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Clinical guidelines English (2) French All (2)

Practice parameter: treatment of nervous system Lyme disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology

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Halperin JJ, Shapiro ED, Logigian E, Belman AL, Dotevall L, Wormser GP, Krupp...

Provides evidence-based recommendations on the treatment of nervous system Lyme disease and post-Lyme syndrome. Three questions were addressed: 1) Which antimicrobial agents are effective? 2) Are different regimens preferred for different manifestations of nervous system Lyme disease? 3) What duration of therapy is needed?

The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America

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Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Kr...

Evidence-based guidelines for the management of patients with Lyme disease, human granulocytic anaplasmosis (formerly known as human granulocytic ehrlichiosis), and babesiosis.

Practice parameter: treatment of nervous system Lyme disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology

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Halperin JJ, Shapiro ED, Logigian E, Belman AL, Dotevall L, Wormser GP, Krupp...

Provides evidence-based recommendations on the treatment of nervous system Lyme disease and post-Lyme syndrome. Three questions were addressed: 1) Which antimicrobial agents are effective? 2) Are different regimens preferred for different manifestations of nervous system Lyme disease? 3) What duration of therapy is needed?

The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America

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Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Kr...

Evidence-based guidelines for the management of patients with Lyme disease, human granulocytic anaplasmosis (formerly known as human granulocytic ehrlichiosis), and babesiosis.

Summaries of systematic reviews English (1) French All (1)

Cochrane Summary: Treatment for the neurological complications of Lyme disease

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Cadavid D, Auwaerter PG, Rumbaugh J, Gelderblom H

Objective: To assess the effects of antibiotics for the treatment of Lyme neuroborreliosis (LNB).

Cochrane Summary: Treatment for the neurological complications of Lyme disease

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Cadavid D, Auwaerter PG, Rumbaugh J, Gelderblom H

Objective: To assess the effects of antibiotics for the treatment of Lyme neuroborreliosis (LNB).

Systematic reviews English (3) French All (3)

Review: Lyme Disease: Emergency Department Considerations

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Applegren ND, Kraus CK

Objective: We sought to review the etiology of LD, describe its clinical presentations and sequela, and provide a practical classification and approach to ED management of patients with LD-related presentations.

Cochrane Systematic Review: Antibiotics for the neurological complications of Lyme disease

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Cadavid D, Auwaerter PG, Rumbaugh J, Gelderblom H

Objective: To assess the effects of antibiotics for the treatment of Lyme neuroborreliosis (LNB).

Review: Lyme disease: clinical diagnosis and treatment

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Hatchette TF, Davis I, Johnston BL

Objective: To review the clinical diagnosis and treatment of Lyme disease for front-line clinicians.

Review: Lyme Disease: Emergency Department Considerations

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Applegren ND, Kraus CK

Objective: We sought to review the etiology of LD, describe its clinical presentations and sequela, and provide a practical classification and approach to ED management of patients with LD-related presentations.

Cochrane Systematic Review: Antibiotics for the neurological complications of Lyme disease

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Cadavid D, Auwaerter PG, Rumbaugh J, Gelderblom H

Objective: To assess the effects of antibiotics for the treatment of Lyme neuroborreliosis (LNB).

Review: Lyme disease: clinical diagnosis and treatment

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Hatchette TF, Davis I, Johnston BL

Objective: To review the clinical diagnosis and treatment of Lyme disease for front-line clinicians.

Key studies English (5) French All (5)

Key study: Validation of a Clinical Prediction Rule to Distinguish Lyme Meningitis From Aseptic Meningitis

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Cohn KA,Thompson AD,Shah SS,Hines EM,Lyons TW,Welsh EJ,Nigrovic LE

Objective: The goal of this study was to test the performance of the Rule of 7's in a multicenter cohort of children with CSF pleocytosis.

Key study: Prospective Validation of a Clinical Prediction Model for Lyme Meningitis in Children

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Garro AC,Rutman M,Simonsen K,Jaeger JL,Chapin K,Lockhart G

Objective: A clinical prediction model was developed to distinguish Lyme meningitis from other causes of aseptic meningitis. Our objective was to prospectively validate this model.

Key study: Lyme neuroborreliosis in children: a prospective study of clinical features, prognosis, and outcome

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Skogman BH, Croner S, Nordwall M, Eknefelt M, Ernerudh J, Forsberg P

Objective: Evaluation of children with clinically suspected neuroborreliosis (NB) is difficult. With a prospective study design we wanted to characterize children with signs and symptoms indicative for NB, investigate clinical outcome and, if possible, identify factors of importance for recovery.

Key study: Prediction of Lyme Meningitis in Children From a Lyme DiseaseEndemic Region: A Logistic-Regression Model Using History, Physical, and Laboratory Findings

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Avery RA, Frank G, Glutting JJ, Eppes SC

Objective: To create a statistical model to predict LM versus AM in children based on history, physical, and laboratory findings during the initial presentation of meningitis.

Key study: Characterization of Lyme Meningitis and Comparison With Viral Meningitis in Children

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Eppes SC,Nelson DK,Lewis LL,Klein JD

Objective: The objectives of this study were to characterize Lyme meningitis (LM) in the pediatric population; to compare LM with viral meningitis (VM) with respect to epidemiology, history and physical examination, and laboratory data; and to provide means of early distinction of Lyme neuroborreliosis from other forms of aseptic meningitis.

Key study: Validation of a Clinical Prediction Rule to Distinguish Lyme Meningitis From Aseptic Meningitis

Visit

Cohn KA,Thompson AD,Shah SS,Hines EM,Lyons TW,Welsh EJ,Nigrovic LE

Objective: The goal of this study was to test the performance of the Rule of 7's in a multicenter cohort of children with CSF pleocytosis.

Key study: Prospective Validation of a Clinical Prediction Model for Lyme Meningitis in Children

Visit

Garro AC,Rutman M,Simonsen K,Jaeger JL,Chapin K,Lockhart G

Objective: A clinical prediction model was developed to distinguish Lyme meningitis from other causes of aseptic meningitis. Our objective was to prospectively validate this model.

Key study: Lyme neuroborreliosis in children: a prospective study of clinical features, prognosis, and outcome

Visit

Skogman BH, Croner S, Nordwall M, Eknefelt M, Ernerudh J, Forsberg P

Objective: Evaluation of children with clinically suspected neuroborreliosis (NB) is difficult. With a prospective study design we wanted to characterize children with signs and symptoms indicative for NB, investigate clinical outcome and, if possible, identify factors of importance for recovery.

Key study: Prediction of Lyme Meningitis in Children From a Lyme DiseaseEndemic Region: A Logistic-Regression Model Using History, Physical, and Laboratory Findings

Visit

Avery RA, Frank G, Glutting JJ, Eppes SC

Objective: To create a statistical model to predict LM versus AM in children based on history, physical, and laboratory findings during the initial presentation of meningitis.

Key study: Characterization of Lyme Meningitis and Comparison With Viral Meningitis in Children

Visit

Eppes SC,Nelson DK,Lewis LL,Klein JD

Objective: The objectives of this study were to characterize Lyme meningitis (LM) in the pediatric population; to compare LM with viral meningitis (VM) with respect to epidemiology, history and physical examination, and laboratory data; and to provide means of early distinction of Lyme neuroborreliosis from other forms of aseptic meningitis.