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Bottom Line Recommendations: Acute Otitis Media (2022)

Bottom Line Recommendations: Acute Otitis Media (2022)

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Dr. Nicole Le Saux

Dr. Nicole Le Saux

Bottom line recommendations for the treatment of acute otitis media. Published online November (2022).

Bottom line recommendations for the treatment of acute otitis media. Published online November (2022).

Evidence Repository: Acute Otitis Media

Evidence Repository: Acute Otitis Media

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Dr. Nicole Le Saux

Dr. Nicole Le Saux

Evidence repositories are collections of best available resources and evidence (clinical guidelines, peer reviewed literature, systematic reviews, etc.), collated by our knowledge synthesis team and content advisors. This evidence repository is not intended to be an exhaustive list of resources for a topic, but rather a curated list of current, evidence-based resources, based on expert consensus of relevance and usability for a general emergency department setting. We search databases (Cochrane Library, PubMed, TRIP Database) and web search engines (Google, Google Scholar) to locate evidence. Additionally, hospital websites are browsed for guidance documents, such as clinical practice guidelines (CPG) for healthcare professionals. 

 

Every effort is made to identify resources that are open access (i.e. publicly available, free of charge, not requiring a subscription). 

 

More information about the creation of our evidence repositories can be found at https://pubmed.ncbi.nlm.nih.gov/28537762/

Evidence repositories are collections of best available resources and evidence (clinical guidelines, peer reviewed literature, systematic reviews, etc.), collated by our knowledge synthesis team and content advisors. This evidence repository is not intended to be an exhaustive list of resources for a topic, but rather a curated list of current, evidence-based resources, based on expert consensus of relevance and usability for a general emergency department setting. We search databases (Cochrane Library, PubMed, TRIP Database) and web search engines (Google, Google Scholar) to locate evidence. Additionally, hospital websites are browsed for guidance documents, such as clinical practice guidelines (CPG) for healthcare professionals. 

 

Every effort is made to identify resources that are open access (i.e. publicly available, free of charge, not requiring a subscription). 

 

More information about the creation of our evidence repositories can be found at https://pubmed.ncbi.nlm.nih.gov/28537762/

Evidence Repository: Acute Agitation

Evidence Repository: Acute Agitation

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Dr. T. Chun, Dr. S. Etches, Dr. S. Duffy

Dr. T. Chun, Dr. S. Etches, Dr. S. Duffy

Evidence repositories are collections of best available resources and evidence (clinical guidelines, peer reviewed literature, systematic reviews, etc.), collated by our knowledge synthesis team and content advisors. This evidence repository is not intended to be an exhaustive list of resources for a topic, but rather a curated list of current, evidence-based resources, based on expert consensus of relevance and usability for a general emergency department setting. We search databases (Cochrane Library, PubMed, TRIP Database) and web search engines (Google, Google Scholar) to locate evidence. Additionally, hospital websites are browsed for guidance documents, such as clinical practice guidelines (CPG) for healthcare professionals. 

 

Every effort is made to identify resources that are open access (i.e. publicly available, free of charge, not requiring a subscription). 

 

More information about the creation of our evidence repositories can be found at https://pubmed.ncbi.nlm.nih.gov/28537762/

Evidence repositories are collections of best available resources and evidence (clinical guidelines, peer reviewed literature, systematic reviews, etc.), collated by our knowledge synthesis team and content advisors. This evidence repository is not intended to be an exhaustive list of resources for a topic, but rather a curated list of current, evidence-based resources, based on expert consensus of relevance and usability for a general emergency department setting. We search databases (Cochrane Library, PubMed, TRIP Database) and web search engines (Google, Google Scholar) to locate evidence. Additionally, hospital websites are browsed for guidance documents, such as clinical practice guidelines (CPG) for healthcare professionals. 

 

Every effort is made to identify resources that are open access (i.e. publicly available, free of charge, not requiring a subscription). 

 

More information about the creation of our evidence repositories can be found at https://pubmed.ncbi.nlm.nih.gov/28537762/

Recommandations de base: Otite moyenne aigue (2022)

Recommandations de base: Otite moyenne aigue (2022)

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Dr. Nicole Le Saux

Dr. Nicole Le Saux

French bottom line recommendations for the treatment of acute otitis media. Published online November, 2022. 

French bottom line recommendations for the treatment of acute otitis media. Published online November, 2022. 

Clinical guidelines

Clinical Practice Guideline: Resuscitation of blue baby and the use of prostaglandins  (2010)

Clinical Practice Guideline: Resuscitation of blue baby and the use of prostaglandins

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Linney M, Gnapragassam J, Wilson P, Rodd I

Linney M, Gnapragassam J, Wilson P, Rodd I

This document relates to the acute management of infants presenting acutely with collapse and/or cyanosis suggestive of congenital heart defect.

This document relates to the acute management of infants presenting acutely with collapse and/or cyanosis suggestive of congenital heart defect.

Systematic reviews

Cochrane Systematic Review: Decongestants and antihistamines for acute otitis media in children

Cochrane Systematic Review: Decongestants and antihistamines for acute otitis media in children

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Coleman C, Moore M.

Coleman C, Moore M.

Objectives: To determine the efficacy of decongestant and antihistamine therapy in children with AOM on outcomes of AOM resolution, symptom resolution, medication side effects, and complications of AOM.

Objectives: To determine the efficacy of decongestant and antihistamine therapy in children with AOM on outcomes of AOM resolution, symptom resolution, medication side effects, and complications of AOM.

Cochrane Systematic Review: Once or twice daily versus three times daily amoxicillin with or without clavulanate for the treatment of acute otitis media

Cochrane Systematic Review: Once or twice daily versus three times daily amoxicillin with or without clavulanate for the treatment of acute otitis media

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Thanaviratananich S, Laopaiboon M, Vatanasapt P.

Thanaviratananich S, Laopaiboon M, Vatanasapt P.

Objectives: To compare the effectiveness of one or two daily doses with three or four daily doses of amoxicillin, with or without clavulanate, for the treatment of AOM in children; and to compare complication rates and adverse reactions.

Objectives: To compare the effectiveness of one or two daily doses with three or four daily doses of amoxicillin, with or without clavulanate, for the treatment of AOM in children; and to compare complication rates and adverse reactions.

Cochrane Systematic Review: Short-course antibiotics for acute otitis media

Cochrane Systematic Review: Short-course antibiotics for acute otitis media

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Kozyrskyj A, Klassen TP, Moffatt M, Harvey K.

Kozyrskyj A, Klassen TP, Moffatt M, Harvey K.

Objectives: To determine the effectiveness of a short course of antibiotics (less than seven days) in comparison to a long course of antibiotics (seven days or greater) for the treatment of AOM in children.

Objectives: To determine the effectiveness of a short course of antibiotics (less than seven days) in comparison to a long course of antibiotics (seven days or greater) for the treatment of AOM in children.

Cochrane Systematic Review: Topical analgesia for acute otitis media

Cochrane Systematic Review: Topical analgesia for acute otitis media

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Foxlee R, Johansson A, Wejfalk J, Dawkins J, Dooley L, Del Mar C.

Foxlee R, Johansson A, Wejfalk J, Dawkins J, Dooley L, Del Mar C.

Objectives: To assess the effectiveness of topical analgesia for AOM.

Objectives: To assess the effectiveness of topical analgesia for AOM.

Cochrane Systematic Review: Antibiotics for the prevention of acute and chronic suppurative otitis media in children

Cochrane Systematic Review: Antibiotics for the prevention of acute and chronic suppurative otitis media in children

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Leach AJ, Morris PS

Leach AJ, Morris PS

OBJECTIVES: To determine the effectiveness of long-term antibiotics (for longer than six weeks) in preventing any AOM, AOM with perforation and C

OBJECTIVES: To determine the effectiveness of long-term antibiotics (for longer than six weeks) in preventing any AOM, AOM with perforation and C

Cochrane Systematic Review: Antibiotics for otitis media with effusion in children

Cochrane Systematic Review: Antibiotics for otitis media with effusion in children

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van Zon A, van der Heijden GJ, van Dongen TM, Burton MJ, Schilder AG

van Zon A, van der Heijden GJ, van Dongen TM, Burton MJ, Schilder AG

OBJECTIVES: To assess the effects of antibiotics in children up to 18 years with OME.

OBJECTIVES: To assess the effects of antibiotics in children up to 18 years with OME.

Cochrane Systematic Review: Antihistamines and/or decongestants for otitis media with effusion (OME) in children

Cochrane Systematic Review: Antihistamines and/or decongestants for otitis media with effusion (OME) in children

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Griffin G, Flynn CA

Griffin G, Flynn CA

OBJECTIVES: The objective of this review was to determine whether antihistamine, decongestant or combination therapy is effective in treating children who present with OME.

OBJECTIVES: The objective of this review was to determine whether antihistamine, decongestant or combination therapy is effective in treating children who present with OME.

Cochrane Systematic Review: Identification of children in the first four years of life for early treatment for otitis media with effusion

Cochrane Systematic Review: Identification of children in the first four years of life for early treatment for otitis media with effusion

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Simpson SA, Thomas CL, van der Linden MK, Macmillan H, van der Wouden JC, Butler C

Simpson SA, Thomas CL, van der Linden MK, Macmillan H, van der Wouden JC, Bu...

OBJECTIVES: The aim of this review was to assess evidence from randomised controlled trials about the effect, on language and behavioural outcomes, of screening and treating children with clinically important OME in the first four years of their life. The focus was on the first four years of life because this is the time of most rapid language development. The consequences of hearing loss are likely to be most serious during this time. In addition, children of this age are least likely to be able to report or seek help for impaired hearing, particularly if these problems have a slow onset and are subtle.

OBJECTIVES: The aim of this review was to assess evidence from randomised controlled trials about the effect, on language and behavioural outcomes, of screening and treating children with clinically important OME in the first four years of their life. The focus was on the first four years of life because this is the time of most rapid language development. The consequences of hearing loss are likely to be most serious during this time. In addition, children of this age are least likely to be able to report or seek help for impaired hearing, particularly if these problems have a slow onset and are subtle.

Cochrane Systematic Review: Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children

Cochrane Systematic Review: Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children

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Simpson SA, Lewis R, van der Voort J, Butler CC

Simpson SA, Lewis R, van der Voort J, Butler CC

OBJECTIVES: To examine the evidence for treating children with hearing loss associated with OME with systemic or topical intranasal steroids.

OBJECTIVES: To examine the evidence for treating children with hearing loss associated with OME with systemic or topical intranasal steroids.

Cochrane Systematic Review: Aerosolized prostacyclin for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)

Cochrane Systematic Review: Aerosolized prostacyclin for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS)

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Afshari A, Brok J, Mller AM, Wetterslev J

Afshari A, Brok J, Mller AM, Wetterslev J

OBJECTIVES: To systematically assess the benefits and harms of aerosolized prostacyclin in critically ill patients with ALI and ARDS.

OBJECTIVES: To systematically assess the benefits and harms of aerosolized prostacyclin in critically ill patients with ALI and ARDS.

Cochrane Systematic Review: High-frequency ventilation versus conventional ventilation for treatment of acute lung injury and acute respiratory distress syndrome

Cochrane Systematic Review: High-frequency ventilation versus conventional ventilation for treatment of acute lung injury and acute respiratory distress syndrome

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Sud S, Sud M, Friedrich JO, Wunsch H, Meade MO, Ferguson ND, Adhikari NK

Sud S, Sud M, Friedrich JO, Wunsch H, Meade MO, Ferguson ND, Adhikari NK

OBJECTIVES: To determine clinical and physiological effects of high frequency oscillation (HFO) in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) compared to conventional ventilation.

OBJECTIVES: To determine clinical and physiological effects of high frequency oscillation (HFO) in patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) compared to conventional ventilation.

Cochrane Systematic Review: Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) and acute lung injury in children and adults

Cochrane Systematic Review: Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) and acute lung injury in children and adults

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Afshari A, Brok J, Mller AM, Wetterslev J. Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) and acute lung injury in children and adults....

Afshari A, Brok J, Mller AM, Wetterslev J. Inhaled nitric oxide for acute re...

OBJECTIVES: To systematically assess the benefits and harms of INO in critically ill patients with AHRF.

OBJECTIVES: To systematically assess the benefits and harms of INO in critically ill patients with AHRF.

Cochrane Systematic Review: Continuous negative extrathoracic pressure or continuous positive airway pressure compared to conventional ventilation for acute hypoxaemic respiratory failure in children

Cochrane Systematic Review: Continuous negative extrathoracic pressure or continuous positive airway pressure compared to conventional ventilation for acute hypoxaemic respiratory failure in children

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Shah PS, Ohlsson A, Shah JP.

Shah PS, Ohlsson A, Shah JP.

Objectives: To assess the effectiveness of CNEP or Ni-CPAP compared to conventional ventilation in children (at least one month old and less than 18 years of age) with AHRF due to non-cardiogenic causes for improving the mortality or morbidity associated with AHRF.

Objectives: To assess the effectiveness of CNEP or Ni-CPAP compared to conventional ventilation in children (at least one month old and less than 18 years of age) with AHRF due to non-cardiogenic causes for improving the mortality or morbidity associated with AHRF.

Cochrane Systematic Review: Decongestants, antihistamines and nasal irrigation for acute sinusitis in children

Cochrane Systematic Review: Decongestants, antihistamines and nasal irrigation for acute sinusitis in children

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Shaikh N, Wald ER, Pi M.

Shaikh N, Wald ER, Pi M.

Objectives: To systematically review the efficacy of decongestants, antihistamines and nasal irrigation in children with clinically diagnosed acute sinusitis. We considered the following four interventions: 1) decongestants versus placebo or no medication, 2) antihistamines versus placebo or no medication, 3) decongestant and antihistamine combination versus placebo or no medication, 4) nasal irrigation versus no irrigation. The primary outcomes of the review were symptom resolution (improvement in symptom score from enrolment to day five and overall symptom burden (as measured by average symptom scores while on therapy).

Objectives: To systematically review the efficacy of decongestants, antihistamines and nasal irrigation in children with clinically diagnosed acute sinusitis. We considered the following four interventions: 1) decongestants versus placebo or no medication, 2) antihistamines versus placebo or no medication, 3) decongestant and antihistamine combination versus placebo or no medication, 4) nasal irrigation versus no irrigation. The primary outcomes of the review were symptom resolution (improvement in symptom score from enrolment to day five and overall symptom burden (as measured by average symptom scores while on therapy).

Cochrane Systematic Review: Honey for acute cough in children

Cochrane Systematic Review: Honey for acute cough in children

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Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh EE.

Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh EE.

Objectives: To evaluate the effectiveness of honey for acute cough in children in ambulatory settings.

Objectives: To evaluate the effectiveness of honey for acute cough in children in ambulatory settings.

Cochrane Systematic Review: Inhaled corticosteroids during acute bronchiolitis in the prevention of post-bronchiolitic wheezing

Cochrane Systematic Review: Inhaled corticosteroids during acute bronchiolitis in the prevention of post-bronchiolitic wheezing

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Blom DJ, Ermers M, Bont L, van Woensel JB, Van Aalderen WM.

Blom DJ, Ermers M, Bont L, van Woensel JB, Van Aalderen WM.

Objectives: The objective of this review was to evaluate the effect of inhaled corticosteroids, started during the acute phase of bronchiolitis, on the prevention of post-bronchiolitic wheezing.

Objectives: The objective of this review was to evaluate the effect of inhaled corticosteroids, started during the acute phase of bronchiolitis, on the prevention of post-bronchiolitic wheezing.

Cochrane Systematic Review: Intranasal steroids for acute sinusitis

Cochrane Systematic Review: Intranasal steroids for acute sinusitis

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Zalmanovici Trestioreanu A, Yaphe J.

Zalmanovici Trestioreanu A, Yaphe J.

Objectives: We examined whether intranasal corticosteroids (INCS) are effective in relieving symptoms of acute sinusitis in adults and children.

Objectives: We examined whether intranasal corticosteroids (INCS) are effective in relieving symptoms of acute sinusitis in adults and children.

Cochrane Systematic Review: Over-the-counter (OTC) medications for acute cough in children and adults in ambulatory settings

Cochrane Systematic Review: Over-the-counter (OTC) medications for acute cough in children and adults in ambulatory settings

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Smith SM, Schroeder K, Fahey T.

Smith SM, Schroeder K, Fahey T.

Objectives: To assess the effects of oral OTC cough preparations for acute cough in children and adults.

Objectives: To assess the effects of oral OTC cough preparations for acute cough in children and adults.

Cochrane Systematic Review: Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults

Cochrane Systematic Review: Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults

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Chang CC, Cheng AC, Chang AB.

Chang CC, Cheng AC, Chang AB.

Objectives: To evaluate the efficacy of OTC cough medications as an adjunct to antibiotics in children and adults with pneumonia.

Objectives: To evaluate the efficacy of OTC cough medications as an adjunct to antibiotics in children and adults with pneumonia.

Cochrane Systematic Review: Pelargonium sidoides extract for treating acute respiratory tract infections

Cochrane Systematic Review: Pelargonium sidoides extract for treating acute respiratory tract infections

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Timmer A, Gnther J, Motschall E, Rcker G, Antes G, Kern WV.

Timmer A, Gnther J, Motschall E, Rcker G, Antes G, Kern WV.

Objectives: To assess the efficacy and safety of P. sidoides for the treatment of ARIs in children and adults.

Objectives: To assess the efficacy and safety of P. sidoides for the treatment of ARIs in children and adults.

Cochrane Systematic Review: Probiotics for preventing acute upper respiratory tract infections

Cochrane Systematic Review: Probiotics for preventing acute upper respiratory tract infections

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Hao Q, Lu Z, Dong BR, Huang CQ, Wu T.

Hao Q, Lu Z, Dong BR, Huang CQ, Wu T.

Objectives: To assess the effectiveness and safety of probiotics for preventing acute URTIs.

Objectives: To assess the effectiveness and safety of probiotics for preventing acute URTIs.

Cochrane Systematic Review: Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections

Cochrane Systematic Review: Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections

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Schuetz P, Mller B, Christ-Crain M, Stolz D, Tamm M, Bouadma L, Luyt CE, Wolff M, Chastre J, Tubach F, Kristoffersen KB, Burkhardt O, Welte T, Schroeder S, N...

Schuetz P, Mller B, Christ-Crain M, Stolz D, Tamm M, Bouadma L, Luyt CE, Wolf...

Objectives: The aim of this systematic review based on individual patient data was to assess the safety and efficacy of using procalcitonin for starting or stopping antibiotics over a large range of patients with varying severity of ARIs and from different clinical settings.

Objectives: The aim of this systematic review based on individual patient data was to assess the safety and efficacy of using procalcitonin for starting or stopping antibiotics over a large range of patients with varying severity of ARIs and from different clinical settings.

Cochrane Systematic Review: Rapid viral diagnosis for acute febrile respiratory illness in children in the Emergency Department

Cochrane Systematic Review: Rapid viral diagnosis for acute febrile respiratory illness in children in the Emergency Department

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Doan Q, Enarson P, Kissoon N, Klassen TP, Johnson DW.

Doan Q, Enarson P, Kissoon N, Klassen TP, Johnson DW.

Objectives: To determine the effect of rapid viral testing in the ED on the rate of precautionary testing, antibiotic use, and length of ED visit.

Objectives: To determine the effect of rapid viral testing in the ED on the rate of precautionary testing, antibiotic use, and length of ED visit.

Cochrane Systematic Review: Saline nasal irrigation for acute upper respiratory tract infections

Cochrane Systematic Review: Saline nasal irrigation for acute upper respiratory tract infections

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Kassel JC, King D, Spurling GK.

Kassel JC, King D, Spurling GK.

Objectives: To evaluate the efficacy of saline nasal irrigation in treating the symptoms of acute URTIs.

Objectives: To evaluate the efficacy of saline nasal irrigation in treating the symptoms of acute URTIs.

Cochrane Systematic Review: Short-term late-generation antibiotics versus longer term penicillin for acute streptococcal pharyngitis in children

Cochrane Systematic Review: Short-term late-generation antibiotics versus longer term penicillin for acute streptococcal pharyngitis in children

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Altamimi S, Khalil A, Khalaiwi KA, Milner RA, Pusic MV, Al Othman MA.

Altamimi S, Khalil A, Khalaiwi KA, Milner RA, Pusic MV, Al Othman MA.

Objectives: To summarize the evidence regarding the efficacy of two to six days of newer oral antibiotics (short duration) compared to 10 days of oral penicillin (standard duration) in treating children with acute GABHS pharyngitis.

Objectives: To summarize the evidence regarding the efficacy of two to six days of newer oral antibiotics (short duration) compared to 10 days of oral penicillin (standard duration) in treating children with acute GABHS pharyngitis.

Cochrane Systematic Review: Steam inhalation or humidified oxygen for acute bronchiolitis in children up to three years of age

Cochrane Systematic Review: Steam inhalation or humidified oxygen for acute bronchiolitis in children up to three years of age

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Umoren R, Odey F, Meremikwu MM.

Umoren R, Odey F, Meremikwu MM.

Objectives: To evaluate the effect of steam inhalation or humidified oxygen to relieve respiratory distress and to evaluate adverse events in children up to three years old with acute bronchiolitis.

Objectives: To evaluate the effect of steam inhalation or humidified oxygen to relieve respiratory distress and to evaluate adverse events in children up to three years old with acute bronchiolitis.

Cochrane Systematic Review: Systemic corticosteroids for acute sinusitis

Cochrane Systematic Review: Systemic corticosteroids for acute sinusitis

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Venekamp RP, Thompson MJ, Hayward G, Heneghan CJ, Del Mar CB, Perera R, Glasziou PP, Rovers MM.

Venekamp RP, Thompson MJ, Hayward G, Heneghan CJ, Del Mar CB, Perera R, Glasz...

Objectives: To assess the effects of systemic corticosteroids on clinical response rates and to determine adverse effects and relapse rates of systemic corticosteroids compared to placebo or standard clinical care in children and adults with acute sinusitis.

Objectives: To assess the effects of systemic corticosteroids on clinical response rates and to determine adverse effects and relapse rates of systemic corticosteroids compared to placebo or standard clinical care in children and adults with acute sinusitis.

Cochrane Systematic Review: Addition of intravenous beta2-agonists to inhaled beta2-agonists for acute asthma

Cochrane Systematic Review: Addition of intravenous beta2-agonists to inhaled beta2-agonists for acute asthma

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Travers AH, Milan SJ, Jones AP, Camargo CA Jr, Rowe BH.

Travers AH, Milan SJ, Jones AP, Camargo CA Jr, Rowe BH.

Objectives: To determine the benefit of adding intravenous (IV) beta(2)-agonists to inhaled beta(2)-agonist therapy for acute asthma treated in the emergency department.

Objectives: To determine the benefit of adding intravenous (IV) beta(2)-agonists to inhaled beta(2)-agonist therapy for acute asthma treated in the emergency department.

Cochrane Systematic Review: Antibiotics for acute asthma

Cochrane Systematic Review: Antibiotics for acute asthma

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Graham V, Lasserson T, Rowe BH.

Graham V, Lasserson T, Rowe BH.

Objectives: To determine the efficacy of antibiotics prescribed in the treatment of acute asthma

Objectives: To determine the efficacy of antibiotics prescribed in the treatment of acute asthma

Cochrane Systematic Review: Antibiotics for persistent cough or wheeze following acute bronchiolitis in children

Cochrane Systematic Review: Antibiotics for persistent cough or wheeze following acute bronchiolitis in children

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McCallum GB, Morris PS, Chang AB.

McCallum GB, Morris PS, Chang AB.

Objectives: To determine the effectiveness of antibiotics compared to a control (no treatment or placebo) for persistent respiratory symptoms (within six months), following acute bronchiolitis.

Objectives: To determine the effectiveness of antibiotics compared to a control (no treatment or placebo) for persistent respiratory symptoms (within six months), following acute bronchiolitis.

Cochrane Systematic Review: Anticholinergic therapy for acute asthma in children

Cochrane Systematic Review: Anticholinergic therapy for acute asthma in children

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Teoh L, Cates CJ, Hurwitz M, Acworth JP, van Asperen P, Chang AB.

Teoh L, Cates CJ, Hurwitz M, Acworth JP, van Asperen P, Chang AB.

Objectives: To determine the effectiveness of only inhaled anticholinergic drugs (i.e. administered alone), compared to a control in children over the age of two years with acute asthma.

Objectives: To determine the effectiveness of only inhaled anticholinergic drugs (i.e. administered alone), compared to a control in children over the age of two years with acute asthma.

Cochrane Systematic Review: Combined inhaled anticholinergics and beta2-agonists for initial treatment of acute asthma in children

Cochrane Systematic Review: Combined inhaled anticholinergics and beta2-agonists for initial treatment of acute asthma in children

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Griffiths B, Ducharme FM.

Griffiths B, Ducharme FM.

Objectives: To determine whether the addition of inhaled anticholinergics to SABAs provides clinical improvement and affects the incidence of adverse effects in children with acute asthma exacerbations.

Objectives: To determine whether the addition of inhaled anticholinergics to SABAs provides clinical improvement and affects the incidence of adverse effects in children with acute asthma exacerbations.

Cochrane Systematic Review: Commercial versus home-made spacers in delivering bronchodilator therapy for acute therapy in children

Cochrane Systematic Review: Commercial versus home-made spacers in delivering bronchodilator therapy for acute therapy in children

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Rodriguez C, Sossa M, Lozano JM.

Rodriguez C, Sossa M, Lozano JM.

Objectives: The aim of this review was to compare the response to inhaled beta-2 agonists delivered through metered-dose inhaler using home-made spacers, to the use of commercially produced spacers, in children with acute exacerbations of wheezing or asthma.

Objectives: The aim of this review was to compare the response to inhaled beta-2 agonists delivered through metered-dose inhaler using home-made spacers, to the use of commercially produced spacers, in children with acute exacerbations of wheezing or asthma.

Cochrane Systematic Review: Corticosteroids for hospitalised children with acute asthma

Cochrane Systematic Review: Corticosteroids for hospitalised children with acute asthma

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Smith M, Iqbal S, Elliott TM, Everard M, Rowe BH.

Smith M, Iqbal S, Elliott TM, Everard M, Rowe BH.

Objectives: To determine the benefit of systemic corticosteroids (oral, intravenous, or intramuscular) compared to placebo and inhaled steroids in acute paediatric asthma.

Objectives: To determine the benefit of systemic corticosteroids (oral, intravenous, or intramuscular) compared to placebo and inhaled steroids in acute paediatric asthma.

Cochrane Systematic Review: Corticosteroids for preventing relapse following acute exacerbations of asthma

Cochrane Systematic Review: Corticosteroids for preventing relapse following acute exacerbations of asthma

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Rowe BH, Spooner CH, Ducharme FM, Bretzlaff JA, Bota GW.

Rowe BH, Spooner CH, Ducharme FM, Bretzlaff JA, Bota GW.

Objectives: To determine the benefit of corticosteroids (oral, intramuscular, or intravenous) for the treatment of asthmatic patients discharged from an acute care setting (i.e. usually the emergency department) after assessment and treatment of an acute asthmatic exacerbation.

Objectives: To determine the benefit of corticosteroids (oral, intramuscular, or intravenous) for the treatment of asthmatic patients discharged from an acute care setting (i.e. usually the emergency department) after assessment and treatment of an acute asthmatic exacerbation.

Cochrane Systematic Review: Early emergency department treatment of acute asthma with systemic corticosteroids

Cochrane Systematic Review: Early emergency department treatment of acute asthma with systemic corticosteroids

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Rowe BH, Spooner C, Ducharme FM, Bretzlaff JA, Bota GW.

Rowe BH, Spooner C, Ducharme FM, Bretzlaff JA, Bota GW.

Objectives: To determine the benefit of treating patients with acute asthma with systemic corticosteroids within an hour of presenting to the emergency department (ED).

Objectives: To determine the benefit of treating patients with acute asthma with systemic corticosteroids within an hour of presenting to the emergency department (ED).

Cochrane Systematic Review: Early use of inhaled corticosteroids in the emergency department treatment of acute asthma

Cochrane Systematic Review: Early use of inhaled corticosteroids in the emergency department treatment of acute asthma

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Edmonds ML, Milan SJ, Camargo CA Jr, Pollack CV, Rowe BH.

Edmonds ML, Milan SJ, Camargo CA Jr, Pollack CV, Rowe BH.

Objectives: To determine the benefit of ICS for the treatment of patients with acute asthma managed in the emergency department (ED).

Objectives: To determine the benefit of ICS for the treatment of patients with acute asthma managed in the emergency department (ED).

Cochrane Systematic Review: Heliox for non-intubated acute asthma patients

Cochrane Systematic Review: Heliox for non-intubated acute asthma patients

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Rodrigo G, Pollack C, Rodrigo C, Rowe BH.

Rodrigo G, Pollack C, Rodrigo C, Rowe BH.

Objectives: To determine the effect of the addition of heliox to standard medical care on the course of acute asthma, as measured by pulmonary function testing and clinical endpoints.

Objectives: To determine the effect of the addition of heliox to standard medical care on the course of acute asthma, as measured by pulmonary function testing and clinical endpoints.

Cochrane Systematic Review: Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma

Cochrane Systematic Review: Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma

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Cates CJ, Welsh EJ, Rowe BH.

Cates CJ, Welsh EJ, Rowe BH.

Objectives: To assess the effects of holding chambers (spacers) compared to nebulisers for the delivery of beta(2)-agonists for acute asthma.

Objectives: To assess the effects of holding chambers (spacers) compared to nebulisers for the delivery of beta(2)-agonists for acute asthma.

Cochrane Systematic Review: Inhaled magnesium sulfate in the treatment of acute asthma

Cochrane Systematic Review: Inhaled magnesium sulfate in the treatment of acute asthma

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Powell C, Dwan K, Milan SJ, Beasley R, Hughes R, Knopp-Sihota JA, Rowe BH.

Powell C, Dwan K, Milan SJ, Beasley R, Hughes R, Knopp-Sihota JA, Rowe BH.

Objectives: To determine the efficacy of inhaled MgSO(4) administered in acute asthma on pulmonary functions and admission rates.Specific aims: To quantify the effects of inhaled MgSO(4) i) in addition to inhaled (2)-agonist, ii) in comparison to inhaled (2)-agonist alone or iii) in addition to combination treatment with inhaled (2) -agonist and ipratropium bromide.

Objectives: To determine the efficacy of inhaled MgSO(4) administered in acute asthma on pulmonary functions and admission rates.Specific aims: To quantify the effects of inhaled MgSO(4) i) in addition to inhaled (2)-agonist, ii) in comparison to inhaled (2)-agonist alone or iii) in addition to combination treatment with inhaled (2) -agonist and ipratropium bromide.

Cochrane Systematic Review: Inhaled steroids for acute asthma following emergency department discharge

Cochrane Systematic Review: Inhaled steroids for acute asthma following emergency department discharge

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Edmonds ML, Milan SJ, Brenner BE, Camargo CA Jr, Rowe BH.

Edmonds ML, Milan SJ, Brenner BE, Camargo CA Jr, Rowe BH.

Objectives: To determine the effectiveness of ICS on outcomes in the treatment of acute asthma following discharge from the ED. To quantify the effectiveness of ICS therapy on acute asthma following ED discharge, when used in addition to, or as a substitute for, systemic corticosteroids.

Objectives: To determine the effectiveness of ICS on outcomes in the treatment of acute asthma following discharge from the ED. To quantify the effectiveness of ICS therapy on acute asthma following ED discharge, when used in addition to, or as a substitute for, systemic corticosteroids.

Cochrane Systematic Review: Intravenous aminophylline for acute severe asthma in children over two years receiving inhaled bronchodilators

Cochrane Systematic Review: Intravenous aminophylline for acute severe asthma in children over two years receiving inhaled bronchodilators

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Mitra A, Bassler D, Goodman K, Lasserson TJ, Ducharme FM.

Mitra A, Bassler D, Goodman K, Lasserson TJ, Ducharme FM.

Objectives: To determine if the addition of intravenous aminophylline produces a beneficial effect in children with acute severe asthma receiving conventional therapy.

Objectives: To determine if the addition of intravenous aminophylline produces a beneficial effect in children with acute severe asthma receiving conventional therapy.

Cochrane Systematic Review: Intravenous beta2-agonists for acute asthma in the emergency department

Cochrane Systematic Review: Intravenous beta2-agonists for acute asthma in the emergency department

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Travers A, Jones AP, Kelly K, Barker SJ, Camargo CA, Rowe BH.

Travers A, Jones AP, Kelly K, Barker SJ, Camargo CA, Rowe BH.

Objectives: To determine the benefit of intravenous (IV) beta2-agonists for severe acute asthma treated in the emergency department.

Objectives: To determine the benefit of intravenous (IV) beta2-agonists for severe acute asthma treated in the emergency department.

Cochrane Systematic Review: Intravenous beta2-agonists versus intravenous aminophylline for acute asthma

Cochrane Systematic Review: Intravenous beta2-agonists versus intravenous aminophylline for acute asthma

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Travers AH, Jones AP, Camargo CA Jr, Milan SJ, Rowe BH.

Travers AH, Jones AP, Camargo CA Jr, Milan SJ, Rowe BH.

Objectives: To compare the benefit of IV beta(2)-agonists versus IV aminophylline for acute asthma treated in the emergency department and in patients admitted to hospital with acute severe asthma.

Objectives: To compare the benefit of IV beta(2)-agonists versus IV aminophylline for acute asthma treated in the emergency department and in patients admitted to hospital with acute severe asthma.

Cochrane Systematic Review: Ketamine for management of acute exacerbations of asthma in children

Cochrane Systematic Review: Ketamine for management of acute exacerbations of asthma in children

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Jat KR, Chawla D.

Jat KR, Chawla D.

Objectives: To evaluate the efficacy of ketamine compared to placebo, no intervention or standard care for management of severe acute asthma in children who had not responded to standard therapy.

Objectives: To evaluate the efficacy of ketamine compared to placebo, no intervention or standard care for management of severe acute asthma in children who had not responded to standard therapy.

Cochrane Systematic Review: Leukotriene receptor antagonists in addition to usual care for acute asthma in adults and children

Cochrane Systematic Review: Leukotriene receptor antagonists in addition to usual care for acute asthma in adults and children

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Watts K, Chavasse RJ.

Watts K, Chavasse RJ.

Objectives: To determine if the addition of a leukotriene receptor antagonist (LTRA) produces a beneficial effect in children and adults with acute asthma who are currently receiving inhaled bronchodilators and systemic corticosteroids.

Objectives: To determine if the addition of a leukotriene receptor antagonist (LTRA) produces a beneficial effect in children and adults with acute asthma who are currently receiving inhaled bronchodilators and systemic corticosteroids.

Cochrane Systematic Review: Magnesium sulfate for treating exacerbations of acute asthma in the emergency department

Cochrane Systematic Review: Magnesium sulfate for treating exacerbations of acute asthma in the emergency department

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Rowe BH, Bretzlaff JA, Bourdon C, Bota GW, Camargo CA Jr.

Rowe BH, Bretzlaff JA, Bourdon C, Bota GW, Camargo CA Jr.

Objectives: To examine the effect of additional intravenous magnesium sulfate in patients with acute asthma managed in the emergency department.

Objectives: To examine the effect of additional intravenous magnesium sulfate in patients with acute asthma managed in the emergency department.

Cochrane Systematic Review: Oral corticosteroids for bronchiectasis (stable and acute exacerbations)

Cochrane Systematic Review: Oral corticosteroids for bronchiectasis (stable and acute exacerbations)

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Lasserson T, Holt K, Greenstone M.

Lasserson T, Holt K, Greenstone M.

Objectives: To determine the efficacy of oral corticosteroids in acute and stable bronchiectasis

Objectives: To determine the efficacy of oral corticosteroids in acute and stable bronchiectasis

Cochrane Systematic Review: Surgical interventions for treating acute fractures or non-union of the middle third of the clavicle

Cochrane Systematic Review: Surgical interventions for treating acute fractures or non-union of the middle third of the clavicle

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Lenza M, Belloti JC, Gomes Dos Santos JB, Matsumoto MH, Faloppa F

Lenza M, Belloti JC, Gomes Dos Santos JB, Matsumoto MH, Faloppa F

OBJECTIVES: To evaluate the effectiveness of different methods of surgical treatment for acute fracture or non-union of the middle third of the clavicle.

OBJECTIVES: To evaluate the effectiveness of different methods of surgical treatment for acute fracture or non-union of the middle third of the clavicle.

Cochrane Systematic Review: Written and verbal information versus verbal information only for patients being discharged from acute hospital settings to home

Cochrane Systematic Review: Written and verbal information versus verbal information only for patients being discharged from acute hospital settings to home

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Johnson A, Sandford J, Tyndall J

Johnson A, Sandford J, Tyndall J

OBJECTIVES: To determine the effectiveness of providing written health information in addition to verbal information for patients and/or significant others being discharged from acute hospital settings to home.

OBJECTIVES: To determine the effectiveness of providing written health information in addition to verbal information for patients and/or significant others being discharged from acute hospital settings to home.

Cochrane Systematic Review: Blood transfusions for treating acute chest syndrome in people with sickle cell disease

Cochrane Systematic Review: Blood transfusions for treating acute chest syndrome in people with sickle cell disease

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Alhashimi D, Fedorowicz Z, Alhashimi F, Dastgiri S

Alhashimi D, Fedorowicz Z, Alhashimi F, Dastgiri S

OBJECTIVES: To assess the effectiveness of blood transfusions, simple and exchange, for treating ACS by comparing improvement in symptoms and clinical outcomes against standard care.

OBJECTIVES: To assess the effectiveness of blood transfusions, simple and exchange, for treating ACS by comparing improvement in symptoms and clinical outcomes against standard care.

Cochrane Systematic Review: Inhaled nitric oxide for acute chest syndrome in people with sickle cell disease

Cochrane Systematic Review: Inhaled nitric oxide for acute chest syndrome in people with sickle cell disease

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Al Hajeri A, Serjeant GR, Fedorowicz Z

Al Hajeri A, Serjeant GR, Fedorowicz Z

OBJECTIVES: To assess the effectiveness of inhaled nitric oxide for treating acute chest syndrome by comparing improvement in symptoms and clinical outcomes against standard care.

OBJECTIVES: To assess the effectiveness of inhaled nitric oxide for treating acute chest syndrome by comparing improvement in symptoms and clinical outcomes against standard care.

Cochrane Systematic Review: Interventions for acute auricular haematoma

Cochrane Systematic Review: Interventions for acute auricular haematoma

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Jones SE, Mahendran S

Jones SE, Mahendran S

OBJECTIVES: To assess the effectiveness of treatment options in acute auricular haematoma.

OBJECTIVES: To assess the effectiveness of treatment options in acute auricular haematoma.

Cochrane Systematic Review: Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children

Cochrane Systematic Review: Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children

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Appleton R, Macleod S, Martland T

Appleton R, Macleod S, Martland T

OBJECTIVES: To review the evidence comparing the efficacy and safety of midazolam, diazepam, lorazepam, phenobarbitone, phenytoin and paraldehyde in treating acute tonic-clonic convulsions and convulsive status epilepticus in children treated in hospital.

OBJECTIVES: To review the evidence comparing the efficacy and safety of midazolam, diazepam, lorazepam, phenobarbitone, phenytoin and paraldehyde in treating acute tonic-clonic convulsions and convulsive status epilepticus in children treated in hospital.

Cochrane Systematic Review: Anti-inflammatory treatment for carditis in acute rheumatic fever

Cochrane Systematic Review: Anti-inflammatory treatment for carditis in acute rheumatic fever

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Cilliers A, Manyemba J, Adler AJ, Saloojee H

Cilliers A, Manyemba J, Adler AJ, Saloojee H

OBJECTIVES: To assess the effects of anti-inflammatory agents such as aspirin, corticosteroids, immunoglobulin and pentoxifylline for preventing or reducing further heart valve damage in patients with acute rheumatic fever.

OBJECTIVES: To assess the effects of anti-inflammatory agents such as aspirin, corticosteroids, immunoglobulin and pentoxifylline for preventing or reducing further heart valve damage in patients with acute rheumatic fever.

Cochrane Systematic Review: Early versus Delayed Refeeding for Children with Acute Diarrhoea

Cochrane Systematic Review: Early versus Delayed Refeeding for Children with Acute Diarrhoea

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Gregorio GV, Dans LF, Silvestre MA

Gregorio GV, Dans LF, Silvestre MA

OBJECTIVES: To compare the efficacy and safety of early and late reintroduction of feeding in children with acute diarrhoea.

OBJECTIVES: To compare the efficacy and safety of early and late reintroduction of feeding in children with acute diarrhoea.

Cochrane Systematic Review: Probiotics for treating acute infectious diarrhoea

Cochrane Systematic Review: Probiotics for treating acute infectious diarrhoea

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Allen SJ, Martinez EG, Gregorio GV, Dans LF

Allen SJ, Martinez EG, Gregorio GV, Dans LF

OBJECTIVES: To assess the effects of probiotics in proven or presumed acute infectious diarrhoea.

OBJECTIVES: To assess the effects of probiotics in proven or presumed acute infectious diarrhoea.

Cochrane Systematic Review: Polymer-based oral rehydration solution for treating acute watery diarrhoea

Cochrane Systematic Review: Polymer-based oral rehydration solution for treating acute watery diarrhoea

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Gregorio GV, Gonzales ML, Dans LF, Martinez EG

Gregorio GV, Gonzales ML, Dans LF, Martinez EG

OBJECTIVES: To compare polymer-based ORS with glucose-based ORS for treating acute watery diarrhoea.

OBJECTIVES: To compare polymer-based ORS with glucose-based ORS for treating acute watery diarrhoea.

Cochrane Systematic Review: Reduced osmolarity oral rehydration solution for treating dehydration caused by acute diarrhoea in children

Cochrane Systematic Review: Reduced osmolarity oral rehydration solution for treating dehydration caused by acute diarrhoea in children

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Hahn S, Kim S, Garner P. Reduced osmolarity oral rehydration solution for treating dehydration caused by acute diarrhoea in children. Cochrane Database Syst...

Hahn S, Kim S, Garner P. Reduced osmolarity oral rehydration solution for tr...

OBJECTIVES: To compare reduced osmolarity ORS with WHO standard ORS in children with acute diarrhoea.

OBJECTIVES: To compare reduced osmolarity ORS with WHO standard ORS in children with acute diarrhoea.

Cochrane Systematic Review: Antifibrinolytic drugs for acute traumatic injury

Cochrane Systematic Review: Antifibrinolytic drugs for acute traumatic injury

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Roberts I, Shakur H, Ker K, Coats T; CRASH-2 Trial collaborators

Roberts I, Shakur H, Ker K, Coats T; CRASH-2 Trial collaborators

OBJECTIVES: To quantify the effects of antifibrinolytic drugs on mortality, vascular occlusive events, surgical intervention and receipt of blood transfusion after acute traumatic injury.

OBJECTIVES: To quantify the effects of antifibrinolytic drugs on mortality, vascular occlusive events, surgical intervention and receipt of blood transfusion after acute traumatic injury.

Cochrane Systematic Review: Bradykinin beta-2 receptor antagonists for acute traumatic brain injury

Cochrane Systematic Review: Bradykinin beta-2 receptor antagonists for acute traumatic brain injury

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Ker K, Blackhall K

Ker K, Blackhall K

OBJECTIVES: The objective was to assess the safety and effectiveness of beta-2 receptor antagonists for TBI.

OBJECTIVES: The objective was to assess the safety and effectiveness of beta-2 receptor antagonists for TBI.

Cochrane Systematic Review: Hyperventilation therapy for acute traumatic brain injury

Cochrane Systematic Review: Hyperventilation therapy for acute traumatic brain injury

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Schierhout G, Roberts I

Schierhout G, Roberts I

OBJECTIVES: To quantify the effect of hyperventilation on death and neurological disability following head injury.

OBJECTIVES: To quantify the effect of hyperventilation on death and neurological disability following head injury.

Cochrane Systematic Review: Progesterone for acute traumatic brain injury

Cochrane Systematic Review: Progesterone for acute traumatic brain injury

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Ma J, Huang S, Qin S, You C

Ma J, Huang S, Qin S, You C

OBJECTIVES: To assess the effectiveness and safety of progesterone in people with acute TBI.

OBJECTIVES: To assess the effectiveness and safety of progesterone in people with acute TBI.

Cochrane Systematic Review: Steroids for acute spinal cord injury

Cochrane Systematic Review: Steroids for acute spinal cord injury

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Bracken MB

Bracken MB

OBJECTIVES: To review randomized trials of steroids for human acute spinal cord injury.

OBJECTIVES: To review randomized trials of steroids for human acute spinal cord injury.

Cochrane Systematic Review: Dipyrone for acute primary headaches

Cochrane Systematic Review: Dipyrone for acute primary headaches

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Ramacciotti AS, Soares BG, Atallah AN

Ramacciotti AS, Soares BG, Atallah AN

OBJECTIVES: To determine the effectiveness and safety of dipyrone for acute primary headaches in adults and children.

OBJECTIVES: To determine the effectiveness and safety of dipyrone for acute primary headaches in adults and children.

Cochrane Systematic Review: Hydromorphone for acute and chronic pain

Cochrane Systematic Review: Hydromorphone for acute and chronic pain

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Quigley C

Quigley C

OBJECTIVES: This review explores and assesses the evidence for the efficacy of hydromorphone in the management of pain.

OBJECTIVES: This review explores and assesses the evidence for the efficacy of hydromorphone in the management of pain.

Cochrane Systematic Review: Antibiotics for acute pyelonephritis in children

Cochrane Systematic Review: Antibiotics for acute pyelonephritis in children

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Hodson EM, Willis NS, Craig JC

Hodson EM, Willis NS, Craig JC

OBJECTIVES: To determine the benefits and harms of different antibiotic regimens for the treatment of acute pyelonephritis in children.

OBJECTIVES: To determine the benefits and harms of different antibiotic regimens for the treatment of acute pyelonephritis in children.

Cochrane Systematic Review: Bicarbonate versus lactate solutions for acute peritoneal dialysis

Cochrane Systematic Review: Bicarbonate versus lactate solutions for acute peritoneal dialysis

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Bai ZG, Yang K, Tian J, Ma B, Liu Y, Jiang L, Tan J, Liu TX, Chi I

Bai ZG, Yang K, Tian J, Ma B, Liu Y, Jiang L, Tan J, Liu TX, Chi I

OBJECTIVES: To look at the benefits and harms of bicarbonate versus lactate solutions in acute PD.

OBJECTIVES: To look at the benefits and harms of bicarbonate versus lactate solutions in acute PD.

Cochrane Systematic Review: Short versus standard duration oral antibiotic therapy for acute urinary tract infection in children

Cochrane Systematic Review: Short versus standard duration oral antibiotic therapy for acute urinary tract infection in children

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Michael M, Hodson EM, Craig JC, Martin S, Moyer VA

Michael M, Hodson EM, Craig JC, Martin S, Moyer VA

OBJECTIVES: The objective of this review was to assess the benefits and harms of short-course (2-4 days) compared to standard duration (7-14 days) oral antibiotic treatment for acute UTI in children.

OBJECTIVES: The objective of this review was to assess the benefits and harms of short-course (2-4 days) compared to standard duration (7-14 days) oral antibiotic treatment for acute UTI in children.

Cochrane Systematic Review: Anticholinergics for neuroleptic-induced acute akathisia

Cochrane Systematic Review: Anticholinergics for neuroleptic-induced acute akathisia

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Rathbone J, Soares-Weiser K

Rathbone J, Soares-Weiser K

OBJECTIVES: To review anticholinergic drugs for neuroleptic-induced acute akathisia.

OBJECTIVES: To review anticholinergic drugs for neuroleptic-induced acute akathisia.

Cochrane Systematic Review: Aloe vera for treating acute and chronic wounds

Cochrane Systematic Review: Aloe vera for treating acute and chronic wounds

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Dat AD, Poon F, Pham KB, Doust J

Dat AD, Poon F, Pham KB, Doust J

OBJECTIVES: To determine the effects of Aloe vera-derived products (for example dressings and topical gels) on the healing of acute wounds (for example lacerations, surgical incisions and burns) and chronic wounds (for example infected wounds, arterial and venous ulcers).

OBJECTIVES: To determine the effects of Aloe vera-derived products (for example dressings and topical gels) on the healing of acute wounds (for example lacerations, surgical incisions and burns) and chronic wounds (for example infected wounds, arterial and venous ulcers).

Cochrane Systematic Review: Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents

Cochrane Systematic Review: Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents

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Fedorowicz Z, Jagannath VA, Carter B

Fedorowicz Z, Jagannath VA, Carter B

OBJECTIVES: To assess the safety and effectiveness of antiemetics on gastroenteritis induced vomiting in children and adolescents.

OBJECTIVES: To assess the safety and effectiveness of antiemetics on gastroenteritis induced vomiting in children and adolescents.

Cochrane Systematic Review: Diclofenac for acute pain in children  (2009)

Cochrane Systematic Review: Diclofenac for acute pain in children

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Standing JF, Savage I, Pritchard D, Waddington M

Standing JF, Savage I, Pritchard D, Waddington M

OBJECTIVES: 1) Assess the efficacy of diclofenac for acute pain in children. 2) Assess the safety of diclofenac for short-term use in children. 3) Identify gaps in the evidence to direct future research.

OBJECTIVES: 1) Assess the efficacy of diclofenac for acute pain in children. 2) Assess the safety of diclofenac for short-term use in children. 3) Identify gaps in the evidence to direct future research.

Cochrane Systematic Review: Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients without chronic broncho-pulmonary disease

Cochrane Systematic Review: Acetylcysteine and carbocysteine for acute upper and lower respiratory tract infections in paediatric patients without chronic broncho-pulmonary disease

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Chalumeau M, Duijvestijn YC

Chalumeau M, Duijvestijn YC

OBJECTIVES: The objective was to assess the efficacy and safety and to establish a benefit-risk ratio of acetylcysteine and carbocysteine as symptomatic treatments for acute upper and lower RTIs in paediatric patients without chronic broncho-pulmonary disease.

OBJECTIVES: The objective was to assess the efficacy and safety and to establish a benefit-risk ratio of acetylcysteine and carbocysteine as symptomatic treatments for acute upper and lower RTIs in paediatric patients without chronic broncho-pulmonary disease.

Cochrane Systematic Review: Advising patients to increase fluid intake for treating acute respiratory infections

Cochrane Systematic Review: Advising patients to increase fluid intake for treating acute respiratory infections

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Guppy MP, Mickan SM, Del Mar CB, Thorning S, Rack A

Guppy MP, Mickan SM, Del Mar CB, Thorning S, Rack A

OBJECTIVES: To answer the following questions.1. Does recommending increased fluid intake as a treatment for acute respiratory infections improve duration and severity of symptoms? 2. Are there adverse effects from recommending increased fluids in people with acute respiratory infections? 3. Are any benefits or harms related to site of infection (upper or lower respiratory tract) or a different severity of illness?

OBJECTIVES: To answer the following questions.1. Does recommending increased fluid intake as a treatment for acute respiratory infections improve duration and severity of symptoms? 2. Are there adverse effects from recommending increased fluids in people with acute respiratory infections? 3. Are any benefits or harms related to site of infection (upper or lower respiratory tract) or a different severity of illness?

Cochrane Systematic Review: Antibiotics for the common cold and acute purulent rhinitis

Cochrane Systematic Review: Antibiotics for the common cold and acute purulent rhinitis

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Kenealy T, Arroll B

Kenealy T, Arroll B

OBJECTIVES: To determine the efficacy of antibiotics compared with placebo for reducing general and specific nasopharyngeal symptoms of acute upper respiratory tract infections (URTIs) (common colds). To determine if antibiotics have any influence on the tcomes for acute purulent rhinitis and acute clear rhinitis lasting less than 10 days before the intervention. To determine whether there are significant adverse outcomes associated with antibiotic therapy for participants with a clinical diagnosis of acute URTI or acute purulent rhinitis.

OBJECTIVES: To determine the efficacy of antibiotics compared with placebo for reducing general and specific nasopharyngeal symptoms of acute upper respiratory tract infections (URTIs) (common colds). To determine if antibiotics have any influence on the tcomes for acute purulent rhinitis and acute clear rhinitis lasting less than 10 days before the intervention. To determine whether there are significant adverse outcomes associated with antibiotic therapy for participants with a clinical diagnosis of acute URTI or acute purulent rhinitis.

Cochrane Systematic Review: Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old

Cochrane Systematic Review: Chest physiotherapy for acute bronchiolitis in paediatric patients between 0 and 24 months old

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Roqu i Figuls M, Gin-Garriga M, Granados Rugeles C, Perrotta C

Roqu i Figuls M, Gin-Garriga M, Granados Rugeles C, Perrotta C

OBJECTIVES: The main objective was to determine the efficacy of chest physiotherapy in infants aged less than 24 months old with acute bronchiolitis. A condary objective was to determine the efficacy of different techniques of chest physiotherapy (for ample, vibration and percussion and passive forced exhalation).

OBJECTIVES: The main objective was to determine the efficacy of chest physiotherapy in infants aged less than 24 months old with acute bronchiolitis. A condary objective was to determine the efficacy of different techniques of chest physiotherapy (for ample, vibration and percussion and passive forced exhalation).

Cochrane Systematic Review: Chest radiograph for acute lower respiratory infections

Cochrane Systematic Review: Chest radiograph for acute lower respiratory infections

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Swingler GH, Zwarenstein M

Swingler GH, Zwarenstein M

OBJECTIVES: To assess the effects of chest radiography on clinical outcome in acute lower respiratory infections.

OBJECTIVES: To assess the effects of chest radiography on clinical outcome in acute lower respiratory infections.

Cochrane Systematic Review: Nebulised hypertonic saline solution for acute bronchiolitis in infants

Cochrane Systematic Review: Nebulised hypertonic saline solution for acute bronchiolitis in infants

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Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP.

Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP.

Objectives: To assess the effects of nebulised hypertonic ( 3%) saline solution in infants with viral bronchiolitis.

Objectives: To assess the effects of nebulised hypertonic ( 3%) saline solution in infants with viral bronchiolitis.

Systematic Review: Management Modalities and Outcomes Following Acute Scaphoid Fractures in Children: A Quantitative Review and Meta-Analysis  (2017)

Systematic Review: Management Modalities and Outcomes Following Acute Scaphoid Fractures in Children: A Quantitative Review and Meta-Analysis

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Shaterian A, Santos PJF, Lee CJ, Evans GRD, Leis A

Shaterian A, Santos PJF, Lee CJ, Evans GRD, Leis A

The objective of this study was to compare clinical outcomes following different treatment modalities for pediatric scaphoid fractures.

The objective of this study was to compare clinical outcomes following different treatment modalities for pediatric scaphoid fractures.

Cochrane Systematic Review: Delayed antibiotics for respiratory infections

Cochrane Systematic Review: Delayed antibiotics for respiratory infections

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Spurling GK, Del Mar CB, Dooley L, Foxlee R, Farley R.

Spurling GK, Del Mar CB, Dooley L, Foxlee R, Farley R.

Objectives: To evaluate the use of delayed antibiotics compared to immediate or no antibiotics as a prescribing strategy for ARTIs. We evaluated clinical outcomes including duration and severity measures for pain, malaise, fever, cough and rhinorrhoea in sore throat, otitis media, bronchitis (cough) and the common cold. We also evaluated the outcomes of antibiotic use, patient satisfaction, antibiotic resistance and re-consultation rates and use of alternative therapies.

Objectives: To evaluate the use of delayed antibiotics compared to immediate or no antibiotics as a prescribing strategy for ARTIs. We evaluated clinical outcomes including duration and severity measures for pain, malaise, fever, cough and rhinorrhoea in sore throat, otitis media, bronchitis (cough) and the common cold. We also evaluated the outcomes of antibiotic use, patient satisfaction, antibiotic resistance and re-consultation rates and use of alternative therapies.

Cochrane Systematic Review: Antibiotics for preventing complications in children with measles

Cochrane Systematic Review: Antibiotics for preventing complications in children with measles

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Kabra SK, Lodha R

Kabra SK, Lodha R

OBJECTIVES: To assess the effects of antibiotics given to children with measles to prevent complications and reduce pneumonia, other morbidities and mortality.

OBJECTIVES: To assess the effects of antibiotics given to children with measles to prevent complications and reduce pneumonia, other morbidities and mortality.

Key studies

Key Study: Adherence behavior in an acute pediatric hand trauma population: A pilot study of parental report of adherence levels and influencing factors  (2016)

Key Study: Adherence behavior in an acute pediatric hand trauma population: A pilot study of parental report of adherence levels and influencing factors

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Cole T, Underhill A, Kennedy S

Cole T, Underhill A, Kennedy S

The hand is a common site of injury in children; however, little is known regarding adherence to hand trauma management in this population.

The hand is a common site of injury in children; however, little is known regarding adherence to hand trauma management in this population.

Key Study: Acute ischemia and pink pulseless hand in 68 of 404 gartland type III supracondylar humeral fractures in children: Urgent management and therapeutic consensus  (2016)

Key Study: Acute ischemia and pink pulseless hand in 68 of 404 gartland type III supracondylar humeral fractures in children: Urgent management and therapeutic consensus

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Louahem D, Cottalorda J

Louahem D, Cottalorda J

The purpose of this retrospective study was to describe our strategy and to determine the guidelines of therapeutic consensus.

The purpose of this retrospective study was to describe our strategy and to determine the guidelines of therapeutic consensus.

Key Study: A clinical decision rule for the use of plain radiography in children after acute wrist injury: development and external validation of the Amsterdam Pediatric Wrist Rules  (2016)

Key Study: A clinical decision rule for the use of plain radiography in children after acute wrist injury: development and external validation of the Amsterdam Pediatric Wrist Rules

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Slaar A, Walenkamp MM, Bentohami A, Maas M, van Rijn RR, Steyerberg EW, Jager LC, Sosef NL, van Velde R, Ultee JM, Goslings JC, Schep NW

Slaar A, Walenkamp MM, Bentohami A, Maas M, van Rijn RR, Steyerberg EW, Jager...

The objective of this study was to develop and validate a clinica decision rule to decide whether radiography in children with wrist trauma is required.

The objective of this study was to develop and validate a clinica decision rule to decide whether radiography in children with wrist trauma is required.

Key Study: Prevalence of Concomitant Acute Bacterial Meningitis in Neonates with Febrile Urinary Tract Infection: A Retrospective Cross-Sectional Study  (2017)

Key Study: Prevalence of Concomitant Acute Bacterial Meningitis in Neonates with Febrile Urinary Tract Infection: A Retrospective Cross-Sectional Study

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Wallace SS, Brown DN, Cruz AT

Wallace SS, Brown DN, Cruz AT

The objective of this study was to describe the frequency of concomitant acute bacterial meningitis in neonates with febrile urinary tract infection.

The objective of this study was to describe the frequency of concomitant acute bacterial meningitis in neonates with febrile urinary tract infection.

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Updated Bottom Line Recommendations: Acute Otitis Media

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Updated Resource for Ear Infections

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OUTCH Study

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Parent tools - UTI and Bronchiolitis

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TREKK Web Design

Posted: Feb 09, 2011  | Project  | Team: Communications  > Communications


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Parent tools - CTV Winnipeg

Posted: Jun 18, 2019  | Announcement  | Team: News and Events 


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Federal Government Renews Support for TREKK

Posted: May 01, 2016  | Announcement  | Team: News and Events 


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Pediatric Respiratory Assessment Measure (PRAM) App

Posted: Dec 08, 2015  | Announcement  | Team: News and Events 


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Top 10 ED tips for families

Posted: Jul 15, 2016  | Announcement  | Team: News and Events 


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2023 Choosing Wisely Research Study with ARCHE & ECHO

Posted: Jun 09, 2023  | Announcement  | Team: News and Events 


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CBC Radio Active Child Health Series

Posted: Sep 08, 2016  | Announcement  | Team: News and Events 


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Updated Resources for Bronchiolitis

Posted: Feb 09, 2021  | Announcement  | Team: News and Events 


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Profiling pediatric pain expert: Dr. Samina Ali

Posted: Mar 18, 2016  | Announcement  | Team: News and Events 


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Treating Gastroenteritis: Evidence for Clinicians

Posted: Apr 10, 2015  | Announcement  | Team: News and Events 
Tags: Gastroenteritis


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New PedsPacs!

Posted: Dec 20, 2018  | Announcement  | Team: News and Events 


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TREKK at CAEP 2018

Posted: Feb 06, 2018  | Announcement  | Team: News and Events 


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Webinar: Mobilizing knowledge to improve pediatric health care

Posted: Mar 29, 2016  | Announcement  | Team: News and Events 


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Why should Canada invest in emergency care for children:

Posted: Jul 18, 2017  | Announcement  | Team: News and Events 


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Gastroenteritis Pathway

Posted: Oct 21, 2013  | Module  | Team: ED Clinical Pathways Implementation  > Pathways


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Predicting the duration of post-concussion symptoms

Posted: Mar 10, 2016  | Announcement  | Team: News and Events 


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TREKK Scholars & Fellows Program

Posted: Jul 05, 2021  | Announcement  | Team: News and Events 



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