Logo

Congenital Heart Defect

1% of babies are born with congenital heart defects, wherein the structure of the heart is abnormal. 1 in 4 of these have critical defects that usually require a procedure or corrective surgery in infancy and some can be fatal if not recognized and treated promptly in the newborn period.

BROWSE EVIDENCE REPOSITORY

 

Bottom Line Recommendations English (1) French All (1)

Bottom Line: Approach to cyanotic congenital heart disease in the newborn

Visit

Cheung C

This document summarizes causes, symptoms, and management of cyanosis in newborns.

Bottom Line: Approach to cyanotic congenital heart disease in the newborn

Visit

Cheung C

This document summarizes causes, symptoms, and management of cyanosis in newborns.

Clinical guidelines English (2) French All (2)

Clinical Practice Guideline: Duct dependant congenital heart disease

Visit

Brierley J, National Health Service Children's Acute Transport Service

Objective: To standardise the initial management of neonates with duct dependent congenital heart disease.

Clinical Practice Guideline: Resuscitation of blue baby and the use of prostaglandins

Visit

Linney M, Gnapragassam J, Wilson P, Rodd I

This document relates to the acute management of infants presenting acutely with collapse and/or cyanosis suggestive of congenital heart defect.

Clinical Practice Guideline: Duct dependant congenital heart disease

Visit

Brierley J, National Health Service Children's Acute Transport Service

Objective: To standardise the initial management of neonates with duct dependent congenital heart disease.

Clinical Practice Guideline: Resuscitation of blue baby and the use of prostaglandins

Visit

Linney M, Gnapragassam J, Wilson P, Rodd I

This document relates to the acute management of infants presenting acutely with collapse and/or cyanosis suggestive of congenital heart defect.

Systematic reviews English (1) French All (1)

Systematic Review: Pulse oximetry screening for critical congenital heart defects in asymptomatic newborn babies: a systematic review and meta-analysis

Visit

Thangaratinam S, Brown K, Zamora J, Khan KS, Ewer AK

Objective: To assess the performance of pulse oximetry as a screening method for the detection of critical congenital heart defects in asymptomatic newborn babies.

Systematic Review: Pulse oximetry screening for critical congenital heart defects in asymptomatic newborn babies: a systematic review and meta-analysis

Visit

Thangaratinam S, Brown K, Zamora J, Khan KS, Ewer AK

Objective: To assess the performance of pulse oximetry as a screening method for the detection of critical congenital heart defects in asymptomatic newborn babies.

Key studies English (17) French All (17)

Overview of studies: Congenital Heart Disease In Pediatric Patients: Recognizing The Undiagnosed And Managing Complications In The Emergency Department

Visit

Judge P, Meckler G

Objective: This review focuses on the recognition and initial management of patients with undiagnosed congenital heart disease presenting to the ED and touches on considerations for postoperative infants and children with complex congenital heart disease.

Key Study: The Critically Ill Infant with Congenital Heart Disease

Visit

Strobel, AM & Lu, N.

Objective: This article presents an approach for identification of infants with congenital heart disorders.

Key Study: Reappraisal of the prostaglandin E1 dose for early newborns with patent ductus arteriosus-dependent pulmonary circulation

Visit

Huang FK, Lin CC, Huang TC, Weng KP, Liu PY, Chen YY, Wang HP, Ger LP, Hsieh KS

Objective: To review our experience of a low initial dose of PGE1 treatment in early newborns with congenital heart disease and patent ductus arteriosus (PDA)-dependent pulmonary flow.

Key Study: Congenital heart disease

Visit

Dolbec K, Mick NW

This publication provides an overview of the presentations of congenital heart defects, and makes diagnosis and management recommendations for emergency physicians.

Key Study: Impact of oxygen saturation targets and oxygen therapy during the transport of neonates with clinically suspected congenital heart disease

Visit

Shivananda S, Kirsh J, Whyte HE, Muthalally K, McNamara PJ

Objective: To determine the effect of average SpO(2) range and oxygen administration during neonatal transport on clinical markers of cardiovascular instability.

Key Study: Approach to diagnosing congenital cardiac disorders

Visit

Hartas GA, Tsounias E, Gupta-Malhotra M

Objective: To give a general picture of the diagnostic approach to a multitude of heart defects.

Key Study: To intubate or not to intubate? Transporting infants on prostaglandin E1

Visit

Meckler GD, Lowe C

This document describes the pretransport and transport management of infants receiving prostaglandin E(1) infusion for congenital heart disease and compares transport complications among unintubated and electively intubated infants.

Overview of studies: Emergency presentation of congenital heart disease in children

Visit

EB Medicine

Objective: To address the evaluation and management of pediatric patients with congenital heart defects in the context of the evidence available from the medical literature.

Key Study: Lessons from transporting newborn infants with known or suspected congenital heart disease

Visit

Bouchut JC, Teyssedre S

This study presents the results of an evaluation of transporting, by a nonspecialized emergency medical service, neonates with known or suspected cardiac abnormalities.

Key Study: Evaluation and management of the cyanotic neonate

Visit

Steinhorn RH

This document discusses the potential challenges in recognizing cyanosis, including the presence of higher concentrations of fetal hemoglobin, and its oxygen binding characteristics.

Key Study: Transporting newborn infants with suspected duct dependent congenital heart disease on low-dose prostaglandin E1 without routine mechanical ventilation

Visit

Browning Carmo KA, Barr P, West M, Hopper NW, White JP, Badawi N

Objective: To evaluate the safety of transporting newborn infants with suspected duct dependent congenital heart disease (CHD) treated with prostaglandin E1 (PGE1) without routine mechanical ventilation.

Key Study: Cardiac emergencies in the first year of life

Visit

Yee L

This document discusses the most common causes of cyanotic and acyanotic heart disease in infants.

Key Study: ABC of clinical electrocardiography: Paediatric electrocardiography

Visit

Goodacre S, McLeod K

General clinicians and junior paediatricians may have little experience of interpreting paediatric electrocardiograms. Although the basic principles of cardiac conduction and depolarisation are the same as for adults, age related changes in the anatomy and physiology of infants and children produce normal ranges for electrocardiographic features that differ from adults and vary with age. Awareness of these differences is the key to correct interpretation of paediatric electrocardiograms.

Key Study: Management of the neonate with symptomatic congenital heart disease

Visit

Penny DJ, Shekerdemian LS

This document addresses some of the principles on which resuscitation and stabilisation of the symptomatic neonate with congenital heart disease may be based.

Key Study: Prevalence and clinical significance of cardiac murmurs in neonates

Visit

Ainsworth S, Wyllie JP, Wren C

Objective: To determine the prevalence and clinical significance of murmurs detected during routine neonatal examination.

Key Study: Differentiation of systemic infection and congenital obstructive left heart disease in the very young infant

Visit

Pickert CB, Moss MM, Fiser DH

This retrospective review of critically ill infants 0 to 28 days of age presenting with either bacterial sepsis or meningitis or a congenital obstructive left heart syndrome (COLHS), identifies historical, physical, or laboratory findings which might differentiate the two groups at presentation.

Key Study: Evaluation of low dose prostaglandin E1 treatment for ductus dependent congenital heart disease

Visit

Kramer HH, Sommer M, Rammos S, Krogmann O

This study reports experience with low-dose prostaglandin E1 (PGE1) treatment of 91 newborns with ductus dependent congenital heart disease (CHD).

Overview of studies: Congenital Heart Disease In Pediatric Patients: Recognizing The Undiagnosed And Managing Complications In The Emergency Department

Visit

Judge P, Meckler G

Objective: This review focuses on the recognition and initial management of patients with undiagnosed congenital heart disease presenting to the ED and touches on considerations for postoperative infants and children with complex congenital heart disease.

Key Study: The Critically Ill Infant with Congenital Heart Disease

Visit

Strobel, AM & Lu, N.

Objective: This article presents an approach for identification of infants with congenital heart disorders.

Key Study: Reappraisal of the prostaglandin E1 dose for early newborns with patent ductus arteriosus-dependent pulmonary circulation

Visit

Huang FK, Lin CC, Huang TC, Weng KP, Liu PY, Chen YY, Wang HP, Ger LP, Hsieh KS

Objective: To review our experience of a low initial dose of PGE1 treatment in early newborns with congenital heart disease and patent ductus arteriosus (PDA)-dependent pulmonary flow.

Key Study: Congenital heart disease

Visit

Dolbec K, Mick NW

This publication provides an overview of the presentations of congenital heart defects, and makes diagnosis and management recommendations for emergency physicians.

Key Study: Impact of oxygen saturation targets and oxygen therapy during the transport of neonates with clinically suspected congenital heart disease

Visit

Shivananda S, Kirsh J, Whyte HE, Muthalally K, McNamara PJ

Objective: To determine the effect of average SpO(2) range and oxygen administration during neonatal transport on clinical markers of cardiovascular instability.

Key Study: Approach to diagnosing congenital cardiac disorders

Visit

Hartas GA, Tsounias E, Gupta-Malhotra M

Objective: To give a general picture of the diagnostic approach to a multitude of heart defects.

Key Study: To intubate or not to intubate? Transporting infants on prostaglandin E1

Visit

Meckler GD, Lowe C

This document describes the pretransport and transport management of infants receiving prostaglandin E(1) infusion for congenital heart disease and compares transport complications among unintubated and electively intubated infants.

Overview of studies: Emergency presentation of congenital heart disease in children

Visit

EB Medicine

Objective: To address the evaluation and management of pediatric patients with congenital heart defects in the context of the evidence available from the medical literature.

Key Study: Lessons from transporting newborn infants with known or suspected congenital heart disease

Visit

Bouchut JC, Teyssedre S

This study presents the results of an evaluation of transporting, by a nonspecialized emergency medical service, neonates with known or suspected cardiac abnormalities.

Key Study: Evaluation and management of the cyanotic neonate

Visit

Steinhorn RH

This document discusses the potential challenges in recognizing cyanosis, including the presence of higher concentrations of fetal hemoglobin, and its oxygen binding characteristics.

Key Study: Transporting newborn infants with suspected duct dependent congenital heart disease on low-dose prostaglandin E1 without routine mechanical ventilation

Visit

Browning Carmo KA, Barr P, West M, Hopper NW, White JP, Badawi N

Objective: To evaluate the safety of transporting newborn infants with suspected duct dependent congenital heart disease (CHD) treated with prostaglandin E1 (PGE1) without routine mechanical ventilation.

Key Study: Cardiac emergencies in the first year of life

Visit

Yee L

This document discusses the most common causes of cyanotic and acyanotic heart disease in infants.

Key Study: ABC of clinical electrocardiography: Paediatric electrocardiography

Visit

Goodacre S, McLeod K

General clinicians and junior paediatricians may have little experience of interpreting paediatric electrocardiograms. Although the basic principles of cardiac conduction and depolarisation are the same as for adults, age related changes in the anatomy and physiology of infants and children produce normal ranges for electrocardiographic features that differ from adults and vary with age. Awareness of these differences is the key to correct interpretation of paediatric electrocardiograms.

Key Study: Management of the neonate with symptomatic congenital heart disease

Visit

Penny DJ, Shekerdemian LS

This document addresses some of the principles on which resuscitation and stabilisation of the symptomatic neonate with congenital heart disease may be based.

Key Study: Prevalence and clinical significance of cardiac murmurs in neonates

Visit

Ainsworth S, Wyllie JP, Wren C

Objective: To determine the prevalence and clinical significance of murmurs detected during routine neonatal examination.

Key Study: Differentiation of systemic infection and congenital obstructive left heart disease in the very young infant

Visit

Pickert CB, Moss MM, Fiser DH

This retrospective review of critically ill infants 0 to 28 days of age presenting with either bacterial sepsis or meningitis or a congenital obstructive left heart syndrome (COLHS), identifies historical, physical, or laboratory findings which might differentiate the two groups at presentation.

Key Study: Evaluation of low dose prostaglandin E1 treatment for ductus dependent congenital heart disease

Visit

Kramer HH, Sommer M, Rammos S, Krogmann O

This study reports experience with low-dose prostaglandin E1 (PGE1) treatment of 91 newborns with ductus dependent congenital heart disease (CHD).