How to use clinical signs of meningitis.
Tracy, A & Waterfield T.
Tracy, A & Waterfield T.
CSF interpretation
The Royal Children's Hospital Melbourne
The Royal Children's Hospital Melbourne
Guideline to help with the interpretation of CSF results for the purpose of diagnosing or excluding meningitis.
Lumbar puncture
The Royal Children's Hospital Melbourne
The Royal Children's Hospital Melbourne
Guideline for performing lumbar puncture.
Meningitis - encephalitis
The Royal Children's Hospital Melbourne
The Royal Children's Hospital Melbourne
Guideline for the assessment and management of meningitis-encephalitis.
Management of Bacterial Meningitis in Children and Young People
Meningitis Research Foundation
Meningitis Research Foundation
Flowchart of management of bacterial meningitis in children and young people, incorporating NICE Bacterial Meningitis and Meningococcal Septicaemia Guideline CG102.
Aseptic Meningitis
Melia M, Johns Hopkins ABX Guide
Melia M, Johns Hopkins ABX Guide
Guideline discussing aseptic meningitis pathogens, clinical presentation, diagnosis, treatment, and pathogen specific therapies.
Early Recognition of Meningitis and Septicaemia
Royal College of Nursing, Meningitis Research Foundation
Royal College of Nursing, Meningitis Research Foundation
Guidance for front line nurses on the early recognition of meningitis and sepsis (what to look for).
How to use clinical signs of meningitis.
Tracy, A & Waterfield T.
Tracy, A & Waterfield T.
CSF interpretation
The Royal Children's Hospital Melbourne
The Royal Children's Hospital Melbourne
Guideline to help with the interpretation of CSF results for the purpose of diagnosing or excluding meningitis.
Lumbar puncture
The Royal Children's Hospital Melbourne
The Royal Children's Hospital Melbourne
Guideline for performing lumbar puncture.
Meningitis - encephalitis
The Royal Children's Hospital Melbourne
The Royal Children's Hospital Melbourne
Guideline for the assessment and management of meningitis-encephalitis.
Management of Bacterial Meningitis in Children and Young People
Meningitis Research Foundation
Meningitis Research Foundation
Flowchart of management of bacterial meningitis in children and young people, incorporating NICE Bacterial Meningitis and Meningococcal Septicaemia Guideline CG102.
Aseptic Meningitis
Melia M, Johns Hopkins ABX Guide
Melia M, Johns Hopkins ABX Guide
Guideline discussing aseptic meningitis pathogens, clinical presentation, diagnosis, treatment, and pathogen specific therapies.
Early Recognition of Meningitis and Septicaemia
Royal College of Nursing, Meningitis Research Foundation
Royal College of Nursing, Meningitis Research Foundation
Guidance for front line nurses on the early recognition of meningitis and sepsis (what to look for).
Meningitis (bacterial) and meningococcal septicaemia in under 16s: recognition, diagnosis and management
National Institute for Health and Care Excellence
National Institute for Health and Care Excellence
Guideline covering recognising, diagnosing and managing bacterial meningitis and meningococcal septicaemia in babies, children and young people under 16.
Guidelines for the management of suspected and confirmed bacterial meningitis in Canadian children older than one month of age
Le Saux N; Canadian Paediatric Society, Infectious Diseases and ImmunizationCommittee
Le Saux N; Canadian Paediatric Society, Infectious Diseases and ImmunizationC...
Statement reviewing the current epidemiology of bacterial meningitis in children beyond the neonatal period and provide guidelines for the empirical management of suspected bacterial meningitis in Canadian children.
Practice parameter: treatment of nervous system Lyme disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology
Halperin JJ, Shapiro ED, Logigian E, Belman AL, Dotevall L, Wormser GP, Krupp L, Gronseth G, Bever CT Jr; Quality Standards Subcommittee of the American Acad...
Halperin JJ, Shapiro ED, Logigian E, Belman AL, Dotevall L, Wormser GP, Krupp...
Provides evidence-based recommendations on the treatment of nervous system Lyme disease and post-Lyme syndrome. Three questions were addressed: 1) Which antimicrobial agents are effective? 2) Are different regimens preferred for different manifestations of nervous system Lyme disease? 3) What duration of therapy is needed?
The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America
Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Krause PJ, Bakken JS, Strle F, Stanek G, Bockenstedt L, Fish D, Dumler JS, Nadelma...
Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Kr...
Evidence-based guidelines for the management of patients with Lyme disease, human granulocytic anaplasmosis (formerly known as human granulocytic ehrlichiosis), and babesiosis.
Practice guidelines for the management of bacterial meningitis
Tunkel AR, Hartman BJ, Kaplan SL, Kaufman BA, Roos KL, Scheld WM, Whitley RJ
Tunkel AR, Hartman BJ, Kaplan SL, Kaufman BA, Roos KL, Scheld WM, Whitley RJ
Practice guidelines to provide clinicians with recommendations for the diagnosis and treatment of bacterial meningitis.
Meningitis (bacterial) and meningococcal septicaemia in under 16s: recognition, diagnosis and management
National Institute for Health and Care Excellence
National Institute for Health and Care Excellence
Guideline covering recognising, diagnosing and managing bacterial meningitis and meningococcal septicaemia in babies, children and young people under 16.
Guidelines for the management of suspected and confirmed bacterial meningitis in Canadian children older than one month of age
Le Saux N; Canadian Paediatric Society, Infectious Diseases and ImmunizationCommittee
Le Saux N; Canadian Paediatric Society, Infectious Diseases and ImmunizationC...
Statement reviewing the current epidemiology of bacterial meningitis in children beyond the neonatal period and provide guidelines for the empirical management of suspected bacterial meningitis in Canadian children.
Practice parameter: treatment of nervous system Lyme disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology
Halperin JJ, Shapiro ED, Logigian E, Belman AL, Dotevall L, Wormser GP, Krupp L, Gronseth G, Bever CT Jr; Quality Standards Subcommittee of the American Acad...
Halperin JJ, Shapiro ED, Logigian E, Belman AL, Dotevall L, Wormser GP, Krupp...
Provides evidence-based recommendations on the treatment of nervous system Lyme disease and post-Lyme syndrome. Three questions were addressed: 1) Which antimicrobial agents are effective? 2) Are different regimens preferred for different manifestations of nervous system Lyme disease? 3) What duration of therapy is needed?
The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America
Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Krause PJ, Bakken JS, Strle F, Stanek G, Bockenstedt L, Fish D, Dumler JS, Nadelma...
Wormser GP, Dattwyler RJ, Shapiro ED, Halperin JJ, Steere AC, Klempner MS, Kr...
Evidence-based guidelines for the management of patients with Lyme disease, human granulocytic anaplasmosis (formerly known as human granulocytic ehrlichiosis), and babesiosis.
Practice guidelines for the management of bacterial meningitis
Tunkel AR, Hartman BJ, Kaplan SL, Kaufman BA, Roos KL, Scheld WM, Whitley RJ
Tunkel AR, Hartman BJ, Kaplan SL, Kaufman BA, Roos KL, Scheld WM, Whitley RJ
Practice guidelines to provide clinicians with recommendations for the diagnosis and treatment of bacterial meningitis.
Cochrane Summary: Fluids for people with acute bacterial meningitis
Maconochie IK, Bhaumik S
Maconochie IK, Bhaumik S
Objective: To evaluate treatment of acute bacterial meningitis with differing volumes of initial fluid administration (up to 72 hours after first presentation) and the effects on death and neurological sequelae.
Cochrane Summary: Treatment for the neurological complications of Lyme disease
Cadavid D, Auwaerter PG, Rumbaugh J, Gelderblom H
Cadavid D, Auwaerter PG, Rumbaugh J, Gelderblom H
Objective: To assess the effects of antibiotics for the treatment of Lyme neuroborreliosis (LNB).
Cochrane Summary: Corticosteroids for bacterial meningitis
Brouwer MC, McIntyre P, Prasad K, Van de Beek D
Brouwer MC, McIntyre P, Prasad K, Van de Beek D
Objective: To examine the effect of adjuvant corticosteroid therapy versus placebo on mortality, hearing loss and neurological sequelae in people of all ages with acute bacterial meningitis.
Summary: Can a Clinical Prediction Rule Reliably Predict Pediatric Bacterial Meningitis?
Ostermayer DG, Koyfman A
Ostermayer DG, Koyfman A
Objective: To determine if a clinical prediction rule can reliably determine which children should be hospitalized and treated with intravenous antibiotics for bacterial meningitis.
Summary: In children with bacterial meningitis, does the addition of dexamethasone to an antibiotic treatment regimen result in a better clinical outcome than the antibiotic regimen alone?: Part A: Evidence-based answer and summary
Fox JL
Fox JL
Objective: To determine the efficacy of adjuvant dexamethasone therapy in paediatric bacterial meningitis.
Cochrane Summary: Fluids for people with acute bacterial meningitis
Maconochie IK, Bhaumik S
Maconochie IK, Bhaumik S
Objective: To evaluate treatment of acute bacterial meningitis with differing volumes of initial fluid administration (up to 72 hours after first presentation) and the effects on death and neurological sequelae.
Cochrane Summary: Treatment for the neurological complications of Lyme disease
Cadavid D, Auwaerter PG, Rumbaugh J, Gelderblom H
Cadavid D, Auwaerter PG, Rumbaugh J, Gelderblom H
Objective: To assess the effects of antibiotics for the treatment of Lyme neuroborreliosis (LNB).
Cochrane Summary: Corticosteroids for bacterial meningitis
Brouwer MC, McIntyre P, Prasad K, Van de Beek D
Brouwer MC, McIntyre P, Prasad K, Van de Beek D
Objective: To examine the effect of adjuvant corticosteroid therapy versus placebo on mortality, hearing loss and neurological sequelae in people of all ages with acute bacterial meningitis.
Summary: Can a Clinical Prediction Rule Reliably Predict Pediatric Bacterial Meningitis?
Ostermayer DG, Koyfman A
Ostermayer DG, Koyfman A
Objective: To determine if a clinical prediction rule can reliably determine which children should be hospitalized and treated with intravenous antibiotics for bacterial meningitis.
Summary: In children with bacterial meningitis, does the addition of dexamethasone to an antibiotic treatment regimen result in a better clinical outcome than the antibiotic regimen alone?: Part A: Evidence-based answer and summary
Fox JL
Fox JL
Objective: To determine the efficacy of adjuvant dexamethasone therapy in paediatric bacterial meningitis.
Review: Emergency Medicine Myths: Computed Tomography of the Head Prior to Lumbar Puncture in Adults with Suspected Bacterial Meningitis - Due Diligence or Antiquated Practice?
April MD, Long B, Koyfman A
April MD, Long B, Koyfman A
Objective: To review the evidence regarding the utility of obtaining head CT prior to lumbar puncture in adults with suspected bacterial meningitis.
Review: Lyme Disease: Emergency Department Considerations
Applegren ND, Kraus CK
Applegren ND, Kraus CK
Objective: We sought to review the etiology of LD, describe its clinical presentations and sequela, and provide a practical classification and approach to ED management of patients with LD-related presentations.
Review: Diagnosis and Treatment of Central Nervous System Infections in the Emergency Department
Dorsett M, Liang SY
Dorsett M, Liang SY
Objective: This review discusses the clinical signs and symptoms that should lead emergency physicians to consider CNS infection, paying particular attention to the sensitivity and specificity of different clinical findings at the bedside. Subsequently, the diagnostic workup and management of patients for whom there is high clinical suspicion for CNS infection is discussed.
Cochrane Systematic Review: Fluid therapy for acute bacterial meningitis
Maconochie IK, Bhaumik S
Maconochie IK, Bhaumik S
Objective: To evaluate treatment of acute bacterial meningitis with differing volumes of initial fluid administration (up to 72 hours after first presentation) and the effects on death and neurological sequelae.
Cochrane Systematic Review: Antibiotics for the neurological complications of Lyme disease
Cadavid D, Auwaerter PG, Rumbaugh J, Gelderblom H
Cadavid D, Auwaerter PG, Rumbaugh J, Gelderblom H
Objective: To assess the effects of antibiotics for the treatment of Lyme neuroborreliosis (LNB).
Cochrane Systematic Review: Corticosteroids for acute bacterial meningitis
Brouwer MC, McIntyre P, Prasad K, Van de Beek D
Brouwer MC, McIntyre P, Prasad K, Van de Beek D
Objective: To examine the effect of adjuvant corticosteroid therapy versus placebo on mortality, hearing loss and neurological sequelae in people of all ages with acute bacterial meningitis.
Review: Lyme disease: clinical diagnosis and treatment
Hatchette TF, Davis I, Johnston BL
Hatchette TF, Davis I, Johnston BL
Objective: To review the clinical diagnosis and treatment of Lyme disease for front-line clinicians.
Systematic Review: Does this child have bacterial meningitis? A systematic review of clinical prediction rules for children with suspected bacterial meningitis
Kulik DM, Uleryk EM, Maguire JL
Kulik DM, Uleryk EM, Maguire JL
Objective: Our aim was to systematically identify and review the quality and performance of published clinical prediction rules (CPRs) for children with suspected bacterial meningitis.
Systematic Review: Meta-analysis of bacterial meningitis score validation studies
Nigrovic LE, Malley R, Kuppermann N
Nigrovic LE, Malley R, Kuppermann N
Objective: The study objective of the present work was to calculate the performance of the Bacterial Meningitis Score by performing a meta-analysis of all published validation studies.
Systematic Review: Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis
Sakushima K, Hayashino Y, Kawaguchi T, Jackson JL, Fukuhara S
Sakushima K, Hayashino Y, Kawaguchi T, Jackson JL, Fukuhara S
Objective: Our study's purpose was to assess the utility of CSF lactate in differentiating bacterial meningitis from aseptic meningitis.
Systematic Review: Clinical features suggestive of meningitis in children: a systematic review of prospective data
Curtis S, Stobart K, Vandermeer B, Simel DL, Klassen T
Curtis S, Stobart K, Vandermeer B, Simel DL, Klassen T
Objective: To seek evidence supporting accuracy of clinical features of pediatric bacterial meningitis.
Review: Treatment of herpes simplex virus infections in pediatric patients: current status and future needs
James SH, Whitley RJ
James SH, Whitley RJ
Objective: To present an overview of the major clinical manifestations of HSV infections in the pediatric population.
Review: Emergency department management of meningitis and encephalitis
Fitch MT, Abrahamian FM, Moran GJ, Talan DA
Fitch MT, Abrahamian FM, Moran GJ, Talan DA
Objective: This article addresses considerations in clinical evaluation, need for CNS imaging before LP, interpretation of cerebrospinal fluid results, standards for and effects of timely antibiotic administration, and recommendations for specific antimicrobial therapy and corticosteroids.
Review: Viral meningitis
Logan SA, MacMahon E
Logan SA, MacMahon E
Objective: In this review we outline the changing epidemiology, discuss key clinical topics, and illustrate how identification of the specific viral cause is beneficial. Neonatal meningitis may be a component of perinatal infection and is not covered here.
Review: Lumbar puncture and brain herniation in acute bacterial meningitis: a review
Joffe AR
Joffe AR
Objective: There has been controversy regarding the risk of cerebral herniation caused by a lumbar puncture (LP) in acute bacterial meningitis (ABM). This review discusses in detail the issues involved in this controversy.
Review: Emergency Medicine Myths: Computed Tomography of the Head Prior to Lumbar Puncture in Adults with Suspected Bacterial Meningitis - Due Diligence or Antiquated Practice?
April MD, Long B, Koyfman A
April MD, Long B, Koyfman A
Objective: To review the evidence regarding the utility of obtaining head CT prior to lumbar puncture in adults with suspected bacterial meningitis.
Review: Lyme Disease: Emergency Department Considerations
Applegren ND, Kraus CK
Applegren ND, Kraus CK
Objective: We sought to review the etiology of LD, describe its clinical presentations and sequela, and provide a practical classification and approach to ED management of patients with LD-related presentations.
Review: Diagnosis and Treatment of Central Nervous System Infections in the Emergency Department
Dorsett M, Liang SY
Dorsett M, Liang SY
Objective: This review discusses the clinical signs and symptoms that should lead emergency physicians to consider CNS infection, paying particular attention to the sensitivity and specificity of different clinical findings at the bedside. Subsequently, the diagnostic workup and management of patients for whom there is high clinical suspicion for CNS infection is discussed.
Cochrane Systematic Review: Fluid therapy for acute bacterial meningitis
Maconochie IK, Bhaumik S
Maconochie IK, Bhaumik S
Objective: To evaluate treatment of acute bacterial meningitis with differing volumes of initial fluid administration (up to 72 hours after first presentation) and the effects on death and neurological sequelae.
Cochrane Systematic Review: Antibiotics for the neurological complications of Lyme disease
Cadavid D, Auwaerter PG, Rumbaugh J, Gelderblom H
Cadavid D, Auwaerter PG, Rumbaugh J, Gelderblom H
Objective: To assess the effects of antibiotics for the treatment of Lyme neuroborreliosis (LNB).
Cochrane Systematic Review: Corticosteroids for acute bacterial meningitis
Brouwer MC, McIntyre P, Prasad K, Van de Beek D
Brouwer MC, McIntyre P, Prasad K, Van de Beek D
Objective: To examine the effect of adjuvant corticosteroid therapy versus placebo on mortality, hearing loss and neurological sequelae in people of all ages with acute bacterial meningitis.
Review: Lyme disease: clinical diagnosis and treatment
Hatchette TF, Davis I, Johnston BL
Hatchette TF, Davis I, Johnston BL
Objective: To review the clinical diagnosis and treatment of Lyme disease for front-line clinicians.
Systematic Review: Does this child have bacterial meningitis? A systematic review of clinical prediction rules for children with suspected bacterial meningitis
Kulik DM, Uleryk EM, Maguire JL
Kulik DM, Uleryk EM, Maguire JL
Objective: Our aim was to systematically identify and review the quality and performance of published clinical prediction rules (CPRs) for children with suspected bacterial meningitis.
Systematic Review: Meta-analysis of bacterial meningitis score validation studies
Nigrovic LE, Malley R, Kuppermann N
Nigrovic LE, Malley R, Kuppermann N
Objective: The study objective of the present work was to calculate the performance of the Bacterial Meningitis Score by performing a meta-analysis of all published validation studies.
Systematic Review: Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis
Sakushima K, Hayashino Y, Kawaguchi T, Jackson JL, Fukuhara S
Sakushima K, Hayashino Y, Kawaguchi T, Jackson JL, Fukuhara S
Objective: Our study's purpose was to assess the utility of CSF lactate in differentiating bacterial meningitis from aseptic meningitis.
Systematic Review: Clinical features suggestive of meningitis in children: a systematic review of prospective data
Curtis S, Stobart K, Vandermeer B, Simel DL, Klassen T
Curtis S, Stobart K, Vandermeer B, Simel DL, Klassen T
Objective: To seek evidence supporting accuracy of clinical features of pediatric bacterial meningitis.
Review: Treatment of herpes simplex virus infections in pediatric patients: current status and future needs
James SH, Whitley RJ
James SH, Whitley RJ
Objective: To present an overview of the major clinical manifestations of HSV infections in the pediatric population.
Review: Emergency department management of meningitis and encephalitis
Fitch MT, Abrahamian FM, Moran GJ, Talan DA
Fitch MT, Abrahamian FM, Moran GJ, Talan DA
Objective: This article addresses considerations in clinical evaluation, need for CNS imaging before LP, interpretation of cerebrospinal fluid results, standards for and effects of timely antibiotic administration, and recommendations for specific antimicrobial therapy and corticosteroids.
Review: Viral meningitis
Logan SA, MacMahon E
Logan SA, MacMahon E
Objective: In this review we outline the changing epidemiology, discuss key clinical topics, and illustrate how identification of the specific viral cause is beneficial. Neonatal meningitis may be a component of perinatal infection and is not covered here.
Review: Lumbar puncture and brain herniation in acute bacterial meningitis: a review
Joffe AR
Joffe AR
Objective: There has been controversy regarding the risk of cerebral herniation caused by a lumbar puncture (LP) in acute bacterial meningitis (ABM). This review discusses in detail the issues involved in this controversy.
Key study: Cranial CT, Lumbar Puncture, and Clinical Deterioration in Bacterial Meningitis: A Nationwide Cohort Study
Costerus JM, Brouwer MC, Sprengers MES, Roosendaal SD, van der Ende A, van de Beek D
Costerus JM, Brouwer MC, Sprengers MES, Roosendaal SD, van der Ende A, van de...
Objective: In 2006, we started a prospective cohort study to identify and characterize host genetic traits and bacterial genetic factors controlling occurrence and outcome of bacterial meningitis (MeninGene). Here, we report data from this study, focusing on complications of LP in adults with community-acquired bacterial meningitis and the role of cranial CT prior to LP.
Key study: Lumbar Puncture Performed Promptly or After Neuroimaging in Acute Bacterial Meningitis in Adults: A Prospective National Cohort Study Evaluating Different Guidelines
Glimker M, Sjlin J, kesson S, Naucler P
Glimker M, Sjlin J, kesson S, Naucler P
Objective: The aim was to evaluate the effect on outcome of adherence to European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), and Swedish guidelines regarding neuroimaging before LP.
Key study: Cranial Imaging Before Lumbar Puncture in Adults With Community-Acquired Meningitis: Clinical Utility and Adherence to the Infectious Diseases Society of America Guidelines
Salazar L, Hasbun R
Salazar L, Hasbun R
Objective: The main objectives of this study were to identify the adherence of clinicians to IDSA guidelines regarding cranial imaging in patients with CAM, to evaluate the clinical and prognostic differences between those patients with and without an indication for cranial imaging, and to assess the clinical impact in management in those with abnormal intracranial findings with or without altered mental status as their sole indication for imaging.
Key study: Adult bacterial meningitis: earlier treatment and improved outcome following guideline revision promoting prompt lumbar puncture
Glimker M, Johansson B, Grindborg , Bottai M, Lindquist L, Sjlin J
Glimker M, Johansson B, Grindborg , Bottai M, Lindquist L, Sjlin J
Objective: Despite guideline emphasis on early treatment, performing CT prior to LP implies a risk of delayed treatment and unfavorable outcome. Therefore, Swedish guidelines were revised in 2009, deleting impaired mental status as a contraindication for LP without prior CT scan. The aim of the present study was to evaluate the guideline revision.
Key study: Prevalence and predictors of bacterial meningitis in young infants with Fever without a source
Martinez E, Mintegi S, Vilar B, Martinez MJ, Lopez A, Catediano E, Gomez B
Martinez E, Mintegi S, Vilar B, Martinez MJ, Lopez A, Catediano E, Gomez B
Objective: Our objectives were to analyze the prevalence and microbiology of bacterial meningitis in this group and its prevalence in relation to clinical and laboratory risk factors.
Key study: Outcomes of invasive meningococcal disease in adults and children in Canada between 2002 and 2011: a prospective cohort study
Sadarangani M, Scheifele DW, Halperin SA, Vaudry W, Le Saux N, Tsang R, Bettinger JA, Investigators of the Canadian Immunization Monitoring Program ACTive (I...
Sadarangani M, Scheifele DW, Halperin SA, Vaudry W, Le Saux N, Tsang R, Betti...
Objective: The objectives of this study were to describe the outcomes following invasive meningococcal disease (IMD) in a prospective cohort of children and adults, and to identify specific risk factors for death and development of neurological and nonneurological complications.
Key study: Improvement of the management of infants, children and adults with a molecular diagnosis of Enterovirus meningitis during two observational study periods
Archimbaud C, Ouchchane L, Mirand A, Chambon M, Demeocq F, Labb A, Laurichesse H, Schmidt J, Clavelou P, Aumatre O, Regagnon C, Bailly JL, Henquell C, Peigue...
Archimbaud C, Ouchchane L, Mirand A, Chambon M, Demeocq F, Labb A, Laurichess...
Objective: The aim of this study was to assess the impact of an EV positive diagnosis on the clinical management of patients admitted for meningitis over the course of two observational study periods (2005 and 2008-09) in the same clinical departments.
Key study: Validation of a Clinical Prediction Rule to Distinguish Lyme Meningitis From Aseptic Meningitis
Cohn KA,Thompson AD,Shah SS,Hines EM,Lyons TW,Welsh EJ,Nigrovic LE
Cohn KA,Thompson AD,Shah SS,Hines EM,Lyons TW,Welsh EJ,Nigrovic LE
Objective: The goal of this study was to test the performance of the Rule of 7's in a multicenter cohort of children with CSF pleocytosis.
Key study: Distinguishing between bacterial and aseptic meningitis in children: European comparison of two clinical decision rules
Dubos F, Korczowski B, Aygun DA, Martinot A, Prat C, Galetto-Lacour A, Casado-Flores J, Taskin E, Leclerc F, Rodrigo C, Gervaix A, Gendrel D, Brart G, Chalum...
Dubos F, Korczowski B, Aygun DA, Martinot A, Prat C, Galetto-Lacour A, Casado...
Objective: To compare the performance of two of these CDRs for children: the Bacterial Meningitis Score (BMS) and the Meningitest.
Key study: Impact of rapid enterovirus molecular diagnosis on the management of infants, children, and adults with aseptic meningitis
Archimbaud C, Chambon M, Bailly JL, Petit I, Henquell C, Mirand A, Aublet-Cuvelier B, Ughetto S, Beytout J, Clavelou P, Labb A, Philippe P, Schmidt J, Regagn...
Archimbaud C, Chambon M, Bailly JL, Petit I, Henquell C, Mirand A, Aublet-Cuv...
Objective: Enteroviruses (EV) are the main etiological agents of aseptic meningitis. Diagnosis is made by detecting the genome using RTPCR. The aim of the study was to evaluate the impact of a positive diagnosis on the management of infants, children, and adults.
Key study: Prospective Validation of a Clinical Prediction Model for Lyme Meningitis in Children
Garro AC,Rutman M,Simonsen K,Jaeger JL,Chapin K,Lockhart G
Garro AC,Rutman M,Simonsen K,Jaeger JL,Chapin K,Lockhart G
Objective: A clinical prediction model was developed to distinguish Lyme meningitis from other causes of aseptic meningitis. Our objective was to prospectively validate this model.
Key study: Lyme neuroborreliosis in children: a prospective study of clinical features, prognosis, and outcome
Skogman BH, Croner S, Nordwall M, Eknefelt M, Ernerudh J, Forsberg P
Skogman BH, Croner S, Nordwall M, Eknefelt M, Ernerudh J, Forsberg P
Objective: Evaluation of children with clinically suspected neuroborreliosis (NB) is difficult. With a prospective study design we wanted to characterize children with signs and symptoms indicative for NB, investigate clinical outcome and, if possible, identify factors of importance for recovery.
Key study: Clinical prediction rule for identifying children with cerebrospinal fluid pleocytosis at very low risk of bacterial meningitis
Nigrovic LE, Kuppermann N, Macias CG, Cannavino CR, Moro-Sutherland DM, Schemmer RD, Schwab SH, Agrawal D, Mansour KM, Bennett JE, Katsogridakis YL, Mohseni ...
Nigrovic LE, Kuppermann N, Macias CG, Cannavino CR, Moro-Sutherland DM, Schem...
Objective: To validate the Bacterial Meningitis Score in the era of widespread pneumococcal conjugate vaccination.
Key study: Prediction of Lyme Meningitis in Children From a Lyme DiseaseEndemic Region: A Logistic-Regression Model Using History, Physical, and Laboratory Findings
Avery RA, Frank G, Glutting JJ, Eppes SC
Avery RA, Frank G, Glutting JJ, Eppes SC
Objective: To create a statistical model to predict LM versus AM in children based on history, physical, and laboratory findings during the initial presentation of meningitis.
Key study: Interpretation of traumatic lumbar punctures: who can go home?
Mazor SS, McNulty JE, Roosevelt GE
Mazor SS, McNulty JE, Roosevelt GE
Objective: To determine whether a ratio of observed to predicted (O:P) cerebrospinal fluid (CSF) white blood cells (WBCs) after a traumatic lumbar puncture (LP) can be used to predict which patients do not have meningitis and can safely be discharged from the hospital.
Key study: Lumbar puncture in pediatric bacterial meningitis: defining the time interval for recovery of cerebrospinal fluid pathogens after parenteral antibiotic pretreatment
Kanegaye JT, Soliemanzadeh P, Bradley JS
Kanegaye JT, Soliemanzadeh P, Bradley JS
Objective: We conducted a retrospective review of children with bacterial meningitis to describe the rate at which parenteral antibiotic pretreatment sterilizes CSF cultures.
Key study: Cerebrospinal fluid findings in aseptic versus bacterial meningitis
Negrini B, Kelleher KJ, Wald ER
Negrini B, Kelleher KJ, Wald ER
Objective: To assess 1) the characteristics of the CSF differential in aseptic versus bacterial meningitis, 2) the influence of duration of illness on the CSF differential, and 3) the role of the CSF differential in discriminating between aseptic versus bacterial meningitis.
Key study: Characterization of Lyme Meningitis and Comparison With Viral Meningitis in Children
Eppes SC,Nelson DK,Lewis LL,Klein JD
Eppes SC,Nelson DK,Lewis LL,Klein JD
Objective: The objectives of this study were to characterize Lyme meningitis (LM) in the pediatric population; to compare LM with viral meningitis (VM) with respect to epidemiology, history and physical examination, and laboratory data; and to provide means of early distinction of Lyme neuroborreliosis from other forms of aseptic meningitis.
Key study: A comparison of ceftriaxone and cefuroxime for the treatment of bacterial meningitis in children
Schaad UB, Suter S, Gianella-Borradori A, Pfenninger J, Auckenthaler R, Bernath O, Cheseaux JJ, Wedgwood J
Schaad UB, Suter S, Gianella-Borradori A, Pfenninger J, Auckenthaler R, Berna...
Objective: To compare ceftriaxone with cefuroxime for the treatment of meningitis, we conducted a study in which 106 children with acute bacterial meningitis were randomly assigned to receive either ceftriaxone (100 mg per kilogram of body weight per day, administered intravenously once daily; n = 53) or cefuroxime (240 mg per kilogram per day, administered intravenously in four equal doses; n = 53).
Key study: Cranial CT, Lumbar Puncture, and Clinical Deterioration in Bacterial Meningitis: A Nationwide Cohort Study
Costerus JM, Brouwer MC, Sprengers MES, Roosendaal SD, van der Ende A, van de Beek D
Costerus JM, Brouwer MC, Sprengers MES, Roosendaal SD, van der Ende A, van de...
Objective: In 2006, we started a prospective cohort study to identify and characterize host genetic traits and bacterial genetic factors controlling occurrence and outcome of bacterial meningitis (MeninGene). Here, we report data from this study, focusing on complications of LP in adults with community-acquired bacterial meningitis and the role of cranial CT prior to LP.
Key study: Lumbar Puncture Performed Promptly or After Neuroimaging in Acute Bacterial Meningitis in Adults: A Prospective National Cohort Study Evaluating Different Guidelines
Glimker M, Sjlin J, kesson S, Naucler P
Glimker M, Sjlin J, kesson S, Naucler P
Objective: The aim was to evaluate the effect on outcome of adherence to European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), and Swedish guidelines regarding neuroimaging before LP.
Key study: Cranial Imaging Before Lumbar Puncture in Adults With Community-Acquired Meningitis: Clinical Utility and Adherence to the Infectious Diseases Society of America Guidelines
Salazar L, Hasbun R
Salazar L, Hasbun R
Objective: The main objectives of this study were to identify the adherence of clinicians to IDSA guidelines regarding cranial imaging in patients with CAM, to evaluate the clinical and prognostic differences between those patients with and without an indication for cranial imaging, and to assess the clinical impact in management in those with abnormal intracranial findings with or without altered mental status as their sole indication for imaging.
Key study: Adult bacterial meningitis: earlier treatment and improved outcome following guideline revision promoting prompt lumbar puncture
Glimker M, Johansson B, Grindborg , Bottai M, Lindquist L, Sjlin J
Glimker M, Johansson B, Grindborg , Bottai M, Lindquist L, Sjlin J
Objective: Despite guideline emphasis on early treatment, performing CT prior to LP implies a risk of delayed treatment and unfavorable outcome. Therefore, Swedish guidelines were revised in 2009, deleting impaired mental status as a contraindication for LP without prior CT scan. The aim of the present study was to evaluate the guideline revision.
Key study: Prevalence and predictors of bacterial meningitis in young infants with Fever without a source
Martinez E, Mintegi S, Vilar B, Martinez MJ, Lopez A, Catediano E, Gomez B
Martinez E, Mintegi S, Vilar B, Martinez MJ, Lopez A, Catediano E, Gomez B
Objective: Our objectives were to analyze the prevalence and microbiology of bacterial meningitis in this group and its prevalence in relation to clinical and laboratory risk factors.
Key study: Outcomes of invasive meningococcal disease in adults and children in Canada between 2002 and 2011: a prospective cohort study
Sadarangani M, Scheifele DW, Halperin SA, Vaudry W, Le Saux N, Tsang R, Bettinger JA, Investigators of the Canadian Immunization Monitoring Program ACTive (I...
Sadarangani M, Scheifele DW, Halperin SA, Vaudry W, Le Saux N, Tsang R, Betti...
Objective: The objectives of this study were to describe the outcomes following invasive meningococcal disease (IMD) in a prospective cohort of children and adults, and to identify specific risk factors for death and development of neurological and nonneurological complications.
Key study: Improvement of the management of infants, children and adults with a molecular diagnosis of Enterovirus meningitis during two observational study periods
Archimbaud C, Ouchchane L, Mirand A, Chambon M, Demeocq F, Labb A, Laurichesse H, Schmidt J, Clavelou P, Aumatre O, Regagnon C, Bailly JL, Henquell C, Peigue...
Archimbaud C, Ouchchane L, Mirand A, Chambon M, Demeocq F, Labb A, Laurichess...
Objective: The aim of this study was to assess the impact of an EV positive diagnosis on the clinical management of patients admitted for meningitis over the course of two observational study periods (2005 and 2008-09) in the same clinical departments.
Key study: Validation of a Clinical Prediction Rule to Distinguish Lyme Meningitis From Aseptic Meningitis
Cohn KA,Thompson AD,Shah SS,Hines EM,Lyons TW,Welsh EJ,Nigrovic LE
Cohn KA,Thompson AD,Shah SS,Hines EM,Lyons TW,Welsh EJ,Nigrovic LE
Objective: The goal of this study was to test the performance of the Rule of 7's in a multicenter cohort of children with CSF pleocytosis.
Key study: Distinguishing between bacterial and aseptic meningitis in children: European comparison of two clinical decision rules
Dubos F, Korczowski B, Aygun DA, Martinot A, Prat C, Galetto-Lacour A, Casado-Flores J, Taskin E, Leclerc F, Rodrigo C, Gervaix A, Gendrel D, Brart G, Chalum...
Dubos F, Korczowski B, Aygun DA, Martinot A, Prat C, Galetto-Lacour A, Casado...
Objective: To compare the performance of two of these CDRs for children: the Bacterial Meningitis Score (BMS) and the Meningitest.
Key study: Impact of rapid enterovirus molecular diagnosis on the management of infants, children, and adults with aseptic meningitis
Archimbaud C, Chambon M, Bailly JL, Petit I, Henquell C, Mirand A, Aublet-Cuvelier B, Ughetto S, Beytout J, Clavelou P, Labb A, Philippe P, Schmidt J, Regagn...
Archimbaud C, Chambon M, Bailly JL, Petit I, Henquell C, Mirand A, Aublet-Cuv...
Objective: Enteroviruses (EV) are the main etiological agents of aseptic meningitis. Diagnosis is made by detecting the genome using RTPCR. The aim of the study was to evaluate the impact of a positive diagnosis on the management of infants, children, and adults.
Key study: Prospective Validation of a Clinical Prediction Model for Lyme Meningitis in Children
Garro AC,Rutman M,Simonsen K,Jaeger JL,Chapin K,Lockhart G
Garro AC,Rutman M,Simonsen K,Jaeger JL,Chapin K,Lockhart G
Objective: A clinical prediction model was developed to distinguish Lyme meningitis from other causes of aseptic meningitis. Our objective was to prospectively validate this model.
Key study: Lyme neuroborreliosis in children: a prospective study of clinical features, prognosis, and outcome
Skogman BH, Croner S, Nordwall M, Eknefelt M, Ernerudh J, Forsberg P
Skogman BH, Croner S, Nordwall M, Eknefelt M, Ernerudh J, Forsberg P
Objective: Evaluation of children with clinically suspected neuroborreliosis (NB) is difficult. With a prospective study design we wanted to characterize children with signs and symptoms indicative for NB, investigate clinical outcome and, if possible, identify factors of importance for recovery.
Key study: Clinical prediction rule for identifying children with cerebrospinal fluid pleocytosis at very low risk of bacterial meningitis
Nigrovic LE, Kuppermann N, Macias CG, Cannavino CR, Moro-Sutherland DM, Schemmer RD, Schwab SH, Agrawal D, Mansour KM, Bennett JE, Katsogridakis YL, Mohseni ...
Nigrovic LE, Kuppermann N, Macias CG, Cannavino CR, Moro-Sutherland DM, Schem...
Objective: To validate the Bacterial Meningitis Score in the era of widespread pneumococcal conjugate vaccination.
Key study: Prediction of Lyme Meningitis in Children From a Lyme DiseaseEndemic Region: A Logistic-Regression Model Using History, Physical, and Laboratory Findings
Avery RA, Frank G, Glutting JJ, Eppes SC
Avery RA, Frank G, Glutting JJ, Eppes SC
Objective: To create a statistical model to predict LM versus AM in children based on history, physical, and laboratory findings during the initial presentation of meningitis.
Key study: Interpretation of traumatic lumbar punctures: who can go home?
Mazor SS, McNulty JE, Roosevelt GE
Mazor SS, McNulty JE, Roosevelt GE
Objective: To determine whether a ratio of observed to predicted (O:P) cerebrospinal fluid (CSF) white blood cells (WBCs) after a traumatic lumbar puncture (LP) can be used to predict which patients do not have meningitis and can safely be discharged from the hospital.
Key study: Lumbar puncture in pediatric bacterial meningitis: defining the time interval for recovery of cerebrospinal fluid pathogens after parenteral antibiotic pretreatment
Kanegaye JT, Soliemanzadeh P, Bradley JS
Kanegaye JT, Soliemanzadeh P, Bradley JS
Objective: We conducted a retrospective review of children with bacterial meningitis to describe the rate at which parenteral antibiotic pretreatment sterilizes CSF cultures.
Key study: Cerebrospinal fluid findings in aseptic versus bacterial meningitis
Negrini B, Kelleher KJ, Wald ER
Negrini B, Kelleher KJ, Wald ER
Objective: To assess 1) the characteristics of the CSF differential in aseptic versus bacterial meningitis, 2) the influence of duration of illness on the CSF differential, and 3) the role of the CSF differential in discriminating between aseptic versus bacterial meningitis.
Key study: Characterization of Lyme Meningitis and Comparison With Viral Meningitis in Children
Eppes SC,Nelson DK,Lewis LL,Klein JD
Eppes SC,Nelson DK,Lewis LL,Klein JD
Objective: The objectives of this study were to characterize Lyme meningitis (LM) in the pediatric population; to compare LM with viral meningitis (VM) with respect to epidemiology, history and physical examination, and laboratory data; and to provide means of early distinction of Lyme neuroborreliosis from other forms of aseptic meningitis.
Key study: A comparison of ceftriaxone and cefuroxime for the treatment of bacterial meningitis in children
Schaad UB, Suter S, Gianella-Borradori A, Pfenninger J, Auckenthaler R, Bernath O, Cheseaux JJ, Wedgwood J
Schaad UB, Suter S, Gianella-Borradori A, Pfenninger J, Auckenthaler R, Berna...
Objective: To compare ceftriaxone with cefuroxime for the treatment of meningitis, we conducted a study in which 106 children with acute bacterial meningitis were randomly assigned to receive either ceftriaxone (100 mg per kilogram of body weight per day, administered intravenously once daily; n = 53) or cefuroxime (240 mg per kilogram per day, administered intravenously in four equal doses; n = 53).