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Cannabis Intoxication

BROWSE INFORMATiON REPOSITORY

 

 
 
Clinical guidelines English (1) French All (1)

Clincal Practice Guildeline: Addressing Pediatric Cannabis Exposure

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American College of Medical Toxicology

The purpose of this was to outline recommendations for clincians treating pediatric patients with actue cannabis intoxication.

Clincal Practice Guildeline: Addressing Pediatric Cannabis Exposure

Visit

American College of Medical Toxicology

The purpose of this was to outline recommendations for clincians treating pediatric patients with actue cannabis intoxication.

Systematic reviews English (2) French All (2)

Systematic Review: Unintentional Cannabis Ingestion in Children: A Systematic Review

Visit

Richards JRS, N. E.; Moulin, A. K.

To analyze published reports of unintentional cannabis ingestions in children to determine presenting signs and symptoms, route of exposure, treatment, and outcome.

Systematic Review: Cannabinoid Hyperemesis Syndrome: Diagnosis, Pathophysiology, and Treatmenta Systematic Review

Visit

Sorensen, C. J., DeSanto, K., Borgelt, L., Phillips, K. T., & Monte, A. A

To summarize the available evidence on CHS diagnosis, pathophysiology, and treatment.

Systematic Review: Unintentional Cannabis Ingestion in Children: A Systematic Review

Visit

Richards JRS, N. E.; Moulin, A. K.

To analyze published reports of unintentional cannabis ingestions in children to determine presenting signs and symptoms, route of exposure, treatment, and outcome.

Systematic Review: Cannabinoid Hyperemesis Syndrome: Diagnosis, Pathophysiology, and Treatmenta Systematic Review

Visit

Sorensen, C. J., DeSanto, K., Borgelt, L., Phillips, K. T., & Monte, A. A

To summarize the available evidence on CHS diagnosis, pathophysiology, and treatment.

Key studies English (32) French All (32)

Key Study: Increased Testing and Health Care Costs for Pediatric Cannabis Exposures

Visit

Bashqoy FH, J. W.; Reiter, P. D.; Wang, G. S.; Borgelt, L. M.

This study aimed to evaluate the process of identifying marijuana exposure in a children's hospital emergency department and compare the cost of diagnostic testing and procedures.

Key Study: Acute cannabis toxicity

Visit

Noble MJH, K.; Hendrickson, R. G.

We describe the clinical effects of, and products associated with, acute exposures to cannabis during the early legalization period of recreational cannabis in Oregon and Alaska.

Key Study: A 21st Century Problem: Cannabis Toxicity in a 13-Month-Old Child

Visit

Levene RJP-C, Elza; Wolfram, Sigrid

We report the case of a 13-month-old female presenting with self-limiting altered mental status and lethargy, with a subsequent diagnosis of tetrahydrocannabinol exposure on confirmatory urine gas chromatography-mass spectrometry.

Key Study: Synthetic Cannabinoid Exposure in Adolescents Presenting for Emergency Care

Visit

Gilley MB, J.; Calello, D. P.; Wax, P.; Finkelstein, Y.; Toxicology Investiga...

The objective of this study was to characterize the clinical picture and management of synthetic cannabinoid exposure in a cohort of adolescents.

Key Study: Marijuana Misadventures in Children: Exploration of a Dose-Response Relationship and Summary of Clinical Effects and Outcomes

Visit

Heizer JWB, L. M.; Bashqoy, F.; Wang, G. S.; Reiter, P. D.

This study aimed to explore a dose-response relationship of delta-9-tetrahydrocannabinol (THC) in THC-nave children after unintentional acute exposure and compare clinical outcomes with non-nave children.

Key Study: Cannabis Intoxication Case Series: The Dangers of Edibles Containing Tetrahydrocannabinol

Visit

Vo KTH, H.; Li, K.; Ho, R. Y.; Wu, A. H. B.; Lynch, K. L.; Smollin, C. G.

Cannabis and its principal active constituent, 9-tetrahydrocannabinol (THC), are increasingly available as edibles resembling commercially available food products. In this case series, we describe a population of predominantly pediatric patients who were inadvertently exposed to a THC-containing product in San Francisco.

Key Study: Intoxicacin por cannabis en menores de 3 aos

Visit

Pinedo-Painous IG-R, Roser; Valls-Lafon, Anna; Muoz-Santanach, David; Martnez...

We present a retrospective, descriptive study of patients aged 3 years or younger who were treated for cannabis poisoning in a pediatric emergency department between 2012 and 2017.

Key Study: Longitudinal associations of social cognition and substance use in childhood and early adolescence: findings from the Avon Longitudinal Study of Parents and Children

Visit

Fluharty, M. E., Heron, J., & Munaf, M. R

We investigated both directions of association within an adolescent birth cohort: the association of social cognition with subsequent substance use, and the association of early substance use with subsequent social cognition

Key Study: Unintentional Cannabis Intoxication in Toddlers

Visit

Claudet IM, S.; Labadie, M.; Manin, C.; Michard-Lenoir, A. P.; Eyer, D.; Dufo...

We sought to evaluate the French national trend of admissions for unintentional cannabis intoxication in children over an 11-year period (20042014).

Key Study: A 10-year review of cannabis exposure in children under 3-years of age: do we need a more global approach?

Visit

Claudet, I., Le Breton, M., Brhin, C., & Franchitto, N

We carried out a retrospective cohort study of children admitted to a pediatric emergency department due to unintentional cannabis exposure over a 10-year period from 2004 to 2014.

Key Study: Drug Misuse in Adolescents Presenting to the Emergency Department

Visit

Finkelstein YG, G.; Hutson, J. R.; Armstrong, J.; Baum, C. R.; Wax, P.; Brent...

Drug misuse is a disturbing, common practice among youth. One in 4 American adolescents reports consuming prescription medications without a clinical indication. We sought to explore current trends of drug misuse in adolescents.

Key Study: Acute intoxication caused by synthetic cannabinoids 5F-ADB and MMB-2201: A case series

Visit

Barcelo BP, S.; Lopez-Corominas, V.; Gomila, I.; Yates, C.; Busardo, F. P.; P...

Here, we report five cases of acute intoxication by synthetic cannabinoids 5F-ADB and MMB-2201 with analytical confirmation

Key Study: Detecting biomarkers of secondhand marijuana smoke in young children

Visit

Wilson, K. M., Torok, M. R., Wei, B., Wang, L., Robinson, M., Sosnoff, C. S.,...

We studied children ages 1 mo to 2 y hospitalized with bronchiolitis in Colorado from 2013 to 2015.

Key Study: Unintentional Pediatric Exposures to Marijuana in Colorado, 2009-2015

Visit

George SamWang,MD1,2; Marie-ClaireLe Lait,MS2; Sara J.Deakyne,MPH3; et al

To compare the incidence of pediatric marijuana exposures evaluated at a children's hospital and regional poison center (RPC) in Colorado before and after recreational marijuana legalization and to compare population rate trends of RPC cases for marijuana exposures with the rest of the United States.

Key Study: Marijuana exposure among children younger than siz years in the United States

Visit

Onders B, Casavant MJ, Spiller HA, Chounthirath T, Smith GA

This study investigates marijuana exposures among children <6 years old in the United States using data from the National Poison Data System.

Key Study: Synthetic Cannabinoid Exposure

Visit

Adair AG, Spencer C.; Greeley, Christopher S.; Coleman, Ryan D.; Shekerdemian...

We present 2 cases of actual or highly suspected synthetic cannabinoid exposure in 2 pediatric patients to demonstrate the wide range of symptoms that can be present in these patients.

Key Study: Treat plays trick on a 3-year-old boy

Visit

Thuy Trang JNC, Arthur K.

Presents a case study of a 3 year old with acute cannabis intoxication.

Key Study: Changes in Cannabis Potency Over the Last 2 Decades (19952014): Analysis of Current Data in the United States

Visit

ElSohly, M. A., Mehmedic, Z., Foster, S., Gon, C., Chandra, S., & Church,...

This report examines the concentration of cannabinoids in illicit cannabis products seized by the U.S. Drug Enforcement Administration over the last 2 decades, with particular emphasis on (9)-tetrahydrocannabinol and cannabidiol.

Key Study: Non-Smoker Exposure to Secondhand Cannabis Smoke. I. Urine Screening and Confirmation Results

Visit

Cone, E. J., Bigelow, G. E., Herrmann, E. S., Mitchell, J. M., LoDico, C., Fl...

A systematic study was conducted of smoke exposure on drug-free participants.

Key Study: Non-smoker exposure to secondhand cannabis smoke II: Effect of room ventilation on the physiological, subjective, and behavioral/cognitive effects.

Visit

Herrmann, E. S., Cone, E. J., Mitchell, J. M., Bigelow, G. E., LoDico, C., Fl...

This report examines the concentration of cannabinoids in illicit cannabis products seized by the U.S. Drug Enforcement Administration over the last 2 decades, with particular emphasis on (9)-tetrahydrocannabinol and cannabidiol.

Key Study: Nonsmoker Exposure to Secondhand Cannabis Smoke. III. Oral Fluid and Blood Drug Concentrations and Corresponding Subjective Effects

Visit

Cone, E. J., Bigelow, G. E., Herrmann, E. S., Mitchell, J. M., LoDico, C., Fl...

The study was designed to produce extreme cannabis smoke exposure conditions tolerable to drug-free nonsmokers

Key Study: Accidental pediatric ingestions of medical marijuana: a 4-year poison center experience

Visit

Lovecchio, F., & Heise, C. W

A study of incidental pediatric cannabis consumption over a 4-year period.

Key Study: A cannabinoid-intoxicated child treated with dexmedetomidine: a case report

Visit

Cipriani, F., Mancino, A., Pulitan, S. M., Piastra, M., & Conti, G.

To our knowledge, this is the first reported case of dexmedetomidine use to support a cannabis intoxicated patient.

Key Study: The Impact of Marijuana Policies on Youth: Clinical, Research, and Legal Update

Visit

Ammerman, S., Ryan, S., Adelman, W. P., & THE COMMITTEE ON SUBSTANCE ABUS...

This technical report updates the 2004 American Academy of Pediatrics technical report on the legalization of marijuana

Key Study: Dangerous Relationships: Asthma and Substance Abuse

Visit

Caponnetto, P., Auditore, R., Russo, C., Alamo, A., Campagna, D., Demma, S., ...

The review emphasizes the importance for clinicians to be alert to the possibility of this substance as a precipitating factor for acute asthma.

Key Study: The Pharmacologic and Clinical Effects of Medical Cannabis

Visit

Borgelt, L. M., Franson, K. L., Nussbaum, A. M., & Wang, G. S.

This article will describe the pharmacology of cannabis, effects of various dosage formulations, therapeutics benefits and risks of cannabis for pain and muscle spasm, and safety concerns of medical cannabis use.

Key Study: Acute intoxication caused by a synthetic cannabinoid in two adolescents

Visit

Heath TSB, Z.; Thompson, A. J.; Tecklenburg, F. W.

In this report, we describe two adolescent patients admitted after they inhaled K2, resulting in loss of consciousness, tachycardia, and diffuse pain.

Key Study: Drug use and screening in pediatric trauma

Visit

Martin KLV, K. N.; Girotti, M. J.; Stewart, T. C.; Parry, N. G.

This article will describe the pharmacology of cannabis, effects of various dosage formulations, therapeutics benefits and risks of cannabis for pain and muscle spasm, and safety concerns of medical cannabis use.

Key Study: Sensitivity and Specificity of Urinary Cannabinoid Detection With Two Immunoassays After Controlled Oral Administration of Cannabinoids to Humans.

Visit

Grauwiler, S. B., Drewe, J., & Scholer, A.

This study aims to describe trends in substance use and screening in the Canadian pediatric trauma population.

Key Study: Ataxia and shaking in a 2-year-old girl: acute marijuana intoxication presenting as seizure.

Visit

Bonkowsky, J. L., Sarco, D., & Pomeroy, S. L

This is a case study of a young girl experiencing cannabis usage.

Key Study: Urine drug screens in overdose patients do not contribute to immediate clinical management

Visit

Montague REG, R. F.; Lewis, J. H.; Shenfield, G. M.

A prospective study assessed whether routine urine drug screens might alter the management of overdose patients.

Key Study: Substance abuse in adolescent trauma

Visit

Loiselle JMB, M. D.; Templeton, J. M., Jr.; Schwartz, G.; Drott, H.

To determine if there is a significant prevalence of drug or alcohol use among adolescents evaluated for significant acute trauma.

Key Study: Increased Testing and Health Care Costs for Pediatric Cannabis Exposures

Visit

Bashqoy FH, J. W.; Reiter, P. D.; Wang, G. S.; Borgelt, L. M.

This study aimed to evaluate the process of identifying marijuana exposure in a children's hospital emergency department and compare the cost of diagnostic testing and procedures.

Key Study: Acute cannabis toxicity

Visit

Noble MJH, K.; Hendrickson, R. G.

We describe the clinical effects of, and products associated with, acute exposures to cannabis during the early legalization period of recreational cannabis in Oregon and Alaska.

Key Study: A 21st Century Problem: Cannabis Toxicity in a 13-Month-Old Child

Visit

Levene RJP-C, Elza; Wolfram, Sigrid

We report the case of a 13-month-old female presenting with self-limiting altered mental status and lethargy, with a subsequent diagnosis of tetrahydrocannabinol exposure on confirmatory urine gas chromatography-mass spectrometry.

Key Study: Synthetic Cannabinoid Exposure in Adolescents Presenting for Emergency Care

Visit

Gilley MB, J.; Calello, D. P.; Wax, P.; Finkelstein, Y.; Toxicology Investiga...

The objective of this study was to characterize the clinical picture and management of synthetic cannabinoid exposure in a cohort of adolescents.

Key Study: Marijuana Misadventures in Children: Exploration of a Dose-Response Relationship and Summary of Clinical Effects and Outcomes

Visit

Heizer JWB, L. M.; Bashqoy, F.; Wang, G. S.; Reiter, P. D.

This study aimed to explore a dose-response relationship of delta-9-tetrahydrocannabinol (THC) in THC-nave children after unintentional acute exposure and compare clinical outcomes with non-nave children.

Key Study: Cannabis Intoxication Case Series: The Dangers of Edibles Containing Tetrahydrocannabinol

Visit

Vo KTH, H.; Li, K.; Ho, R. Y.; Wu, A. H. B.; Lynch, K. L.; Smollin, C. G.

Cannabis and its principal active constituent, 9-tetrahydrocannabinol (THC), are increasingly available as edibles resembling commercially available food products. In this case series, we describe a population of predominantly pediatric patients who were inadvertently exposed to a THC-containing product in San Francisco.

Key Study: Intoxicacin por cannabis en menores de 3 aos

Visit

Pinedo-Painous IG-R, Roser; Valls-Lafon, Anna; Muoz-Santanach, David; Martnez...

We present a retrospective, descriptive study of patients aged 3 years or younger who were treated for cannabis poisoning in a pediatric emergency department between 2012 and 2017.

Key Study: Longitudinal associations of social cognition and substance use in childhood and early adolescence: findings from the Avon Longitudinal Study of Parents and Children

Visit

Fluharty, M. E., Heron, J., & Munaf, M. R

We investigated both directions of association within an adolescent birth cohort: the association of social cognition with subsequent substance use, and the association of early substance use with subsequent social cognition

Key Study: Unintentional Cannabis Intoxication in Toddlers

Visit

Claudet IM, S.; Labadie, M.; Manin, C.; Michard-Lenoir, A. P.; Eyer, D.; Dufo...

We sought to evaluate the French national trend of admissions for unintentional cannabis intoxication in children over an 11-year period (20042014).

Key Study: A 10-year review of cannabis exposure in children under 3-years of age: do we need a more global approach?

Visit

Claudet, I., Le Breton, M., Brhin, C., & Franchitto, N

We carried out a retrospective cohort study of children admitted to a pediatric emergency department due to unintentional cannabis exposure over a 10-year period from 2004 to 2014.

Key Study: Drug Misuse in Adolescents Presenting to the Emergency Department

Visit

Finkelstein YG, G.; Hutson, J. R.; Armstrong, J.; Baum, C. R.; Wax, P.; Brent...

Drug misuse is a disturbing, common practice among youth. One in 4 American adolescents reports consuming prescription medications without a clinical indication. We sought to explore current trends of drug misuse in adolescents.

Key Study: Acute intoxication caused by synthetic cannabinoids 5F-ADB and MMB-2201: A case series

Visit

Barcelo BP, S.; Lopez-Corominas, V.; Gomila, I.; Yates, C.; Busardo, F. P.; P...

Here, we report five cases of acute intoxication by synthetic cannabinoids 5F-ADB and MMB-2201 with analytical confirmation

Key Study: Detecting biomarkers of secondhand marijuana smoke in young children

Visit

Wilson, K. M., Torok, M. R., Wei, B., Wang, L., Robinson, M., Sosnoff, C. S.,...

We studied children ages 1 mo to 2 y hospitalized with bronchiolitis in Colorado from 2013 to 2015.

Key Study: Unintentional Pediatric Exposures to Marijuana in Colorado, 2009-2015

Visit

George SamWang,MD1,2; Marie-ClaireLe Lait,MS2; Sara J.Deakyne,MPH3; et al

To compare the incidence of pediatric marijuana exposures evaluated at a children's hospital and regional poison center (RPC) in Colorado before and after recreational marijuana legalization and to compare population rate trends of RPC cases for marijuana exposures with the rest of the United States.

Key Study: Marijuana exposure among children younger than siz years in the United States

Visit

Onders B, Casavant MJ, Spiller HA, Chounthirath T, Smith GA

This study investigates marijuana exposures among children <6 years old in the United States using data from the National Poison Data System.

Key Study: Synthetic Cannabinoid Exposure

Visit

Adair AG, Spencer C.; Greeley, Christopher S.; Coleman, Ryan D.; Shekerdemian...

We present 2 cases of actual or highly suspected synthetic cannabinoid exposure in 2 pediatric patients to demonstrate the wide range of symptoms that can be present in these patients.

Key Study: Treat plays trick on a 3-year-old boy

Visit

Thuy Trang JNC, Arthur K.

Presents a case study of a 3 year old with acute cannabis intoxication.

Key Study: Changes in Cannabis Potency Over the Last 2 Decades (19952014): Analysis of Current Data in the United States

Visit

ElSohly, M. A., Mehmedic, Z., Foster, S., Gon, C., Chandra, S., & Church,...

This report examines the concentration of cannabinoids in illicit cannabis products seized by the U.S. Drug Enforcement Administration over the last 2 decades, with particular emphasis on (9)-tetrahydrocannabinol and cannabidiol.

Key Study: Non-Smoker Exposure to Secondhand Cannabis Smoke. I. Urine Screening and Confirmation Results

Visit

Cone, E. J., Bigelow, G. E., Herrmann, E. S., Mitchell, J. M., LoDico, C., Fl...

A systematic study was conducted of smoke exposure on drug-free participants.

Key Study: Non-smoker exposure to secondhand cannabis smoke II: Effect of room ventilation on the physiological, subjective, and behavioral/cognitive effects.

Visit

Herrmann, E. S., Cone, E. J., Mitchell, J. M., Bigelow, G. E., LoDico, C., Fl...

This report examines the concentration of cannabinoids in illicit cannabis products seized by the U.S. Drug Enforcement Administration over the last 2 decades, with particular emphasis on (9)-tetrahydrocannabinol and cannabidiol.

Key Study: Nonsmoker Exposure to Secondhand Cannabis Smoke. III. Oral Fluid and Blood Drug Concentrations and Corresponding Subjective Effects

Visit

Cone, E. J., Bigelow, G. E., Herrmann, E. S., Mitchell, J. M., LoDico, C., Fl...

The study was designed to produce extreme cannabis smoke exposure conditions tolerable to drug-free nonsmokers

Key Study: Accidental pediatric ingestions of medical marijuana: a 4-year poison center experience

Visit

Lovecchio, F., & Heise, C. W

A study of incidental pediatric cannabis consumption over a 4-year period.

Key Study: A cannabinoid-intoxicated child treated with dexmedetomidine: a case report

Visit

Cipriani, F., Mancino, A., Pulitan, S. M., Piastra, M., & Conti, G.

To our knowledge, this is the first reported case of dexmedetomidine use to support a cannabis intoxicated patient.

Key Study: The Impact of Marijuana Policies on Youth: Clinical, Research, and Legal Update

Visit

Ammerman, S., Ryan, S., Adelman, W. P., & THE COMMITTEE ON SUBSTANCE ABUS...

This technical report updates the 2004 American Academy of Pediatrics technical report on the legalization of marijuana

Key Study: Dangerous Relationships: Asthma and Substance Abuse

Visit

Caponnetto, P., Auditore, R., Russo, C., Alamo, A., Campagna, D., Demma, S., ...

The review emphasizes the importance for clinicians to be alert to the possibility of this substance as a precipitating factor for acute asthma.

Key Study: The Pharmacologic and Clinical Effects of Medical Cannabis

Visit

Borgelt, L. M., Franson, K. L., Nussbaum, A. M., & Wang, G. S.

This article will describe the pharmacology of cannabis, effects of various dosage formulations, therapeutics benefits and risks of cannabis for pain and muscle spasm, and safety concerns of medical cannabis use.

Key Study: Acute intoxication caused by a synthetic cannabinoid in two adolescents

Visit

Heath TSB, Z.; Thompson, A. J.; Tecklenburg, F. W.

In this report, we describe two adolescent patients admitted after they inhaled K2, resulting in loss of consciousness, tachycardia, and diffuse pain.

Key Study: Drug use and screening in pediatric trauma

Visit

Martin KLV, K. N.; Girotti, M. J.; Stewart, T. C.; Parry, N. G.

This article will describe the pharmacology of cannabis, effects of various dosage formulations, therapeutics benefits and risks of cannabis for pain and muscle spasm, and safety concerns of medical cannabis use.

Key Study: Sensitivity and Specificity of Urinary Cannabinoid Detection With Two Immunoassays After Controlled Oral Administration of Cannabinoids to Humans.

Visit

Grauwiler, S. B., Drewe, J., & Scholer, A.

This study aims to describe trends in substance use and screening in the Canadian pediatric trauma population.

Key Study: Ataxia and shaking in a 2-year-old girl: acute marijuana intoxication presenting as seizure.

Visit

Bonkowsky, J. L., Sarco, D., & Pomeroy, S. L

This is a case study of a young girl experiencing cannabis usage.

Key Study: Urine drug screens in overdose patients do not contribute to immediate clinical management

Visit

Montague REG, R. F.; Lewis, J. H.; Shenfield, G. M.

A prospective study assessed whether routine urine drug screens might alter the management of overdose patients.

Key Study: Substance abuse in adolescent trauma

Visit

Loiselle JMB, M. D.; Templeton, J. M., Jr.; Schwartz, G.; Drott, H.

To determine if there is a significant prevalence of drug or alcohol use among adolescents evaluated for significant acute trauma.