years of age.
Objective: To assess the effect of PCVs in preventing AOM in children up to 12 years of age.
Systematic Review: Clinical practice guidelines for acute otitis media in children: a systematic review and appraisal of European national guidelines
Suzuki, H.G. et al.
Suzuki, H.G. et al.
Objective: To appraise European guidelines for acute otitis media (AOM) in children, including methodological quality, level of evidence (LoE), astrength of recommendations (SoR), and consideration of antibiotic stewardship
Objective: To appraise European guidelines for acute otitis media (AOM) in children, including methodological quality, level of evidence (LoE), astrength of recommendations (SoR), and consideration of antibiotic stewardship
Cochrane Systematic Review: Antibiotics for otitis media with effusion in children
van Zon A, van der Heijden GJ, van Dongen TM, Burton MJ, Schilder AG
van Zon A, van der Heijden GJ, van Dongen TM, Burton MJ, Schilder AG
OBJECTIVES: To assess the effects of antibiotics in children up to 18 years with OME.
OBJECTIVES: To assess the effects of antibiotics in children up to 18 years with OME.
Cochrane Systematic Review: Antihistamines and/or decongestants for otitis media with effusion (OME) in children
Griffin G, Flynn CA
Griffin G, Flynn CA
OBJECTIVES: The objective of this review was to determine whether antihistamine, decongestant or combination therapy is effective in treating children who present with OME.
OBJECTIVES: The objective of this review was to determine whether antihistamine, decongestant or combination therapy is effective in treating children who present with OME.
Cochrane Systematic Review: Identification of children in the first four years of life for early treatment for otitis media with effusion
Simpson SA, Thomas CL, van der Linden MK, Macmillan H, van der Wouden JC, Butler C
Simpson SA, Thomas CL, van der Linden MK, Macmillan H, van der Wouden JC, Bu...
OBJECTIVES: The aim of this review was to assess evidence from randomised controlled trials about the effect, on language and behavioural outcomes, of screening and treating children with clinically important OME in the first four years of their life. The focus was on the first four years of life because this is the time of most rapid language development. The consequences of hearing loss are likely to be most serious during this time. In addition, children of this age are least likely to be able to report or seek help for impaired hearing, particularly if these problems have a slow onset and are subtle.
OBJECTIVES: The aim of this review was to assess evidence from randomised controlled trials about the effect, on language and behavioural outcomes, of screening and treating children with clinically important OME in the first four years of their life. The focus was on the first four years of life because this is the time of most rapid language development. The consequences of hearing loss are likely to be most serious during this time. In addition, children of this age are least likely to be able to report or seek help for impaired hearing, particularly if these problems have a slow onset and are subtle.
Cochrane Systematic Review: Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children
Simpson SA, Lewis R, van der Voort J, Butler CC
Simpson SA, Lewis R, van der Voort J, Butler CC
OBJECTIVES: To examine the evidence for treating children with hearing loss associated with OME with systemic or topical intranasal steroids.
OBJECTIVES: To examine the evidence for treating children with hearing loss associated with OME with systemic or topical intranasal steroids.
Cochrane Systematic Review: Antibiotics for otitis media with effusion in children
Venekamp RP, Burton MJ, van Dongen TM, van der Heijden GJ, van Zon A, Schilder AG
Venekamp RP, Burton MJ, van Dongen TM, van der Heijden GJ, van Zon A, Schilde...
Objective: To assess the benefits and harms of oral antibiotics in children up to 18 years with OME.
Objective: To assess the benefits and harms of oral antibiotics in children up to 18 years with OME.
Cochrane Systematic Review: Aerosolized prostacyclin for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)
Afshari A, Brok J, Mller AM, Wetterslev J
Afshari A, Brok J, Mller AM, Wetterslev J
OBJECTIVES: To systematically assess the benefits and harms of aerosolized prostacyclin in critically ill patients with ALI and ARDS.
OBJECTIVES: To systematically assess the benefits and harms of aerosolized prostacyclin in critically ill patients with ALI and ARDS.
Cochrane Systematic Review: High-frequency ventilation versus conventional ventilation for treatment of acute lung injury and acute respiratory distress syndrome
Sud S, Sud M, Friedrich JO, Wunsch H, Meade MO, Ferguson ND, Adhikari NK
Sud S, Sud M, Friedrich JO, Wunsch H, Meade MO, Ferguson ND, Adhikari NK
OBJECTIVES: To determine clinical and physiological effects of high frequency oscillation (HFO) in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) compared to conventional ventilation.
OBJECTIVES: To determine clinical and physiological effects of high frequency oscillation (HFO) in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) compared to conventional ventilation.
Cochrane Systematic Review: Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) and acute lung injury in children and adults
Afshari A, Brok J, Mller AM, Wetterslev J. Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) and acute lung injury in children and adults....
Afshari A, Brok J, Mller AM, Wetterslev J. Inhaled nitric oxide for acute re...
OBJECTIVES: To systematically assess the benefits and harms of INO in critically ill patients with AHRF.
OBJECTIVES: To systematically assess the benefits and harms of INO in critically ill patients with AHRF.
Cochrane Systematic Review: Continuous negative extrathoracic pressure or continuous positive airway pressure compared to conventional ventilation for acute hypoxaemic respiratory failure in children
Shah PS, Ohlsson A, Shah JP.
Shah PS, Ohlsson A, Shah JP.
Objectives: To assess the effectiveness of CNEP or Ni-CPAP compared to conventional ventilation in children (at least one month old and less than 18 years of age) with AHRF due to non-cardiogenic causes for improving the mortality or morbidity associated with AHRF.
Objectives: To assess the effectiveness of CNEP or Ni-CPAP compared to conventional ventilation in children (at least one month old and less than 18 years of age) with AHRF due to non-cardiogenic causes for improving the mortality or morbidity associated with AHRF.
Cochrane Systematic Review: Decongestants, antihistamines and nasal irrigation for acute sinusitis in children
Shaikh N, Wald ER, Pi M.
Shaikh N, Wald ER, Pi M.
Objectives: To systematically review the efficacy of decongestants, antihistamines and nasal irrigation in children with clinically diagnosed acute sinusitis. We considered the following four interventions: 1) decongestants versus placebo or no medication, 2) antihistamines versus placebo or no medication, 3) decongestant and antihistamine combination versus placebo or no medication, 4) nasal irrigation versus no irrigation. The primary outcomes of the review were symptom resolution (improvement in symptom score from enrolment to day five and overall symptom burden (as measured by average symptom scores while on therapy).
Objectives: To systematically review the efficacy of decongestants, antihistamines and nasal irrigation in children with clinically diagnosed acute sinusitis. We considered the following four interventions: 1) decongestants versus placebo or no medication, 2) antihistamines versus placebo or no medication, 3) decongestant and antihistamine combination versus placebo or no medication, 4) nasal irrigation versus no irrigation. The primary outcomes of the review were symptom resolution (improvement in symptom score from enrolment to day five and overall symptom burden (as measured by average symptom scores while on therapy).
Cochrane Systematic Review: Honey for acute cough in children
Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh EE.
Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh EE.
Objectives: To evaluate the effectiveness of honey for acute cough in children in ambulatory settings.
Objectives: To evaluate the effectiveness of honey for acute cough in children in ambulatory settings.
Cochrane Systematic Review: Inhaled corticosteroids during acute bronchiolitis in the prevention of post-bronchiolitic wheezing
Blom DJ, Ermers M, Bont L, van Woensel JB, Van Aalderen WM.
Blom DJ, Ermers M, Bont L, van Woensel JB, Van Aalderen WM.
Objectives: The objective of this review was to evaluate the effect of inhaled corticosteroids, started during the acute phase of bronchiolitis, on the prevention of post-bronchiolitic wheezing.
Objectives: The objective of this review was to evaluate the effect of inhaled corticosteroids, started during the acute phase of bronchiolitis, on the prevention of post-bronchiolitic wheezing.
Cochrane Systematic Review: Intranasal steroids for acute sinusitis
Zalmanovici Trestioreanu A, Yaphe J.
Zalmanovici Trestioreanu A, Yaphe J.
Objectives: We examined whether intranasal corticosteroids (INCS) are effective in relieving symptoms of acute sinusitis in adults and children.
Objectives: We examined whether intranasal corticosteroids (INCS) are effective in relieving symptoms of acute sinusitis in adults and children.
Cochrane Systematic Review: Over-the-counter (OTC) medications for acute cough in children and adults in ambulatory settings
Smith SM, Schroeder K, Fahey T.
Smith SM, Schroeder K, Fahey T.
Objectives: To assess the effects of oral OTC cough preparations for acute cough in children and adults.
Objectives: To assess the effects of oral OTC cough preparations for acute cough in children and adults.
Cochrane Systematic Review: Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults
Chang CC, Cheng AC, Chang AB.
Chang CC, Cheng AC, Chang AB.
Objectives: To evaluate the efficacy of OTC cough medications as an adjunct to antibiotics in children and adults with pneumonia.
Objectives: To evaluate the efficacy of OTC cough medications as an adjunct to antibiotics in children and adults with pneumonia.
Cochrane Systematic Review: Pelargonium sidoides extract for treating acute respiratory tract infections
Timmer A, Gnther J, Motschall E, Rcker G, Antes G, Kern WV.
Timmer A, Gnther J, Motschall E, Rcker G, Antes G, Kern WV.
Objectives: To assess the efficacy and safety of P. sidoides for the treatment of ARIs in children and adults.
Objectives: To assess the efficacy and safety of P. sidoides for the treatment of ARIs in children and adults.
Cochrane Systematic Review: Probiotics for preventing acute upper respiratory tract infections
Hao Q, Lu Z, Dong BR, Huang CQ, Wu T.
Hao Q, Lu Z, Dong BR, Huang CQ, Wu T.
Objectives: To assess the effectiveness and safety of probiotics for preventing acute URTIs.
Objectives: To assess the effectiveness and safety of probiotics for preventing acute URTIs.
Cochrane Systematic Review: Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections
Schuetz P, Mller B, Christ-Crain M, Stolz D, Tamm M, Bouadma L, Luyt CE, Wolff M, Chastre J, Tubach F, Kristoffersen KB, Burkhardt O, Welte T, Schroeder S, N...
Schuetz P, Mller B, Christ-Crain M, Stolz D, Tamm M, Bouadma L, Luyt CE, Wolf...
Objectives: The aim of this systematic review based on individual patient data was to assess the safety and efficacy of using procalcitonin for starting or stopping antibiotics over a large range of patients with varying severity of ARIs and from different clinical settings.
Objectives: The aim of this systematic review based on individual patient data was to assess the safety and efficacy of using procalcitonin for starting or stopping antibiotics over a large range of patients with varying severity of ARIs and from different clinical settings.
Cochrane Systematic Review: Rapid viral diagnosis for acute febrile respiratory illness in children in the Emergency Department
Doan Q, Enarson P, Kissoon N, Klassen TP, Johnson DW.
Doan Q, Enarson P, Kissoon N, Klassen TP, Johnson DW.
Objectives: To determine the effect of rapid viral testing in the ED on the rate of precautionary testing, antibiotic use, and length of ED visit.
Objectives: To determine the effect of rapid viral testing in the ED on the rate of precautionary testing, antibiotic use, and length of ED visit.
Cochrane Systematic Review: Saline nasal irrigation for acute upper respiratory tract infections
Kassel JC, King D, Spurling GK.
Kassel JC, King D, Spurling GK.
Objectives: To evaluate the efficacy of saline nasal irrigation in treating the symptoms of acute URTIs.
Objectives: To evaluate the efficacy of saline nasal irrigation in treating the symptoms of acute URTIs.
Cochrane Systematic Review: Short-term late-generation antibiotics versus longer term penicillin for acute streptococcal pharyngitis in children
Altamimi S, Khalil A, Khalaiwi KA, Milner RA, Pusic MV, Al Othman MA.
Altamimi S, Khalil A, Khalaiwi KA, Milner RA, Pusic MV, Al Othman MA.
Objectives: To summarize the evidence regarding the efficacy of two to six days of newer oral antibiotics (short duration) compared to 10 days of oral penicillin (standard duration) in treating children with acute GABHS pharyngitis.
Objectives: To summarize the evidence regarding the efficacy of two to six days of newer oral antibiotics (short duration) compared to 10 days of oral penicillin (standard duration) in treating children with acute GABHS pharyngitis.
Cochrane Systematic Review: Steam inhalation or humidified oxygen for acute bronchiolitis in children up to three years of age
Umoren R, Odey F, Meremikwu MM.
Umoren R, Odey F, Meremikwu MM.
Objectives: To evaluate the effect of steam inhalation or humidified oxygen to relieve respiratory distress and to evaluate adverse events in children up to three years old with acute bronchiolitis.
Objectives: To evaluate the effect of steam inhalation or humidified oxygen to relieve respiratory distress and to evaluate adverse events in children up to three years old with acute bronchiolitis.
Cochrane Systematic Review: Systemic corticosteroids for acute sinusitis
Venekamp RP, Thompson MJ, Hayward G, Heneghan CJ, Del Mar CB, Perera R, Glasziou PP, Rovers MM.
Venekamp RP, Thompson MJ, Hayward G, Heneghan CJ, Del Mar CB, Perera R, Glasz...
Objectives: To assess the effects of systemic corticosteroids on clinical response rates and to determine adverse effects and relapse rates of systemic corticosteroids compared to placebo or standard clinical care in children and adults with acute sinusitis.
Objectives: To assess the effects of systemic corticosteroids on clinical response rates and to determine adverse effects and relapse rates of systemic corticosteroids compared to placebo or standard clinical care in children and adults with acute sinusitis.
Cochrane Systematic Review: Addition of intravenous beta2-agonists to inhaled beta2-agonists for acute asthma
Travers AH, Milan SJ, Jones AP, Camargo CA Jr, Rowe BH.
Travers AH, Milan SJ, Jones AP, Camargo CA Jr, Rowe BH.
Objectives: To determine the benefit of adding intravenous (IV) beta(2)-agonists to inhaled beta(2)-agonist therapy for acute asthma treated in the emergency department.
Objectives: To determine the benefit of adding intravenous (IV) beta(2)-agonists to inhaled beta(2)-agonist therapy for acute asthma treated in the emergency department.
Cochrane Systematic Review: Antibiotics for acute asthma
Graham V, Lasserson T, Rowe BH.
Graham V, Lasserson T, Rowe BH.
Objectives: To determine the efficacy of antibiotics prescribed in the treatment of acute asthma
Objectives: To determine the efficacy of antibiotics prescribed in the treatment of acute asthma
Cochrane Systematic Review: Antibiotics for persistent cough or wheeze following acute bronchiolitis in children
McCallum GB, Morris PS, Chang AB.
McCallum GB, Morris PS, Chang AB.
Objectives: To determine the effectiveness of antibiotics compared to a control (no treatment or placebo) for persistent respiratory symptoms (within six months), following acute bronchiolitis.
Objectives: To determine the effectiveness of antibiotics compared to a control (no treatment or placebo) for persistent respiratory symptoms (within six months), following acute bronchiolitis.
Cochrane Systematic Review: Anticholinergic therapy for acute asthma in children
Teoh L, Cates CJ, Hurwitz M, Acworth JP, van Asperen P, Chang AB.
Teoh L, Cates CJ, Hurwitz M, Acworth JP, van Asperen P, Chang AB.
Objectives: To determine the effectiveness of only inhaled anticholinergic drugs (i.e. administered alone), compared to a control in children over the age of two years with acute asthma.
Objectives: To determine the effectiveness of only inhaled anticholinergic drugs (i.e. administered alone), compared to a control in children over the age of two years with acute asthma.
Cochrane Systematic Review: Combined inhaled anticholinergics and beta2-agonists for initial treatment of acute asthma in children
Griffiths B, Ducharme FM.
Griffiths B, Ducharme FM.
Objectives: To determine whether the addition of inhaled anticholinergics to SABAs provides clinical improvement and affects the incidence of adverse effects in children with acute asthma exacerbations.
Objectives: To determine whether the addition of inhaled anticholinergics to SABAs provides clinical improvement and affects the incidence of adverse effects in children with acute asthma exacerbations.
Cochrane Systematic Review: Commercial versus home-made spacers in delivering bronchodilator therapy for acute therapy in children
Rodriguez C, Sossa M, Lozano JM.
Rodriguez C, Sossa M, Lozano JM.
Objectives: The aim of this review was to compare the response to inhaled beta-2 agonists delivered through metered-dose inhaler using home-made spacers, to the use of commercially produced spacers, in children with acute exacerbations of wheezing or asthma.
Objectives: The aim of this review was to compare the response to inhaled beta-2 agonists delivered through metered-dose inhaler using home-made spacers, to the use of commercially produced spacers, in children with acute exacerbations of wheezing or asthma.
Cochrane Systematic Review: Corticosteroids for hospitalised children with acute asthma
Smith M, Iqbal S, Elliott TM, Everard M, Rowe BH.
Smith M, Iqbal S, Elliott TM, Everard M, Rowe BH.
Objectives: To determine the benefit of systemic corticosteroids (oral, intravenous, or intramuscular) compared to placebo and inhaled steroids in acute paediatric asthma.
Objectives: To determine the benefit of systemic corticosteroids (oral, intravenous, or intramuscular) compared to placebo and inhaled steroids in acute paediatric asthma.
Cochrane Systematic Review: Corticosteroids for preventing relapse following acute exacerbations of asthma
Rowe BH, Spooner CH, Ducharme FM, Bretzlaff JA, Bota GW.
Rowe BH, Spooner CH, Ducharme FM, Bretzlaff JA, Bota GW.
Objectives: To determine the benefit of corticosteroids (oral, intramuscular, or intravenous) for the treatment of asthmatic patients discharged from an acute care setting (i.e. usually the emergency department) after assessment and treatment of an acute asthmatic exacerbation.
Objectives: To determine the benefit of corticosteroids (oral, intramuscular, or intravenous) for the treatment of asthmatic patients discharged from an acute care setting (i.e. usually the emergency department) after assessment and treatment of an acute asthmatic exacerbation.
Cochrane Systematic Review: Early emergency department treatment of acute asthma with systemic corticosteroids
Rowe BH, Spooner C, Ducharme FM, Bretzlaff JA, Bota GW.
Rowe BH, Spooner C, Ducharme FM, Bretzlaff JA, Bota GW.
Objectives: To determine the benefit of treating patients with acute asthma with systemic corticosteroids within an hour of presenting to the emergency department (ED).
Objectives: To determine the benefit of treating patients with acute asthma with systemic corticosteroids within an hour of presenting to the emergency department (ED).
Cochrane Systematic Review: Early use of inhaled corticosteroids in the emergency department treatment of acute asthma
Edmonds ML, Milan SJ, Camargo CA Jr, Pollack CV, Rowe BH.
Edmonds ML, Milan SJ, Camargo CA Jr, Pollack CV, Rowe BH.
Objectives: To determine the benefit of ICS for the treatment of patients with acute asthma managed in the emergency department (ED).
Objectives: To determine the benefit of ICS for the treatment of patients with acute asthma managed in the emergency department (ED).
Cochrane Systematic Review: Heliox for non-intubated acute asthma patients
Rodrigo G, Pollack C, Rodrigo C, Rowe BH.
Rodrigo G, Pollack C, Rodrigo C, Rowe BH.
Objectives: To determine the effect of the addition of heliox to standard medical care on the course of acute asthma, as measured by pulmonary function testing and clinical endpoints.
Objectives: To determine the effect of the addition of heliox to standard medical care on the course of acute asthma, as measured by pulmonary function testing and clinical endpoints.
Cochrane Systematic Review: Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma
Cates CJ, Welsh EJ, Rowe BH.
Cates CJ, Welsh EJ, Rowe BH.
Objectives: To assess the effects of holding chambers (spacers) compared to nebulisers for the delivery of beta(2)-agonists for acute asthma.
Objectives: To assess the effects of holding chambers (spacers) compared to nebulisers for the delivery of beta(2)-agonists for acute asthma.
Cochrane Systematic Review: Inhaled magnesium sulfate in the treatment of acute asthma
Powell C, Dwan K, Milan SJ, Beasley R, Hughes R, Knopp-Sihota JA, Rowe BH.
Powell C, Dwan K, Milan SJ, Beasley R, Hughes R, Knopp-Sihota JA, Rowe BH.
Objectives: To determine the efficacy of inhaled MgSO(4) administered in acute asthma on pulmonary functions and admission rates.Specific aims: To quantify the effects of inhaled MgSO(4) i) in addition to inhaled (2)-agonist, ii) in comparison to inhaled (2)-agonist alone or iii) in addition to combination treatment with inhaled (2) -agonist and ipratropium bromide.
Objectives: To determine the efficacy of inhaled MgSO(4) administered in acute asthma on pulmonary functions and admission rates.Specific aims: To quantify the effects of inhaled MgSO(4) i) in addition to inhaled (2)-agonist, ii) in comparison to inhaled (2)-agonist alone or iii) in addition to combination treatment with inhaled (2) -agonist and ipratropium bromide.
Cochrane Systematic Review: Inhaled steroids for acute asthma following emergency department discharge
Edmonds ML, Milan SJ, Brenner BE, Camargo CA Jr, Rowe BH.
Edmonds ML, Milan SJ, Brenner BE, Camargo CA Jr, Rowe BH.
Objectives: To determine the effectiveness of ICS on outcomes in the treatment of acute asthma following discharge from the ED. To quantify the effectiveness of ICS therapy on acute asthma following ED discharge, when used in addition to, or as a substitute for, systemic corticosteroids.
Objectives: To determine the effectiveness of ICS on outcomes in the treatment of acute asthma following discharge from the ED. To quantify the effectiveness of ICS therapy on acute asthma following ED discharge, when used in addition to, or as a substitute for, systemic corticosteroids.
Cochrane Systematic Review: Intravenous aminophylline for acute severe asthma in children over two years receiving inhaled bronchodilators
Mitra A, Bassler D, Goodman K, Lasserson TJ, Ducharme FM.
Mitra A, Bassler D, Goodman K, Lasserson TJ, Ducharme FM.
Objectives: To determine if the addition of intravenous aminophylline produces a beneficial effect in children with acute severe asthma receiving conventional therapy.
Objectives: To determine if the addition of intravenous aminophylline produces a beneficial effect in children with acute severe asthma receiving conventional therapy.
Cochrane Systematic Review: Intravenous beta2-agonists for acute asthma in the emergency department
Travers A, Jones AP, Kelly K, Barker SJ, Camargo CA, Rowe BH.
Travers A, Jones AP, Kelly K, Barker SJ, Camargo CA, Rowe BH.
Objectives: To determine the benefit of intravenous (IV) beta2-agonists for severe acute asthma treated in the emergency department.
Objectives: To determine the benefit of intravenous (IV) beta2-agonists for severe acute asthma treated in the emergency department.
Cochrane Systematic Review: Intravenous beta2-agonists versus intravenous aminophylline for acute asthma
Travers AH, Jones AP, Camargo CA Jr, Milan SJ, Rowe BH.
Travers AH, Jones AP, Camargo CA Jr, Milan SJ, Rowe BH.
Objectives: To compare the benefit of IV beta(2)-agonists versus IV aminophylline for acute asthma treated in the emergency department and in patients admitted to hospital with acute severe asthma.
Objectives: To compare the benefit of IV beta(2)-agonists versus IV aminophylline for acute asthma treated in the emergency department and in patients admitted to hospital with acute severe asthma.
Cochrane Systematic Review: Ketamine for management of acute exacerbations of asthma in children
Jat KR, Chawla D.
Jat KR, Chawla D.
Objectives: To evaluate the efficacy of ketamine compared to placebo, no intervention or standard care for management of severe acute asthma in children who had not responded to standard therapy.
Objectives: To evaluate the efficacy of ketamine compared to placebo, no intervention or standard care for management of severe acute asthma in children who had not responded to standard therapy.
Cochrane Systematic Review: Leukotriene receptor antagonists in addition to usual care for acute asthma in adults and children
Watts K, Chavasse RJ.
Watts K, Chavasse RJ.
Objectives: To determine if the addition of a leukotriene receptor antagonist (LTRA) produces a beneficial effect in children and adults with acute asthma who are currently receiving inhaled bronchodilators and systemic corticosteroids.
Objectives: To determine if the addition of a leukotriene receptor antagonist (LTRA) produces a beneficial effect in children and adults with acute asthma who are currently receiving inhaled bronchodilators and systemic corticosteroids.
Cochrane Systematic Review: Magnesium sulfate for treating exacerbations of acute asthma in the emergency department
Rowe BH, Bretzlaff JA, Bourdon C, Bota GW, Camargo CA Jr.
Rowe BH, Bretzlaff JA, Bourdon C, Bota GW, Camargo CA Jr.
Objectives: To examine the effect of additional intravenous magnesium sulfate in patients with acute asthma managed in the emergency department.
Objectives: To examine the effect of additional intravenous magnesium sulfate in patients with acute asthma managed in the emergency department.
Cochrane Systematic Review: Oral corticosteroids for bronchiectasis (stable and acute exacerbations)
Lasserson T, Holt K, Greenstone M.
Lasserson T, Holt K, Greenstone M.
Objectives: To determine the efficacy of oral corticosteroids in acute and stable bronchiectasis
Objectives: To determine the efficacy of oral corticosteroids in acute and stable bronchiectasis
Cochrane Systematic Review: Surgical interventions for treating acute fractures or non-union of the middle third of the clavicle
Lenza M, Belloti JC, Gomes Dos Santos JB, Matsumoto MH, Faloppa F
Lenza M, Belloti JC, Gomes Dos Santos JB, Matsumoto MH, Faloppa F
OBJECTIVES: To evaluate the effectiveness of different methods of surgical treatment for acute fracture or non-union of the middle third of the clavicle.
OBJECTIVES: To evaluate the effectiveness of different methods of surgical treatment for acute fracture or non-union of the middle third of the clavicle.
Cochrane Systematic Review: Written and verbal information versus verbal information only for patients being discharged from acute hospital settings to home
Johnson A, Sandford J, Tyndall J
Johnson A, Sandford J, Tyndall J
OBJECTIVES: To determine the effectiveness of providing written health information in addition to verbal information for patients and/or significant others being discharged from acute hospital settings to home.
OBJECTIVES: To determine the effectiveness of providing written health information in addition to verbal information for patients and/or significant others being discharged from acute hospital settings to home.
Cochrane Systematic Review: Blood transfusions for treating acute chest syndrome in people with sickle cell disease
Alhashimi D, Fedorowicz Z, Alhashimi F, Dastgiri S
Alhashimi D, Fedorowicz Z, Alhashimi F, Dastgiri S
OBJECTIVES: To assess the effectiveness of blood transfusions, simple and exchange, for treating ACS by comparing improvement in symptoms and clinical outcomes against standard care.
OBJECTIVES: To assess the effectiveness of blood transfusions, simple and exchange, for treating ACS by comparing improvement in symptoms and clinical outcomes against standard care.
Cochrane Systematic Review: Inhaled nitric oxide for acute chest syndrome in people with sickle cell disease
Al Hajeri A, Serjeant GR, Fedorowicz Z
Al Hajeri A, Serjeant GR, Fedorowicz Z
OBJECTIVES: To assess the effectiveness of inhaled nitric oxide for treating acute chest syndrome by comparing improvement in symptoms and clinical outcomes against standard care.
OBJECTIVES: To assess the effectiveness of inhaled nitric oxide for treating acute chest syndrome by comparing improvement in symptoms and clinical outcomes against standard care.
Cochrane Systematic Review: Interventions for acute auricular haematoma
Jones SE, Mahendran S
Jones SE, Mahendran S
OBJECTIVES: To assess the effectiveness of treatment options in acute auricular haematoma.
OBJECTIVES: To assess the effectiveness of treatment options in acute auricular haematoma.
Cochrane Systematic Review: Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children
Appleton R, Macleod S, Martland T
Appleton R, Macleod S, Martland T
OBJECTIVES: To review the evidence comparing the efficacy and safety of midazolam, diazepam, lorazepam, phenobarbitone, phenytoin and paraldehyde in treating acute tonic-clonic convulsions and convulsive status epilepticus in children treated in hospital.
OBJECTIVES: To review the evidence comparing the efficacy and safety of midazolam, diazepam, lorazepam, phenobarbitone, phenytoin and paraldehyde in treating acute tonic-clonic convulsions and convulsive status epilepticus in children treated in hospital.
Cochrane Systematic Review: Anti-inflammatory treatment for carditis in acute rheumatic fever
Cilliers A, Manyemba J, Adler AJ, Saloojee H
Cilliers A, Manyemba J, Adler AJ, Saloojee H
OBJECTIVES: To assess the effects of anti-inflammatory agents such as aspirin, corticosteroids, immunoglobulin and pentoxifylline for preventing or reducing further heart valve damage in patients with acute rheumatic fever.
OBJECTIVES: To assess the effects of anti-inflammatory agents such as aspirin, corticosteroids, immunoglobulin and pentoxifylline for preventing or reducing further heart valve damage in patients with acute rheumatic fever.
Cochrane Systematic Review: Early versus Delayed Refeeding for Children with Acute Diarrhoea
Gregorio GV, Dans LF, Silvestre MA
Gregorio GV, Dans LF, Silvestre MA
OBJECTIVES: To compare the efficacy and safety of early and late reintroduction of feeding in children with acute diarrhoea.
OBJECTIVES: To compare the efficacy and safety of early and late reintroduction of feeding in children with acute diarrhoea.
Cochrane Systematic Review: Probiotics for treating acute infectious diarrhoea
Allen SJ, Martinez EG, Gregorio GV, Dans LF
Allen SJ, Martinez EG, Gregorio GV, Dans LF
OBJECTIVES: To assess the effects of probiotics in proven or presumed acute infectious diarrhoea.
OBJECTIVES: To assess the effects of probiotics in proven or presumed acute infectious diarrhoea.
Cochrane Systematic Review: Polymer-based oral rehydration solution for treating acute watery diarrhoea
Gregorio GV, Gonzales ML, Dans LF, Martinez EG
Gregorio GV, Gonzales ML, Dans LF, Martinez EG
OBJECTIVES: To compare polymer-based ORS with glucose-based ORS for treating acute watery diarrhoea.
OBJECTIVES: To compare polymer-based ORS with glucose-based ORS for treating acute watery diarrhoea.
Cochrane Systematic Review: Reduced osmolarity oral rehydration solution for treating dehydration caused by acute diarrhoea in children
Hahn S, Kim S, Garner P. Reduced osmolarity oral rehydration solution for treating dehydration caused by acute diarrhoea in children. Cochrane Database Syst...
Hahn S, Kim S, Garner P. Reduced osmolarity oral rehydration solution for tr...
OBJECTIVES: To compare reduced osmolarity ORS with WHO standard ORS in children with acute diarrhoea.
OBJECTIVES: To compare reduced osmolarity ORS with WHO standard ORS in children with acute diarrhoea.
Cochrane Systematic Review: Antifibrinolytic drugs for acute traumatic injury
Roberts I, Shakur H, Ker K, Coats T; CRASH-2 Trial collaborators
Roberts I, Shakur H, Ker K, Coats T; CRASH-2 Trial collaborators
OBJECTIVES: To quantify the effects of antifibrinolytic drugs on mortality, vascular occlusive events, surgical intervention and receipt of blood transfusion after acute traumatic injury.
OBJECTIVES: To quantify the effects of antifibrinolytic drugs on mortality, vascular occlusive events, surgical intervention and receipt of blood transfusion after acute traumatic injury.
Cochrane Systematic Review: Bradykinin beta-2 receptor antagonists for acute traumatic brain injury
Ker K, Blackhall K
Ker K, Blackhall K
OBJECTIVES: The objective was to assess the safety and effectiveness of beta-2 receptor antagonists for TBI.
OBJECTIVES: The objective was to assess the safety and effectiveness of beta-2 receptor antagonists for TBI.
Cochrane Systematic Review: Hyperventilation therapy for acute traumatic brain injury
Schierhout G, Roberts I
Schierhout G, Roberts I
OBJECTIVES: To quantify the effect of hyperventilation on death and neurological disability following head injury.
OBJECTIVES: To quantify the effect of hyperventilation on death and neurological disability following head injury.
Cochrane Systematic Review: Progesterone for acute traumatic brain injury
Ma J, Huang S, Qin S, You C
Ma J, Huang S, Qin S, You C
OBJECTIVES: To assess the effectiveness and safety of progesterone in people with acute TBI.
OBJECTIVES: To assess the effectiveness and safety of progesterone in people with acute TBI.
Cochrane Systematic Review: Steroids for acute spinal cord injury
Bracken MB
Bracken MB
OBJECTIVES: To review randomized trials of steroids for human acute spinal cord injury.
OBJECTIVES: To review randomized trials of steroids for human acute spinal cord injury.
Cochrane Systematic Review: Dipyrone for acute primary headaches
Ramacciotti AS, Soares BG, Atallah AN
Ramacciotti AS, Soares BG, Atallah AN
OBJECTIVES: To determine the effectiveness and safety of dipyrone for acute primary headaches in adults and children.
OBJECTIVES: To determine the effectiveness and safety of dipyrone for acute primary headaches in adults and children.
Cochrane Systematic Review: Hydromorphone for acute and chronic pain
Quigley C
Quigley C
OBJECTIVES: This review explores and assesses the evidence for the efficacy of hydromorphone in the management of pain.
OBJECTIVES: This review explores and assesses the evidence for the efficacy of hydromorphone in the management of pain.
Cochrane Systematic Review: Antibiotics for acute pyelonephritis in children
Hodson EM, Willis NS, Craig JC
Hodson EM, Willis NS, Craig JC
OBJECTIVES: To determine the benefits and harms of different antibiotic regimens for the treatment of acute pyelonephritis in children.
OBJECTIVES: To determine the benefits and harms of different antibiotic regimens for the treatment of acute pyelonephritis in children.
Cochrane Systematic Review: Bicarbonate versus lactate solutions for acute peritoneal dialysis
Bai ZG, Yang K, Tian J, Ma B, Liu Y, Jiang L, Tan J, Liu TX, Chi I
Bai ZG, Yang K, Tian J, Ma B, Liu Y, Jiang L, Tan J, Liu TX, Chi I
OBJECTIVES: To look at the benefits and harms of bicarbonate versus lactate solutions in acute PD.
OBJECTIVES: To look at the benefits and harms of bicarbonate versus lactate solutions in acute PD.
Cochrane Systematic Review: Short versus standard duration oral antibiotic therapy for acute urinary tract infection in children
Michael M, Hodson EM, Craig JC, Martin S, Moyer VA
Michael M, Hodson EM, Craig JC, Martin S, Moyer VA
OBJECTIVES: The objective of this review was to assess the benefits and harms of short-course (2-4 days) compared to standard duration (7-14 days) oral antibiotic treatment for acute UTI in children.
OBJECTIVES: The objective of this review was to assess the benefits and harms of short-course (2-4 days) compared to standard duration (7-14 days) oral antibiotic treatment for acute UTI in children.
Cochrane Systematic Review: Anticholinergics for neuroleptic-induced acute akathisia
Rathbone J, Soares-Weiser K
Rathbone J, Soares-Weiser K
OBJECTIVES: To review anticholinergic drugs for neuroleptic-induced acute akathisia.
OBJECTIVES: To review anticholinergic drugs for neuroleptic-induced acute akathisia.
Cochrane Systematic Review: Aloe vera for treating acute and chronic wounds
Dat AD, Poon F, Pham KB, Doust J
Dat AD, Poon F, Pham KB, Doust J
OBJECTIVES: To determine the effects of Aloe vera-derived products (for example dressings and topical gels) on the healing of acute wounds (for example lacerations, surgical incisions and burns) and chronic wounds (for example infected wounds, arterial and venous ulcers).
OBJECTIVES: To determine the effects of Aloe vera-derived products (for example dressings and topical gels) on the healing of acute wounds (for example lacerations, surgical incisions and burns) and chronic wounds (for example infected wounds, arterial and venous ulcers).
Cochrane Systematic Review: Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents
Fedorowicz Z, Jagannath VA, Carter B
Fedorowicz Z, Jagannath VA, Carter B
OBJECTIVES: To assess the safety and effectiveness of antiemetics on gastroenteritis induced vomiting in children and adolescents.
OBJECTIVES: To assess the safety and effectiveness of antiemetics on gastroenteritis induced vomiting in children and adolescents.
Cochrane Systematic Review: Diclofenac for acute pain in children
Standing JF, Savage I, Pritchard D, Waddington M
Standing JF, Savage I, Pritchard D, Waddington M
OBJECTIVES: 1) Assess the efficacy of diclofenac for acute pain in children. 2) Assess the safety of diclofenac for short-term use in children. 3) Identify gaps in the evidence to direct future research.
OBJECTIVES: 1) Assess the efficacy of diclofenac for acute pain in children. 2) Assess the safety of diclofenac for short-term use in children. 3) Identify gaps in the evidence to direct future research.
Cochrane Systematic Review: Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients without chronic broncho-pulmonary disease
Chalumeau M, Duijvestijn YC
Chalumeau M, Duijvestijn YC
OBJECTIVES: The objective was to assess the efficacy and safety and to establish a benefit-risk ratio of acetylcysteine and carbocysteine as symptomatic treatments for acute upper and lower RTIs in paediatric patients without chronic broncho-pulmonary disease.
OBJECTIVES: The objective was to assess the efficacy and safety and to establish a benefit-risk ratio of acetylcysteine and carbocysteine as symptomatic treatments for acute upper and lower RTIs in paediatric patients without chronic broncho-pulmonary disease.
Cochrane Systematic Review: Advising patients to increase fluid intake for treating acute respiratory infections
Guppy MP, Mickan SM, Del Mar CB, Thorning S, Rack A
Guppy MP, Mickan SM, Del Mar CB, Thorning S, Rack A
OBJECTIVES: To answer the following questions.1. Does recommending increased fluid intake as a treatment for acute respiratory infections improve duration and severity of symptoms? 2. Are there adverse effects from recommending increased fluids in people with acute respiratory infections? 3. Are any benefits or harms related to site of infection (upper or lower respiratory tract) or a different severity of illness?
OBJECTIVES: To answer the following questions.1. Does recommending increased fluid intake as a treatment for acute respiratory infections improve duration and severity of symptoms? 2. Are there adverse effects from recommending increased fluids in people with acute respiratory infections? 3. Are any benefits or harms related to site of infection (upper or lower respiratory tract) or a different severity of illness?
Cochrane Systematic Review: Antibiotics for the common cold and acute purulent rhinitis
Kenealy T, Arroll B
Kenealy T, Arroll B
OBJECTIVES: To determine the efficacy of antibiotics compared with placebo for reducing general and specific nasopharyngeal symptoms of acute upper respiratory tract infections (URTIs) (common colds). To determine if antibiotics have any influence on the tcomes for acute purulent rhinitis and acute clear rhinitis lasting less than 10 days before the intervention. To determine whether there are significant adverse outcomes associated with antibiotic therapy for participants with a clinical diagnosis of acute URTI or acute purulent rhinitis.
OBJECTIVES: To determine the efficacy of antibiotics compared with placebo for reducing general and specific nasopharyngeal symptoms of acute upper respiratory tract infections (URTIs) (common colds). To determine if antibiotics have any influence on the tcomes for acute purulent rhinitis and acute clear rhinitis lasting less than 10 days before the intervention. To determine whether there are significant adverse outcomes associated with antibiotic therapy for participants with a clinical diagnosis of acute URTI or acute purulent rhinitis.
Cochrane Systematic Review: Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old
Roqu i Figuls M, Gin-Garriga M, Granados Rugeles C, Perrotta C
Roqu i Figuls M, Gin-Garriga M, Granados Rugeles C, Perrotta C
OBJECTIVES: The main objective was to determine the efficacy of chest physiotherapy in infants aged less than 24 months old with acute bronchiolitis. A condary objective was to determine the efficacy of different techniques of chest physiotherapy (for ample, vibration and percussion and passive forced exhalation).
OBJECTIVES: The main objective was to determine the efficacy of chest physiotherapy in infants aged less than 24 months old with acute bronchiolitis. A condary objective was to determine the efficacy of different techniques of chest physiotherapy (for ample, vibration and percussion and passive forced exhalation).
Cochrane Systematic Review: Chest radiograph for acute lower respiratory infections
Swingler GH, Zwarenstein M
Swingler GH, Zwarenstein M
OBJECTIVES: To assess the effects of chest radiography on clinical outcome in acute lower respiratory infections.
OBJECTIVES: To assess the effects of chest radiography on clinical outcome in acute lower respiratory infections.
Cochrane Systematic Review: Nebulised hypertonic saline solution for acute bronchiolitis in infants
Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP.
Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP.
Objectives: To assess the effects of nebulised hypertonic ( 3%) saline solution in infants with viral bronchiolitis.
Objectives: To assess the effects of nebulised hypertonic ( 3%) saline solution in infants with viral bronchiolitis.
Systematic Review: Corticosteroids for acute traumatic brain injury
Alderson P, Roberts I
Alderson P, Roberts I
To quantify the effectiveness and safety of corticosteroids in the treatment ofacutetraumatic brain injury.
To quantify the effectiveness and safety of corticosteroids in the treatment ofacutetraumatic brain injury.
Review: Caring for the child with an autism spectrum disorder in the acute care setting
Scarpinato N, Bradley J, Kurbjun K, Bateman X, Holtzer B, Ely B
Scarpinato N, Bradley J, Kurbjun K, Bateman X, Holtzer B, Ely B
This article explores the challenges that patients with autism spectrum disorders face when hospitalized and provides assessment strategies and plan-of-care suggestions for nursing caregivers.
This article explores the challenges that patients with autism spectrum disorders face when hospitalized and provides assessment strategies and plan-of-care suggestions for nursing caregivers.
Antifibrinolytic drugs for acute traumatic injury
Ker K, Roberts I, Shakur H, Coats TJ,
Ker K, Roberts I, Shakur H, Coats TJ,
Review to assess the effect of antifibrinolytic drugs in patients with acute traumatic injury.
Review to assess the effect of antifibrinolytic drugs in patients with acute traumatic injury.
Systematic Review: Management Modalities and Outcomes Following Acute Scaphoid Fractures in Children: A Quantitative Review and Meta-Analysis
Shaterian A, Santos PJF, Lee CJ, Evans GRD, Leis A
Shaterian A, Santos PJF, Lee CJ, Evans GRD, Leis A
The objective of this study was to compare clinical outcomes following different treatment modalities for pediatric scaphoid fractures.
The objective of this study was to compare clinical outcomes following different treatment modalities for pediatric scaphoid fractures.
Cochrane Systematic Review: Fluid therapy for acute bacterial meningitis
Maconochie IK, Bhaumik S
Maconochie IK, Bhaumik S
Objective: To evaluate treatment of acute bacterial meningitis with differing volumes of initial fluid administration (up to 72 hours after first presentation) and the effects on death and neurological sequelae.
Objective: To evaluate treatment of acute bacterial meningitis with differing volumes of initial fluid administration (up to 72 hours after first presentation) and the effects on death and neurological sequelae.
Cochrane Systematic Review: Corticosteroids for acute bacterial meningitis
Brouwer MC, McIntyre P, Prasad K, Van de Beek D
Brouwer MC, McIntyre P, Prasad K, Van de Beek D
Objective: To examine the effect of adjuvant corticosteroid therapy versus placebo on mortality, hearing loss and neurological sequelae in people of all ages with acute bacterial meningitis.
Objective: To examine the effect of adjuvant corticosteroid therapy versus placebo on mortality, hearing loss and neurological sequelae in people of all ages with acute bacterial meningitis.
Review: Lumbar puncture and brain herniation in acute bacterial meningitis: a review
Joffe AR
Joffe AR
Objective: There has been controversy regarding the risk of cerebral herniation caused by a lumbar puncture (LP) in acute bacterial meningitis (ABM). This review discusses in detail the issues involved in this controversy.
Objective: There has been controversy regarding the risk of cerebral herniation caused by a lumbar puncture (LP) in acute bacterial meningitis (ABM). This review discusses in detail the issues involved in this controversy.
Systematic Review: Screening for Suicide Risk in the Pediatric Emergency and Acute Care Setting
Wintersteen MB, Diamond GS, Fein JA
Wintersteen MB, Diamond GS, Fein JA
Objective: reviews epidemiology, psychiatric comorbidities, risk factors, warning signs, screening measures, and issues related to screening for suicide risk in the pediatric emergency department and acute care settings.
Objective: reviews epidemiology, psychiatric comorbidities, risk factors, warning signs, screening measures, and issues related to screening for suicide risk in the pediatric emergency department and acute care settings.
Systematic review: Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2: a systematic review.
Abrams JY, Godfred-Cato SE, Oster ME, et al.
Abrams JY, Godfred-Cato SE, Oster ME, et al.
Objective: To develop a more comprehensive description of multisystem inflammatory syndrome in children (MIS-C), a novel syndrome linked to severe acute respiratory syndrome coronavirus 2, by conducting a systematic analysis of studies from different settings that used various inclusion criteria.
Objective: To develop a more comprehensive description of multisystem inflammatory syndrome in children (MIS-C), a novel syndrome linked to severe acute respiratory syndrome coronavirus 2, by conducting a systematic analysis of studies from different settings that used various inclusion criteria.
Systematic Review: Pediatric clinical practice guidelines for acute procedural pain: a systematic review
Lee GY, Yamada J, Kyololo O, Shorkey A, Stevens B
Lee GY, Yamada J, Kyololo O, Shorkey A, Stevens B
Objective: To systematically review the quality of existing practice guidelines for acute procedural pain in children and provide recommendations for their use.
Objective: To systematically review the quality of existing practice guidelines for acute procedural pain in children and provide recommendations for their use.
Systematic Review: Digital Technology Distraction for Acute Pain in Children: AMeta-analysis
Michelle Gates,Lisa Hartling,Jocelyn Shulhan-Kilroy,Tara MacGregor,Samantha Guitard,Aireen Wingert,Robin Featherstone,Ben Vandermeer,Naveen Poonai,Janeva Kir...
Michelle Gates,Lisa Hartling,Jocelyn Shulhan-Kilroy,Tara MacGregor,Samantha G...
Objective:To determine the effect of digital technology distraction on pain and distress in children experiencing acutely painful conditions or procedures.
Objective:To determine the effect of digital technology distraction on pain and distress in children experiencing acutely painful conditions or procedures.
Systematic Review: Clinical efficacy of virtual reality for acute procedural pain management: A systematic review and meta-analysis
Evelyn Chan, Samantha Foster , Ryan Sambell , Paul Leong
Evelyn Chan, Samantha Foster , Ryan Sambell , Paul Leong
There is no comprehensive, high-quality systematic review that specifically assesses the efficacy of virtual reality on acutely painful healthcare interventions, nor has there been any quantitative data synthesis on this topic. We therefore conducted a sy
There is no comprehensive, high-quality systematic review that specifically assesses the efficacy of virtual reality on acutely painful healthcare interventions, nor has there been any quantitative data synthesis on this topic. We therefore conducted a sy
The role of inhaled methoxyflurane in acute pain management
Porter KM, Dayan AD, Dickerson S, Middleton PM.
Porter KM, Dayan AD, Dickerson S, Middleton PM.
Methoxyflurane is an inhaled analgesic administered via a disposable inhaler which has been used in Australia for over 40 years for the management of pain associated with trauma and for medical procedures in children and adults. Now available in 16 countr
Methoxyflurane is an inhaled analgesic administered via a disposable inhaler which has been used in Australia for over 40 years for the management of pain associated with trauma and for medical procedures in children and adults. Now available in 16 countr
Cochrane Systematic Review: Delayed antibiotics for respiratory infections
Spurling GK, Del Mar CB, Dooley L, Foxlee R, Farley R.
Spurling GK, Del Mar CB, Dooley L, Foxlee R, Farley R.
Objectives: To evaluate the use of delayed antibiotics compared to immediate or no antibiotics as a prescribing strategy for ARTIs. We evaluated clinical outcomes including duration and severity measures for pain, malaise, fever, cough and rhinorrhoea in sore throat, otitis media, bronchitis (cough) and the common cold. We also evaluated the outcomes of antibiotic use, patient satisfaction, antibiotic resistance and re-consultation rates and use of alternative therapies.
Objectives: To evaluate the use of delayed antibiotics compared to immediate or no antibiotics as a prescribing strategy for ARTIs. We evaluated clinical outcomes including duration and severity measures for pain, malaise, fever, cough and rhinorrhoea in sore throat, otitis media, bronchitis (cough) and the common cold. We also evaluated the outcomes of antibiotic use, patient satisfaction, antibiotic resistance and re-consultation rates and use of alternative therapies.
Cochrane Systematic Review: Antibiotics for preventing complications in children with measles
Kabra SK, Lodha R
Kabra SK, Lodha R
OBJECTIVES: To assess the effects of antibiotics given to children with measles to prevent complications and reduce pneumonia, other morbidities and mortality.
OBJECTIVES: To assess the effects of antibiotics given to children with measles to prevent complications and reduce pneumonia, other morbidities and mortality.
Review: From paper to practice: Strategies for improving antibiotic stewardship in the pediatric ambulatory setting.
Bozzella MJ, Harik N, Newland JG, Hamdy RF
Bozzella MJ, Harik N, Newland JG, Hamdy RF
Objective: The intent with this review is to provide an overview of strategies that pediatric providers can take from paper to practice.
Objective: The intent with this review is to provide an overview of strategies that pediatric providers can take from paper to practice.
Systematic Review: Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis
Costelloe C, Metcalfe C, Lovering A, Mant D, Hay AD
Costelloe C, Metcalfe C, Lovering A, Mant D, Hay AD
Objective: To systematically review the literature and, where appropriate, meta-analyse studies investigating subsequent antibiotic resistance in individuals prescribed antibiotics in primary care.
Objective: To systematically review the literature and, where appropriate, meta-analyse studies investigating subsequent antibiotic resistance in individuals prescribed antibiotics in primary care.
Key study: Symptomatic and asymptomatic respiratory viral infections in the first year of life: association with acute otitis media development
Chonmaitree T, Alvarez-Fernandez P, Jennings K, Trujillo R, Marom T, Loeffelholz MJ, Miller AL, McCormick DP, Patel JA, Pyles RB
Chonmaitree T, Alvarez-Fernandez P, Jennings K, Trujillo R, Marom T, Loeffelh...
Objective: This study determined the epidemiologic characteristics and etiology of asymptomatic upper respiratory tract infection in the first year of life and the association with acute otitis media complication.
Objective: This study determined the epidemiologic characteristics and etiology of asymptomatic upper respiratory tract infection in the first year of life and the association with acute otitis media complication.
Key study: Treatment of acute otitis media in children under 2 years of age
Hoberman A, Paradise JL, Rockette HE, Shaikh N, Wald ER, Kearney DH, Colborn DK, Kurs-Lasky M, Bhatnagar S, Haralam MA, Zoffel LM, Jenkins C, Pope MA, Balent...
Hoberman A, Paradise JL, Rockette HE, Shaikh N, Wald ER, Kearney DH, Colborn ...
Objective: We undertook this clinical trial to determine the extent to which antimicrobial treatment affects the course of both symptoms and signs of acute otitis media, irrespective of the apparent severity of the disease, among children 6 to 23 months of age in whom the diagnosis of acute otitis media is quite certain.
Objective: We undertook this clinical trial to determine the extent to which antimicrobial treatment affects the course of both symptoms and signs of acute otitis media, irrespective of the apparent severity of the disease, among children 6 to 23 months of age in whom the diagnosis of acute otitis media is quite certain.
Key study: A placebo-controlled trial of antimicrobial treatment for acute otitis media
Thtinen PA, Laine MK, Huovinen P, Jalava J, Ruuskanen O, Ruohola A
Thtinen PA, Laine MK, Huovinen P, Jalava J, Ruuskanen O, Ruohola A
Objective: We conducted a randomized, double-blind, placebo-controlled study of the efficacy of antimicrobial therapy in the age group with the highest incidence of acute otitis media. Our aim was to assess the efficacy of antimicrobial treatment for acute otitis media when strict diagnostic criteria are used and the antimicrobial coverage and dosage of the active treatment are adequate.
Objective: We conducted a randomized, double-blind, placebo-controlled study of the efficacy of antimicrobial therapy in the age group with the highest incidence of acute otitis media. Our aim was to assess the efficacy of antimicrobial treatment for acute otitis media when strict diagnostic criteria are used and the antimicrobial coverage and dosage of the active treatment are adequate.
Key study: Acute otitis media in children presenting to the emergency department: Is it diagnosed and managed appropriately?
Niroshan Balasundaram, Dung Phan, Daniel Mazzoni, Elliot Duong, Amy Sweeny, Chris Del Mar and Gerben Keijzers
Niroshan Balasundaram, Dung Phan, Daniel Mazzoni, Elliot Duong, Amy Sweeny, C...
Objective: To describe the diagnostic and management practice in children with acute otitis media (AOM) presenting to the emergency department (ED) and compare diagnosis and management against existing guidelines.
Objective: To describe the diagnostic and management practice in children with acute otitis media (AOM) presenting to the emergency department (ED) and compare diagnosis and management against existing guidelines.
Key study: Diagnostic Accuracy, Prescription Behavior, and Watchful Waiting Efficacy for Pediatric Acute Otitis Media
Brinker DL Jr, MacGeorge EL, Hackman N
Brinker DL Jr, MacGeorge EL, Hackman N
Objective: To assess the implications and recommendations to improve antibiotic stewardship through watchful waiting as an alternative to immediate antibiotic treatment in children with AOM.
Objective: To assess the implications and recommendations to improve antibiotic stewardship through watchful waiting as an alternative to immediate antibiotic treatment in children with AOM.
Key study: Optimising pain management in children with acute otitis media through a primary care-based multifaceted educational intervention: study protocol for a cluster randomised controlled trial
van Uum RT, Venekamp RP, Sjoukes A, van de Pol AC, de Wit GA, Schilder AGM, Damoiseaux RAMJ,
van Uum RT, Venekamp RP, Sjoukes A, van de Pol AC, de Wit GA, Schilder AGM, D...
Objective: We have developed a primary care-based multifaceted educational intervention to optimise pain management in children with AOM, and we trial its clinical and cost effectiveness.
Objective: We have developed a primary care-based multifaceted educational intervention to optimise pain management in children with AOM, and we trial its clinical and cost effectiveness.
Key study: Shortened Antimicrobial Treatment for Acute Otitis Media in Young Children
Hoberman A, Paradise JL, Rockette HE, Kearney DH, Bhatnagar S, Shope TR, Martin JM, Kurs-Lasky M, Copelli SJ, Colborn DK, Block SL, Labella JJ, Lynch TG, Coh...
Hoberman A, Paradise JL, Rockette HE, Kearney DH, Bhatnagar S, Shope TR, Mart...
Objective: Given methodologic limitations in available publications, we undertook the current trial involving children 6 to 23 months of age to determine whether limiting antimicrobial treatment to 5 days rather than using the standard 10-day regimen would afford equivalent outcomes and whether doing so also for subsequent episodes would lead to a reduction in the overall use of antimicrobial treatment, with a resulting reduction in the development of antimicrobial resistance.
Objective: Given methodologic limitations in available publications, we undertook the current trial involving children 6 to 23 months of age to determine whether limiting antimicrobial treatment to 5 days rather than using the standard 10-day regimen would afford equivalent outcomes and whether doing so also for subsequent episodes would lead to a reduction in the overall use of antimicrobial treatment, with a resulting reduction in the development of antimicrobial resistance.
Key study: Use of symptoms and risk factors to predict acute otitis media in infants
McCormick DP, Jennings K, Ede LC, Alvarez-Fernandez P, Patel J, Chonmaitree T
McCormick DP, Jennings K, Ede LC, Alvarez-Fernandez P, Patel J, Chonmaitree T
Objective: The purpose of this study was to evaluate the usefulness of symptoms and other risk factors in predicting the presence of AOM in infants.
Objective: The purpose of this study was to evaluate the usefulness of symptoms and other risk factors in predicting the presence of AOM in infants.
Key Study: Invasive bacterial Infections in afebrile infants diagnosed with acute otitis media
Son H McLaren 1, Andrea T Cruz 2, Kenneth Yen, et al. Pediatrics
Son H McLaren 1, Andrea T Cruz 2, Kenneth Yen, et al. Pediatrics
Objective: to determine the prevalence of invasive bacterial infections (IBIs) and adverse events in afebrile infants with acute otitis media (AOM).
Objective: to determine the prevalence of invasive bacterial infections (IBIs) and adverse events in afebrile infants with acute otitis media (AOM).
Key Study: Anaesthetic-analgesic ear drops to reduce antibiotic consumption in children with acute otitis media: the CEDAR RCT
Hay, A.D. et al.
Hay, A.D. et al.
Objective: The Childrens Ear Pain Study (CEDAR) investigated whether or not providing anaestheticanalgesic ear drops reduced antibiotic consumption in children with AOM. Secondary objectives included pain control and cost-effectiveness.
Objective: The Childrens Ear Pain Study (CEDAR) investigated whether or not providing anaestheticanalgesic ear drops reduced antibiotic consumption in children with AOM. Secondary objectives included pain control and cost-effectiveness.
Key Study: Acute care clinical indicators associated with discharge outcomes in children with severe traumatic brain injury
Vavilala MS, Kernic MA, Wang J, Kannan N, Mink RB, Wainwright MS, Groner JI, Bell MJ, Giza CC, Zatzick DF, Ellenbogen RG, Boyle LN, Mitchell PH, Rivara FP
Vavilala MS, Kernic MA, Wang J, Kannan N, Mink RB, Wainwright MS, Groner JI, ...
The effect of the 2003 severe pediatric traumatic brain injury (TBI) guidelines on outcomes has not been examined. We aimed to develop a set ofacutecare guideline-influenced clinical indicators of adherence and tested the relationship between these indicators during the first 72 hours after hospital admission and discharge outcomes.
The effect of the 2003 severe pediatric traumatic brain injury (TBI) guidelines on outcomes has not been examined. We aimed to develop a set ofacutecare guideline-influenced clinical indicators of adherence and tested the relationship between these indicators during the first 72 hours after hospital admission and discharge outcomes.
Key Study: Acute EEG findings in children with febrile status epilepticus: results of the FEBSTAT study
Nordli DR Jr, Mosh SL, Shinnar S, Hesdorffer DC, Sogawa Y, Pellock JM, Lewis DV, Frank LM, Shinnar RC, Sun S
Nordli DR Jr, Mosh SL, Shinnar S, Hesdorffer DC, Sogawa Y, Pellock JM, Lewis ...
Objective: The FEBSTAT (Consequences of Prolonged Febrile Seizures) study prospectively addresses the relationships among serial EEG, MRI, and clinical follow-up in a cohort of children followed from the time of presentation with febrile status epilepticus.
Objective: The FEBSTAT (Consequences of Prolonged Febrile Seizures) study prospectively addresses the relationships among serial EEG, MRI, and clinical follow-up in a cohort of children followed from the time of presentation with febrile status epilepticus.
Key Study: Photographing Injuries in the Acute Care Setting: Development and Evaluation of a Standardized Protocol for Research, Forensics, and Clinical Practice
Bloemen EM, Rosen T, Cline Schiroo JA, Clark S, Mulcare MR, Stern ME, Mysliwiec R, Flomenbaum NE, Lachs MS, Hargarten S
Bloemen EM, Rosen T, Cline Schiroo JA, Clark S, Mulcare MR, Stern ME, Mysliwi...
Our goal was to develop and evaluate a protocol for standardized photography of injuries that may be broadly applied.
Our goal was to develop and evaluate a protocol for standardized photography of injuries that may be broadly applied.
Key Study: Clinical risk score for persistent postconcussion symptoms among children with acute concussion in the ED
Zemek R, Barrowman N, Freedman SB, Gravel J, Gagnon I, McGahern C, Aglipay M, Sangha G, Boutis K, Beer D, Craig W, Burns E, Farion KJ, Mikrogianakis A, Barlo...
Zemek R, Barrowman N, Freedman SB, Gravel J, Gagnon I, McGahern C, Aglipay M,...
Objective: To derive and validate a clinical risk score for persistent postconcussion symptoms among children presenting to the emergency department.
Objective: To derive and validate a clinical risk score for persistent postconcussion symptoms among children presenting to the emergency department.
Key Study: Adherence behavior in an acute pediatric hand trauma population: A pilot study of parental report of adherence levels and influencing factors
Cole T, Underhill A, Kennedy S
Cole T, Underhill A, Kennedy S
The hand is a common site of injury in children; however, little is known regarding adherence to hand trauma management in this population.
The hand is a common site of injury in children; however, little is known regarding adherence to hand trauma management in this population.
Key Study: Acute ischemia and pink pulseless hand in 68 of 404 gartland type III supracondylar humeral fractures in children: Urgent management and therapeutic consensus
Louahem D, Cottalorda J
Louahem D, Cottalorda J
The purpose of this retrospective study was to describe our strategy and to determine the guidelines of therapeutic consensus.
The purpose of this retrospective study was to describe our strategy and to determine the guidelines of therapeutic consensus.
Key Study: A clinical decision rule for the use of plain radiography in children after acute wrist injury: development and external validation of the Amsterdam Pediatric Wrist Rules
Slaar A, Walenkamp MM, Bentohami A, Maas M, van Rijn RR, Steyerberg EW, Jager LC, Sosef NL, van Velde R, Ultee JM, Goslings JC, Schep NW
Slaar A, Walenkamp MM, Bentohami A, Maas M, van Rijn RR, Steyerberg EW, Jager...
The objective of this study was to develop and validate a clinica decision rule to decide whether radiography in children with wrist trauma is required.
The objective of this study was to develop and validate a clinica decision rule to decide whether radiography in children with wrist trauma is required.
Key Study: The role of dexamethasone in decreasing early recurrence of acute intussusception in children: A retrospective study
Efrati Y, Klin B, Kozer E, Abu-Kishk I
Efrati Y, Klin B, Kozer E, Abu-Kishk I
The purpose of this study was to examine the role of dexamethasone in decreasing early RI.
The purpose of this study was to examine the role of dexamethasone in decreasing early RI.
Key Study: Prevalence and Impact of Admission Acute Traumatic Coagulopathy on Treatment Intensity, Resource Use, and Mortality: An Evaluation of 956 Severely Injured Children and Adolescents
Liras IN, Caplan HW, Stensballe J, Wade CE, Cox CS, Cotton BA
Liras IN, Caplan HW, Stensballe J, Wade CE, Cox CS, Cotton BA
The purpose of this study was to assess the prevalence and impact of arrival coagulopathy, determined by viscoelastic hemostatic testing, in severely injured children.
The purpose of this study was to assess the prevalence and impact of arrival coagulopathy, determined by viscoelastic hemostatic testing, in severely injured children.
Key Study: Prevalence of Concomitant Acute Bacterial Meningitis in Neonates with Febrile Urinary Tract Infection: A Retrospective Cross-Sectional Study
Wallace SS, Brown DN, Cruz AT
Wallace SS, Brown DN, Cruz AT
The objective of this study was to describe the frequency of concomitant acute bacterial meningitis in neonates with febrile urinary tract infection.
The objective of this study was to describe the frequency of concomitant acute bacterial meningitis in neonates with febrile urinary tract infection.
Key study: Lumbar Puncture Performed Promptly or After Neuroimaging in Acute Bacterial Meningitis in Adults: A Prospective National Cohort Study Evaluating Different Guidelines
Glimker M, Sjlin J, kesson S, Naucler P
Glimker M, Sjlin J, kesson S, Naucler P
Objective: The aim was to evaluate the effect on outcome of adherence to European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), and Swedish guidelines regarding neuroimaging before LP.
Objective: The aim was to evaluate the effect on outcome of adherence to European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), and Swedish guidelines regarding neuroimaging before LP.
Key Study: A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma
Clark, E, Plint, AC, Correll, R, et al
Clark, E, Plint, AC, Correll, R, et al
To determine which of 3 analgesics, acetaminophen, ibuprofen, or codeine, given as a single dose, provides the most efficacious analgesia for children presenting to the emergency department with pain from acute musculoskeletal injuries.
To determine which of 3 analgesics, acetaminophen, ibuprofen, or codeine, given as a single dose, provides the most efficacious analgesia for children presenting to the emergency department with pain from acute musculoskeletal injuries.
Key Study: Acute cannabis toxicity
Noble MJH, K.; Hendrickson, R. G.
Noble MJH, K.; Hendrickson, R. G.
We describe the clinical effects of, and products associated with, acute exposures to cannabis during the early legalization period of recreational cannabis in Oregon and Alaska.
We describe the clinical effects of, and products associated with, acute exposures to cannabis during the early legalization period of recreational cannabis in Oregon and Alaska.
Key Study: Acute intoxication caused by synthetic cannabinoids 5F-ADB and MMB-2201: A case series
Barcelo BP, S.; Lopez-Corominas, V.; Gomila, I.; Yates, C.; Busardo, F. P.; Pellegrini, M.
Barcelo BP, S.; Lopez-Corominas, V.; Gomila, I.; Yates, C.; Busardo, F. P.; P...
Here, we report five cases of acute intoxication by synthetic cannabinoids 5F-ADB and MMB-2201 with analytical confirmation
Here, we report five cases of acute intoxication by synthetic cannabinoids 5F-ADB and MMB-2201 with analytical confirmation
Key Study: Acute intoxication caused by a synthetic cannabinoid in two adolescents
Heath TSB, Z.; Thompson, A. J.; Tecklenburg, F. W.
Heath TSB, Z.; Thompson, A. J.; Tecklenburg, F. W.
In this report, we describe two adolescent patients admitted after they inhaled K2, resulting in loss of consciousness, tachycardia, and diffuse pain.
In this report, we describe two adolescent patients admitted after they inhaled K2, resulting in loss of consciousness, tachycardia, and diffuse pain.
Key Study: Ataxia and shaking in a 2-year-old girl: acute marijuana intoxication presenting as seizure.
Bonkowsky, J. L., Sarco, D., & Pomeroy, S. L
Bonkowsky, J. L., Sarco, D., & Pomeroy, S. L
This is a case study of a young girl experiencing cannabis usage.
This is a case study of a young girl experiencing cannabis usage.
Key Study: Pediatric Abdominal X-rays in the Acute Care Setting Are We Overdiagnosing Constipation?
Malik Muhammad Anwar ul Haq, Hernando Lyons, Madiha Halim
Malik Muhammad Anwar ul Haq, Hernando Lyons, Madiha Halim
To determine 1) the sensitivity and specificity of plain AXR in the diagnosis of constipation and 2) the effect of age, race, gender, comorbid conditions, and practice setting on the diagnosis of constipation.
To determine 1) the sensitivity and specificity of plain AXR in the diagnosis of constipation and 2) the effect of age, race, gender, comorbid conditions, and practice setting on the diagnosis of constipation.
Key study: Severe acute respiratory syndrome coronavirus 2 clinical syndromes and predictors of disease severity in hospitalized children and youth.
Fernandes DM, Oliveira CR, Guerguis S, et al.
Fernandes DM, Oliveira CR, Guerguis S, et al.
Objective: To characterize the demographic and clinical features of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) syndromes and identify admission variables predictive of disease severity.
Objective: To characterize the demographic and clinical features of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) syndromes and identify admission variables predictive of disease severity.
Key study: Association between early participation in physical activity following acute concussion and persistent postconcussive symptoms in children and adolescents
Grool AM, Aglipay M, Momoli F, et al.
Grool AM, Aglipay M, Momoli F, et al.
To investigate the association between participation in physical activity within 7 days postinjury and incidence of persistent postconcussive symptoms (PPCS).
To investigate the association between participation in physical activity within 7 days postinjury and incidence of persistent postconcussive symptoms (PPCS).
High flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: a multicenter randomized controlled trial (TRAMONTANE study).
Milsi C, Essouri S, Pouyau R, Liet JM, Afanetti M, Portefaix A, et al.
Milsi C, Essouri S, Pouyau R, Liet JM, Afanetti M, Portefaix A, et al.
Nasal continuous positive airway pressure (nCPAP) is currently the gold standard for respiratory support for moderate to severe acute viral bronchiolitis (AVB). Although oxygen delivery via high flow nasal cannula (HFNC) is increasingly used, evidence of its efficacy and safety is lacking in infants. In young infants with moderate to severe AVB, initial management with HFNC did not have a failure rate similar to that of nCPAP.
Nasal continuous positive airway pressure (nCPAP) is currently the gold standard for respiratory support for moderate to severe acute viral bronchiolitis (AVB). Although oxygen delivery via high flow nasal cannula (HFNC) is increasingly used, evidence of its efficacy and safety is lacking in infants. In young infants with moderate to severe AVB, initial management with HFNC did not have a failure rate similar to that of nCPAP.
Use of high-flow nasal cannula support in the emergency department reduces the need for intubation in pediatric acute respiratory insufficiency.
Wing R, James C, Maranda LS, Armsby CC.
Wing R, James C, Maranda LS, Armsby CC.
The objective of this study was to determine whether the use of heated, humidified, high-flow nasal cannula (HFNC) therapy is associated with a decreased need for intubation in patients presenting to a pediatric emergency department (PED) and admitted to a pediatric intensive care unit (PICU) with acute respiratory insufficiency (ARI). High-flow nasal cannula used early in the development of pediatric ARI is associated with a decreased the need for intubation and mechanical ventilation.
The objective of this study was to determine whether the use of heated, humidified, high-flow nasal cannula (HFNC) therapy is associated with a decreased need for intubation in patients presenting to a pediatric emergency department (PED) and admitted to a pediatric intensive care unit (PICU) with acute respiratory insufficiency (ARI). High-flow nasal cannula used early in the development of pediatric ARI is associated with a decreased the need for intubation and mechanical ventilation.
Acute Kidney Injury in Critically Ill Children Admitted to the PICU for Diabetic Ketoacidosis. A Retrospective Study.
Weissbach A, Zur N, Kaplan E, Kadmon G, Gendler Y, Nahum E.
Weissbach A, Zur N, Kaplan E, Kadmon G, Gendler Y, Nahum E.
Acute kidney injury in the critically ill pediatric population is associated with worse outcome. The aim of this study was to assess the prevalence, associated clinical variables, and outcomes of acute kidney injury in children admitted to the PICU with diabetic ketoacidosis.
Acute kidney injury in the critically ill pediatric population is associated with worse outcome. The aim of this study was to assess the prevalence, associated clinical variables, and outcomes of acute kidney injury in children admitted to the PICU with diabetic ketoacidosis.
A randomized controlled trial of intranasal-midazolam versus intravenous-diazepam for acute childhood seizures
Thakker A, Shanbag P.
Thakker A, Shanbag P.
The objective of this study is to compare the safety and efficacy of midazolam given intranasally with diazepam given intravenously in the treatment of acute childhood seizures.
The objective of this study is to compare the safety and efficacy of midazolam given intranasally with diazepam given intravenously in the treatment of acute childhood seizures.
Efficacy and safety of intravenous sodium valproate versus phenobarbital in controlling convulsive status epilepticus and acute prolonged convulsive seizures in children: a randomised trial
Malamiri RA, Ghaempanah M, Khosroshahi N, Nikkhah A, Bavarian B, Ashrafi MR.
Malamiri RA, Ghaempanah M, Khosroshahi N, Nikkhah A, Bavarian B, Ashrafi MR.
Benzodiazepines, phenobarbital, and phenytoin are the most commonly used anticonvulsants for controlling status epilepticus and acute prolonged seizures. However, these medications have several well-known adverse effects. Previous studies on both adults and children have shown the efficacy and safety of rapid infusion of valproate in controlling status epilepticus. However, few well-designed randomised trials have been carried out in children, and there remains a paucity of data regarding intravenous sodium valproate use in children. Therefore, our aim was to compare the efficacy and safety of rapid loading of valproate with those of intravenous phenobarbital in children with status epilepticus and acute prolonged seizures.
Benzodiazepines, phenobarbital, and phenytoin are the most commonly used anticonvulsants for controlling status epilepticus and acute prolonged seizures. However, these medications have several well-known adverse effects. Previous studies on both adults and children have shown the efficacy and safety of rapid infusion of valproate in controlling status epilepticus. However, few well-designed randomised trials have been carried out in children, and there remains a paucity of data regarding intravenous sodium valproate use in children. Therefore, our aim was to compare the efficacy and safety of rapid loading of valproate with those of intravenous phenobarbital in children with status epilepticus and acute prolonged seizures.
Intranasal midazolam compared with intravenous diazepam in patients suffering from acute seizure: a randomized clinical trial
Javadzadeh M, Sheibani K, Hashemieh M, Saneifard H.
Javadzadeh M, Sheibani K, Hashemieh M, Saneifard H.
Acute seizure attack is a stressful experience both for health care personnel and parents. These attacks might cause morbidity and mortality among patients, so reliable methods to control the seizure preferably at home should be developed. This study was performed to measure the time needed to control seizure attacks using intranasal midazolam compared to the common treatment (intravenous diazepam) and to evaluate its probable side effects.
Acute seizure attack is a stressful experience both for health care personnel and parents. These attacks might cause morbidity and mortality among patients, so reliable methods to control the seizure preferably at home should be developed. This study was performed to measure the time needed to control seizure attacks using intranasal midazolam compared to the common treatment (intravenous diazepam) and to evaluate its probable side effects.
Intranasal versus intravenous lorazepam for control of acute seizures in children: a randomized open-label study
Arya R, Gulati S, Kabra M, Sahu JK, Kalra V.
Arya R, Gulati S, Kabra M, Sahu JK, Kalra V.
Intravenous lorazepam is considered the drug of first choice for control of acute convulsive seizures. However, resource or personnel constraints necessitate the study of alternative routes and medications. This study compared the efficacy and adverse effects of intranasal versus intravenous lorazepam in children aged 6-14 years who presented with acute seizures.
Intravenous lorazepam is considered the drug of first choice for control of acute convulsive seizures. However, resource or personnel constraints necessitate the study of alternative routes and medications. This study compared the efficacy and adverse effects of intranasal versus intravenous lorazepam in children aged 6-14 years who presented with acute seizures.
Intramuscular midazolam vs intravenous diazepam for acute seizures
Shah I, Deshmukh CT.
Shah I, Deshmukh CT.
To determine effectiveness of intramuscular midazolam to control acute seizures in children as compared to intravenous diazepam.
To determine effectiveness of intramuscular midazolam to control acute seizures in children as compared to intravenous diazepam.
Comparison of intranasal midazolam with intravenous diazepam for treating acute seizures in children
Mahmoudian T, Zadeh MM.
Mahmoudian T, Zadeh MM.
Midazolam, a water-soluble benzodiazepine, is usually given intravenously in status epilepticus. The aim of this study was to determine whether intranasal midazolam is as safe and effective as intravenous diazepam in the treatment of acute childhood seizures. Seventy children aged 2 months to 15 years with acute seizures (febrile or afebrile) admitted to the pediatric emergency department of a general hospital during a 14-month period were eligible for inclusion. Intranasal midazolam 0.2 mg/kg and intravenous diazepam 0.2 mg/kg were administered after intravenous lines were established. Intranasal midazolam and intravenous diazepam were equally effective. The mean time to control of seizures was 3.58 (SD 1.68) minutes in the midazolam group and 2.94 (SD 2.62) in the diazepam group, not counting the time required to insert the intravenous line. No significant side effects were observed in either group. Although intranasal midazolam was as safe and effective as diazepam, seizures were controlled more quickly with intravenous diazepam than with intranasal midazolam. Intranasal midazolam can possibly be used not only in medical centers, but also in general practice and at home after appropriate instructions are given to families of children with recurrent seizures.
Midazolam, a water-soluble benzodiazepine, is usually given intravenously in status epilepticus. The aim of this study was to determine whether intranasal midazolam is as safe and effective as intravenous diazepam in the treatment of acute childhood seizures. Seventy children aged 2 months to 15 years with acute seizures (febrile or afebrile) admitted to the pediatric emergency department of a general hospital during a 14-month period were eligible for inclusion. Intranasal midazolam 0.2 mg/kg and intravenous diazepam 0.2 mg/kg were administered after intravenous lines were established. Intranasal midazolam and intravenous diazepam were equally effective. The mean time to control of seizures was 3.58 (SD 1.68) minutes in the midazolam group and 2.94 (SD 2.62) in the diazepam group, not counting the time required to insert the intravenous line. No significant side effects were observed in either group. Although intranasal midazolam was as safe and effective as diazepam, seizures were controlled more quickly with intravenous diazepam than with intranasal midazolam. Intranasal midazolam can possibly be used not only in medical centers, but also in general practice and at home after appropriate instructions are given to families of children with recurrent seizures.
Effects of intranasal midazolam and rectal diazepam on acute convulsions in children: prospective randomized study
Figin T, Gurer Y, Tezi T, Senbil N, Zorlu P, Okuyaz C, et al.
Figin T, Gurer Y, Tezi T, Senbil N, Zorlu P, Okuyaz C, et al.
In this study, the effects and side effects of rectal diazepam and intranasal midazolam were compared in the treatment of acute convulsions in children to develop a practical and safe treatment protocol.
In this study, the effects and side effects of rectal diazepam and intranasal midazolam were compared in the treatment of acute convulsions in children to develop a practical and safe treatment protocol.
Intravenous levetiracetam in acute repetitive seizures and status epilepticus in children: experience from a children's hospital
McTague A, Kneen R, Kumar R, Spinty S, Appleton R.
McTague A, Kneen R, Kumar R, Spinty S, Appleton R.
To report the effectiveness and safety of intravenous levetiracetam in the treatment of children with acute repeated seizures, and status epilepticus in a children's hospital.
To report the effectiveness and safety of intravenous levetiracetam in the treatment of children with acute repeated seizures, and status epilepticus in a children's hospital.
Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus.
Appleton R, Sweeney A, Choonara I, Robson J, Molyneux E.
Appleton R, Sweeney A, Choonara I, Robson J, Molyneux E.
Lorazepam was compared with diazepam for the treatment of acute convulsions and status epilepticus in 102 children in a prospective, open, 'odd and even dates' trial. Convulsions were controlled in 76 per cent of patients treated with a single dose of lorazepam and 51 per cent of patients treated with a single dose of diazepam. Significantly fewer patients treated with lorazepam required additional anticonvulsants to terminate the seizure. Respiratory depression occurred in 3 per cent of lorazepam-treated patients and 15 per cent of diazepam-treated patients. No patient who received lorazepam required admission to the intensive care unit for either respiratory depression or persisting status epilepticus. Rectally administered lorazepam appeared to be particularly valuable (100 per cent efficacy) when venous access was not possible.
Lorazepam was compared with diazepam for the treatment of acute convulsions and status epilepticus in 102 children in a prospective, open, 'odd and even dates' trial. Convulsions were controlled in 76 per cent of patients treated with a single dose of lorazepam and 51 per cent of patients treated with a single dose of diazepam. Significantly fewer patients treated with lorazepam required additional anticonvulsants to terminate the seizure. Respiratory depression occurred in 3 per cent of lorazepam-treated patients and 15 per cent of diazepam-treated patients. No patient who received lorazepam required admission to the intensive care unit for either respiratory depression or persisting status epilepticus. Rectally administered lorazepam appeared to be particularly valuable (100 per cent efficacy) when venous access was not possible.
Intravenous levetiracetam in Thai children and adolescents with status epilepticus and acute repetitive seizures
Khongkhatithum C, Thampratankul L, Wiwattanadittakul N, Visudtibhan A.
Khongkhatithum C, Thampratankul L, Wiwattanadittakul N, Visudtibhan A.
This study investigated the safety and the efficacy of levetiracetam for intravenous treatment of convulsive status epilepticus and acute repetitive seizures in children and adolescents.
This study investigated the safety and the efficacy of levetiracetam for intravenous treatment of convulsive status epilepticus and acute repetitive seizures in children and adolescents.
Safety and efficacy of intravenous valproate in pediatric status epilepticus and acute repetitive seizures
Yu KT, Mills S, Thompson N, Cunanan C.
Yu KT, Mills S, Thompson N, Cunanan C.
To evaluate the safety and efficacy of intravenous valproate (VPA) loading in children with status epilepticus (SE) or acute repetitive seizures.
To evaluate the safety and efficacy of intravenous valproate (VPA) loading in children with status epilepticus (SE) or acute repetitive seizures.
Executive summary: Evaluation and management of children and adolescents with acute mental health or behavioral problems. Part I: Common clinical challenges of patients with mental health and/or behavioral emergencies
Chun, T. H., S. E. Mace, E. R. Katz, J. E. Shook, J. M. Callahan, G. P. Conners, E. E. Conway, N. C. Dudley, T. K. Gross, N. E. Lane, C. G. Macias, N. L. Tim...
Chun, T. H., S. E. Mace, E. R. Katz, J. E. Shook, J. M. Callahan, G. P. Conne...
Resource - Acute Procedural Pain Toolkits
Canadian Association of Paediatric Health Centres Pain Community of Practice
Canadian Association of Paediatric Health Centres Pain Community of Practice
These Toolkits are a resource for clinicians who work with children that may experience acute procedural pain and support moving best practice recommendations into practice. Based on the best research evidence and clinical practice, these Toolkits
These Toolkits are a resource for clinicians who work with children that may experience acute procedural pain and support moving best practice recommendations into practice. Based on the best research evidence and clinical practice, these Toolkits
Drug management for acute tonicclonic convulsions including convulsive status epilepticus in children
McTague A, Martland T, Appleton R.
McTague A, Martland T, Appleton R.
To evaluate the effectiveness and safety of anticonvulsant drugs used to treat any acute tonicclonic convulsion of any duration, including established convulsive (tonicclonic) status epilepticus in children who present to a hospital or emergency medical department.
To evaluate the effectiveness and safety of anticonvulsant drugs used to treat any acute tonicclonic convulsion of any duration, including established convulsive (tonicclonic) status epilepticus in children who present to a hospital or emergency medical department.
An Evidence-Based Approach to Minimizing Acute Procedural Pain in the Emergency Department and Beyond. Pediatr Emerg Care 2016;32(1):36-42.
Ali S, McGrath T, Drendel AL
Ali S, McGrath T, Drendel AL
Objective: This review article aims to provide a summary of several strategies, which are supported by definitive and systematically reviewed evidence, that can be implemented alone or in combination to reduce procedural pain and anxiety for children in t
Objective: This review article aims to provide a summary of several strategies, which are supported by definitive and systematically reviewed evidence, that can be implemented alone or in combination to reduce procedural pain and anxiety for children in t
Ketamine use for acute agitation in the emergency department
Hopper, A. B., G. M. Vilke, E. M. Castillo, A. Campillo, T. Davie and M. P. Wilson
Hopper, A. B., G. M. Vilke, E. M. Castillo, A. Campillo, T. Davie and M. P. W...
Ketamine sedation for patients with acute agitation and psychiatric illness requiring aeromedical retrieval
Le Cong, M., B. Gynther, E. Hunter and P. Schuller
Le Cong, M., B. Gynther, E. Hunter and P. Schuller
Ketamine reduces the need for intubation in patients with acute severe mental illness and agitation requiring transport to definitive care: An observational study
Parsch, C. S., A. Boonstra, D. Teubner, W. Emmerton, B. McKenny and D. Y. Ellis
Parsch, C. S., A. Boonstra, D. Teubner, W. Emmerton, B. McKenny and D. Y. Ellis
Pharmacogenetics of acute treatment of depression and anxiety in children and adolescents
Kronenberg, S., A. Apter, M. Carmel, A. Frisch and A. Weizman
Kronenberg, S., A. Apter, M. Carmel, A. Frisch and A. Weizman
Comparison of risperidone orodispersible tablet and intramuscular haloperidol in the treatment of acute psychotic agitation: a randomized open, prospective study
Lim, H. K., J. J. Kim, C. U. Pae, C. U. Lee, C. Lee and I. H. Paik
Lim, H. K., J. J. Kim, C. U. Pae, C. U. Lee, C. Lee and I. H. Paik
Management of acute undifferentiated agitation in the emergency department: a randomized double-blind trial of droperidol, ziprasidone, and midazolam
Martel, M., A. Sterzinger, J. Miner, J. Clinton and M. Biros
Martel, M., A. Sterzinger, J. Miner, J. Clinton and M. Biros
A single-dose, randomized, double-blind, placebo-controlled trial of sublingual asenapine for acute agitation
Pratts, M., L. Citrome, W. Grant, L. Leso and L. A. Opler
Pratts, M., L. Citrome, W. Grant, L. Leso and L. A. Opler
A randomized, double-blind study of paliperidone extended-release in treatment of acute schizophrenia in adolescents
Singh, J., A. Robb, U. Vijapurkar, I. Nuamah and D. Hough
Singh, J., A. Robb, U. Vijapurkar, I. Nuamah and D. Hough
Risperidone versus haloperidol, in combination with lorazepam, in the treatment of acute agitation and psychosis: a pilot, randomized, double-blind, placebo-controlled trial
Veser, F. H., B. D. Veser, J. T. McMullan, J. Zealberg and G. W. Currier
Veser, F. H., B. D. Veser, J. T. McMullan, J. Zealberg and G. W. Currier