Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death. Canadian epidemiological data indicate that the rate of children who visited emergency departments between 2006-2014 for anaphylaxis more than doubled. Although fatalities are rare, anaphylaxis must always be considered a medical emergency requiring immediate treatment.
Evidence Repository: Anaphylaxis (2023)
Dr. Waleed Alqurashi and Dr. Anne Ellis
Dr. Waleed Alqurashi and Dr. Anne Ellis
For a list of references that informed this Bottom Line Recommendation, see the Evidence Repository: Anaphylaxis (2023).
Bottom Line Recommendations: Anaphylaxis
Dr. Waleed Alqurashi & Dr. Anne Ellis
Dr. Waleed Alqurashi & Dr. Anne Ellis
Bottom line recommendations for the treatment and management of pediatric anaphylaxis - version 1.2. Published online: December 2018.
Video for Parents & Families: Understanding and Managing your Child's Anaphylaxis
ECHO Research and ARCHE
ECHO Research and ARCHE
Anaphylaxis is a severe allergic reaction that involves two or more parts of the body and happens quickly. Watch this video to learn how to recognize anaphylaxis and what can help mange your child's anaphylaxis.
Anaphylaxis Order Set
TREKK Anaphylaxis PedsPac
TREKK Anaphylaxis PedsPac
This order set is for management of pediatric anaphylaxis in the ED. This document is adaptable to your hospitals form policy. Published online: March 2020, Version 1.2.
Caring for a child with food allergy: A guide on what you need to know
This visual guide is for caregivers like grandparents, babysitters, and coaches, and provides easy-to-understand information that's essential for managing food allergy and anaphylaxis.
Anaphylaxis References and Development Team
TREKK Anaphylaxis PedsPac
TREKK Anaphylaxis PedsPac
This document outlines the references used and team involved in the development of the anaphylaxis PedsPac. Published online: October 2018.
Anaphylaxis Algorithm
TREKK Anaphylaxis PedsPac
TREKK Anaphylaxis PedsPac
This point of care algorithm is to guide initial management of pediatric anaphylaxis in the Emergency Department. Published online: December 2018, Version 1.1.
Anaphylaxis Pocket Card
TREKK Anaphylaxis PedsPac
TREKK Anaphylaxis PedsPac
This pocket card contains tips to manage pediatric patients with anaphylaxis. Updated online: April 2019, Version 1.2.
Canadian Anaphylaxis Action Plan for Kids
Dr. Waleed Alqurashi
Dr. Waleed Alqurashi
Video for Healthcare Providers: Anaphylaxis in Kids
Infographic for Parents & Families: How to Manage your Child's Anaphylaxis Reaction
ECHO Research and ARCHE
ECHO Research and ARCHE
Recommandations de Base: Anaphylaxie
Alqurashi W and TREKK Network
Alqurashi W and TREKK Network
Bottom line recommendations for the treatment and management of pediatric anaphylaxis - en francais. Published online: October 2018.
Feuille D’ordonnances Pré-Rédigées pour L’Anaphylaxie
PedsPac de TREKK sur l'Anaphylaxie
PedsPac de TREKK sur l'Anaphylaxie
This French order set is for management of pediatric anaphylaxis in the ED and is adaptable to your hospitals form policy. Published online: March 2020, Version 1.2.
Anaphylaxis References and Development Team
TREKK Anaphylaxis PedsPac
TREKK Anaphylaxis PedsPac
This document outlines the references used and team involved in the development of the anaphylaxis PedsPac. Published online: October 2018.
Carte de Poche pour LAnaphylaxie
PedsPac de TREKK sur l'Anaphylaxie
PedsPac de TREKK sur l'Anaphylaxie
This pocket card contains tips to manage pediatric patients with anaphylaxis. Published online: April 2019, Version 1.2.
Algorithme pour LAnaphylaxie
PedsPac de TREKK sur l'Anaphylaxie
PedsPac de TREKK sur l'Anaphylaxie
This point of care algorithm is to guide initial management of pediatric anaphylaxis in the Emergency Department. Published online: April 2019, Version 1.1.
Prendre soin d’un enfant avec des allergies alimentaires : ce que vous devez savoir
Ce guide visuel s'adressant aux personnes qui s'occupent d'enfants, comme les grands-parents, les gardiennes et les entraineurs, fournit des renseignements essentiels pour gerer les allergies aliementaires et l'anaphylaxie qui sont faciles a comprendre.
Video (French): Le plan d’action Canadien pour l’anaphylaxie chez les enfants
Evidence Repository: Anaphylaxis (2023)
Dr. Waleed Alqurashi and Dr. Anne Ellis
Dr. Waleed Alqurashi and Dr. Anne Ellis
For a list of references that informed this Bottom Line Recommendation, see the Evidence Repository: Anaphylaxis (2023).
Bottom Line Recommendations: Anaphylaxis
Dr. Waleed Alqurashi & Dr. Anne Ellis
Dr. Waleed Alqurashi & Dr. Anne Ellis
Bottom line recommendations for the treatment and management of pediatric anaphylaxis - version 1.2. Published online: December 2018.
Recommandations de Base: Anaphylaxie
Alqurashi W and TREKK Network
Alqurashi W and TREKK Network
Bottom line recommendations for the treatment and management of pediatric anaphylaxis - en francais. Published online: October 2018.
Video for Parents & Families: Understanding and Managing your Child's Anaphylaxis
ECHO Research and ARCHE
ECHO Research and ARCHE
Anaphylaxis is a severe allergic reaction that involves two or more parts of the body and happens quickly. Watch this video to learn how to recognize anaphylaxis and what can help mange your child's anaphylaxis.
Feuille D’ordonnances Pré-Rédigées pour L’Anaphylaxie
PedsPac de TREKK sur l'Anaphylaxie
PedsPac de TREKK sur l'Anaphylaxie
This French order set is for management of pediatric anaphylaxis in the ED and is adaptable to your hospitals form policy. Published online: March 2020, Version 1.2.
Anaphylaxis Order Set
TREKK Anaphylaxis PedsPac
TREKK Anaphylaxis PedsPac
This order set is for management of pediatric anaphylaxis in the ED. This document is adaptable to your hospitals form policy. Published online: March 2020, Version 1.2.
Caring for a child with food allergy: A guide on what you need to know
This visual guide is for caregivers like grandparents, babysitters, and coaches, and provides easy-to-understand information that's essential for managing food allergy and anaphylaxis.
Anaphylaxis References and Development Team
TREKK Anaphylaxis PedsPac
TREKK Anaphylaxis PedsPac
This document outlines the references used and team involved in the development of the anaphylaxis PedsPac. Published online: October 2018.
Anaphylaxis Algorithm
TREKK Anaphylaxis PedsPac
TREKK Anaphylaxis PedsPac
This point of care algorithm is to guide initial management of pediatric anaphylaxis in the Emergency Department. Published online: December 2018, Version 1.1.
Anaphylaxis Pocket Card
TREKK Anaphylaxis PedsPac
TREKK Anaphylaxis PedsPac
This pocket card contains tips to manage pediatric patients with anaphylaxis. Updated online: April 2019, Version 1.2.
Carte de Poche pour LAnaphylaxie
PedsPac de TREKK sur l'Anaphylaxie
PedsPac de TREKK sur l'Anaphylaxie
This pocket card contains tips to manage pediatric patients with anaphylaxis. Published online: April 2019, Version 1.2.
Algorithme pour LAnaphylaxie
PedsPac de TREKK sur l'Anaphylaxie
PedsPac de TREKK sur l'Anaphylaxie
This point of care algorithm is to guide initial management of pediatric anaphylaxis in the Emergency Department. Published online: April 2019, Version 1.1.
Prendre soin d’un enfant avec des allergies alimentaires : ce que vous devez savoir
Ce guide visuel s'adressant aux personnes qui s'occupent d'enfants, comme les grands-parents, les gardiennes et les entraineurs, fournit des renseignements essentiels pour gerer les allergies aliementaires et l'anaphylaxie qui sont faciles a comprendre.
Canadian Anaphylaxis Action Plan for Kids
Dr. Waleed Alqurashi
Dr. Waleed Alqurashi
Video for Healthcare Providers: Anaphylaxis in Kids
Infographic for Parents & Families: How to Manage your Child's Anaphylaxis Reaction
ECHO Research and ARCHE
ECHO Research and ARCHE
Video (French): Le plan d’action Canadien pour l’anaphylaxie chez les enfants
Clinical Practice Guideline: Time to revisit the definition and clinical criteria for anaphylaxis?
Turner PJ, Worm M, Ansotegui IJ, et al.
Turner PJ, Worm M, Ansotegui IJ, et al.
The objective of this was to overview and discuss current definitions of anaphylaxis.
Clinical Practice Guideline: CSACI position statement: Newer generation H1-antihistamines are safer than first-generation H1-antihistamines and should be the first-line antihistamines for the treatment of allergic rhinitis and urticaria.
Fein MN, Fischer DA, OKeefe AW, Sussman GL
Fein MN, Fischer DA, OKeefe AW, Sussman GL
The objective of this was to overview the effects of new and old h1 antihistamines.
Clinical Practice Guideline: Anaphylaxis in Schools & Other Settings, 3rd Edition Revised
Canadian Society of Allergy and Clinical Immunology
Canadian Society of Allergy and Clinical Immunology
This manual has been developed for primarily non-medical people. It consists of an updated Consensus Statement and an Appendices section from the Canadian Society of Allergy and Clinical Immunology. The Consensus Statement provides recommendations for the management of anaphylaxis in the community, which are based on the most current research. The Appendices section provides resources that will help individuals at risk of anaphylaxis, educators, caregivers, and parents understand the basics of anaphylaxis.
Position Statement: CSACI position statement - epinephrine auto-injectors and children < 15 kg
Halbrich M, Mack DP, Carr S, Watson W, Kim H
Halbrich M, Mack DP, Carr S, Watson W, Kim H
This position statement addresses a number of questions regarding epinephrine administration/prescribing suggestions for the infant under 15kg who is at risk for anaphylaxis, including: What are possible consequences of administering a larger than recommended dose of epinephrine? Are there other ways to prescribe the recommended dose of epinephrine? What are the consequences of not administering epinephrine? What does the Canadian Society for Allergy and Clinical Immunology suggest for the infant less than 15kg?
Clinical Practice Guideline: Anaphylaxis--a practice parameter update 2015
Lieberman P, Nicklas RA, Randolph C, Oppenheimer J, Bernstein D, Bernstein J, Ellis A, Golden DB, Greenberger P, Kemp S, Khan D, Ledford D, Lieberman J, Metc...
Lieberman P, Nicklas RA, Randolph C, Oppenheimer J, Bernstein D, Bernstein J,...
The objective of this parameter is to update these previous versions and ultimately to improve the care of patients by providing the practicing physician with an evidence-based approach to the diagnosis and management of anaphylactic events.
Clinical Practice Guideline: 2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines
Simons FE, Ebisawa M, Sanchez-Borges M, Thong BY, Worm M, Tanno LK, Lockey RF, El-Gamal YM, Brown SG, Park HS, Sheikh A
Simons FE, Ebisawa M, Sanchez-Borges M, Thong BY, Worm M, Tanno LK, Lockey RF...
The World Allergy Organization (WAO) Guidelines for the assessment and management of anaphylaxis provide a unique global perspective on this increasingly common, potentially life-threatening disease. Recommendations made in the original WAO Anaphylaxis Guidelines remain clinically valid and relevant, and are a widely accessed and frequently cited resource. In this 2015 update of the evidence supporting recommendations in the Guidelines, new information based on anaphylaxis publications from January 2014 through mid- 2015 is summarized.
Clinical Practice Guideline: Emergency department diagnosis and treatment of anaphylaxis: a practice parameter
Campbell RL, Li JT, Nicklas RA, Sadosty AT, Members of the Joint Task Force Practice Parameter Workgroup
Campbell RL, Li JT, Nicklas RA, Sadosty AT, Members of the Joint Task Force P...
The recommendations made in this document about the management of anaphylaxis apply to anaphylaxis that occurs in an ED setting. Some of these recommendations might be different if anaphylaxis occurs in an office setting.
Clinical Practice Guideline: Anaphylaxis: Guidelines from the European Academy of Allergy and Clinical Immunology
Muraro A, Roberts G, Worm M, Bil MB, Brockow K, Fernndez Rivas M, Santos AF, Zolkipli ZQ, Bellou A, Beyer K, Bindslev-Jensen C, Cardona V, Clark AT, Demoly P...
Muraro A, Roberts G, Worm M, Bil MB, Brockow K, Fernndez Rivas M, Santos AF, ...
Anaphylaxis is a clinical emergency, and all healthcare professionals should be familiar with its recognition and acute and ongoing management. These guidelines have been prepared by the European Academy of Allergy and Clinical Immunology (EAACI) Taskforce on Anaphylaxis. They aim to provide evidence-based recommendations for the recognition, risk factor assessment, and the management of patients who are at risk of, are experiencing, or have experienced anaphylaxis.
Clinical Practice Guideline: World Allergy Organization guidelines for the assessment and management of anaphylaxis
Simons FE, Ardusso LR, Bil MB, El-Gamal YM, Ledford DK, Ring J, Sanchez-Borges M, Senna GE, Sheikh A, Thong BY, World Allergy Organization
Simons FE, Ardusso LR, Bil MB, El-Gamal YM, Ledford DK, Ring J, Sanchez-Borge...
The illustrated World Allergy Organization (WAO) Anaphylaxis Guidelines were created in response to absence of global guidelines for anaphylaxis. They incorporate contributions from more than 100 allergy/immunology specialists on 6 continents. Recommendations are based on the best evidence available, supported by references published to the end of December 2010. The Guidelines review patient risk factors for severe or fatal anaphylaxis, co-factors that amplify anaphylaxis, and anaphylaxis in vulnerable patients, including pregnant women, infants, the elderly, and those with cardiovascular disease. They focus on the supreme importance of making a prompt clinical diagnosis and on the basic initial treatment that is urgently needed and should be possible even in a low resource environment.
Clinical Practice Guideline: Time to revisit the definition and clinical criteria for anaphylaxis?
Turner PJ, Worm M, Ansotegui IJ, et al.
Turner PJ, Worm M, Ansotegui IJ, et al.
The objective of this was to overview and discuss current definitions of anaphylaxis.
Clinical Practice Guideline: CSACI position statement: Newer generation H1-antihistamines are safer than first-generation H1-antihistamines and should be the first-line antihistamines for the treatment of allergic rhinitis and urticaria.
Fein MN, Fischer DA, OKeefe AW, Sussman GL
Fein MN, Fischer DA, OKeefe AW, Sussman GL
The objective of this was to overview the effects of new and old h1 antihistamines.
Clinical Practice Guideline: Anaphylaxis in Schools & Other Settings, 3rd Edition Revised
Canadian Society of Allergy and Clinical Immunology
Canadian Society of Allergy and Clinical Immunology
This manual has been developed for primarily non-medical people. It consists of an updated Consensus Statement and an Appendices section from the Canadian Society of Allergy and Clinical Immunology. The Consensus Statement provides recommendations for the management of anaphylaxis in the community, which are based on the most current research. The Appendices section provides resources that will help individuals at risk of anaphylaxis, educators, caregivers, and parents understand the basics of anaphylaxis.
Position Statement: CSACI position statement - epinephrine auto-injectors and children < 15 kg
Halbrich M, Mack DP, Carr S, Watson W, Kim H
Halbrich M, Mack DP, Carr S, Watson W, Kim H
This position statement addresses a number of questions regarding epinephrine administration/prescribing suggestions for the infant under 15kg who is at risk for anaphylaxis, including: What are possible consequences of administering a larger than recommended dose of epinephrine? Are there other ways to prescribe the recommended dose of epinephrine? What are the consequences of not administering epinephrine? What does the Canadian Society for Allergy and Clinical Immunology suggest for the infant less than 15kg?
Clinical Practice Guideline: Anaphylaxis--a practice parameter update 2015
Lieberman P, Nicklas RA, Randolph C, Oppenheimer J, Bernstein D, Bernstein J, Ellis A, Golden DB, Greenberger P, Kemp S, Khan D, Ledford D, Lieberman J, Metc...
Lieberman P, Nicklas RA, Randolph C, Oppenheimer J, Bernstein D, Bernstein J,...
The objective of this parameter is to update these previous versions and ultimately to improve the care of patients by providing the practicing physician with an evidence-based approach to the diagnosis and management of anaphylactic events.
Clinical Practice Guideline: 2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines
Simons FE, Ebisawa M, Sanchez-Borges M, Thong BY, Worm M, Tanno LK, Lockey RF, El-Gamal YM, Brown SG, Park HS, Sheikh A
Simons FE, Ebisawa M, Sanchez-Borges M, Thong BY, Worm M, Tanno LK, Lockey RF...
The World Allergy Organization (WAO) Guidelines for the assessment and management of anaphylaxis provide a unique global perspective on this increasingly common, potentially life-threatening disease. Recommendations made in the original WAO Anaphylaxis Guidelines remain clinically valid and relevant, and are a widely accessed and frequently cited resource. In this 2015 update of the evidence supporting recommendations in the Guidelines, new information based on anaphylaxis publications from January 2014 through mid- 2015 is summarized.
Clinical Practice Guideline: Emergency department diagnosis and treatment of anaphylaxis: a practice parameter
Campbell RL, Li JT, Nicklas RA, Sadosty AT, Members of the Joint Task Force Practice Parameter Workgroup
Campbell RL, Li JT, Nicklas RA, Sadosty AT, Members of the Joint Task Force P...
The recommendations made in this document about the management of anaphylaxis apply to anaphylaxis that occurs in an ED setting. Some of these recommendations might be different if anaphylaxis occurs in an office setting.
Clinical Practice Guideline: Anaphylaxis: Guidelines from the European Academy of Allergy and Clinical Immunology
Muraro A, Roberts G, Worm M, Bil MB, Brockow K, Fernndez Rivas M, Santos AF, Zolkipli ZQ, Bellou A, Beyer K, Bindslev-Jensen C, Cardona V, Clark AT, Demoly P...
Muraro A, Roberts G, Worm M, Bil MB, Brockow K, Fernndez Rivas M, Santos AF, ...
Anaphylaxis is a clinical emergency, and all healthcare professionals should be familiar with its recognition and acute and ongoing management. These guidelines have been prepared by the European Academy of Allergy and Clinical Immunology (EAACI) Taskforce on Anaphylaxis. They aim to provide evidence-based recommendations for the recognition, risk factor assessment, and the management of patients who are at risk of, are experiencing, or have experienced anaphylaxis.
Clinical Practice Guideline: World Allergy Organization guidelines for the assessment and management of anaphylaxis
Simons FE, Ardusso LR, Bil MB, El-Gamal YM, Ledford DK, Ring J, Sanchez-Borges M, Senna GE, Sheikh A, Thong BY, World Allergy Organization
Simons FE, Ardusso LR, Bil MB, El-Gamal YM, Ledford DK, Ring J, Sanchez-Borge...
The illustrated World Allergy Organization (WAO) Anaphylaxis Guidelines were created in response to absence of global guidelines for anaphylaxis. They incorporate contributions from more than 100 allergy/immunology specialists on 6 continents. Recommendations are based on the best evidence available, supported by references published to the end of December 2010. The Guidelines review patient risk factors for severe or fatal anaphylaxis, co-factors that amplify anaphylaxis, and anaphylaxis in vulnerable patients, including pregnant women, infants, the elderly, and those with cardiovascular disease. They focus on the supreme importance of making a prompt clinical diagnosis and on the basic initial treatment that is urgently needed and should be possible even in a low resource environment.
Cochrane Summary: Glucocorticoids for the treatment of anaphylaxis
Choo K, Simons FR, Sheikh A
Choo K, Simons FR, Sheikh A
To overview literature of emergency treatment of anaphylaxis
Cochrane Summary: Glucocorticoids for the treatment of anaphylaxis
Choo K, Simons FR, Sheikh A
Choo K, Simons FR, Sheikh A
To overview literature of emergency treatment of anaphylaxis
Review:Cardiac safety of second-generation H1 -antihistamines when updosed in chronic spontaneous urticaria
Cataldi M, Maurer M, Taglialatela M, Church MK.
Cataldi M, Maurer M, Taglialatela M, Church MK.
To overview literature cardiac health and second wave antihistamines
Review: Guiding Principles for the Recognition, Diagnosis, and Management of Infants With Anaphylaxis: An Expert Panel Consensus
Greenhawt, M., Gupta, R. S., Meadows, J. A., Pistiner, M., Spergel, J. M., Camargo, C. A., Jr, Simons, F., Lieberman, P. L
Greenhawt, M., Gupta, R. S., Meadows, J. A., Pistiner, M., Spergel, J. M., Ca...
To overview the current recommendations for yes
Review: Evaluation of Prehospital Management in a Canadian Emergency Department Anaphylaxis Cohort.
Gabrielli S, Clarke A, Morris J, et al.
Gabrielli S, Clarke A, Morris J, et al.
To assess prehospital management of anaphylaxis by measuring the effect of epinephrine use compared with antihistamines and corticosteroids on negative outcomes of anaphylaxis (intensive care unit/hospital ward admission, multiple doses of epinephrine in the emergency department [ED], and intravenous fluids given in the ED).
Review: Duration of Observation for Detecting a Biphasic Reaction in Anaphylaxis: A Meta-Analysis.
Kim TH, Yoon SH, Hong H, Kang HR, Cho SH, Lee SY.
Kim TH, Yoon SH, Hong H, Kang HR, Cho SH, Lee SY.
to determine a practical observation time for detecting a biphasic reaction after resolution of the initial anaphylactic reaction.
Review: Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of data from The European Anaphylaxis Registry.
Worm M, Francuzik W, Renaudin JM, et al.
Worm M, Francuzik W, Renaudin JM, et al.
To identify and prioritize factors associated with an increased risk of developing severe anaphylaxis.
Review: Epinephrine auto-injector needle lengths Can both subcutaneous and periosteal / intraosseous injection be avoided ?
Dreborg S, Kim L, Tsai G, Kim H.
Dreborg S, Kim L, Tsai G, Kim H.
To discuss suitable EAI needle lengths based on ultrasound measurements related to weight.
Review: Do Corticosteroids Prevent Biphasic Anaphylaxis?
Alqurashi W, Ellis AK
Alqurashi W, Ellis AK
This review analyzes the use of corticosteroids for reducing anaphylaxis severity and preventing biphasic anaphylaxis.
Review: Quality indicators for the acute and long-term management of anaphylaxis: a systematic review.
Dhami S, Sheikh A, Muraro A, et al.
Dhami S, Sheikh A, Muraro A, et al.
To identify quality indicators to support the acute and long-term management of anaphylaxis.
Review: Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase.
Motola D, Donati M, Biagi C, et al.
Motola D, Donati M, Biagi C, et al.
comparative analysis of the safety profiles of H1antihistamines using data from the WHO database
Comprehensive Review: Pitfalls in the use of epinephrine for anaphylaxis: patient and provider opportunities for improvement
Cohen MB, Saunders SS, Wise SK, Nassif S, Platt MP
Cohen MB, Saunders SS, Wise SK, Nassif S, Platt MP
The purpose of this study was to identify the scope of epinephrine pitfalls and opportunities for improvement in the management of allergy emergencies.
Systematic Review: Time of Onset and Predictors of Biphasic Anaphylactic Reactions: A Systematic Review and Meta-analysis
Lee S, Bellolio MF, Hess EP, Erwin P, Murad MH, Campbell RL
Lee S, Bellolio MF, Hess EP, Erwin P, Murad MH, Campbell RL
The aim of this study was to evaluate the time of onset and predictors of biphasic anaphylactic reactions.
Review: Anaphylaxis: Unique aspects of clinical diagnosis and management in infants (birth to age 2 years)
Simons FE, Sampson HA
Simons FE, Sampson HA
In this rostrum we aim to increase awareness of anaphylaxis in infancy in order to improve clinical diagnosis, management, and prevention of recurrences.
Review: Risk multipliers for severe food anaphylaxis
Smith PK, Hourihane JO, Lieberman P
Smith PK, Hourihane JO, Lieberman P
This paper reviews the factors that contribute to the risk of severe anaphylactic events and provides a framework for the ongoing management of patients at risk of severe food allergy.
Systematic Review: H2-antihistamines for the treatment of anaphylaxis with and without shock: a systematic review
Nurmatov UB, Rhatigan E, Simons FE, Sheikh A
Nurmatov UB, Rhatigan E, Simons FE, Sheikh A
The objective of this systematic review was to assess the benefits and harms of H2-antihistamines in the treatment of anaphylaxis.
Cochrane Systematic Review: Glucocorticoids for the treatment of anaphylaxis
Choo KJ, Simons FE, Sheikh A
Choo KJ, Simons FE, Sheikh A
We sought to assess the benefits and harms of glucocorticoid treatment during episodes of anaphylaxis.
Cochrane Systematic Review: Adrenaline auto-injectors for the treatment of anaphylaxis with and without cardiovascular collapse in the community
Sheikh A, Simons FE, Barbour V, Worth A
Sheikh A, Simons FE, Barbour V, Worth A
The objective of this systematic review was to assess the effectiveness of adrenaline (epinephrine) auto-injectors in relieving respiratory, cardiovascular, and other symptoms during episodes of anaphylaxis that occur in the community.
Cochrane Systematic Review: H1-antihistamines for the treatment of anaphylaxis with and without shock
Sheikh A, ten Broek VM, Brown SG, Simons FE
Sheikh A, ten Broek VM, Brown SG, Simons FE
The objective of this systematic review was to assess the benefits and harm of H1-antihistamines in the treatment of anaphylaxis.
Review:Cardiac safety of second-generation H1 -antihistamines when updosed in chronic spontaneous urticaria
Cataldi M, Maurer M, Taglialatela M, Church MK.
Cataldi M, Maurer M, Taglialatela M, Church MK.
To overview literature cardiac health and second wave antihistamines
Review: Guiding Principles for the Recognition, Diagnosis, and Management of Infants With Anaphylaxis: An Expert Panel Consensus
Greenhawt, M., Gupta, R. S., Meadows, J. A., Pistiner, M., Spergel, J. M., Camargo, C. A., Jr, Simons, F., Lieberman, P. L
Greenhawt, M., Gupta, R. S., Meadows, J. A., Pistiner, M., Spergel, J. M., Ca...
To overview the current recommendations for yes
Review: Evaluation of Prehospital Management in a Canadian Emergency Department Anaphylaxis Cohort.
Gabrielli S, Clarke A, Morris J, et al.
Gabrielli S, Clarke A, Morris J, et al.
To assess prehospital management of anaphylaxis by measuring the effect of epinephrine use compared with antihistamines and corticosteroids on negative outcomes of anaphylaxis (intensive care unit/hospital ward admission, multiple doses of epinephrine in the emergency department [ED], and intravenous fluids given in the ED).
Review: Duration of Observation for Detecting a Biphasic Reaction in Anaphylaxis: A Meta-Analysis.
Kim TH, Yoon SH, Hong H, Kang HR, Cho SH, Lee SY.
Kim TH, Yoon SH, Hong H, Kang HR, Cho SH, Lee SY.
to determine a practical observation time for detecting a biphasic reaction after resolution of the initial anaphylactic reaction.
Review: Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of data from The European Anaphylaxis Registry.
Worm M, Francuzik W, Renaudin JM, et al.
Worm M, Francuzik W, Renaudin JM, et al.
To identify and prioritize factors associated with an increased risk of developing severe anaphylaxis.
Review: Epinephrine auto-injector needle lengths Can both subcutaneous and periosteal / intraosseous injection be avoided ?
Dreborg S, Kim L, Tsai G, Kim H.
Dreborg S, Kim L, Tsai G, Kim H.
To discuss suitable EAI needle lengths based on ultrasound measurements related to weight.
Review: Do Corticosteroids Prevent Biphasic Anaphylaxis?
Alqurashi W, Ellis AK
Alqurashi W, Ellis AK
This review analyzes the use of corticosteroids for reducing anaphylaxis severity and preventing biphasic anaphylaxis.
Review: Quality indicators for the acute and long-term management of anaphylaxis: a systematic review.
Dhami S, Sheikh A, Muraro A, et al.
Dhami S, Sheikh A, Muraro A, et al.
To identify quality indicators to support the acute and long-term management of anaphylaxis.
Review: Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase.
Motola D, Donati M, Biagi C, et al.
Motola D, Donati M, Biagi C, et al.
comparative analysis of the safety profiles of H1antihistamines using data from the WHO database
Comprehensive Review: Pitfalls in the use of epinephrine for anaphylaxis: patient and provider opportunities for improvement
Cohen MB, Saunders SS, Wise SK, Nassif S, Platt MP
Cohen MB, Saunders SS, Wise SK, Nassif S, Platt MP
The purpose of this study was to identify the scope of epinephrine pitfalls and opportunities for improvement in the management of allergy emergencies.
Systematic Review: Time of Onset and Predictors of Biphasic Anaphylactic Reactions: A Systematic Review and Meta-analysis
Lee S, Bellolio MF, Hess EP, Erwin P, Murad MH, Campbell RL
Lee S, Bellolio MF, Hess EP, Erwin P, Murad MH, Campbell RL
The aim of this study was to evaluate the time of onset and predictors of biphasic anaphylactic reactions.
Review: Anaphylaxis: Unique aspects of clinical diagnosis and management in infants (birth to age 2 years)
Simons FE, Sampson HA
Simons FE, Sampson HA
In this rostrum we aim to increase awareness of anaphylaxis in infancy in order to improve clinical diagnosis, management, and prevention of recurrences.
Review: Risk multipliers for severe food anaphylaxis
Smith PK, Hourihane JO, Lieberman P
Smith PK, Hourihane JO, Lieberman P
This paper reviews the factors that contribute to the risk of severe anaphylactic events and provides a framework for the ongoing management of patients at risk of severe food allergy.
Systematic Review: H2-antihistamines for the treatment of anaphylaxis with and without shock: a systematic review
Nurmatov UB, Rhatigan E, Simons FE, Sheikh A
Nurmatov UB, Rhatigan E, Simons FE, Sheikh A
The objective of this systematic review was to assess the benefits and harms of H2-antihistamines in the treatment of anaphylaxis.
Cochrane Systematic Review: Glucocorticoids for the treatment of anaphylaxis
Choo KJ, Simons FE, Sheikh A
Choo KJ, Simons FE, Sheikh A
We sought to assess the benefits and harms of glucocorticoid treatment during episodes of anaphylaxis.
Cochrane Systematic Review: Adrenaline auto-injectors for the treatment of anaphylaxis with and without cardiovascular collapse in the community
Sheikh A, Simons FE, Barbour V, Worth A
Sheikh A, Simons FE, Barbour V, Worth A
The objective of this systematic review was to assess the effectiveness of adrenaline (epinephrine) auto-injectors in relieving respiratory, cardiovascular, and other symptoms during episodes of anaphylaxis that occur in the community.
Cochrane Systematic Review: H1-antihistamines for the treatment of anaphylaxis with and without shock
Sheikh A, ten Broek VM, Brown SG, Simons FE
Sheikh A, ten Broek VM, Brown SG, Simons FE
The objective of this systematic review was to assess the benefits and harm of H1-antihistamines in the treatment of anaphylaxis.
Key Study: Biphasic Reactions in Emergency Department Anaphylaxis Patients: A Prospective Cohort Study
Liu X, Lee S, Lohse CM, Hardy CT, Campbell RL.
Liu X, Lee S, Lohse CM, Hardy CT, Campbell RL.
To evaluate biphasic reaction rates and associated risk factors.
Key Study: Simulation of Health and Economic Benefits of Extended Observation of Resolved Anaphylaxis
Shaker M, Wallace D, Golden DBK, Oppenheimer J, Greenhawt M
Shaker M, Wallace D, Golden DBK, Oppenheimer J, Greenhawt M
What is the cost-effectiveness of 1 hour vs 6 to 24 hours of medical observation for biphasic anaphylaxis?
Key Study: An economic evaluation of immediate vs non-immediate activation of emergency medical services after epinephrine use for peanut-induced anaphylaxis
Shaker M, Kanaoka T, Feenan L, Greenhawt M.
Shaker M, Kanaoka T, Feenan L, Greenhawt M.
To evaluate the cost-effectiveness of this strategy, vs a watchful waiting approach before activating emergency medical services (EMS).
Key Study: Epinephrine Use for Anaphylaxis - A Multi-Incident Analysis
Institute for Safe Medication Practices Canada
Institute for Safe Medication Practices Canada
This multi-incident analysis was conducted to identify factors contributing to errors when epinephrine was used for the treatment of anaphylaxis and to suggest strategies to prevent or minimize potential harm when epinephrine is used for this indication.
Key Study: The Risk of Recurrent Anaphylaxis
O'Keefe A, Clarke A, St Pierre Y, Mill J, Asai Y, Eisman H, La Vieille S, Alizadehfar R, Joseph L, Morris J, Gravel J, Ben-Shoshan M
O'Keefe A, Clarke A, St Pierre Y, Mill J, Asai Y, Eisman H, La Vieille S, Ali...
factors contributing to errors when epinephrine was
Key Study: Lacerations and Embedded Needles Caused by Epinephrine Autoinjector Use in Children
Brown JC, Tuuri RE, Akhter S, Guerra LD, Goodman IS, Myers SR, Nozicka C, Manzi S, Long K, Turner T, Conners GP, Thompson RW, Park E
Brown JC, Tuuri RE, Akhter S, Guerra LD, Goodman IS, Myers SR, Nozicka C, Man...
used for the treatment of anaphylaxis and to suggest
Key Study: Embedded Needles Caused by Epinephrine Autoinjector Use in Children
Dreborg S, Wen X, Kim L, Tsai G, Nevis I, Potts R, Chiu J, Dominic A, Kim H
Dreborg S, Wen X, Kim L, Tsai G, Nevis I, Potts R, Chiu J, Dominic A, Kim H
strategies to prevent or minimize potential harm
Key Study: Increasing visits for anaphylaxis and the benefits of early epinephrine administration: A 4-year study at a pediatric emergency department in Montreal, Canada
Hochstadter E, Clarke A, De Schryver S, LaVieille S, Alizadehfar R, Joseph L, Eisman H, Ben-Shoshan M
Hochstadter E, Clarke A, De Schryver S, LaVieille S, Alizadehfar R, Joseph L,...
when epinephrine is used for this indication.
Key Study: Epidemiology and clinical predictors of biphasic reactions in children with anaphylaxis
Alqurashi W, Stiell I, Chan K, Neto G, Alsadoon A, Wells G
Alqurashi W, Stiell I, Chan K, Neto G, Alsadoon A, Wells G
The objective of this study was to investigate the incidence and clinical predictors of biphasic reactions in children presenting to the emergency department (ED) with anaphylaxis.
Key Study: Early treatment of food-induced anaphylaxis with epinephrine is associated with a lower risk of hospitalization
Fleming JT, Clark S, Camargo CA Jr, Rudders SA
Fleming JT, Clark S, Camargo CA Jr, Rudders SA
The objective of this study was to identify factors associated with early epinephrine treatment for FIA and to specifically examine the association between early epinephrine treatment and hospitalization.
Key Study: Patients' ability to treat anaphylaxis using adrenaline autoinjectors: a randomized controlled trial
Umasunthar T, Procktor A, Hodes M, Smith JG, Gore C, Cox HE, Marrs T, Hanna H, Phillips K, Pinto C, Turner PJ, Warner JO, Boyle RJ
Umasunthar T, Procktor A, Hodes M, Smith JG, Gore C, Cox HE, Marrs T, Hanna H...
Previous work has shown patients commonly misuse adrenaline autoinjectors (AAI). It is unclear whether this is due to inadequate training, or poor device design. We undertook a prospective randomized controlled trial to evaluate ability to administer adrenaline using different AAI devices.
Key Study: Biphasic Reactions in Emergency Department Anaphylaxis Patients: A Prospective Cohort Study
Liu X, Lee S, Lohse CM, Hardy CT, Campbell RL.
Liu X, Lee S, Lohse CM, Hardy CT, Campbell RL.
To evaluate biphasic reaction rates and associated risk factors.
Key Study: Simulation of Health and Economic Benefits of Extended Observation of Resolved Anaphylaxis
Shaker M, Wallace D, Golden DBK, Oppenheimer J, Greenhawt M
Shaker M, Wallace D, Golden DBK, Oppenheimer J, Greenhawt M
What is the cost-effectiveness of 1 hour vs 6 to 24 hours of medical observation for biphasic anaphylaxis?
Key Study: An economic evaluation of immediate vs non-immediate activation of emergency medical services after epinephrine use for peanut-induced anaphylaxis
Shaker M, Kanaoka T, Feenan L, Greenhawt M.
Shaker M, Kanaoka T, Feenan L, Greenhawt M.
To evaluate the cost-effectiveness of this strategy, vs a watchful waiting approach before activating emergency medical services (EMS).
Key Study: Epinephrine Use for Anaphylaxis - A Multi-Incident Analysis
Institute for Safe Medication Practices Canada
Institute for Safe Medication Practices Canada
This multi-incident analysis was conducted to identify factors contributing to errors when epinephrine was used for the treatment of anaphylaxis and to suggest strategies to prevent or minimize potential harm when epinephrine is used for this indication.
Key Study: The Risk of Recurrent Anaphylaxis
O'Keefe A, Clarke A, St Pierre Y, Mill J, Asai Y, Eisman H, La Vieille S, Alizadehfar R, Joseph L, Morris J, Gravel J, Ben-Shoshan M
O'Keefe A, Clarke A, St Pierre Y, Mill J, Asai Y, Eisman H, La Vieille S, Ali...
factors contributing to errors when epinephrine was
Key Study: Lacerations and Embedded Needles Caused by Epinephrine Autoinjector Use in Children
Brown JC, Tuuri RE, Akhter S, Guerra LD, Goodman IS, Myers SR, Nozicka C, Manzi S, Long K, Turner T, Conners GP, Thompson RW, Park E
Brown JC, Tuuri RE, Akhter S, Guerra LD, Goodman IS, Myers SR, Nozicka C, Man...
used for the treatment of anaphylaxis and to suggest
Key Study: Embedded Needles Caused by Epinephrine Autoinjector Use in Children
Dreborg S, Wen X, Kim L, Tsai G, Nevis I, Potts R, Chiu J, Dominic A, Kim H
Dreborg S, Wen X, Kim L, Tsai G, Nevis I, Potts R, Chiu J, Dominic A, Kim H
strategies to prevent or minimize potential harm
Key Study: Increasing visits for anaphylaxis and the benefits of early epinephrine administration: A 4-year study at a pediatric emergency department in Montreal, Canada
Hochstadter E, Clarke A, De Schryver S, LaVieille S, Alizadehfar R, Joseph L, Eisman H, Ben-Shoshan M
Hochstadter E, Clarke A, De Schryver S, LaVieille S, Alizadehfar R, Joseph L,...
when epinephrine is used for this indication.
Key Study: Epidemiology and clinical predictors of biphasic reactions in children with anaphylaxis
Alqurashi W, Stiell I, Chan K, Neto G, Alsadoon A, Wells G
Alqurashi W, Stiell I, Chan K, Neto G, Alsadoon A, Wells G
The objective of this study was to investigate the incidence and clinical predictors of biphasic reactions in children presenting to the emergency department (ED) with anaphylaxis.
Key Study: Early treatment of food-induced anaphylaxis with epinephrine is associated with a lower risk of hospitalization
Fleming JT, Clark S, Camargo CA Jr, Rudders SA
Fleming JT, Clark S, Camargo CA Jr, Rudders SA
The objective of this study was to identify factors associated with early epinephrine treatment for FIA and to specifically examine the association between early epinephrine treatment and hospitalization.
Key Study: Patients' ability to treat anaphylaxis using adrenaline autoinjectors: a randomized controlled trial
Umasunthar T, Procktor A, Hodes M, Smith JG, Gore C, Cox HE, Marrs T, Hanna H, Phillips K, Pinto C, Turner PJ, Warner JO, Boyle RJ
Umasunthar T, Procktor A, Hodes M, Smith JG, Gore C, Cox HE, Marrs T, Hanna H...
Previous work has shown patients commonly misuse adrenaline autoinjectors (AAI). It is unclear whether this is due to inadequate training, or poor device design. We undertook a prospective randomized controlled trial to evaluate ability to administer adrenaline using different AAI devices.
Video: Canadian Anaphylaxis Action Plan for Kids (Kids' CAP)
Video: Canadian Anaphylaxis Action Plan for Kids (Kids' CAP)