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Key Resources English (10) French (1) All (11)

Fact Sheet: Pediatric COVID-19

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TREKK Network

Fact sheet for the treatment and management of pediatric COVID-19 (novel coronavirus)

The 2019 Novel Coronavirus (COVID-19)

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Information on COVID-19 from Caring for Kids for parents and families. 

COVID-19 information and resources for paediatricians

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COVID-19 and Canadas Kids

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Canadian Association of Emergency Physicians - COVID-19 Information, Resources and Advocacy Centre

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Emergency Medicine Cases: Practical COVID-19 resources for front line healthcare professionals

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eMagazine No Mercy for the Coronas

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Looking for resources to understand the scientific realities of the COVID-19 virus and pandemic? Check out this children's science magazine, No Mercy for the Coronas, an engaging and accessible illustrated resource for kids (and parents!) to better understand viruses like COVID-19.
 
This e-magazine was created by La Liberté and POP Comm, and developed with the participation of scientists and researchers at Children’s Hospital Research Institute of Manitoba (CHRIM), University of Manitoba and St. Boniface Hospital Albrechtsen Research Centre’s Youth BIOlab Jeunesse.

No Mercy for the Coronas! is for all those who wish to offer children a scientifically reliable resource during this global health crisis affecting all ages and all aspects of society. You can read or download this free magazine in English or French.

VIDEO: COVID-19 (updated)

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In this video Dr. Anthony Crocco (Sketchy EBM) outlines the symptoms of COVID-19, how to protect yourself and your family, what to do to be well and when to worry. This video is not a substitute for medical care. Please consult Public Health or your health professional for medical advice.

 

World Health Organization: Parenting in the time of COVID-19

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World Health Organization

To help parents interact constructively with their children during this time of confinement, the World Health Organization created these six one-page tips for parents cover planning one-on-one time, staying positive, creating a daily routine, avoiding bad behaviour, managing stress, and talking about COVID-19. 

 

 

Clinical management of patients with moderate to severe COVID-19 - Interim guidance

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Government of Canada

Fiche Dinformation: COVID-19 pdiatrique (nouveau coronavirus)

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TREKK Network

Fact sheet for the treatment and management of pediatric COVID-19 (novel coronavirus) - French

Fact Sheet: Pediatric COVID-19

Download

TREKK Network

Fact sheet for the treatment and management of pediatric COVID-19 (novel coronavirus)

The 2019 Novel Coronavirus (COVID-19)

Visit

Information on COVID-19 from Caring for Kids for parents and families. 

Fiche Dinformation: COVID-19 pdiatrique (nouveau coronavirus)

Download

TREKK Network

Fact sheet for the treatment and management of pediatric COVID-19 (novel coronavirus) - French

COVID-19 information and resources for paediatricians

Visit

COVID-19 and Canadas Kids

Visit

Canadian Association of Emergency Physicians - COVID-19 Information, Resources and Advocacy Centre

Visit

Emergency Medicine Cases: Practical COVID-19 resources for front line healthcare professionals

Visit

eMagazine No Mercy for the Coronas

Visit

Looking for resources to understand the scientific realities of the COVID-19 virus and pandemic? Check out this children's science magazine, No Mercy for the Coronas, an engaging and accessible illustrated resource for kids (and parents!) to better understand viruses like COVID-19.
 
This e-magazine was created by La Liberté and POP Comm, and developed with the participation of scientists and researchers at Children’s Hospital Research Institute of Manitoba (CHRIM), University of Manitoba and St. Boniface Hospital Albrechtsen Research Centre’s Youth BIOlab Jeunesse.

No Mercy for the Coronas! is for all those who wish to offer children a scientifically reliable resource during this global health crisis affecting all ages and all aspects of society. You can read or download this free magazine in English or French.

VIDEO: COVID-19 (updated)

Visit

In this video Dr. Anthony Crocco (Sketchy EBM) outlines the symptoms of COVID-19, how to protect yourself and your family, what to do to be well and when to worry. This video is not a substitute for medical care. Please consult Public Health or your health professional for medical advice.

 

World Health Organization: Parenting in the time of COVID-19

Visit

World Health Organization

To help parents interact constructively with their children during this time of confinement, the World Health Organization created these six one-page tips for parents cover planning one-on-one time, staying positive, creating a daily routine, avoiding bad behaviour, managing stress, and talking about COVID-19. 

 

 

Clinical management of patients with moderate to severe COVID-19 - Interim guidance

Visit

Government of Canada

Clinical guidelines English (4) French All (4)

Guideline: COVID in children with diabetes

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International Society for Pediatric and Adolescent Diabetes (ISPAD)

The International Society for Pediatric and Adolescent Diabetes (ISPAD) Clinical Practice Consensus Guidelines 2018 for management of diabetic ketoacidosis (DKA) and the hyperglycemic hyperosmolar state provide comprehensive guidance for management of DKA in young people. Intravenous infusion of insulin for treating DKA may necessitate intensive care unit admission in hospitals in some parts of the world. During the Coronavirus Disease 2019 (COVID-19) pandemic, ICU services may need to be prioritised for care of affected individuals

Consensus statement: Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts consensus statement.

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Shen K, Yang Y, Wang T, et al.

This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections. The present consensus statement summarizes current strategies on diagnosis, treatment, and prevention of 2019-nCoV infection in children.

Info page: What Does the Coronavirus Disease 2019 (COVID-19) Mean for Families?

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Thompson LA, Rasmussen SA

Objective: To prepare families for COVID-19 in the US.

Info page: Coronavirus Disease 2019 (COVID-2019) Information for Pediatric Healthcare Providers.

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US Centers for Disease Control and Prevention.

To inform pediatric healthcare providers of information available on children with COVID-19.

Guideline: COVID in children with diabetes

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International Society for Pediatric and Adolescent Diabetes (ISPAD)

The International Society for Pediatric and Adolescent Diabetes (ISPAD) Clinical Practice Consensus Guidelines 2018 for management of diabetic ketoacidosis (DKA) and the hyperglycemic hyperosmolar state provide comprehensive guidance for management of DKA in young people. Intravenous infusion of insulin for treating DKA may necessitate intensive care unit admission in hospitals in some parts of the world. During the Coronavirus Disease 2019 (COVID-19) pandemic, ICU services may need to be prioritised for care of affected individuals

Consensus statement: Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts consensus statement.

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Shen K, Yang Y, Wang T, et al.

This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections. The present consensus statement summarizes current strategies on diagnosis, treatment, and prevention of 2019-nCoV infection in children.

Info page: What Does the Coronavirus Disease 2019 (COVID-19) Mean for Families?

Visit

Thompson LA, Rasmussen SA

Objective: To prepare families for COVID-19 in the US.

Info page: Coronavirus Disease 2019 (COVID-2019) Information for Pediatric Healthcare Providers.

Visit

US Centers for Disease Control and Prevention.

To inform pediatric healthcare providers of information available on children with COVID-19.

Systematic reviews English (9) French All (9)

Systematic review: Cardiovascular impact of COVID-19 with a focus on children: a systematic review.

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Rodriguez-Gonzalez M, Castellano-Martinez A, Cascales-Poyatos HM, Perez-Revir...

Aim: To summarize the current knowledge about the potential cardiovascular involvement in pediatric COVID-19 in order to give a perspective on how to take care of them during the current pandemic emergency.

Systematic review: Characteristics of pediatric multi-system inflammatory syndrome (PMIS) associated with COVID-19: a meta-analysis and insights into pathogenesis.

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Zou H, Lu J, Liu J, et al.

Objectives: There was an outbreak of pediatric multisystem inflammation syndrome (PMIS) was observed in multiple countries recently, and this syndrome was suspected to be associated with SARS-CoV-2 infection. At present, there is still no standardized diagnostic criteria and treatment regimen for PMIS, while the etiology and pathogenesis still remain unclear.

Systematic review: Clinical characteristics of COVID-19 in children: a systematic review.

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Yasuhara J, Kuno T, Takagi H, Sumitomo N.

Objective: Our aim was to investigate the clinical characteristics of COVID-19 in children.

Systematic review: Clinical manifestations of children with COVID-19: a systematic review.

Visit

de Souza TH, Nadal JA, Nogueira RJN, Pereira RM, Brando MB

Objective: The aim of this study was to describe the clinical, laboratorial, and radiological characteristics of children with COVID-19.

Systematic review: COVID-19 in 7780 pediatric patients: a systematic review.

Visit

Hoang A, Chorath K, Moreira A, et al.

Objective: This review characterizes clinical symptoms, laboratory, and imaging findings, as well as therapies provided to confirmed pediatric cases of COVID-19.

Systematic review: Epidemiological and clinical characteristics of COVID-19 in children: a systematic review and meta-analysis.

Visit

Li B, Zhang S, Zhang R, Chen X, Wang Y, Zhu C.

Objective: This systematic review with meta-analysis aimed to evaluate the epidemiological spectrum and clinical characteristics of children infected with SARS-CoV-2.

Systematic review: Multisystem inflammatory syndrome associated with COVID-19 from the pediatric emergency physician's point of view.

Visit

Junior H, Sakano TMS, Rodrigues RM, et al.

Objective: Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease (COVID-19) is a rare and challenging diagnosis requiring early treatment. The diagnostic criteria involve clinical, laboratory, and complementary tests. This review aims to draw pediatrician attention to this diagnosis, suggesting early treatment strategies, and proposing a pediatric emergency care flowchart.

Systematic review: Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2: a systematic review.

Visit

Abrams JY, Godfred-Cato SE, Oster ME, et al.

Objective: To develop a more comprehensive description of multisystem inflammatory syndrome in children (MIS-C), a novel syndrome linked to severe acute respiratory syndrome coronavirus 2, by conducting a systematic analysis of studies from different settings that used various inclusion criteria.

Systematic review: Prevalence, clinical characteristics, and outcomes of pediatric COVID-19: a systematic review and meta-analysis.

Visit

Badal S, Bajgain KT, Badal S, Thapa R, Bajgain BB, Santana MJ.

Introduction: The novel coronavirus pandemic is an ongoing challenge faced by the public and health care systems around the globe. Majority of information and evidence gathered so far regarding COVID-19 has been derived from data and studies in adult populations. Crucial information regarding the characterization, clinical symptomatology, sequelae, and overall outcomes in the pediatric population is lacking. As such, we aimed to conduct a comprehensive meta-analysis and systematic review to collect and analyze current evidence about COVID-19 in the pediatric population.

Systematic review: Cardiovascular impact of COVID-19 with a focus on children: a systematic review.

Visit

Rodriguez-Gonzalez M, Castellano-Martinez A, Cascales-Poyatos HM, Perez-Revir...

Aim: To summarize the current knowledge about the potential cardiovascular involvement in pediatric COVID-19 in order to give a perspective on how to take care of them during the current pandemic emergency.

Systematic review: Characteristics of pediatric multi-system inflammatory syndrome (PMIS) associated with COVID-19: a meta-analysis and insights into pathogenesis.

Visit

Zou H, Lu J, Liu J, et al.

Objectives: There was an outbreak of pediatric multisystem inflammation syndrome (PMIS) was observed in multiple countries recently, and this syndrome was suspected to be associated with SARS-CoV-2 infection. At present, there is still no standardized diagnostic criteria and treatment regimen for PMIS, while the etiology and pathogenesis still remain unclear.

Systematic review: Clinical characteristics of COVID-19 in children: a systematic review.

Visit

Yasuhara J, Kuno T, Takagi H, Sumitomo N.

Objective: Our aim was to investigate the clinical characteristics of COVID-19 in children.

Systematic review: Clinical manifestations of children with COVID-19: a systematic review.

Visit

de Souza TH, Nadal JA, Nogueira RJN, Pereira RM, Brando MB

Objective: The aim of this study was to describe the clinical, laboratorial, and radiological characteristics of children with COVID-19.

Systematic review: COVID-19 in 7780 pediatric patients: a systematic review.

Visit

Hoang A, Chorath K, Moreira A, et al.

Objective: This review characterizes clinical symptoms, laboratory, and imaging findings, as well as therapies provided to confirmed pediatric cases of COVID-19.

Systematic review: Epidemiological and clinical characteristics of COVID-19 in children: a systematic review and meta-analysis.

Visit

Li B, Zhang S, Zhang R, Chen X, Wang Y, Zhu C.

Objective: This systematic review with meta-analysis aimed to evaluate the epidemiological spectrum and clinical characteristics of children infected with SARS-CoV-2.

Systematic review: Multisystem inflammatory syndrome associated with COVID-19 from the pediatric emergency physician's point of view.

Visit

Junior H, Sakano TMS, Rodrigues RM, et al.

Objective: Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease (COVID-19) is a rare and challenging diagnosis requiring early treatment. The diagnostic criteria involve clinical, laboratory, and complementary tests. This review aims to draw pediatrician attention to this diagnosis, suggesting early treatment strategies, and proposing a pediatric emergency care flowchart.

Systematic review: Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2: a systematic review.

Visit

Abrams JY, Godfred-Cato SE, Oster ME, et al.

Objective: To develop a more comprehensive description of multisystem inflammatory syndrome in children (MIS-C), a novel syndrome linked to severe acute respiratory syndrome coronavirus 2, by conducting a systematic analysis of studies from different settings that used various inclusion criteria.

Systematic review: Prevalence, clinical characteristics, and outcomes of pediatric COVID-19: a systematic review and meta-analysis.

Visit

Badal S, Bajgain KT, Badal S, Thapa R, Bajgain BB, Santana MJ.

Introduction: The novel coronavirus pandemic is an ongoing challenge faced by the public and health care systems around the globe. Majority of information and evidence gathered so far regarding COVID-19 has been derived from data and studies in adult populations. Crucial information regarding the characterization, clinical symptomatology, sequelae, and overall outcomes in the pediatric population is lacking. As such, we aimed to conduct a comprehensive meta-analysis and systematic review to collect and analyze current evidence about COVID-19 in the pediatric population.

Key studies English (30) French All (30)

Key study: Pointofcare lung ultrasound findings in the pediatric emergency clinic during the COVID19 pandemic.

Visit

Tre E, Korkmaz MF, Aksoy FD, et al.

Objective: To describe our experience concerning lung ultrasound (LUS) in the pediatric emergency clinic, and to investigate the diagnostic value of LUS in coronavirus disease-2019 (COVID-19).

Key study: Asymptomatic cases in a family cluster with SARS-CoV-2 infection

Visit

Wu X, Li T, Ou X, et al

Objective: To report the findings from different types of clinical specimens collected from 82 infected individuals

Key study: SARS-CoV-2 Infection in Children.

Visit

Lu X, Zhang L, Du H, et al

Objective: In order to determine the spectrum of disease in children, we evaluated children infected with SARS-CoV-2 and treated at the Wuhan Childrens Hospital, the only center assigned by the central government for treating infected children under 16 years of age in Wuhan.

Key study: A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features

Visit

Jiehao C, Jing X, Daojiong L, et al

Objective: To report the clinical and epidemiological features in children with coronavirus diseases (COVID) in China.

Key study: Clinical features of paediatric patients with COVID-19: a report of two family clusters.

Visit

Ji L, Chao S, Wang Y, et al.

Objective: To retrospectively review two confirmed pediatric cases from two family clusters. Both clinical features and laboratory examination results of the children and their family members were described.

Key study: Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China.

Visit

Dong Y, Mo X, Hu Y, et al.

Objective: This study examined the epidemiological characteristics and transmission patterns of 2143 pediatric patients with COVID-19, using a retrospective analytical approach.

Key study: Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China

Visit

Wei M, Yuan J, Liu Y, et al.,

Objective: For this retrospective study, authors identified all hospitalized infants diagnosed with COVID-19 infection between December 8, 2019, and February 6, 2020, in China and described demographic, epidemiologic, and clinical features.

Key study: Clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children

Visit

Hong H et al.,

Objective: To describe the clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children

Key study: Report on the Epidemiological Features of Coronavirus Disease 2019 (COVID-19) Outbreak in the Republic of Korea from January 19 to March 2, 2020.

Visit

Korean Society of Infectious Diseases, Korean Society of Pediatric Infectious...

Objective: This report summarizes the epidemiologic features and the snapshots of the outbreak in the Republic of Korea from January 19 and March 2, 2020.

Key study: Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single centers observational study.

Visit

Sun D, Li H, Lu X, et al.,

Objective: To describe the clinical features of severe pediatric patients with COVID-19.

Key study: Clinical presentation and virological assessment of hospitalized cases of coronavirus disease 2019 in a travel-associated transmission cluster.

Visit

Woelfel R, Corman VM, Guggemos W, et al.,

Objective: To study the viral load courses by RT-PCR in oro- and nasopharyngeal swabs, sputum, stool, blood, and urine in nine hospitalized cases. Infectious virus was detected by cell culture.

Key study: Acral cutaneous lesions in the time of COVID-19.

Visit

Recalcati S, Barbagallo T, Frasin LA, et al.

Objective: We report here on peculiar (perniosislike) skin lesions, unreported in the previous years, observed in young outpatients visited in our dermatologic unit in the last 4 weeks of COVID19 pandemic (MarchApril 2020).

Key study: Children with Covid-19 in pediatric emergency departments in Italy.

Visit

Parri N, Lenge M, Buonsenso D, Coronavirus Infection in Public Emergency Depa...

Objective: The Coronavirus Infection in Pediatric Emergency Departments (CONFIDENCE) study involved a cohort of 100 Italian children younger than 18 years of age with Covid-19 confirmed by reverse-transcriptasepolymerase-chain-reaction testing of nasal or nasopharyngeal swabs who were assessed between March 3 and March 27 in 17 pediatric emergency departments. Here, we describe the results of the CONFIDENCE study and compare them with those from three cohorts in previously published analyses.

Key study: Chilblain-like lesions during COVID-19 epidemic: a preliminary study on 63 patients.

Visit

PiccoloV,NeriI, FilippeschiC, et al.

Objective: We have recently noticed an outbreak of chilblainlike lesions in Italy contemporarily to COVID19 epidemic. Due to the wellknown lockdownrelated difficulties to visit the patients, we created a Google form aimed to collect information about patients presenting with these singular clinical findings. An easy to access and quick tool was chosen by the investigators in order to permit the other colleagues to spend the least amount of time, given the severe health emergency.

Key study: The characteristics of household transmission of COVID-19.

Visit

Li W, Zhang B, Lu J, et al.

Objective: Since December 2019, SARS-CoV-2 has extended to most parts of China with >80 000 cases and to at least 100 countries with >60 000 international cases as of 15 March 2020. Here we used a household cohort study to determine the features of household transmission of COVID-19.

Key study: Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases.

Visit

Casas CG, Catal A, Hernndez GC, et al.

Objectives: To describe the cutaneous manifestations of COVID-19 disease and to relate them to other clinical findings.

Key study: Assessment of 135794 pediatric patients tested for severe scute respiratory syndrome coronavirus across the United States.

Visit

Bailey LC, Razzaghi H, Burrows EK, et al.

Objective: To describe testing for SARS-CoV-2 and the epidemiology of infected patients.

Key study: Baseline characteristics, management, and outcomes of 55,270 children and adolescents diagnosed with COVID-19 and 1,952,693 with influenza in France, Germany, Spain, South Korea and the United States: an international network cohort study.

Visit

Duarte-Salles T, Vizcaya D, Pistillo A, et al.

Objectives To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children/adolescents diagnosed or hospitalized with COVID-19. Secondly, to describe health outcomes amongst children/adolescents diagnosed with previous seasonal influenza. Design International network cohort.

Key study: Cardiac abnormalities seen in pediatric patients during the SARS-CoV2 pandemic: an international experience.

Visit

Clark BC, Sanchez-de-Toledo J, Bautista-Rodriguez C, et al.

Objective: To describe the cardiac manifestations found in an international cohort of 55 pediatric cases with multi-system inflammatory syndrome (MIS-C) during the SARS-CoV2 pandemic.

Key study: COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study.

Visit

Gtzinger F, Santiago-Garca B, Noguera-Julin A, et al.

Objective: This study aimed to capture key data on children and adolescents with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection across Europe to inform physicians and health-care service planning during the ongoing pandemic.

Key study: Severe acute respiratory syndrome coronavirus 2 clinical syndromes and predictors of disease severity in hospitalized children and youth.

Visit

Fernandes DM, Oliveira CR, Guerguis S, et al.

Objective: To characterize the demographic and clinical features of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) syndromes and identify admission variables predictive of disease severity.

Key study: Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome.

Visit

Pereira MFB, Litvinov N, Farhat SCL, et al.

Objectives: To assess the outcomes of pediatric patients with laboratory-confirmed coronavirus disease (COVID-19) with or without multisystem inflammatory syndrome in children (MIS-C).

Key study: A case series of pediatric croup with COVID-19.

Visit

Venn AMR, Schmidt JM, Mullan PC.

Objective: We describe three previously healthy children, admitted from our emergency department (ED) to our free-standing children's hospital, as the first documented cases of croup as a manifestation of SARS-CoV-2 infection.

Key study: Anosmia and ageusia: not an uncommon presentation of COVID-19 infection in children and adolescents.

Visit

Mak PQ, Chung KS, Wong JS, Shek CC, Kwan MY.

Objective: We report three cases of pediatric patients with COVID-19 infection who presented with anosmia and/or ageusia.

Summary: Emergency preparedness and response: multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19).

Visit

Centers for Disease Control and Prevention

Objective: Providing 1) background information on several cases of a recently reported multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19); and 2) a case definition for this syndrome.

Key study: Characteristics and outcomes of children with Coronavirus disease 2019 (COVID-19) infection admitted to US and Canadian pediatric intensive care units.

Visit

Shekerdemian L, Mahmood N, Wolfe K, et al.

Objective To provide an early description and characterization of COVID-19 infection in North American PICUs, focusing on mode of presentation, presence of comorbidities, severity of disease, therapeutic interventions, clinical trajectory, and early outcomes.

Summary: Coronavirus disease 2019 in children United States, February 12-April 2, 2020.

Visit

US Centers for Disease Control and Prevention

Objective: To describe COVID-19 in children and adolescents in the United States.

Key study: Pediatric critical care and COVID19.

Visit

Gonzlez-Dambrauskas S, Vsquez-Hoyos P, Camporesi A, et al.

Objective: We provide preliminary insights into our first 17 children from 10 PICUs in Chile, Colombia, Italy, Spain, and the United States.

Key study: Clinical characteristics of children with Coronavirus disease 2019 in Hubei, China.

Visit

Zheng F, Liao C, Fan Q, et al.

Objective: The objective of this study is to describe the clinical characteristics of 25 hospitalized pediatric COVID-19.

Key study: Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding

Visit

Xu Y, Li X, Zhu B, et al.

Objective: We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA.

Key study: Pointofcare lung ultrasound findings in the pediatric emergency clinic during the COVID19 pandemic.

Visit

Tre E, Korkmaz MF, Aksoy FD, et al.

Objective: To describe our experience concerning lung ultrasound (LUS) in the pediatric emergency clinic, and to investigate the diagnostic value of LUS in coronavirus disease-2019 (COVID-19).

Key study: Asymptomatic cases in a family cluster with SARS-CoV-2 infection

Visit

Wu X, Li T, Ou X, et al

Objective: To report the findings from different types of clinical specimens collected from 82 infected individuals

Key study: SARS-CoV-2 Infection in Children.

Visit

Lu X, Zhang L, Du H, et al

Objective: In order to determine the spectrum of disease in children, we evaluated children infected with SARS-CoV-2 and treated at the Wuhan Childrens Hospital, the only center assigned by the central government for treating infected children under 16 years of age in Wuhan.

Key study: A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features

Visit

Jiehao C, Jing X, Daojiong L, et al

Objective: To report the clinical and epidemiological features in children with coronavirus diseases (COVID) in China.

Key study: Clinical features of paediatric patients with COVID-19: a report of two family clusters.

Visit

Ji L, Chao S, Wang Y, et al.

Objective: To retrospectively review two confirmed pediatric cases from two family clusters. Both clinical features and laboratory examination results of the children and their family members were described.

Key study: Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China.

Visit

Dong Y, Mo X, Hu Y, et al.

Objective: This study examined the epidemiological characteristics and transmission patterns of 2143 pediatric patients with COVID-19, using a retrospective analytical approach.

Key study: Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China

Visit

Wei M, Yuan J, Liu Y, et al.,

Objective: For this retrospective study, authors identified all hospitalized infants diagnosed with COVID-19 infection between December 8, 2019, and February 6, 2020, in China and described demographic, epidemiologic, and clinical features.

Key study: Clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children

Visit

Hong H et al.,

Objective: To describe the clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children

Key study: Report on the Epidemiological Features of Coronavirus Disease 2019 (COVID-19) Outbreak in the Republic of Korea from January 19 to March 2, 2020.

Visit

Korean Society of Infectious Diseases, Korean Society of Pediatric Infectious...

Objective: This report summarizes the epidemiologic features and the snapshots of the outbreak in the Republic of Korea from January 19 and March 2, 2020.

Key study: Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single centers observational study.

Visit

Sun D, Li H, Lu X, et al.,

Objective: To describe the clinical features of severe pediatric patients with COVID-19.

Key study: Clinical presentation and virological assessment of hospitalized cases of coronavirus disease 2019 in a travel-associated transmission cluster.

Visit

Woelfel R, Corman VM, Guggemos W, et al.,

Objective: To study the viral load courses by RT-PCR in oro- and nasopharyngeal swabs, sputum, stool, blood, and urine in nine hospitalized cases. Infectious virus was detected by cell culture.

Key study: Acral cutaneous lesions in the time of COVID-19.

Visit

Recalcati S, Barbagallo T, Frasin LA, et al.

Objective: We report here on peculiar (perniosislike) skin lesions, unreported in the previous years, observed in young outpatients visited in our dermatologic unit in the last 4 weeks of COVID19 pandemic (MarchApril 2020).

Key study: Children with Covid-19 in pediatric emergency departments in Italy.

Visit

Parri N, Lenge M, Buonsenso D, Coronavirus Infection in Public Emergency Depa...

Objective: The Coronavirus Infection in Pediatric Emergency Departments (CONFIDENCE) study involved a cohort of 100 Italian children younger than 18 years of age with Covid-19 confirmed by reverse-transcriptasepolymerase-chain-reaction testing of nasal or nasopharyngeal swabs who were assessed between March 3 and March 27 in 17 pediatric emergency departments. Here, we describe the results of the CONFIDENCE study and compare them with those from three cohorts in previously published analyses.

Key study: Chilblain-like lesions during COVID-19 epidemic: a preliminary study on 63 patients.

Visit

PiccoloV,NeriI, FilippeschiC, et al.

Objective: We have recently noticed an outbreak of chilblainlike lesions in Italy contemporarily to COVID19 epidemic. Due to the wellknown lockdownrelated difficulties to visit the patients, we created a Google form aimed to collect information about patients presenting with these singular clinical findings. An easy to access and quick tool was chosen by the investigators in order to permit the other colleagues to spend the least amount of time, given the severe health emergency.

Key study: The characteristics of household transmission of COVID-19.

Visit

Li W, Zhang B, Lu J, et al.

Objective: Since December 2019, SARS-CoV-2 has extended to most parts of China with >80 000 cases and to at least 100 countries with >60 000 international cases as of 15 March 2020. Here we used a household cohort study to determine the features of household transmission of COVID-19.

Key study: Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases.

Visit

Casas CG, Catal A, Hernndez GC, et al.

Objectives: To describe the cutaneous manifestations of COVID-19 disease and to relate them to other clinical findings.

Key study: Assessment of 135794 pediatric patients tested for severe scute respiratory syndrome coronavirus across the United States.

Visit

Bailey LC, Razzaghi H, Burrows EK, et al.

Objective: To describe testing for SARS-CoV-2 and the epidemiology of infected patients.

Key study: Baseline characteristics, management, and outcomes of 55,270 children and adolescents diagnosed with COVID-19 and 1,952,693 with influenza in France, Germany, Spain, South Korea and the United States: an international network cohort study.

Visit

Duarte-Salles T, Vizcaya D, Pistillo A, et al.

Objectives To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children/adolescents diagnosed or hospitalized with COVID-19. Secondly, to describe health outcomes amongst children/adolescents diagnosed with previous seasonal influenza. Design International network cohort.

Key study: Cardiac abnormalities seen in pediatric patients during the SARS-CoV2 pandemic: an international experience.

Visit

Clark BC, Sanchez-de-Toledo J, Bautista-Rodriguez C, et al.

Objective: To describe the cardiac manifestations found in an international cohort of 55 pediatric cases with multi-system inflammatory syndrome (MIS-C) during the SARS-CoV2 pandemic.

Key study: COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study.

Visit

Gtzinger F, Santiago-Garca B, Noguera-Julin A, et al.

Objective: This study aimed to capture key data on children and adolescents with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection across Europe to inform physicians and health-care service planning during the ongoing pandemic.

Key study: Severe acute respiratory syndrome coronavirus 2 clinical syndromes and predictors of disease severity in hospitalized children and youth.

Visit

Fernandes DM, Oliveira CR, Guerguis S, et al.

Objective: To characterize the demographic and clinical features of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) syndromes and identify admission variables predictive of disease severity.

Key study: Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome.

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Pereira MFB, Litvinov N, Farhat SCL, et al.

Objectives: To assess the outcomes of pediatric patients with laboratory-confirmed coronavirus disease (COVID-19) with or without multisystem inflammatory syndrome in children (MIS-C).

Key study: A case series of pediatric croup with COVID-19.

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Venn AMR, Schmidt JM, Mullan PC.

Objective: We describe three previously healthy children, admitted from our emergency department (ED) to our free-standing children's hospital, as the first documented cases of croup as a manifestation of SARS-CoV-2 infection.

Key study: Anosmia and ageusia: not an uncommon presentation of COVID-19 infection in children and adolescents.

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Mak PQ, Chung KS, Wong JS, Shek CC, Kwan MY.

Objective: We report three cases of pediatric patients with COVID-19 infection who presented with anosmia and/or ageusia.

Summary: Emergency preparedness and response: multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19).

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Centers for Disease Control and Prevention

Objective: Providing 1) background information on several cases of a recently reported multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19); and 2) a case definition for this syndrome.

Key study: Characteristics and outcomes of children with Coronavirus disease 2019 (COVID-19) infection admitted to US and Canadian pediatric intensive care units.

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Shekerdemian L, Mahmood N, Wolfe K, et al.

Objective To provide an early description and characterization of COVID-19 infection in North American PICUs, focusing on mode of presentation, presence of comorbidities, severity of disease, therapeutic interventions, clinical trajectory, and early outcomes.

Summary: Coronavirus disease 2019 in children United States, February 12-April 2, 2020.

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US Centers for Disease Control and Prevention

Objective: To describe COVID-19 in children and adolescents in the United States.

Key study: Pediatric critical care and COVID19.

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Gonzlez-Dambrauskas S, Vsquez-Hoyos P, Camporesi A, et al.

Objective: We provide preliminary insights into our first 17 children from 10 PICUs in Chile, Colombia, Italy, Spain, and the United States.

Key study: Clinical characteristics of children with Coronavirus disease 2019 in Hubei, China.

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Zheng F, Liao C, Fan Q, et al.

Objective: The objective of this study is to describe the clinical characteristics of 25 hospitalized pediatric COVID-19.

Key study: Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding

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Xu Y, Li X, Zhu B, et al.

Objective: We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA.

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Overview of systematic reviews: Systematic review of reviews of symptoms and signs of COVID-19 in children and adolescents.

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Viner RM, Ward JL, Hudson LD, et al.

Objective: To undertake a systematic review of reviews of the prevalence of symptoms and signs of COVID-19 in those aged under 20 years.

Overview of systematic reviews: Systematic review of reviews of symptoms and signs of COVID-19 in children and adolescents.

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Viner RM, Ward JL, Hudson LD, et al.

Objective: To undertake a systematic review of reviews of the prevalence of symptoms and signs of COVID-19 in those aged under 20 years.

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