How to use clinical signs of meningitis.
Tracy, A & Waterfield T.
Tracy, A & Waterfield T.
CSF interpretation
The Royal Children's Hospital Melbourne
The Royal Children's Hospital Melbourne
Guideline to help with the interpretation of CSF results for the purpose of diagnosing or excluding meningitis.
Lumbar puncture
The Royal Children's Hospital Melbourne
The Royal Children's Hospital Melbourne
Guideline for performing lumbar puncture.
Meningitis - encephalitis
The Royal Children's Hospital Melbourne
The Royal Children's Hospital Melbourne
Guideline for the assessment and management of meningitis-encephalitis.
Aseptic Meningitis
Melia M, Johns Hopkins ABX Guide
Melia M, Johns Hopkins ABX Guide
Guideline discussing aseptic meningitis pathogens, clinical presentation, diagnosis, treatment, and pathogen specific therapies.
Early Recognition of Meningitis and Septicaemia
Royal College of Nursing, Meningitis Research Foundation
Royal College of Nursing, Meningitis Research Foundation
Guidance for front line nurses on the early recognition of meningitis and sepsis (what to look for).
How to use clinical signs of meningitis.
Tracy, A & Waterfield T.
Tracy, A & Waterfield T.
CSF interpretation
The Royal Children's Hospital Melbourne
The Royal Children's Hospital Melbourne
Guideline to help with the interpretation of CSF results for the purpose of diagnosing or excluding meningitis.
Lumbar puncture
The Royal Children's Hospital Melbourne
The Royal Children's Hospital Melbourne
Guideline for performing lumbar puncture.
Meningitis - encephalitis
The Royal Children's Hospital Melbourne
The Royal Children's Hospital Melbourne
Guideline for the assessment and management of meningitis-encephalitis.
Aseptic Meningitis
Melia M, Johns Hopkins ABX Guide
Melia M, Johns Hopkins ABX Guide
Guideline discussing aseptic meningitis pathogens, clinical presentation, diagnosis, treatment, and pathogen specific therapies.
Early Recognition of Meningitis and Septicaemia
Royal College of Nursing, Meningitis Research Foundation
Royal College of Nursing, Meningitis Research Foundation
Guidance for front line nurses on the early recognition of meningitis and sepsis (what to look for).
Review: Diagnosis and Treatment of Central Nervous System Infections in the Emergency Department
Dorsett M, Liang SY
Dorsett M, Liang SY
Objective: This review discusses the clinical signs and symptoms that should lead emergency physicians to consider CNS infection, paying particular attention to the sensitivity and specificity of different clinical findings at the bedside. Subsequently, the diagnostic workup and management of patients for whom there is high clinical suspicion for CNS infection is discussed.
Systematic Review: Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis
Sakushima K, Hayashino Y, Kawaguchi T, Jackson JL, Fukuhara S
Sakushima K, Hayashino Y, Kawaguchi T, Jackson JL, Fukuhara S
Objective: Our study's purpose was to assess the utility of CSF lactate in differentiating bacterial meningitis from aseptic meningitis.
Systematic Review: Clinical features suggestive of meningitis in children: a systematic review of prospective data
Curtis S, Stobart K, Vandermeer B, Simel DL, Klassen T
Curtis S, Stobart K, Vandermeer B, Simel DL, Klassen T
Objective: To seek evidence supporting accuracy of clinical features of pediatric bacterial meningitis.
Review: Treatment of herpes simplex virus infections in pediatric patients: current status and future needs
James SH, Whitley RJ
James SH, Whitley RJ
Objective: To present an overview of the major clinical manifestations of HSV infections in the pediatric population.
Review: Emergency department management of meningitis and encephalitis
Fitch MT, Abrahamian FM, Moran GJ, Talan DA
Fitch MT, Abrahamian FM, Moran GJ, Talan DA
Objective: This article addresses considerations in clinical evaluation, need for CNS imaging before LP, interpretation of cerebrospinal fluid results, standards for and effects of timely antibiotic administration, and recommendations for specific antimicrobial therapy and corticosteroids.
Review: Viral meningitis
Logan SA, MacMahon E
Logan SA, MacMahon E
Objective: In this review we outline the changing epidemiology, discuss key clinical topics, and illustrate how identification of the specific viral cause is beneficial. Neonatal meningitis may be a component of perinatal infection and is not covered here.
Review: Diagnosis and Treatment of Central Nervous System Infections in the Emergency Department
Dorsett M, Liang SY
Dorsett M, Liang SY
Objective: This review discusses the clinical signs and symptoms that should lead emergency physicians to consider CNS infection, paying particular attention to the sensitivity and specificity of different clinical findings at the bedside. Subsequently, the diagnostic workup and management of patients for whom there is high clinical suspicion for CNS infection is discussed.
Systematic Review: Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis
Sakushima K, Hayashino Y, Kawaguchi T, Jackson JL, Fukuhara S
Sakushima K, Hayashino Y, Kawaguchi T, Jackson JL, Fukuhara S
Objective: Our study's purpose was to assess the utility of CSF lactate in differentiating bacterial meningitis from aseptic meningitis.
Systematic Review: Clinical features suggestive of meningitis in children: a systematic review of prospective data
Curtis S, Stobart K, Vandermeer B, Simel DL, Klassen T
Curtis S, Stobart K, Vandermeer B, Simel DL, Klassen T
Objective: To seek evidence supporting accuracy of clinical features of pediatric bacterial meningitis.
Review: Treatment of herpes simplex virus infections in pediatric patients: current status and future needs
James SH, Whitley RJ
James SH, Whitley RJ
Objective: To present an overview of the major clinical manifestations of HSV infections in the pediatric population.
Review: Emergency department management of meningitis and encephalitis
Fitch MT, Abrahamian FM, Moran GJ, Talan DA
Fitch MT, Abrahamian FM, Moran GJ, Talan DA
Objective: This article addresses considerations in clinical evaluation, need for CNS imaging before LP, interpretation of cerebrospinal fluid results, standards for and effects of timely antibiotic administration, and recommendations for specific antimicrobial therapy and corticosteroids.
Review: Viral meningitis
Logan SA, MacMahon E
Logan SA, MacMahon E
Objective: In this review we outline the changing epidemiology, discuss key clinical topics, and illustrate how identification of the specific viral cause is beneficial. Neonatal meningitis may be a component of perinatal infection and is not covered here.
Key study: Cranial Imaging Before Lumbar Puncture in Adults With Community-Acquired Meningitis: Clinical Utility and Adherence to the Infectious Diseases Society of America Guidelines
Salazar L, Hasbun R
Salazar L, Hasbun R
Objective: The main objectives of this study were to identify the adherence of clinicians to IDSA guidelines regarding cranial imaging in patients with CAM, to evaluate the clinical and prognostic differences between those patients with and without an indication for cranial imaging, and to assess the clinical impact in management in those with abnormal intracranial findings with or without altered mental status as their sole indication for imaging.
Key study: Improvement of the management of infants, children and adults with a molecular diagnosis of Enterovirus meningitis during two observational study periods
Archimbaud C, Ouchchane L, Mirand A, Chambon M, Demeocq F, Labb A, Laurichesse H, Schmidt J, Clavelou P, Aumatre O, Regagnon C, Bailly JL, Henquell C, Peigue...
Archimbaud C, Ouchchane L, Mirand A, Chambon M, Demeocq F, Labb A, Laurichess...
Objective: The aim of this study was to assess the impact of an EV positive diagnosis on the clinical management of patients admitted for meningitis over the course of two observational study periods (2005 and 2008-09) in the same clinical departments.
Key study: Impact of rapid enterovirus molecular diagnosis on the management of infants, children, and adults with aseptic meningitis
Archimbaud C, Chambon M, Bailly JL, Petit I, Henquell C, Mirand A, Aublet-Cuvelier B, Ughetto S, Beytout J, Clavelou P, Labb A, Philippe P, Schmidt J, Regagn...
Archimbaud C, Chambon M, Bailly JL, Petit I, Henquell C, Mirand A, Aublet-Cuv...
Objective: Enteroviruses (EV) are the main etiological agents of aseptic meningitis. Diagnosis is made by detecting the genome using RTPCR. The aim of the study was to evaluate the impact of a positive diagnosis on the management of infants, children, and adults.
Key study: Interpretation of traumatic lumbar punctures: who can go home?
Mazor SS, McNulty JE, Roosevelt GE
Mazor SS, McNulty JE, Roosevelt GE
Objective: To determine whether a ratio of observed to predicted (O:P) cerebrospinal fluid (CSF) white blood cells (WBCs) after a traumatic lumbar puncture (LP) can be used to predict which patients do not have meningitis and can safely be discharged from the hospital.
Key study: Cerebrospinal fluid findings in aseptic versus bacterial meningitis
Negrini B, Kelleher KJ, Wald ER
Negrini B, Kelleher KJ, Wald ER
Objective: To assess 1) the characteristics of the CSF differential in aseptic versus bacterial meningitis, 2) the influence of duration of illness on the CSF differential, and 3) the role of the CSF differential in discriminating between aseptic versus bacterial meningitis.
Key study: Cranial Imaging Before Lumbar Puncture in Adults With Community-Acquired Meningitis: Clinical Utility and Adherence to the Infectious Diseases Society of America Guidelines
Salazar L, Hasbun R
Salazar L, Hasbun R
Objective: The main objectives of this study were to identify the adherence of clinicians to IDSA guidelines regarding cranial imaging in patients with CAM, to evaluate the clinical and prognostic differences between those patients with and without an indication for cranial imaging, and to assess the clinical impact in management in those with abnormal intracranial findings with or without altered mental status as their sole indication for imaging.
Key study: Improvement of the management of infants, children and adults with a molecular diagnosis of Enterovirus meningitis during two observational study periods
Archimbaud C, Ouchchane L, Mirand A, Chambon M, Demeocq F, Labb A, Laurichesse H, Schmidt J, Clavelou P, Aumatre O, Regagnon C, Bailly JL, Henquell C, Peigue...
Archimbaud C, Ouchchane L, Mirand A, Chambon M, Demeocq F, Labb A, Laurichess...
Objective: The aim of this study was to assess the impact of an EV positive diagnosis on the clinical management of patients admitted for meningitis over the course of two observational study periods (2005 and 2008-09) in the same clinical departments.
Key study: Impact of rapid enterovirus molecular diagnosis on the management of infants, children, and adults with aseptic meningitis
Archimbaud C, Chambon M, Bailly JL, Petit I, Henquell C, Mirand A, Aublet-Cuvelier B, Ughetto S, Beytout J, Clavelou P, Labb A, Philippe P, Schmidt J, Regagn...
Archimbaud C, Chambon M, Bailly JL, Petit I, Henquell C, Mirand A, Aublet-Cuv...
Objective: Enteroviruses (EV) are the main etiological agents of aseptic meningitis. Diagnosis is made by detecting the genome using RTPCR. The aim of the study was to evaluate the impact of a positive diagnosis on the management of infants, children, and adults.
Key study: Interpretation of traumatic lumbar punctures: who can go home?
Mazor SS, McNulty JE, Roosevelt GE
Mazor SS, McNulty JE, Roosevelt GE
Objective: To determine whether a ratio of observed to predicted (O:P) cerebrospinal fluid (CSF) white blood cells (WBCs) after a traumatic lumbar puncture (LP) can be used to predict which patients do not have meningitis and can safely be discharged from the hospital.
Key study: Cerebrospinal fluid findings in aseptic versus bacterial meningitis
Negrini B, Kelleher KJ, Wald ER
Negrini B, Kelleher KJ, Wald ER
Objective: To assess 1) the characteristics of the CSF differential in aseptic versus bacterial meningitis, 2) the influence of duration of illness on the CSF differential, and 3) the role of the CSF differential in discriminating between aseptic versus bacterial meningitis.