Logo

Procedural sedation and analgesia, commonly referred to as “sedation,” is a treatment strategy to relieve pain, anxiety and suppress patient movements during diagnostic and therapeutic procedures by administering anxiolytic, sedative, analgesic, and/or dissociative drugs. The goal is to minimize patient awareness and discomfort while maintaining patient safety. Sedation depth should vary in accordance with the specific needs of the patient and procedure.

BROWSE EVIDENCE REPOSITORY

 

Systematic reviews English (9) French All (9)

Systematic Review: Intranasal ketamine for procedural sedation and analgesia in children

Visit

Poonai N, Canton K, Ali S, Hendrikx S, Shah A, Miller M, Joubert G, Rieder M,...

Evidence suggests ketamine can be administered intranasally. This study reviews the evidence for intranasal ketamine for procedural sedation and analgesia in children.

Review: Update on pharmacological management of procedural sedation in children

Visit

Roback MG, Carlson DW, Babl FE, Kennedy RM

This review provides an update on pharmacological techniques for procedural sedation for children outside the operating room.

Systematic Review: Nitrous oxide provides safe and effective analgesia for minor paediatric procedures--a systematic review

Visit

Pedersen RS, Bayat A, Steen NP, Jacobsson ML

The aim of this review was to investigate the safety and efficacy of nitrous oxide during brief, but painful paediatric procedures and to compare nitrous oxide with some of the commonly used pharmacological and non-pharmacological treatments for relieving anxiety and mild to moderate pain in Denmark.

Systematic Review: Intravenous vs intramuscular ketamine for pediatric procedural sedation by emergency medicine specialists: a review

Visit

Deasy C, Babl FE

This review investigated existing evidence to determine whether ketamine should be best administered intravenously or intramuscularly.

Systematic Review: Professional skills and competence for safe and effective procedural sedation in children: recommendations based on a systematic review of the literature

Visit

Leroy PL, Schipper DM, Knape HJ

This review investigated which skills and competence were imperative to assure optimal effectiveness and safety of procedural sedation (PS) in children and analyzed the underlying levels of evidence.

Systematic Review: Predictors of emesis and recovery agitation with emergency department ketamine sedation: an individual-patient data meta-analysis of 8,282 children

Visit

Green SM, Roback MG, Krauss B, Brown L, McGlone RG, Agrawal D, McKee M, Weiss...

Ketamine is widely used in emergency departments (EDs) to facilitate painful procedures; however, existing descriptors of predictors of emesis and recovery agitation are derived from relatively small studies.

Systematic Review: Predictors of airway and respiratory adverse events with ketamine sedation in the emergency department: an individual-patient data meta-analysis of 8,282 children

Visit

Green SM, Roback MG, Krauss B, Brown L, McGlone RG, Agrawal D, McKee M, Weiss...

Although ketamine is one of the most commonly used sedatives to facilitate painful procedures for children in the emergency department (ED), existing studies have not been large enough to identify clinical factors that are predictive of uncommon airway and respiratory adverse events.

Systematic Review: Sedation and analgesia for pediatric fracture reduction in the emergency department: a systematic review

Visit

Migita RT, Klein EJ, Garrison MM

This review assessed the safety and efficacy of various forms of analgesia and sedation for fracture reduction in pediatric patients in the emergency department, as observed in randomized controlled trials in pediatric populations.

Systematic Review: Clinical policy: evidence-based approach to pharmacologic agents used in pediatric sedation and analgesia in the emergency department

Visit

Mace SE, Barata IA, Cravero JP, Dalsey WC, Godwin SA, Kennedy RM, Malley KC, ...

This document is a clinical policy on pediatric procedural sedation.

Systematic Review: Intranasal ketamine for procedural sedation and analgesia in children

Visit

Poonai N, Canton K, Ali S, Hendrikx S, Shah A, Miller M, Joubert G, Rieder M,...

Evidence suggests ketamine can be administered intranasally. This study reviews the evidence for intranasal ketamine for procedural sedation and analgesia in children.

Review: Update on pharmacological management of procedural sedation in children

Visit

Roback MG, Carlson DW, Babl FE, Kennedy RM

This review provides an update on pharmacological techniques for procedural sedation for children outside the operating room.

Systematic Review: Nitrous oxide provides safe and effective analgesia for minor paediatric procedures--a systematic review

Visit

Pedersen RS, Bayat A, Steen NP, Jacobsson ML

The aim of this review was to investigate the safety and efficacy of nitrous oxide during brief, but painful paediatric procedures and to compare nitrous oxide with some of the commonly used pharmacological and non-pharmacological treatments for relieving anxiety and mild to moderate pain in Denmark.

Systematic Review: Intravenous vs intramuscular ketamine for pediatric procedural sedation by emergency medicine specialists: a review

Visit

Deasy C, Babl FE

This review investigated existing evidence to determine whether ketamine should be best administered intravenously or intramuscularly.

Systematic Review: Professional skills and competence for safe and effective procedural sedation in children: recommendations based on a systematic review of the literature

Visit

Leroy PL, Schipper DM, Knape HJ

This review investigated which skills and competence were imperative to assure optimal effectiveness and safety of procedural sedation (PS) in children and analyzed the underlying levels of evidence.

Systematic Review: Predictors of emesis and recovery agitation with emergency department ketamine sedation: an individual-patient data meta-analysis of 8,282 children

Visit

Green SM, Roback MG, Krauss B, Brown L, McGlone RG, Agrawal D, McKee M, Weiss...

Ketamine is widely used in emergency departments (EDs) to facilitate painful procedures; however, existing descriptors of predictors of emesis and recovery agitation are derived from relatively small studies.

Systematic Review: Predictors of airway and respiratory adverse events with ketamine sedation in the emergency department: an individual-patient data meta-analysis of 8,282 children

Visit

Green SM, Roback MG, Krauss B, Brown L, McGlone RG, Agrawal D, McKee M, Weiss...

Although ketamine is one of the most commonly used sedatives to facilitate painful procedures for children in the emergency department (ED), existing studies have not been large enough to identify clinical factors that are predictive of uncommon airway and respiratory adverse events.

Systematic Review: Sedation and analgesia for pediatric fracture reduction in the emergency department: a systematic review

Visit

Migita RT, Klein EJ, Garrison MM

This review assessed the safety and efficacy of various forms of analgesia and sedation for fracture reduction in pediatric patients in the emergency department, as observed in randomized controlled trials in pediatric populations.

Systematic Review: Clinical policy: evidence-based approach to pharmacologic agents used in pediatric sedation and analgesia in the emergency department

Visit

Mace SE, Barata IA, Cravero JP, Dalsey WC, Godwin SA, Kennedy RM, Malley KC, ...

This document is a clinical policy on pediatric procedural sedation.