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Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death. Canadian epidemiological data indicate that the rate of children who visited emergency departments between 2006-2014 for anaphylaxis more than doubled. Although fatalities are rare, anaphylaxis must always be considered a medical emergency requiring immediate treatment.

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Key Resources 

Evidence Repository: Anaphylaxis (2023)

Evidence Repository: Anaphylaxis (2023)

Download

Dr. Waleed Alqurashi and Dr. Anne Ellis

Dr. Waleed Alqurashi and Dr. Anne Ellis

For a list of references that informed this Bottom Line Recommendation, see the Evidence Repository: Anaphylaxis (2023).

Bottom Line Recommendations: Anaphylaxis  (2021)

Bottom Line Recommendations: Anaphylaxis

Download

Dr. Waleed Alqurashi & Dr. Anne Ellis

Dr. Waleed Alqurashi & Dr. Anne Ellis

Bottom line recommendations for the treatment and management of pediatric anaphylaxis - version 1.2. Published online: December 2018.

Video for Parents & Families: Understanding and Managing your Child's Anaphylaxis  (2021)

Video for Parents & Families: Understanding and Managing your Child's Anaphylaxis

Visit

ECHO Research and ARCHE

ECHO Research and ARCHE

Anaphylaxis is a severe allergic reaction that involves two or more parts of the body and happens quickly. Watch this video to learn how to recognize anaphylaxis and what can help mange your child's anaphylaxis.

Anaphylaxis Order Set  (2020)

Anaphylaxis Order Set

Download

TREKK Anaphylaxis PedsPac

TREKK Anaphylaxis PedsPac

This order set is for management of pediatric anaphylaxis in the ED. This document is adaptable to your hospitals form policy. Published online: March 2020, Version 1.2.

Caring for a child with food allergy: A guide on what you need to know

Caring for a child with food allergy: A guide on what you need to know

Visit

This visual guide is for caregivers like grandparents, babysitters, and coaches, and provides easy-to-understand information that's essential for managing food allergy and anaphylaxis.  

Anaphylaxis References and Development Team  (2018)

Anaphylaxis References and Development Team

Download

TREKK Anaphylaxis PedsPac

TREKK Anaphylaxis PedsPac

This document outlines the references used and team involved in the development of the anaphylaxis PedsPac. Published online: October 2018.

Anaphylaxis Algorithm  (2018)

Anaphylaxis Algorithm

Download

TREKK Anaphylaxis PedsPac

TREKK Anaphylaxis PedsPac

This point of care algorithm is to guide initial management of pediatric anaphylaxis in the Emergency Department. Published online: December 2018, Version 1.1.

Anaphylaxis Pocket Card  (2018)

Anaphylaxis Pocket Card

Download

TREKK Anaphylaxis PedsPac

TREKK Anaphylaxis PedsPac

This pocket card contains tips to manage pediatric patients with anaphylaxis. Updated online: April 2019, Version 1.2.

Canadian Anaphylaxis Action Plan for Kids

Canadian Anaphylaxis Action Plan for Kids

Download

Dr. Waleed Alqurashi

Dr. Waleed Alqurashi

Video for Healthcare Providers: Anaphylaxis in Kids

Video for Healthcare Providers: Anaphylaxis in Kids

Visit

Infographic for Parents & Families: How to Manage your Child's Anaphylaxis Reaction

Infographic for Parents & Families: How to Manage your Child's Anaphylaxis Reaction

Visit

ECHO Research and ARCHE

ECHO Research and ARCHE

An anaphylactic reaction, or anaphylaxis, is a severe allergic reaction. Symptoms can start very quickly and it could be life-threatening. 
 
Anaphylaxis is caused by an allergen that triggers an immune response in the body. This is your body’s way of trying to protect itself. Common allergens include food, some insects (like bees or wasps), and medications.

Recommandations de Base: Anaphylaxie  (2021)

Recommandations de Base: Anaphylaxie

Download

Alqurashi W and TREKK Network

Alqurashi W and TREKK Network

Bottom line recommendations for the treatment and management of pediatric anaphylaxis - en francais. Published online: October 2018.

Feuille D’ordonnances Pré-Rédigées pour L’Anaphylaxie  (2020)

Feuille D’ordonnances Pré-Rédigées pour L’Anaphylaxie

Download

PedsPac de TREKK sur l'Anaphylaxie

PedsPac de TREKK sur l'Anaphylaxie

This French order set is for management of pediatric anaphylaxis in the ED and is adaptable to your hospitals form policy. Published online: March 2020, Version 1.2.

Anaphylaxis References and Development Team  (2018)

Anaphylaxis References and Development Team

Download

TREKK Anaphylaxis PedsPac

TREKK Anaphylaxis PedsPac

This document outlines the references used and team involved in the development of the anaphylaxis PedsPac. Published online: October 2018.

Carte de Poche pour LAnaphylaxie  (2018)

Carte de Poche pour LAnaphylaxie

Download

PedsPac de TREKK sur l'Anaphylaxie

PedsPac de TREKK sur l'Anaphylaxie

This pocket card contains tips to manage pediatric patients with anaphylaxis. Published online: April 2019, Version 1.2.

Algorithme pour LAnaphylaxie  (2018)

Algorithme pour LAnaphylaxie

Download

PedsPac de TREKK sur l'Anaphylaxie

PedsPac de TREKK sur l'Anaphylaxie

This point of care algorithm is to guide initial management of pediatric anaphylaxis in the Emergency Department. Published online: April 2019, Version 1.1.

Prendre soin d’un enfant avec des allergies alimentaires : ce que vous devez savoir

Prendre soin d’un enfant avec des allergies alimentaires : ce que vous devez savoir

Visit

Ce guide visuel s'adressant aux personnes qui s'occupent d'enfants, comme les grands-parents, les gardiennes et les entraineurs, fournit des renseignements essentiels pour gerer les allergies aliementaires et l'anaphylaxie qui sont faciles a comprendre. 

Video (French): Le plan d’action Canadien pour l’anaphylaxie chez les enfants

Video (French): Le plan d’action Canadien pour l’anaphylaxie chez les enfants

Visit

Evidence Repository: Anaphylaxis (2023)

Evidence Repository: Anaphylaxis (2023)

Download

Dr. Waleed Alqurashi and Dr. Anne Ellis

Dr. Waleed Alqurashi and Dr. Anne Ellis

For a list of references that informed this Bottom Line Recommendation, see the Evidence Repository: Anaphylaxis (2023).

Bottom Line Recommendations: Anaphylaxis  (2021)

Bottom Line Recommendations: Anaphylaxis

Download

Dr. Waleed Alqurashi & Dr. Anne Ellis

Dr. Waleed Alqurashi & Dr. Anne Ellis

Bottom line recommendations for the treatment and management of pediatric anaphylaxis - version 1.2. Published online: December 2018.

Recommandations de Base: Anaphylaxie  (2021)

Recommandations de Base: Anaphylaxie

Download

Alqurashi W and TREKK Network

Alqurashi W and TREKK Network

Bottom line recommendations for the treatment and management of pediatric anaphylaxis - en francais. Published online: October 2018.

Video for Parents & Families: Understanding and Managing your Child's Anaphylaxis  (2021)

Video for Parents & Families: Understanding and Managing your Child's Anaphylaxis

Visit

ECHO Research and ARCHE

ECHO Research and ARCHE

Anaphylaxis is a severe allergic reaction that involves two or more parts of the body and happens quickly. Watch this video to learn how to recognize anaphylaxis and what can help mange your child's anaphylaxis.

Feuille D’ordonnances Pré-Rédigées pour L’Anaphylaxie  (2020)

Feuille D’ordonnances Pré-Rédigées pour L’Anaphylaxie

Download

PedsPac de TREKK sur l'Anaphylaxie

PedsPac de TREKK sur l'Anaphylaxie

This French order set is for management of pediatric anaphylaxis in the ED and is adaptable to your hospitals form policy. Published online: March 2020, Version 1.2.

Anaphylaxis Order Set  (2020)

Anaphylaxis Order Set

Download

TREKK Anaphylaxis PedsPac

TREKK Anaphylaxis PedsPac

This order set is for management of pediatric anaphylaxis in the ED. This document is adaptable to your hospitals form policy. Published online: March 2020, Version 1.2.

Caring for a child with food allergy: A guide on what you need to know

Caring for a child with food allergy: A guide on what you need to know

Visit

This visual guide is for caregivers like grandparents, babysitters, and coaches, and provides easy-to-understand information that's essential for managing food allergy and anaphylaxis.  

Anaphylaxis References and Development Team  (2018)

Anaphylaxis References and Development Team

Download

TREKK Anaphylaxis PedsPac

TREKK Anaphylaxis PedsPac

This document outlines the references used and team involved in the development of the anaphylaxis PedsPac. Published online: October 2018.

Anaphylaxis Algorithm  (2018)

Anaphylaxis Algorithm

Download

TREKK Anaphylaxis PedsPac

TREKK Anaphylaxis PedsPac

This point of care algorithm is to guide initial management of pediatric anaphylaxis in the Emergency Department. Published online: December 2018, Version 1.1.

Anaphylaxis Pocket Card  (2018)

Anaphylaxis Pocket Card

Download

TREKK Anaphylaxis PedsPac

TREKK Anaphylaxis PedsPac

This pocket card contains tips to manage pediatric patients with anaphylaxis. Updated online: April 2019, Version 1.2.

Carte de Poche pour LAnaphylaxie  (2018)

Carte de Poche pour LAnaphylaxie

Download

PedsPac de TREKK sur l'Anaphylaxie

PedsPac de TREKK sur l'Anaphylaxie

This pocket card contains tips to manage pediatric patients with anaphylaxis. Published online: April 2019, Version 1.2.

Algorithme pour LAnaphylaxie  (2018)

Algorithme pour LAnaphylaxie

Download

PedsPac de TREKK sur l'Anaphylaxie

PedsPac de TREKK sur l'Anaphylaxie

This point of care algorithm is to guide initial management of pediatric anaphylaxis in the Emergency Department. Published online: April 2019, Version 1.1.

Prendre soin d’un enfant avec des allergies alimentaires : ce que vous devez savoir

Prendre soin d’un enfant avec des allergies alimentaires : ce que vous devez savoir

Visit

Ce guide visuel s'adressant aux personnes qui s'occupent d'enfants, comme les grands-parents, les gardiennes et les entraineurs, fournit des renseignements essentiels pour gerer les allergies aliementaires et l'anaphylaxie qui sont faciles a comprendre. 

Canadian Anaphylaxis Action Plan for Kids

Canadian Anaphylaxis Action Plan for Kids

Download

Dr. Waleed Alqurashi

Dr. Waleed Alqurashi

Video for Healthcare Providers: Anaphylaxis in Kids

Video for Healthcare Providers: Anaphylaxis in Kids

Visit

Infographic for Parents & Families: How to Manage your Child's Anaphylaxis Reaction

Infographic for Parents & Families: How to Manage your Child's Anaphylaxis Reaction

Visit

ECHO Research and ARCHE

ECHO Research and ARCHE

An anaphylactic reaction, or anaphylaxis, is a severe allergic reaction. Symptoms can start very quickly and it could be life-threatening. 
 
Anaphylaxis is caused by an allergen that triggers an immune response in the body. This is your body’s way of trying to protect itself. Common allergens include food, some insects (like bees or wasps), and medications.

Video (French): Le plan d’action Canadien pour l’anaphylaxie chez les enfants

Video (French): Le plan d’action Canadien pour l’anaphylaxie chez les enfants

Visit

Clinical guidelines 

Clinical Practice Guideline: Time to revisit the definition and clinical criteria for anaphylaxis?  (2019)

Clinical Practice Guideline: Time to revisit the definition and clinical criteria for anaphylaxis?

Visit

Turner PJ, Worm M, Ansotegui IJ, et al.

Turner PJ, Worm M, Ansotegui IJ, et al.

The objective of this was to overview and discuss current definitions of anaphylaxis.

Clinical Practice Guideline: CSACI position statement: Newer generation H1-antihistamines are safer than first-generation H1-antihistamines and should be the first-line antihistamines for the treatment of allergic rhinitis and urticaria.  (2019)

Clinical Practice Guideline: CSACI position statement: Newer generation H1-antihistamines are safer than first-generation H1-antihistamines and should be the first-line antihistamines for the treatment of allergic rhinitis and urticaria.

Visit

Fein MN, Fischer DA, OKeefe AW, Sussman GL

Fein MN, Fischer DA, OKeefe AW, Sussman GL

The objective of this was to overview the effects of new and old h1 antihistamines.

Clinical Practice Guideline: Anaphylaxis in Schools & Other Settings, 3rd Edition Revised  (2016)

Clinical Practice Guideline: Anaphylaxis in Schools & Other Settings, 3rd Edition Revised

Visit

Canadian Society of Allergy and Clinical Immunology

Canadian Society of Allergy and Clinical Immunology

This manual has been developed for primarily non-medical people. It consists of an updated Consensus Statement and an Appendices section from the Canadian Society of Allergy and Clinical Immunology. The Consensus Statement provides recommendations for the management of anaphylaxis in the community, which are based on the most current research. The Appendices section provides resources that will help individuals at risk of anaphylaxis, educators, caregivers, and parents understand the basics of anaphylaxis.

Position Statement: CSACI position statement - epinephrine auto-injectors and children < 15 kg  (2015)

Position Statement: CSACI position statement - epinephrine auto-injectors and children < 15 kg

Visit

Halbrich M, Mack DP, Carr S, Watson W, Kim H

Halbrich M, Mack DP, Carr S, Watson W, Kim H

This position statement addresses a number of questions regarding epinephrine administration/prescribing suggestions for the infant under 15kg who is at risk for anaphylaxis, including: What are possible consequences of administering a larger than recommended dose of epinephrine? Are there other ways to prescribe the recommended dose of epinephrine? What are the consequences of not administering epinephrine? What does the Canadian Society for Allergy and Clinical Immunology suggest for the infant less than 15kg?

Clinical Practice Guideline: Anaphylaxis--a practice parameter update 2015  (2015)

Clinical Practice Guideline: Anaphylaxis--a practice parameter update 2015

Visit

Lieberman P, Nicklas RA, Randolph C, Oppenheimer J, Bernstein D, Bernstein J, Ellis A, Golden DB, Greenberger P, Kemp S, Khan D, Ledford D, Lieberman J, Metc...

Lieberman P, Nicklas RA, Randolph C, Oppenheimer J, Bernstein D, Bernstein J,...

The objective of this parameter is to update these previous versions and ultimately to improve the care of patients by providing the practicing physician with an evidence-based approach to the diagnosis and management of anaphylactic events.

Clinical Practice Guideline: 2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines  (2015)

Clinical Practice Guideline: 2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines

Visit

Simons FE, Ebisawa M, Sanchez-Borges M, Thong BY, Worm M, Tanno LK, Lockey RF, El-Gamal YM, Brown SG, Park HS, Sheikh A

Simons FE, Ebisawa M, Sanchez-Borges M, Thong BY, Worm M, Tanno LK, Lockey RF...

The World Allergy Organization (WAO) Guidelines for the assessment and management of anaphylaxis provide a unique global perspective on this increasingly common, potentially life-threatening disease. Recommendations made in the original WAO Anaphylaxis Guidelines remain clinically valid and relevant, and are a widely accessed and frequently cited resource. In this 2015 update of the evidence supporting recommendations in the Guidelines, new information based on anaphylaxis publications from January 2014 through mid- 2015 is summarized.

Clinical Practice Guideline: Emergency department diagnosis and treatment of anaphylaxis: a practice parameter  (2014)

Clinical Practice Guideline: Emergency department diagnosis and treatment of anaphylaxis: a practice parameter

Visit

Campbell RL, Li JT, Nicklas RA, Sadosty AT, Members of the Joint Task Force Practice Parameter Workgroup

Campbell RL, Li JT, Nicklas RA, Sadosty AT, Members of the Joint Task Force P...

The recommendations made in this document about the management of anaphylaxis apply to anaphylaxis that occurs in an ED setting. Some of these recommendations might be different if anaphylaxis occurs in an office setting.

Clinical Practice Guideline: Anaphylaxis: Guidelines from the European Academy of Allergy and Clinical Immunology  (2014)

Clinical Practice Guideline: Anaphylaxis: Guidelines from the European Academy of Allergy and Clinical Immunology

Visit

Muraro A, Roberts G, Worm M, Bil MB, Brockow K, Fernndez Rivas M, Santos AF, Zolkipli ZQ, Bellou A, Beyer K, Bindslev-Jensen C, Cardona V, Clark AT, Demoly P...

Muraro A, Roberts G, Worm M, Bil MB, Brockow K, Fernndez Rivas M, Santos AF, ...

Anaphylaxis is a clinical emergency, and all healthcare professionals should be familiar with its recognition and acute and ongoing management. These guidelines have been prepared by the European Academy of Allergy and Clinical Immunology (EAACI) Taskforce on Anaphylaxis. They aim to provide evidence-based recommendations for the recognition, risk factor assessment, and the management of patients who are at risk of, are experiencing, or have experienced anaphylaxis.

Clinical Practice Guideline: World Allergy Organization guidelines for the assessment and management of anaphylaxis  (2011)

Clinical Practice Guideline: World Allergy Organization guidelines for the assessment and management of anaphylaxis

Visit

Simons FE, Ardusso LR, Bil MB, El-Gamal YM, Ledford DK, Ring J, Sanchez-Borges M, Senna GE, Sheikh A, Thong BY, World Allergy Organization

Simons FE, Ardusso LR, Bil MB, El-Gamal YM, Ledford DK, Ring J, Sanchez-Borge...

The illustrated World Allergy Organization (WAO) Anaphylaxis Guidelines were created in response to absence of global guidelines for anaphylaxis. They incorporate contributions from more than 100 allergy/immunology specialists on 6 continents. Recommendations are based on the best evidence available, supported by references published to the end of December 2010. The Guidelines review patient risk factors for severe or fatal anaphylaxis, co-factors that amplify anaphylaxis, and anaphylaxis in vulnerable patients, including pregnant women, infants, the elderly, and those with cardiovascular disease. They focus on the supreme importance of making a prompt clinical diagnosis and on the basic initial treatment that is urgently needed and should be possible even in a low resource environment.

Clinical Practice Guideline: Time to revisit the definition and clinical criteria for anaphylaxis?  (2019)

Clinical Practice Guideline: Time to revisit the definition and clinical criteria for anaphylaxis?

Visit

Turner PJ, Worm M, Ansotegui IJ, et al.

Turner PJ, Worm M, Ansotegui IJ, et al.

The objective of this was to overview and discuss current definitions of anaphylaxis.

Clinical Practice Guideline: CSACI position statement: Newer generation H1-antihistamines are safer than first-generation H1-antihistamines and should be the first-line antihistamines for the treatment of allergic rhinitis and urticaria.  (2019)

Clinical Practice Guideline: CSACI position statement: Newer generation H1-antihistamines are safer than first-generation H1-antihistamines and should be the first-line antihistamines for the treatment of allergic rhinitis and urticaria.

Visit

Fein MN, Fischer DA, OKeefe AW, Sussman GL

Fein MN, Fischer DA, OKeefe AW, Sussman GL

The objective of this was to overview the effects of new and old h1 antihistamines.

Clinical Practice Guideline: Anaphylaxis in Schools & Other Settings, 3rd Edition Revised  (2016)

Clinical Practice Guideline: Anaphylaxis in Schools & Other Settings, 3rd Edition Revised

Visit

Canadian Society of Allergy and Clinical Immunology

Canadian Society of Allergy and Clinical Immunology

This manual has been developed for primarily non-medical people. It consists of an updated Consensus Statement and an Appendices section from the Canadian Society of Allergy and Clinical Immunology. The Consensus Statement provides recommendations for the management of anaphylaxis in the community, which are based on the most current research. The Appendices section provides resources that will help individuals at risk of anaphylaxis, educators, caregivers, and parents understand the basics of anaphylaxis.

Position Statement: CSACI position statement - epinephrine auto-injectors and children < 15 kg  (2015)

Position Statement: CSACI position statement - epinephrine auto-injectors and children < 15 kg

Visit

Halbrich M, Mack DP, Carr S, Watson W, Kim H

Halbrich M, Mack DP, Carr S, Watson W, Kim H

This position statement addresses a number of questions regarding epinephrine administration/prescribing suggestions for the infant under 15kg who is at risk for anaphylaxis, including: What are possible consequences of administering a larger than recommended dose of epinephrine? Are there other ways to prescribe the recommended dose of epinephrine? What are the consequences of not administering epinephrine? What does the Canadian Society for Allergy and Clinical Immunology suggest for the infant less than 15kg?

Clinical Practice Guideline: Anaphylaxis--a practice parameter update 2015  (2015)

Clinical Practice Guideline: Anaphylaxis--a practice parameter update 2015

Visit

Lieberman P, Nicklas RA, Randolph C, Oppenheimer J, Bernstein D, Bernstein J, Ellis A, Golden DB, Greenberger P, Kemp S, Khan D, Ledford D, Lieberman J, Metc...

Lieberman P, Nicklas RA, Randolph C, Oppenheimer J, Bernstein D, Bernstein J,...

The objective of this parameter is to update these previous versions and ultimately to improve the care of patients by providing the practicing physician with an evidence-based approach to the diagnosis and management of anaphylactic events.

Clinical Practice Guideline: 2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines  (2015)

Clinical Practice Guideline: 2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines

Visit

Simons FE, Ebisawa M, Sanchez-Borges M, Thong BY, Worm M, Tanno LK, Lockey RF, El-Gamal YM, Brown SG, Park HS, Sheikh A

Simons FE, Ebisawa M, Sanchez-Borges M, Thong BY, Worm M, Tanno LK, Lockey RF...

The World Allergy Organization (WAO) Guidelines for the assessment and management of anaphylaxis provide a unique global perspective on this increasingly common, potentially life-threatening disease. Recommendations made in the original WAO Anaphylaxis Guidelines remain clinically valid and relevant, and are a widely accessed and frequently cited resource. In this 2015 update of the evidence supporting recommendations in the Guidelines, new information based on anaphylaxis publications from January 2014 through mid- 2015 is summarized.

Clinical Practice Guideline: Emergency department diagnosis and treatment of anaphylaxis: a practice parameter  (2014)

Clinical Practice Guideline: Emergency department diagnosis and treatment of anaphylaxis: a practice parameter

Visit

Campbell RL, Li JT, Nicklas RA, Sadosty AT, Members of the Joint Task Force Practice Parameter Workgroup

Campbell RL, Li JT, Nicklas RA, Sadosty AT, Members of the Joint Task Force P...

The recommendations made in this document about the management of anaphylaxis apply to anaphylaxis that occurs in an ED setting. Some of these recommendations might be different if anaphylaxis occurs in an office setting.

Clinical Practice Guideline: Anaphylaxis: Guidelines from the European Academy of Allergy and Clinical Immunology  (2014)

Clinical Practice Guideline: Anaphylaxis: Guidelines from the European Academy of Allergy and Clinical Immunology

Visit

Muraro A, Roberts G, Worm M, Bil MB, Brockow K, Fernndez Rivas M, Santos AF, Zolkipli ZQ, Bellou A, Beyer K, Bindslev-Jensen C, Cardona V, Clark AT, Demoly P...

Muraro A, Roberts G, Worm M, Bil MB, Brockow K, Fernndez Rivas M, Santos AF, ...

Anaphylaxis is a clinical emergency, and all healthcare professionals should be familiar with its recognition and acute and ongoing management. These guidelines have been prepared by the European Academy of Allergy and Clinical Immunology (EAACI) Taskforce on Anaphylaxis. They aim to provide evidence-based recommendations for the recognition, risk factor assessment, and the management of patients who are at risk of, are experiencing, or have experienced anaphylaxis.

Clinical Practice Guideline: World Allergy Organization guidelines for the assessment and management of anaphylaxis  (2011)

Clinical Practice Guideline: World Allergy Organization guidelines for the assessment and management of anaphylaxis

Visit

Simons FE, Ardusso LR, Bil MB, El-Gamal YM, Ledford DK, Ring J, Sanchez-Borges M, Senna GE, Sheikh A, Thong BY, World Allergy Organization

Simons FE, Ardusso LR, Bil MB, El-Gamal YM, Ledford DK, Ring J, Sanchez-Borge...

The illustrated World Allergy Organization (WAO) Anaphylaxis Guidelines were created in response to absence of global guidelines for anaphylaxis. They incorporate contributions from more than 100 allergy/immunology specialists on 6 continents. Recommendations are based on the best evidence available, supported by references published to the end of December 2010. The Guidelines review patient risk factors for severe or fatal anaphylaxis, co-factors that amplify anaphylaxis, and anaphylaxis in vulnerable patients, including pregnant women, infants, the elderly, and those with cardiovascular disease. They focus on the supreme importance of making a prompt clinical diagnosis and on the basic initial treatment that is urgently needed and should be possible even in a low resource environment.

Summaries of systematic reviews 

Cochrane Summary: Glucocorticoids for the treatment of anaphylaxis  (2012)

Cochrane Summary: Glucocorticoids for the treatment of anaphylaxis

Visit

Choo K, Simons FR, Sheikh A

Choo K, Simons FR, Sheikh A

To overview literature of emergency treatment of anaphylaxis

Cochrane Summary: Glucocorticoids for the treatment of anaphylaxis  (2012)

Cochrane Summary: Glucocorticoids for the treatment of anaphylaxis

Visit

Choo K, Simons FR, Sheikh A

Choo K, Simons FR, Sheikh A

To overview literature of emergency treatment of anaphylaxis

Systematic reviews 

Review:Cardiac safety of second-generation H1 -antihistamines when updosed in chronic spontaneous urticaria  (2019)

Review:Cardiac safety of second-generation H1 -antihistamines when updosed in chronic spontaneous urticaria

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Cataldi M, Maurer M, Taglialatela M, Church MK.

Cataldi M, Maurer M, Taglialatela M, Church MK.

To overview literature cardiac health and second wave antihistamines

Review: Guiding Principles for the Recognition, Diagnosis, and Management of Infants With Anaphylaxis: An Expert Panel Consensus  (2019)

Review: Guiding Principles for the Recognition, Diagnosis, and Management of Infants With Anaphylaxis: An Expert Panel Consensus

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Greenhawt, M., Gupta, R. S., Meadows, J. A., Pistiner, M., Spergel, J. M., Camargo, C. A., Jr, Simons, F., Lieberman, P. L

Greenhawt, M., Gupta, R. S., Meadows, J. A., Pistiner, M., Spergel, J. M., Ca...

To overview the current recommendations for yes

Review: Evaluation of Prehospital Management in a Canadian Emergency Department Anaphylaxis Cohort.  (2019)

Review: Evaluation of Prehospital Management in a Canadian Emergency Department Anaphylaxis Cohort.

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Gabrielli S, Clarke A, Morris J, et al.

Gabrielli S, Clarke A, Morris J, et al.

To assess prehospital management of anaphylaxis by measuring the effect of epinephrine use compared with antihistamines and corticosteroids on negative outcomes of anaphylaxis (intensive care unit/hospital ward admission, multiple doses of epinephrine in the emergency department [ED], and intravenous fluids given in the ED).

Review: Duration of Observation for Detecting a Biphasic Reaction in Anaphylaxis: A Meta-Analysis.  (2019)

Review: Duration of Observation for Detecting a Biphasic Reaction in Anaphylaxis: A Meta-Analysis.

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Kim TH, Yoon SH, Hong H, Kang HR, Cho SH, Lee SY.

Kim TH, Yoon SH, Hong H, Kang HR, Cho SH, Lee SY.

to determine a practical observation time for detecting a biphasic reaction after resolution of the initial anaphylactic reaction.

Review: Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of data from The European Anaphylaxis Registry.  (2018)

Review: Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of data from The European Anaphylaxis Registry.

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Worm M, Francuzik W, Renaudin JM, et al.

Worm M, Francuzik W, Renaudin JM, et al.

To identify and prioritize factors associated with an increased risk of developing severe anaphylaxis.

Review: Epinephrine auto-injector needle lengths Can both subcutaneous and periosteal / intraosseous injection be avoided ?  (2018)

Review: Epinephrine auto-injector needle lengths Can both subcutaneous and periosteal / intraosseous injection be avoided ?

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Dreborg S, Kim L, Tsai G, Kim H.

Dreborg S, Kim L, Tsai G, Kim H.

To discuss suitable EAI needle lengths based on ultrasound measurements related to weight.

Review: Do Corticosteroids Prevent Biphasic Anaphylaxis?  (2017)

Review: Do Corticosteroids Prevent Biphasic Anaphylaxis?

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Alqurashi W, Ellis AK

Alqurashi W, Ellis AK

This review analyzes the use of corticosteroids for reducing anaphylaxis severity and preventing biphasic anaphylaxis.

Review: Quality indicators for the acute and long-term management of anaphylaxis: a systematic review.  (2017)

Review: Quality indicators for the acute and long-term management of anaphylaxis: a systematic review.

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Dhami S, Sheikh A, Muraro A, et al.

Dhami S, Sheikh A, Muraro A, et al.

To identify quality indicators to support the acute and long-term management of anaphylaxis.

Review: Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase.  (2017)

Review: Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase.

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Motola D, Donati M, Biagi C, et al.

Motola D, Donati M, Biagi C, et al.

comparative analysis of the safety profiles of H1antihistamines using data from the WHO database

Comprehensive Review: Pitfalls in the use of epinephrine for anaphylaxis: patient and provider opportunities for improvement  (2016)

Comprehensive Review: Pitfalls in the use of epinephrine for anaphylaxis: patient and provider opportunities for improvement

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Cohen MB, Saunders SS, Wise SK, Nassif S, Platt MP

Cohen MB, Saunders SS, Wise SK, Nassif S, Platt MP

The purpose of this study was to identify the scope of epinephrine pitfalls and opportunities for improvement in the management of allergy emergencies.

Systematic Review: Time of Onset and Predictors of Biphasic Anaphylactic Reactions: A Systematic Review and Meta-analysis  (2015)

Systematic Review: Time of Onset and Predictors of Biphasic Anaphylactic Reactions: A Systematic Review and Meta-analysis

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Lee S, Bellolio MF, Hess EP, Erwin P, Murad MH, Campbell RL

Lee S, Bellolio MF, Hess EP, Erwin P, Murad MH, Campbell RL

The aim of this study was to evaluate the time of onset and predictors of biphasic anaphylactic reactions.

Review: Anaphylaxis: Unique aspects of clinical diagnosis and management in infants (birth to age 2 years)  (2015)

Review: Anaphylaxis: Unique aspects of clinical diagnosis and management in infants (birth to age 2 years)

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Simons FE, Sampson HA

Simons FE, Sampson HA

In this rostrum we aim to increase awareness of anaphylaxis in infancy in order to improve clinical diagnosis, management, and prevention of recurrences.

Review: Risk multipliers for severe food anaphylaxis  (2015)

Review: Risk multipliers for severe food anaphylaxis

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Smith PK, Hourihane JO, Lieberman P

Smith PK, Hourihane JO, Lieberman P

This paper reviews the factors that contribute to the risk of severe anaphylactic events and provides a framework for the ongoing management of patients at risk of severe food allergy.

Systematic Review: H2-antihistamines for the treatment of anaphylaxis with and without shock: a systematic review  (2014)

Systematic Review: H2-antihistamines for the treatment of anaphylaxis with and without shock: a systematic review

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Nurmatov UB, Rhatigan E, Simons FE, Sheikh A

Nurmatov UB, Rhatigan E, Simons FE, Sheikh A

The objective of this systematic review was to assess the benefits and harms of H2-antihistamines in the treatment of anaphylaxis.

Cochrane Systematic Review: Glucocorticoids for the treatment of anaphylaxis  (2012)

Cochrane Systematic Review: Glucocorticoids for the treatment of anaphylaxis

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Choo KJ, Simons FE, Sheikh A

Choo KJ, Simons FE, Sheikh A

We sought to assess the benefits and harms of glucocorticoid treatment during episodes of anaphylaxis.

Cochrane Systematic Review: Adrenaline auto-injectors for the treatment of anaphylaxis with and without cardiovascular collapse in the community  (2012)

Cochrane Systematic Review: Adrenaline auto-injectors for the treatment of anaphylaxis with and without cardiovascular collapse in the community

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Sheikh A, Simons FE, Barbour V, Worth A

Sheikh A, Simons FE, Barbour V, Worth A

The objective of this systematic review was to assess the effectiveness of adrenaline (epinephrine) auto-injectors in relieving respiratory, cardiovascular, and other symptoms during episodes of anaphylaxis that occur in the community.

Cochrane Systematic Review: H1-antihistamines for the treatment of anaphylaxis with and without shock  (2007)

Cochrane Systematic Review: H1-antihistamines for the treatment of anaphylaxis with and without shock

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Sheikh A, ten Broek VM, Brown SG, Simons FE

Sheikh A, ten Broek VM, Brown SG, Simons FE

The objective of this systematic review was to assess the benefits and harm of H1-antihistamines in the treatment of anaphylaxis.

Review:Cardiac safety of second-generation H1 -antihistamines when updosed in chronic spontaneous urticaria  (2019)

Review:Cardiac safety of second-generation H1 -antihistamines when updosed in chronic spontaneous urticaria

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Cataldi M, Maurer M, Taglialatela M, Church MK.

Cataldi M, Maurer M, Taglialatela M, Church MK.

To overview literature cardiac health and second wave antihistamines

Review: Guiding Principles for the Recognition, Diagnosis, and Management of Infants With Anaphylaxis: An Expert Panel Consensus  (2019)

Review: Guiding Principles for the Recognition, Diagnosis, and Management of Infants With Anaphylaxis: An Expert Panel Consensus

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Greenhawt, M., Gupta, R. S., Meadows, J. A., Pistiner, M., Spergel, J. M., Camargo, C. A., Jr, Simons, F., Lieberman, P. L

Greenhawt, M., Gupta, R. S., Meadows, J. A., Pistiner, M., Spergel, J. M., Ca...

To overview the current recommendations for yes

Review: Evaluation of Prehospital Management in a Canadian Emergency Department Anaphylaxis Cohort.  (2019)

Review: Evaluation of Prehospital Management in a Canadian Emergency Department Anaphylaxis Cohort.

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Gabrielli S, Clarke A, Morris J, et al.

Gabrielli S, Clarke A, Morris J, et al.

To assess prehospital management of anaphylaxis by measuring the effect of epinephrine use compared with antihistamines and corticosteroids on negative outcomes of anaphylaxis (intensive care unit/hospital ward admission, multiple doses of epinephrine in the emergency department [ED], and intravenous fluids given in the ED).

Review: Duration of Observation for Detecting a Biphasic Reaction in Anaphylaxis: A Meta-Analysis.  (2019)

Review: Duration of Observation for Detecting a Biphasic Reaction in Anaphylaxis: A Meta-Analysis.

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Kim TH, Yoon SH, Hong H, Kang HR, Cho SH, Lee SY.

Kim TH, Yoon SH, Hong H, Kang HR, Cho SH, Lee SY.

to determine a practical observation time for detecting a biphasic reaction after resolution of the initial anaphylactic reaction.

Review: Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of data from The European Anaphylaxis Registry.  (2018)

Review: Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of data from The European Anaphylaxis Registry.

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Worm M, Francuzik W, Renaudin JM, et al.

Worm M, Francuzik W, Renaudin JM, et al.

To identify and prioritize factors associated with an increased risk of developing severe anaphylaxis.

Review: Epinephrine auto-injector needle lengths Can both subcutaneous and periosteal / intraosseous injection be avoided ?  (2018)

Review: Epinephrine auto-injector needle lengths Can both subcutaneous and periosteal / intraosseous injection be avoided ?

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Dreborg S, Kim L, Tsai G, Kim H.

Dreborg S, Kim L, Tsai G, Kim H.

To discuss suitable EAI needle lengths based on ultrasound measurements related to weight.

Review: Do Corticosteroids Prevent Biphasic Anaphylaxis?  (2017)

Review: Do Corticosteroids Prevent Biphasic Anaphylaxis?

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Alqurashi W, Ellis AK

Alqurashi W, Ellis AK

This review analyzes the use of corticosteroids for reducing anaphylaxis severity and preventing biphasic anaphylaxis.

Review: Quality indicators for the acute and long-term management of anaphylaxis: a systematic review.  (2017)

Review: Quality indicators for the acute and long-term management of anaphylaxis: a systematic review.

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Dhami S, Sheikh A, Muraro A, et al.

Dhami S, Sheikh A, Muraro A, et al.

To identify quality indicators to support the acute and long-term management of anaphylaxis.

Review: Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase.  (2017)

Review: Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase.

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Motola D, Donati M, Biagi C, et al.

Motola D, Donati M, Biagi C, et al.

comparative analysis of the safety profiles of H1antihistamines using data from the WHO database

Comprehensive Review: Pitfalls in the use of epinephrine for anaphylaxis: patient and provider opportunities for improvement  (2016)

Comprehensive Review: Pitfalls in the use of epinephrine for anaphylaxis: patient and provider opportunities for improvement

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Cohen MB, Saunders SS, Wise SK, Nassif S, Platt MP

Cohen MB, Saunders SS, Wise SK, Nassif S, Platt MP

The purpose of this study was to identify the scope of epinephrine pitfalls and opportunities for improvement in the management of allergy emergencies.

Systematic Review: Time of Onset and Predictors of Biphasic Anaphylactic Reactions: A Systematic Review and Meta-analysis  (2015)

Systematic Review: Time of Onset and Predictors of Biphasic Anaphylactic Reactions: A Systematic Review and Meta-analysis

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Lee S, Bellolio MF, Hess EP, Erwin P, Murad MH, Campbell RL

Lee S, Bellolio MF, Hess EP, Erwin P, Murad MH, Campbell RL

The aim of this study was to evaluate the time of onset and predictors of biphasic anaphylactic reactions.

Review: Anaphylaxis: Unique aspects of clinical diagnosis and management in infants (birth to age 2 years)  (2015)

Review: Anaphylaxis: Unique aspects of clinical diagnosis and management in infants (birth to age 2 years)

Visit

Simons FE, Sampson HA

Simons FE, Sampson HA

In this rostrum we aim to increase awareness of anaphylaxis in infancy in order to improve clinical diagnosis, management, and prevention of recurrences.

Review: Risk multipliers for severe food anaphylaxis  (2015)

Review: Risk multipliers for severe food anaphylaxis

Visit

Smith PK, Hourihane JO, Lieberman P

Smith PK, Hourihane JO, Lieberman P

This paper reviews the factors that contribute to the risk of severe anaphylactic events and provides a framework for the ongoing management of patients at risk of severe food allergy.

Systematic Review: H2-antihistamines for the treatment of anaphylaxis with and without shock: a systematic review  (2014)

Systematic Review: H2-antihistamines for the treatment of anaphylaxis with and without shock: a systematic review

Visit

Nurmatov UB, Rhatigan E, Simons FE, Sheikh A

Nurmatov UB, Rhatigan E, Simons FE, Sheikh A

The objective of this systematic review was to assess the benefits and harms of H2-antihistamines in the treatment of anaphylaxis.

Cochrane Systematic Review: Glucocorticoids for the treatment of anaphylaxis  (2012)

Cochrane Systematic Review: Glucocorticoids for the treatment of anaphylaxis

Visit

Choo KJ, Simons FE, Sheikh A

Choo KJ, Simons FE, Sheikh A

We sought to assess the benefits and harms of glucocorticoid treatment during episodes of anaphylaxis.

Cochrane Systematic Review: Adrenaline auto-injectors for the treatment of anaphylaxis with and without cardiovascular collapse in the community  (2012)

Cochrane Systematic Review: Adrenaline auto-injectors for the treatment of anaphylaxis with and without cardiovascular collapse in the community

Visit

Sheikh A, Simons FE, Barbour V, Worth A

Sheikh A, Simons FE, Barbour V, Worth A

The objective of this systematic review was to assess the effectiveness of adrenaline (epinephrine) auto-injectors in relieving respiratory, cardiovascular, and other symptoms during episodes of anaphylaxis that occur in the community.

Cochrane Systematic Review: H1-antihistamines for the treatment of anaphylaxis with and without shock  (2007)

Cochrane Systematic Review: H1-antihistamines for the treatment of anaphylaxis with and without shock

Visit

Sheikh A, ten Broek VM, Brown SG, Simons FE

Sheikh A, ten Broek VM, Brown SG, Simons FE

The objective of this systematic review was to assess the benefits and harm of H1-antihistamines in the treatment of anaphylaxis.

Key studies 

Key Study: Biphasic Reactions in Emergency Department Anaphylaxis Patients: A Prospective Cohort Study  (2020)

Key Study: Biphasic Reactions in Emergency Department Anaphylaxis Patients: A Prospective Cohort Study

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Liu X, Lee S, Lohse CM, Hardy CT, Campbell RL.

Liu X, Lee S, Lohse CM, Hardy CT, Campbell RL.

To evaluate biphasic reaction rates and associated risk factors.

Key Study: Simulation of Health and Economic Benefits of Extended Observation of Resolved Anaphylaxis  (2019)

Key Study: Simulation of Health and Economic Benefits of Extended Observation of Resolved Anaphylaxis

Visit

Shaker M, Wallace D, Golden DBK, Oppenheimer J, Greenhawt M

Shaker M, Wallace D, Golden DBK, Oppenheimer J, Greenhawt M

What is the cost-effectiveness of 1 hour vs 6 to 24 hours of medical observation for biphasic anaphylaxis?

Key Study: An economic evaluation of immediate vs non-immediate activation of emergency medical services after epinephrine use for peanut-induced anaphylaxis  (2019)

Key Study: An economic evaluation of immediate vs non-immediate activation of emergency medical services after epinephrine use for peanut-induced anaphylaxis

Visit

Shaker M, Kanaoka T, Feenan L, Greenhawt M.

Shaker M, Kanaoka T, Feenan L, Greenhawt M.

To evaluate the cost-effectiveness of this strategy, vs a watchful waiting approach before activating emergency medical services (EMS).

Key Study: Epinephrine Use for Anaphylaxis - A Multi-Incident Analysis  (2017)

Key Study: Epinephrine Use for Anaphylaxis - A Multi-Incident Analysis

Visit

Institute for Safe Medication Practices Canada

Institute for Safe Medication Practices Canada

This multi-incident analysis was conducted to identify factors contributing to errors when epinephrine was used for the treatment of anaphylaxis and to suggest strategies to prevent or minimize potential harm when epinephrine is used for this indication.

Key Study: The Risk of Recurrent Anaphylaxis  (2017)

Key Study: The Risk of Recurrent Anaphylaxis

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O'Keefe A, Clarke A, St Pierre Y, Mill J, Asai Y, Eisman H, La Vieille S, Alizadehfar R, Joseph L, Morris J, Gravel J, Ben-Shoshan M

O'Keefe A, Clarke A, St Pierre Y, Mill J, Asai Y, Eisman H, La Vieille S, Ali...

factors contributing to errors when epinephrine was

Key Study: Lacerations and Embedded Needles Caused by Epinephrine Autoinjector Use in Children  (2016)

Key Study: Lacerations and Embedded Needles Caused by Epinephrine Autoinjector Use in Children

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Brown JC, Tuuri RE, Akhter S, Guerra LD, Goodman IS, Myers SR, Nozicka C, Manzi S, Long K, Turner T, Conners GP, Thompson RW, Park E

Brown JC, Tuuri RE, Akhter S, Guerra LD, Goodman IS, Myers SR, Nozicka C, Man...

used for the treatment of anaphylaxis and to suggest

Key Study: Embedded Needles Caused by Epinephrine Autoinjector Use in Children  (2016)

Key Study: Embedded Needles Caused by Epinephrine Autoinjector Use in Children

Visit

Dreborg S, Wen X, Kim L, Tsai G, Nevis I, Potts R, Chiu J, Dominic A, Kim H

Dreborg S, Wen X, Kim L, Tsai G, Nevis I, Potts R, Chiu J, Dominic A, Kim H

strategies to prevent or minimize potential harm

Key Study: Increasing visits for anaphylaxis and the benefits of early epinephrine administration: A 4-year study at a pediatric emergency department in Montreal, Canada  (2016)

Key Study: Increasing visits for anaphylaxis and the benefits of early epinephrine administration: A 4-year study at a pediatric emergency department in Montreal, Canada

Visit

Hochstadter E, Clarke A, De Schryver S, LaVieille S, Alizadehfar R, Joseph L, Eisman H, Ben-Shoshan M

Hochstadter E, Clarke A, De Schryver S, LaVieille S, Alizadehfar R, Joseph L,...

when epinephrine is used for this indication.

Key Study: Epidemiology and clinical predictors of biphasic reactions in children with anaphylaxis  (2015)

Key Study: Epidemiology and clinical predictors of biphasic reactions in children with anaphylaxis

Visit

Alqurashi W, Stiell I, Chan K, Neto G, Alsadoon A, Wells G

Alqurashi W, Stiell I, Chan K, Neto G, Alsadoon A, Wells G

The objective of this study was to investigate the incidence and clinical predictors of biphasic reactions in children presenting to the emergency department (ED) with anaphylaxis.

Key Study: Early treatment of food-induced anaphylaxis with epinephrine is associated with a lower risk of hospitalization  (2015)

Key Study: Early treatment of food-induced anaphylaxis with epinephrine is associated with a lower risk of hospitalization

Visit

Fleming JT, Clark S, Camargo CA Jr, Rudders SA

Fleming JT, Clark S, Camargo CA Jr, Rudders SA

The objective of this study was to identify factors associated with early epinephrine treatment for FIA and to specifically examine the association between early epinephrine treatment and hospitalization.

Key Study: Patients' ability to treat anaphylaxis using adrenaline autoinjectors: a randomized controlled trial  (2015)

Key Study: Patients' ability to treat anaphylaxis using adrenaline autoinjectors: a randomized controlled trial

Visit

Umasunthar T, Procktor A, Hodes M, Smith JG, Gore C, Cox HE, Marrs T, Hanna H, Phillips K, Pinto C, Turner PJ, Warner JO, Boyle RJ

Umasunthar T, Procktor A, Hodes M, Smith JG, Gore C, Cox HE, Marrs T, Hanna H...

Previous work has shown patients commonly misuse adrenaline autoinjectors (AAI). It is unclear whether this is due to inadequate training, or poor device design. We undertook a prospective randomized controlled trial to evaluate ability to administer adrenaline using different AAI devices.

Key Study: Biphasic Reactions in Emergency Department Anaphylaxis Patients: A Prospective Cohort Study  (2020)

Key Study: Biphasic Reactions in Emergency Department Anaphylaxis Patients: A Prospective Cohort Study

Visit

Liu X, Lee S, Lohse CM, Hardy CT, Campbell RL.

Liu X, Lee S, Lohse CM, Hardy CT, Campbell RL.

To evaluate biphasic reaction rates and associated risk factors.

Key Study: Simulation of Health and Economic Benefits of Extended Observation of Resolved Anaphylaxis  (2019)

Key Study: Simulation of Health and Economic Benefits of Extended Observation of Resolved Anaphylaxis

Visit

Shaker M, Wallace D, Golden DBK, Oppenheimer J, Greenhawt M

Shaker M, Wallace D, Golden DBK, Oppenheimer J, Greenhawt M

What is the cost-effectiveness of 1 hour vs 6 to 24 hours of medical observation for biphasic anaphylaxis?

Key Study: An economic evaluation of immediate vs non-immediate activation of emergency medical services after epinephrine use for peanut-induced anaphylaxis  (2019)

Key Study: An economic evaluation of immediate vs non-immediate activation of emergency medical services after epinephrine use for peanut-induced anaphylaxis

Visit

Shaker M, Kanaoka T, Feenan L, Greenhawt M.

Shaker M, Kanaoka T, Feenan L, Greenhawt M.

To evaluate the cost-effectiveness of this strategy, vs a watchful waiting approach before activating emergency medical services (EMS).

Key Study: Epinephrine Use for Anaphylaxis - A Multi-Incident Analysis  (2017)

Key Study: Epinephrine Use for Anaphylaxis - A Multi-Incident Analysis

Visit

Institute for Safe Medication Practices Canada

Institute for Safe Medication Practices Canada

This multi-incident analysis was conducted to identify factors contributing to errors when epinephrine was used for the treatment of anaphylaxis and to suggest strategies to prevent or minimize potential harm when epinephrine is used for this indication.

Key Study: The Risk of Recurrent Anaphylaxis  (2017)

Key Study: The Risk of Recurrent Anaphylaxis

Visit

O'Keefe A, Clarke A, St Pierre Y, Mill J, Asai Y, Eisman H, La Vieille S, Alizadehfar R, Joseph L, Morris J, Gravel J, Ben-Shoshan M

O'Keefe A, Clarke A, St Pierre Y, Mill J, Asai Y, Eisman H, La Vieille S, Ali...

factors contributing to errors when epinephrine was

Key Study: Lacerations and Embedded Needles Caused by Epinephrine Autoinjector Use in Children  (2016)

Key Study: Lacerations and Embedded Needles Caused by Epinephrine Autoinjector Use in Children

Visit

Brown JC, Tuuri RE, Akhter S, Guerra LD, Goodman IS, Myers SR, Nozicka C, Manzi S, Long K, Turner T, Conners GP, Thompson RW, Park E

Brown JC, Tuuri RE, Akhter S, Guerra LD, Goodman IS, Myers SR, Nozicka C, Man...

used for the treatment of anaphylaxis and to suggest

Key Study: Embedded Needles Caused by Epinephrine Autoinjector Use in Children  (2016)

Key Study: Embedded Needles Caused by Epinephrine Autoinjector Use in Children

Visit

Dreborg S, Wen X, Kim L, Tsai G, Nevis I, Potts R, Chiu J, Dominic A, Kim H

Dreborg S, Wen X, Kim L, Tsai G, Nevis I, Potts R, Chiu J, Dominic A, Kim H

strategies to prevent or minimize potential harm

Key Study: Increasing visits for anaphylaxis and the benefits of early epinephrine administration: A 4-year study at a pediatric emergency department in Montreal, Canada  (2016)

Key Study: Increasing visits for anaphylaxis and the benefits of early epinephrine administration: A 4-year study at a pediatric emergency department in Montreal, Canada

Visit

Hochstadter E, Clarke A, De Schryver S, LaVieille S, Alizadehfar R, Joseph L, Eisman H, Ben-Shoshan M

Hochstadter E, Clarke A, De Schryver S, LaVieille S, Alizadehfar R, Joseph L,...

when epinephrine is used for this indication.

Key Study: Epidemiology and clinical predictors of biphasic reactions in children with anaphylaxis  (2015)

Key Study: Epidemiology and clinical predictors of biphasic reactions in children with anaphylaxis

Visit

Alqurashi W, Stiell I, Chan K, Neto G, Alsadoon A, Wells G

Alqurashi W, Stiell I, Chan K, Neto G, Alsadoon A, Wells G

The objective of this study was to investigate the incidence and clinical predictors of biphasic reactions in children presenting to the emergency department (ED) with anaphylaxis.

Key Study: Early treatment of food-induced anaphylaxis with epinephrine is associated with a lower risk of hospitalization  (2015)

Key Study: Early treatment of food-induced anaphylaxis with epinephrine is associated with a lower risk of hospitalization

Visit

Fleming JT, Clark S, Camargo CA Jr, Rudders SA

Fleming JT, Clark S, Camargo CA Jr, Rudders SA

The objective of this study was to identify factors associated with early epinephrine treatment for FIA and to specifically examine the association between early epinephrine treatment and hospitalization.

Key Study: Patients' ability to treat anaphylaxis using adrenaline autoinjectors: a randomized controlled trial  (2015)

Key Study: Patients' ability to treat anaphylaxis using adrenaline autoinjectors: a randomized controlled trial

Visit

Umasunthar T, Procktor A, Hodes M, Smith JG, Gore C, Cox HE, Marrs T, Hanna H, Phillips K, Pinto C, Turner PJ, Warner JO, Boyle RJ

Umasunthar T, Procktor A, Hodes M, Smith JG, Gore C, Cox HE, Marrs T, Hanna H...

Previous work has shown patients commonly misuse adrenaline autoinjectors (AAI). It is unclear whether this is due to inadequate training, or poor device design. We undertook a prospective randomized controlled trial to evaluate ability to administer adrenaline using different AAI devices.

Other 

Video: Canadian Anaphylaxis Action Plan for Kids (Kids' CAP)  (2019)

Video: Canadian Anaphylaxis Action Plan for Kids (Kids' CAP)

Visit

The Canadian Anaphylaxis Action Plan for Kids (Kids’ CAP) is a tool to educate children and caregivers about anaphylaxis. The main focus of this tool is to answer two questions: 1) How to recognize the symptoms of anaphylaxis; 2) What are the appropriate treatment steps of a child experiencing an anaphylactic reaction. The action plan document was developed by a research team at the Children's Hospital of Eastern Ontario (CHEO) in 2015 and include validated pictograms with written instructions that are easily understood by students at grade 7 and above.

Video: Canadian Anaphylaxis Action Plan for Kids (Kids' CAP)  (2019)

Video: Canadian Anaphylaxis Action Plan for Kids (Kids' CAP)

Visit

The Canadian Anaphylaxis Action Plan for Kids (Kids’ CAP) is a tool to educate children and caregivers about anaphylaxis. The main focus of this tool is to answer two questions: 1) How to recognize the symptoms of anaphylaxis; 2) What are the appropriate treatment steps of a child experiencing an anaphylactic reaction. The action plan document was developed by a research team at the Children's Hospital of Eastern Ontario (CHEO) in 2015 and include validated pictograms with written instructions that are easily understood by students at grade 7 and above.


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