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All systematic reviews

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Acute Agitation English (2) French All (2)

A Retrospective Review of Antipsychotic Medications Administered to Psychiatric Patients in a Tertiary Care Pediatric Emergency Department  (2019)

A Retrospective Review of Antipsychotic Medications Administered to Psychiatric Patients in a Tertiary Care Pediatric Emergency Department

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Rudolf, F., K. Hollenbach, K. L. Carstairs and S. D. Carstairs

Rudolf, F., K. Hollenbach, K. L. Carstairs and S. D. Carstairs

Safety and effectiveness of physostigmine: a 10-year retrospective review*  (2018)

Safety and effectiveness of physostigmine: a 10-year retrospective review*

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Arens, A. M., K. Shah, S. Al-Abri, K. R. Olson and T. Kearney

Arens, A. M., K. Shah, S. Al-Abri, K. R. Olson and T. Kearney

A Retrospective Review of Antipsychotic Medications Administered to Psychiatric Patients in a Tertiary Care Pediatric Emergency Department  (2019)

A Retrospective Review of Antipsychotic Medications Administered to Psychiatric Patients in a Tertiary Care Pediatric Emergency Department

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Rudolf, F., K. Hollenbach, K. L. Carstairs and S. D. Carstairs

Rudolf, F., K. Hollenbach, K. L. Carstairs and S. D. Carstairs

Safety and effectiveness of physostigmine: a 10-year retrospective review*  (2018)

Safety and effectiveness of physostigmine: a 10-year retrospective review*

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Arens, A. M., K. Shah, S. Al-Abri, K. R. Olson and T. Kearney

Arens, A. M., K. Shah, S. Al-Abri, K. R. Olson and T. Kearney

Acute Otitis Media English (12) French All (12)

Cochrane Review: Pneumococcal conjugate vaccines for preventing acute otitis media in children  (2020)

Cochrane Review: Pneumococcal conjugate vaccines for preventing acute otitis media in children

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de Svaux JLH, Venekamp RP, Lutje V, Hak E, Schilder AGM, Sanders EAM, Damoiseaux RAMJ de

de Svaux JLH, Venekamp RP, Lutje V, Hak E, Schilder AGM, Sanders EAM, Damoise...

Objective: To assess the effect of PCVs in preventing AOM in children up to 12 years of age.

Systematic Review: Clinical practice guidelines for acute otitis media in children: a systematic review and appraisal of European national guidelines  (2020)

Systematic Review: Clinical practice guidelines for acute otitis media in children: a systematic review and appraisal of European national guidelines

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Suzuki, H.G. et al.

Suzuki, H.G. et al.

Objective: To appraise European guidelines for acute otitis media (AOM) in children, including methodological quality, level of evidence (LoE), astrength of recommendations (SoR), and consideration of antibiotic stewardship

Systematic Review: A systematic review and meta-analysis of antimicrobial resistance in paediatric acute otitis media  (2019)

Systematic Review: A systematic review and meta-analysis of antimicrobial resistance in paediatric acute otitis media

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Michael W. Mathera, Michael Drinnana, John D. Perryc, Steven Powellb, Janet A. Wilsonb, Jason Powella

Michael W. Mathera, Michael Drinnana, John D. Perryc, Steven Powellb, Janet A...

Objective: We present a comprehensive review and meta-analysis, of both the microbiology and antimicrobial resistance of AOM organisms to commonly used antimicrobial agents, with the aim of informing responsible antimicrobial stewardship.

Cochrane Review: Probiotics for preventing acute otitis media in children  (2019)

Cochrane Review: Probiotics for preventing acute otitis media in children

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Scott AM, Clark J, Julien B, Islam F, Roos K, Grimwood K, Little P, Del Mar CB

Scott AM, Clark J, Julien B, Islam F, Roos K, Grimwood K, Little P, Del Mar CB

Objective: To assess the effects of probiotics to prevent the occurrence and reduce the severity of acute otitis media in children.

Review: From paper to practice: Strategies for improving antibiotic stewardship in the pediatric ambulatory setting.  (2018)

Review: From paper to practice: Strategies for improving antibiotic stewardship in the pediatric ambulatory setting.

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Bozzella MJ, Harik N, Newland JG, Hamdy RF

Bozzella MJ, Harik N, Newland JG, Hamdy RF

Objective: The intent with this review is to provide an overview of strategies that pediatric providers can take from paper to practice.

Cochrane Systematic Review: Systemic corticosteroids for acute otitis media in children  (2018)

Cochrane Systematic Review: Systemic corticosteroids for acute otitis media in children

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Ranakusuma RW, Pitoyo Y, Safitri ED, Thorning S, Beller EM, Sastroasmoro S, Del Mar CB

Ranakusuma RW, Pitoyo Y, Safitri ED, Thorning S, Beller EM, Sastroasmoro S, D...

Objective: To assess the effects of systemic corticosteroids (oral or parenteral), with or without antibiotics, for AOM in children.

Cochrane Systematic Review: Influenza vaccines for preventing acute otitis media in infants and children  (2017)

Cochrane Systematic Review: Influenza vaccines for preventing acute otitis media in infants and children

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Norhayati MN, Ho JJ, Azman MY

Norhayati MN, Ho JJ, Azman MY

Objective: To assess the effectiveness of influenza vaccine in reducing the occurrence of acute otitis media in infants and children.

Review: Antibiotic therapy for children with acute otitis media  (2017)

Review: Antibiotic therapy for children with acute otitis media

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Sakulchit T, Goldman RD

Sakulchit T, Goldman RD

Objective: Review of AOM and the evidence regarding use of antibiotics or watchful waiting to treat children at different levels of disease severity.

Cochrane Systematic Review: Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children  (2016)

Cochrane Systematic Review: Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children

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Sjoukes A, Venekamp RP, van de Pol AC, Hay AD, Little P, Schilder AG, Damoiseaux RA

Sjoukes A, Venekamp RP, van de Pol AC, Hay AD, Little P, Schilder AG, Damoise...

Objective: Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM. Our secondary objective was to assess the effectiveness of NSAIDs compared with paracetamol in children with AOM.

Cochrane Systematic Review: Antibiotics for otitis media with effusion in children  (2016)

Cochrane Systematic Review: Antibiotics for otitis media with effusion in children

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Venekamp RP, Burton MJ, van Dongen TM, van der Heijden GJ, van Zon A, Schilder AG

Venekamp RP, Burton MJ, van Dongen TM, van der Heijden GJ, van Zon A, Schilde...

Objective: To assess the benefits and harms of oral antibiotics in children up to 18 years with OME.

Cochrane Systematic Review: Antibiotics for acute otitis media in children  (2015)

Cochrane Systematic Review: Antibiotics for acute otitis media in children

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Venekamp RP, Sanders SL, Glasziou PP, Del Mar CB, Rovers MM

Venekamp RP, Sanders SL, Glasziou PP, Del Mar CB, Rovers MM

Objective: To assess the effects of antibiotics for children with AOM.

Systematic Review: Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis  (2010)

Systematic Review: Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis

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Costelloe C, Metcalfe C, Lovering A, Mant D, Hay AD

Costelloe C, Metcalfe C, Lovering A, Mant D, Hay AD

Objective: To systematically review the literature and, where appropriate, meta-analyse studies investigating subsequent antibiotic resistance in individuals prescribed antibiotics in primary care.

Cochrane Review: Pneumococcal conjugate vaccines for preventing acute otitis media in children  (2020)

Cochrane Review: Pneumococcal conjugate vaccines for preventing acute otitis media in children

Download

de Svaux JLH, Venekamp RP, Lutje V, Hak E, Schilder AGM, Sanders EAM, Damoiseaux RAMJ de

de Svaux JLH, Venekamp RP, Lutje V, Hak E, Schilder AGM, Sanders EAM, Damoise...

Objective: To assess the effect of PCVs in preventing AOM in children up to 12 years of age.

Systematic Review: Clinical practice guidelines for acute otitis media in children: a systematic review and appraisal of European national guidelines  (2020)

Systematic Review: Clinical practice guidelines for acute otitis media in children: a systematic review and appraisal of European national guidelines

Download

Suzuki, H.G. et al.

Suzuki, H.G. et al.

Objective: To appraise European guidelines for acute otitis media (AOM) in children, including methodological quality, level of evidence (LoE), astrength of recommendations (SoR), and consideration of antibiotic stewardship

Systematic Review: A systematic review and meta-analysis of antimicrobial resistance in paediatric acute otitis media  (2019)

Systematic Review: A systematic review and meta-analysis of antimicrobial resistance in paediatric acute otitis media

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Michael W. Mathera, Michael Drinnana, John D. Perryc, Steven Powellb, Janet A. Wilsonb, Jason Powella

Michael W. Mathera, Michael Drinnana, John D. Perryc, Steven Powellb, Janet A...

Objective: We present a comprehensive review and meta-analysis, of both the microbiology and antimicrobial resistance of AOM organisms to commonly used antimicrobial agents, with the aim of informing responsible antimicrobial stewardship.

Cochrane Review: Probiotics for preventing acute otitis media in children  (2019)

Cochrane Review: Probiotics for preventing acute otitis media in children

Download

Scott AM, Clark J, Julien B, Islam F, Roos K, Grimwood K, Little P, Del Mar CB

Scott AM, Clark J, Julien B, Islam F, Roos K, Grimwood K, Little P, Del Mar CB

Objective: To assess the effects of probiotics to prevent the occurrence and reduce the severity of acute otitis media in children.

Review: From paper to practice: Strategies for improving antibiotic stewardship in the pediatric ambulatory setting.  (2018)

Review: From paper to practice: Strategies for improving antibiotic stewardship in the pediatric ambulatory setting.

Visit

Bozzella MJ, Harik N, Newland JG, Hamdy RF

Bozzella MJ, Harik N, Newland JG, Hamdy RF

Objective: The intent with this review is to provide an overview of strategies that pediatric providers can take from paper to practice.

Cochrane Systematic Review: Systemic corticosteroids for acute otitis media in children  (2018)

Cochrane Systematic Review: Systemic corticosteroids for acute otitis media in children

Visit

Ranakusuma RW, Pitoyo Y, Safitri ED, Thorning S, Beller EM, Sastroasmoro S, Del Mar CB

Ranakusuma RW, Pitoyo Y, Safitri ED, Thorning S, Beller EM, Sastroasmoro S, D...

Objective: To assess the effects of systemic corticosteroids (oral or parenteral), with or without antibiotics, for AOM in children.

Cochrane Systematic Review: Influenza vaccines for preventing acute otitis media in infants and children  (2017)

Cochrane Systematic Review: Influenza vaccines for preventing acute otitis media in infants and children

Visit

Norhayati MN, Ho JJ, Azman MY

Norhayati MN, Ho JJ, Azman MY

Objective: To assess the effectiveness of influenza vaccine in reducing the occurrence of acute otitis media in infants and children.

Review: Antibiotic therapy for children with acute otitis media  (2017)

Review: Antibiotic therapy for children with acute otitis media

Visit

Sakulchit T, Goldman RD

Sakulchit T, Goldman RD

Objective: Review of AOM and the evidence regarding use of antibiotics or watchful waiting to treat children at different levels of disease severity.

Cochrane Systematic Review: Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children  (2016)

Cochrane Systematic Review: Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children

Visit

Sjoukes A, Venekamp RP, van de Pol AC, Hay AD, Little P, Schilder AG, Damoiseaux RA

Sjoukes A, Venekamp RP, van de Pol AC, Hay AD, Little P, Schilder AG, Damoise...

Objective: Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM. Our secondary objective was to assess the effectiveness of NSAIDs compared with paracetamol in children with AOM.

Cochrane Systematic Review: Antibiotics for otitis media with effusion in children  (2016)

Cochrane Systematic Review: Antibiotics for otitis media with effusion in children

Visit

Venekamp RP, Burton MJ, van Dongen TM, van der Heijden GJ, van Zon A, Schilder AG

Venekamp RP, Burton MJ, van Dongen TM, van der Heijden GJ, van Zon A, Schilde...

Objective: To assess the benefits and harms of oral antibiotics in children up to 18 years with OME.

Cochrane Systematic Review: Antibiotics for acute otitis media in children  (2015)

Cochrane Systematic Review: Antibiotics for acute otitis media in children

Visit

Venekamp RP, Sanders SL, Glasziou PP, Del Mar CB, Rovers MM

Venekamp RP, Sanders SL, Glasziou PP, Del Mar CB, Rovers MM

Objective: To assess the effects of antibiotics for children with AOM.

Systematic Review: Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis  (2010)

Systematic Review: Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis

Visit

Costelloe C, Metcalfe C, Lovering A, Mant D, Hay AD

Costelloe C, Metcalfe C, Lovering A, Mant D, Hay AD

Objective: To systematically review the literature and, where appropriate, meta-analyse studies investigating subsequent antibiotic resistance in individuals prescribed antibiotics in primary care.

Anaphylaxis English (17) French All (17)

Review:Cardiac safety of second-generation H1 -antihistamines when updosed in chronic spontaneous urticaria  (2019)

Review:Cardiac safety of second-generation H1 -antihistamines when updosed in chronic spontaneous urticaria

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Cataldi M, Maurer M, Taglialatela M, Church MK.

Cataldi M, Maurer M, Taglialatela M, Church MK.

To overview literature cardiac health and second wave antihistamines

Review: Guiding Principles for the Recognition, Diagnosis, and Management of Infants With Anaphylaxis: An Expert Panel Consensus  (2019)

Review: Guiding Principles for the Recognition, Diagnosis, and Management of Infants With Anaphylaxis: An Expert Panel Consensus

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Greenhawt, M., Gupta, R. S., Meadows, J. A., Pistiner, M., Spergel, J. M., Camargo, C. A., Jr, Simons, F., Lieberman, P. L

Greenhawt, M., Gupta, R. S., Meadows, J. A., Pistiner, M., Spergel, J. M., Ca...

To overview the current recommendations for yes

Review: Evaluation of Prehospital Management in a Canadian Emergency Department Anaphylaxis Cohort.  (2019)

Review: Evaluation of Prehospital Management in a Canadian Emergency Department Anaphylaxis Cohort.

Visit

Gabrielli S, Clarke A, Morris J, et al.

Gabrielli S, Clarke A, Morris J, et al.

To assess prehospital management of anaphylaxis by measuring the effect of epinephrine use compared with antihistamines and corticosteroids on negative outcomes of anaphylaxis (intensive care unit/hospital ward admission, multiple doses of epinephrine in the emergency department [ED], and intravenous fluids given in the ED).

Review: Duration of Observation for Detecting a Biphasic Reaction in Anaphylaxis: A Meta-Analysis.  (2019)

Review: Duration of Observation for Detecting a Biphasic Reaction in Anaphylaxis: A Meta-Analysis.

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Kim TH, Yoon SH, Hong H, Kang HR, Cho SH, Lee SY.

Kim TH, Yoon SH, Hong H, Kang HR, Cho SH, Lee SY.

to determine a practical observation time for detecting a biphasic reaction after resolution of the initial anaphylactic reaction.

Review: Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of data from The European Anaphylaxis Registry.  (2018)

Review: Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of data from The European Anaphylaxis Registry.

Visit

Worm M, Francuzik W, Renaudin JM, et al.

Worm M, Francuzik W, Renaudin JM, et al.

To identify and prioritize factors associated with an increased risk of developing severe anaphylaxis.

Review: Epinephrine auto-injector needle lengths Can both subcutaneous and periosteal / intraosseous injection be avoided ?  (2018)

Review: Epinephrine auto-injector needle lengths Can both subcutaneous and periosteal / intraosseous injection be avoided ?

Visit

Dreborg S, Kim L, Tsai G, Kim H.

Dreborg S, Kim L, Tsai G, Kim H.

To discuss suitable EAI needle lengths based on ultrasound measurements related to weight.

Review: Do Corticosteroids Prevent Biphasic Anaphylaxis?  (2017)

Review: Do Corticosteroids Prevent Biphasic Anaphylaxis?

Visit

Alqurashi W, Ellis AK

Alqurashi W, Ellis AK

This review analyzes the use of corticosteroids for reducing anaphylaxis severity and preventing biphasic anaphylaxis.

Review: Quality indicators for the acute and long-term management of anaphylaxis: a systematic review.  (2017)

Review: Quality indicators for the acute and long-term management of anaphylaxis: a systematic review.

Visit

Dhami S, Sheikh A, Muraro A, et al.

Dhami S, Sheikh A, Muraro A, et al.

To identify quality indicators to support the acute and long-term management of anaphylaxis.

Review: Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase.  (2017)

Review: Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase.

Visit

Motola D, Donati M, Biagi C, et al.

Motola D, Donati M, Biagi C, et al.

comparative analysis of the safety profiles of H1antihistamines using data from the WHO database

Comprehensive Review: Pitfalls in the use of epinephrine for anaphylaxis: patient and provider opportunities for improvement  (2016)

Comprehensive Review: Pitfalls in the use of epinephrine for anaphylaxis: patient and provider opportunities for improvement

Visit

Cohen MB, Saunders SS, Wise SK, Nassif S, Platt MP

Cohen MB, Saunders SS, Wise SK, Nassif S, Platt MP

The purpose of this study was to identify the scope of epinephrine pitfalls and opportunities for improvement in the management of allergy emergencies.

Systematic Review: Time of Onset and Predictors of Biphasic Anaphylactic Reactions: A Systematic Review and Meta-analysis  (2015)

Systematic Review: Time of Onset and Predictors of Biphasic Anaphylactic Reactions: A Systematic Review and Meta-analysis

Visit

Lee S, Bellolio MF, Hess EP, Erwin P, Murad MH, Campbell RL

Lee S, Bellolio MF, Hess EP, Erwin P, Murad MH, Campbell RL

The aim of this study was to evaluate the time of onset and predictors of biphasic anaphylactic reactions.

Review: Anaphylaxis: Unique aspects of clinical diagnosis and management in infants (birth to age 2 years)  (2015)

Review: Anaphylaxis: Unique aspects of clinical diagnosis and management in infants (birth to age 2 years)

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Simons FE, Sampson HA

Simons FE, Sampson HA

In this rostrum we aim to increase awareness of anaphylaxis in infancy in order to improve clinical diagnosis, management, and prevention of recurrences.

Review: Risk multipliers for severe food anaphylaxis  (2015)

Review: Risk multipliers for severe food anaphylaxis

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Smith PK, Hourihane JO, Lieberman P

Smith PK, Hourihane JO, Lieberman P

This paper reviews the factors that contribute to the risk of severe anaphylactic events and provides a framework for the ongoing management of patients at risk of severe food allergy.

Systematic Review: H2-antihistamines for the treatment of anaphylaxis with and without shock: a systematic review  (2014)

Systematic Review: H2-antihistamines for the treatment of anaphylaxis with and without shock: a systematic review

Visit

Nurmatov UB, Rhatigan E, Simons FE, Sheikh A

Nurmatov UB, Rhatigan E, Simons FE, Sheikh A

The objective of this systematic review was to assess the benefits and harms of H2-antihistamines in the treatment of anaphylaxis.

Cochrane Systematic Review: Glucocorticoids for the treatment of anaphylaxis  (2012)

Cochrane Systematic Review: Glucocorticoids for the treatment of anaphylaxis

Visit

Choo KJ, Simons FE, Sheikh A

Choo KJ, Simons FE, Sheikh A

We sought to assess the benefits and harms of glucocorticoid treatment during episodes of anaphylaxis.

Cochrane Systematic Review: Adrenaline auto-injectors for the treatment of anaphylaxis with and without cardiovascular collapse in the community  (2012)

Cochrane Systematic Review: Adrenaline auto-injectors for the treatment of anaphylaxis with and without cardiovascular collapse in the community

Visit

Sheikh A, Simons FE, Barbour V, Worth A

Sheikh A, Simons FE, Barbour V, Worth A

The objective of this systematic review was to assess the effectiveness of adrenaline (epinephrine) auto-injectors in relieving respiratory, cardiovascular, and other symptoms during episodes of anaphylaxis that occur in the community.

Cochrane Systematic Review: H1-antihistamines for the treatment of anaphylaxis with and without shock  (2007)

Cochrane Systematic Review: H1-antihistamines for the treatment of anaphylaxis with and without shock

Visit

Sheikh A, ten Broek VM, Brown SG, Simons FE

Sheikh A, ten Broek VM, Brown SG, Simons FE

The objective of this systematic review was to assess the benefits and harm of H1-antihistamines in the treatment of anaphylaxis.

Review:Cardiac safety of second-generation H1 -antihistamines when updosed in chronic spontaneous urticaria  (2019)

Review:Cardiac safety of second-generation H1 -antihistamines when updosed in chronic spontaneous urticaria

Visit

Cataldi M, Maurer M, Taglialatela M, Church MK.

Cataldi M, Maurer M, Taglialatela M, Church MK.

To overview literature cardiac health and second wave antihistamines

Review: Guiding Principles for the Recognition, Diagnosis, and Management of Infants With Anaphylaxis: An Expert Panel Consensus  (2019)

Review: Guiding Principles for the Recognition, Diagnosis, and Management of Infants With Anaphylaxis: An Expert Panel Consensus

Visit

Greenhawt, M., Gupta, R. S., Meadows, J. A., Pistiner, M., Spergel, J. M., Camargo, C. A., Jr, Simons, F., Lieberman, P. L

Greenhawt, M., Gupta, R. S., Meadows, J. A., Pistiner, M., Spergel, J. M., Ca...

To overview the current recommendations for yes

Review: Evaluation of Prehospital Management in a Canadian Emergency Department Anaphylaxis Cohort.  (2019)

Review: Evaluation of Prehospital Management in a Canadian Emergency Department Anaphylaxis Cohort.

Visit

Gabrielli S, Clarke A, Morris J, et al.

Gabrielli S, Clarke A, Morris J, et al.

To assess prehospital management of anaphylaxis by measuring the effect of epinephrine use compared with antihistamines and corticosteroids on negative outcomes of anaphylaxis (intensive care unit/hospital ward admission, multiple doses of epinephrine in the emergency department [ED], and intravenous fluids given in the ED).

Review: Duration of Observation for Detecting a Biphasic Reaction in Anaphylaxis: A Meta-Analysis.  (2019)

Review: Duration of Observation for Detecting a Biphasic Reaction in Anaphylaxis: A Meta-Analysis.

Visit

Kim TH, Yoon SH, Hong H, Kang HR, Cho SH, Lee SY.

Kim TH, Yoon SH, Hong H, Kang HR, Cho SH, Lee SY.

to determine a practical observation time for detecting a biphasic reaction after resolution of the initial anaphylactic reaction.

Review: Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of data from The European Anaphylaxis Registry.  (2018)

Review: Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of data from The European Anaphylaxis Registry.

Visit

Worm M, Francuzik W, Renaudin JM, et al.

Worm M, Francuzik W, Renaudin JM, et al.

To identify and prioritize factors associated with an increased risk of developing severe anaphylaxis.

Review: Epinephrine auto-injector needle lengths Can both subcutaneous and periosteal / intraosseous injection be avoided ?  (2018)

Review: Epinephrine auto-injector needle lengths Can both subcutaneous and periosteal / intraosseous injection be avoided ?

Visit

Dreborg S, Kim L, Tsai G, Kim H.

Dreborg S, Kim L, Tsai G, Kim H.

To discuss suitable EAI needle lengths based on ultrasound measurements related to weight.

Review: Do Corticosteroids Prevent Biphasic Anaphylaxis?  (2017)

Review: Do Corticosteroids Prevent Biphasic Anaphylaxis?

Visit

Alqurashi W, Ellis AK

Alqurashi W, Ellis AK

This review analyzes the use of corticosteroids for reducing anaphylaxis severity and preventing biphasic anaphylaxis.

Review: Quality indicators for the acute and long-term management of anaphylaxis: a systematic review.  (2017)

Review: Quality indicators for the acute and long-term management of anaphylaxis: a systematic review.

Visit

Dhami S, Sheikh A, Muraro A, et al.

Dhami S, Sheikh A, Muraro A, et al.

To identify quality indicators to support the acute and long-term management of anaphylaxis.

Review: Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase.  (2017)

Review: Safety profile of H1-antihistamines in pediatrics: an analysis based on data from VigiBase.

Visit

Motola D, Donati M, Biagi C, et al.

Motola D, Donati M, Biagi C, et al.

comparative analysis of the safety profiles of H1antihistamines using data from the WHO database

Comprehensive Review: Pitfalls in the use of epinephrine for anaphylaxis: patient and provider opportunities for improvement  (2016)

Comprehensive Review: Pitfalls in the use of epinephrine for anaphylaxis: patient and provider opportunities for improvement

Visit

Cohen MB, Saunders SS, Wise SK, Nassif S, Platt MP

Cohen MB, Saunders SS, Wise SK, Nassif S, Platt MP

The purpose of this study was to identify the scope of epinephrine pitfalls and opportunities for improvement in the management of allergy emergencies.

Systematic Review: Time of Onset and Predictors of Biphasic Anaphylactic Reactions: A Systematic Review and Meta-analysis  (2015)

Systematic Review: Time of Onset and Predictors of Biphasic Anaphylactic Reactions: A Systematic Review and Meta-analysis

Visit

Lee S, Bellolio MF, Hess EP, Erwin P, Murad MH, Campbell RL

Lee S, Bellolio MF, Hess EP, Erwin P, Murad MH, Campbell RL

The aim of this study was to evaluate the time of onset and predictors of biphasic anaphylactic reactions.

Review: Anaphylaxis: Unique aspects of clinical diagnosis and management in infants (birth to age 2 years)  (2015)

Review: Anaphylaxis: Unique aspects of clinical diagnosis and management in infants (birth to age 2 years)

Visit

Simons FE, Sampson HA

Simons FE, Sampson HA

In this rostrum we aim to increase awareness of anaphylaxis in infancy in order to improve clinical diagnosis, management, and prevention of recurrences.

Review: Risk multipliers for severe food anaphylaxis  (2015)

Review: Risk multipliers for severe food anaphylaxis

Visit

Smith PK, Hourihane JO, Lieberman P

Smith PK, Hourihane JO, Lieberman P

This paper reviews the factors that contribute to the risk of severe anaphylactic events and provides a framework for the ongoing management of patients at risk of severe food allergy.

Systematic Review: H2-antihistamines for the treatment of anaphylaxis with and without shock: a systematic review  (2014)

Systematic Review: H2-antihistamines for the treatment of anaphylaxis with and without shock: a systematic review

Visit

Nurmatov UB, Rhatigan E, Simons FE, Sheikh A

Nurmatov UB, Rhatigan E, Simons FE, Sheikh A

The objective of this systematic review was to assess the benefits and harms of H2-antihistamines in the treatment of anaphylaxis.

Cochrane Systematic Review: Glucocorticoids for the treatment of anaphylaxis  (2012)

Cochrane Systematic Review: Glucocorticoids for the treatment of anaphylaxis

Visit

Choo KJ, Simons FE, Sheikh A

Choo KJ, Simons FE, Sheikh A

We sought to assess the benefits and harms of glucocorticoid treatment during episodes of anaphylaxis.

Cochrane Systematic Review: Adrenaline auto-injectors for the treatment of anaphylaxis with and without cardiovascular collapse in the community  (2012)

Cochrane Systematic Review: Adrenaline auto-injectors for the treatment of anaphylaxis with and without cardiovascular collapse in the community

Visit

Sheikh A, Simons FE, Barbour V, Worth A

Sheikh A, Simons FE, Barbour V, Worth A

The objective of this systematic review was to assess the effectiveness of adrenaline (epinephrine) auto-injectors in relieving respiratory, cardiovascular, and other symptoms during episodes of anaphylaxis that occur in the community.

Cochrane Systematic Review: H1-antihistamines for the treatment of anaphylaxis with and without shock  (2007)

Cochrane Systematic Review: H1-antihistamines for the treatment of anaphylaxis with and without shock

Visit

Sheikh A, ten Broek VM, Brown SG, Simons FE

Sheikh A, ten Broek VM, Brown SG, Simons FE

The objective of this systematic review was to assess the benefits and harm of H1-antihistamines in the treatment of anaphylaxis.

Asthma English (9) French All (9)

Cochrane Systematic Review: Intravenous and nebulized magnesium sulfate for treating acute asthma in adults and children: a systematic review and meta-analysis

Cochrane Systematic Review: Intravenous and nebulized magnesium sulfate for treating acute asthma in adults and children: a systematic review and meta-analysis

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Shan, Z, Rong, Y, Yang, W, Wang, D, Yao, P, Xie, J, Liu, L,

Shan, Z, Rong, Y, Yang, W, Wang, D, Yao, P, Xie, J, Liu, L,

This systematic review and meta-analysis was conducted to estimate the effects of intravenous and nebulized magnesium sulfate on treating adults and children with acute asthma.

Cochrane Systematic Review: Dexamethasone for acute asthma exacerbations in children: a meta-analysis (2014)

Cochrane Systematic Review: Dexamethasone for acute asthma exacerbations in children: a meta-analysis (2014)

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Keeney, GE, Gray, MP, Morrison, AK, Levas, MN, Kessler, EA, Hill, GD, Gorelick, MH, Jackson, JL,

Keeney, GE, Gray, MP, Morrison, AK, Levas, MN, Kessler, EA, Hill, GD, Gorelic...

This systematic review and meta-analysis aimed to determine whether intramuscular or oral dexamethasone is equivalent or superior to a 5-day course of oral prednisone or prednisolone. The primary outcome of interest was return visits or hospital readmissions.

Cochrane Systematic Review: Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma (2013)

Cochrane Systematic Review: Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma (2013)

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Cates, CJ, Welsh, EJ, Rowe, BH,

Cates, CJ, Welsh, EJ, Rowe, BH,

Objectives: To assess the effects of holding chambers (spacers) compared to nebulisers for the delivery of beta(2)-agonists for acute asthma. This review includes a total of 1897 children and 729 adults in 39 trials. Thirty-three trials were conducted in the emergency room and equivalent community settings, and six trials were on inpatients with acute asthma (207 children and 28 adults).

Cochrane Systematic Review: Combined inhaled anticholinergics and short-acting beta2-agonists for initial treatment of acute asthma in children (2013)

Cochrane Systematic Review: Combined inhaled anticholinergics and short-acting beta2-agonists for initial treatment of acute asthma in children (2013)

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Griffiths, B, Ducharme, FM,

Griffiths, B, Ducharme, FM,

Objectives: To determine whether the addition of inhaled anticholinergics to SABAs provides clinical improvement and affects the incidence of adverse effects in children with acute asthma exacerbations.

Cochrane Systematic Review: Inhaled steroids for acute asthma following emergency department discharge (2012)

Cochrane Systematic Review: Inhaled steroids for acute asthma following emergency department discharge (2012)

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Edmonds, ML, Milan, SJ, Brenner, BE, Camargo, CA Jr, Rowe, BH,

Edmonds, ML, Milan, SJ, Brenner, BE, Camargo, CA Jr, Rowe, BH,

Objectives: To determine the effectiveness of ICS on outcomes in the treatment of acute asthma following discharge from the ED. To quantify the effectiveness of ICS therapy on acute asthma following ED discharge, when used in addition to, or as a substitute for, systemic corticosteroids.

Cochrane Systematic Review: Ketamine for management of acute exacerbations of asthma in children (2012)

Cochrane Systematic Review: Ketamine for management of acute exacerbations of asthma in children (2012)

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Jat, KR, Chawla, D,

Jat, KR, Chawla, D,

Objectives: To evaluate the efficacy of ketamine compared to placebo, no intervention or standard care for management of severe acute asthma in children who had not responded to standard therapy.

Cochrane Systematic Review: Interventions for educating children who are at risk of asthma-related emergency department attendance (2009)

Cochrane Systematic Review: Interventions for educating children who are at risk of asthma-related emergency department attendance (2009)

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Boyd, M, Lasserson, TJ, McKean, MC, Gibson, PG, Ducharme, FM, Haby, M,

Boyd, M, Lasserson, TJ, McKean, MC, Gibson, PG, Ducharme, FM, Haby, M,

Objectives: To conduct a systematic review of the literature and update the previous review as to whether asthma education leads to improved health outcomes in children who have attended the emergency room for asthma.

Cochrane Systematic Review: Magnesium sulfate for treating exacerbations of acute asthma in the emergency department (2000)

Cochrane Systematic Review: Magnesium sulfate for treating exacerbations of acute asthma in the emergency department (2000)

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Rowe, BH, Bretzlaff, JA, Bourdon, C, Bota, GW, Camargo, CA Jr,

Rowe, BH, Bretzlaff, JA, Bourdon, C, Bota, GW, Camargo, CA Jr,

Objectives: To examine the effect of additional intravenous magnesium sulfate in patients with acute asthma managed in the emergency department. Seven trials were included (5 adult, 2 pediatric).

Cochrane Systematic Review: Early emergency department treatment of acute asthma with systemic corticosteroids (2000)

Cochrane Systematic Review: Early emergency department treatment of acute asthma with systemic corticosteroids (2000)

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Rowe, BH, Spooner, C, Ducharme, FM, Bretzlaff, JA, Bota, GW,

Rowe, BH, Spooner, C, Ducharme, FM, Bretzlaff, JA, Bota, GW,

Objectives: To determine the benefit of treating patients with acute asthma with systemic corticosteroids within an hour of presenting to the emergency department (ED).

Cochrane Systematic Review: Intravenous and nebulized magnesium sulfate for treating acute asthma in adults and children: a systematic review and meta-analysis

Cochrane Systematic Review: Intravenous and nebulized magnesium sulfate for treating acute asthma in adults and children: a systematic review and meta-analysis

Visit

Shan, Z, Rong, Y, Yang, W, Wang, D, Yao, P, Xie, J, Liu, L,

Shan, Z, Rong, Y, Yang, W, Wang, D, Yao, P, Xie, J, Liu, L,

This systematic review and meta-analysis was conducted to estimate the effects of intravenous and nebulized magnesium sulfate on treating adults and children with acute asthma.

Cochrane Systematic Review: Dexamethasone for acute asthma exacerbations in children: a meta-analysis (2014)

Cochrane Systematic Review: Dexamethasone for acute asthma exacerbations in children: a meta-analysis (2014)

Visit

Keeney, GE, Gray, MP, Morrison, AK, Levas, MN, Kessler, EA, Hill, GD, Gorelick, MH, Jackson, JL,

Keeney, GE, Gray, MP, Morrison, AK, Levas, MN, Kessler, EA, Hill, GD, Gorelic...

This systematic review and meta-analysis aimed to determine whether intramuscular or oral dexamethasone is equivalent or superior to a 5-day course of oral prednisone or prednisolone. The primary outcome of interest was return visits or hospital readmissions.

Cochrane Systematic Review: Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma (2013)

Cochrane Systematic Review: Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma (2013)

Visit

Cates, CJ, Welsh, EJ, Rowe, BH,

Cates, CJ, Welsh, EJ, Rowe, BH,

Objectives: To assess the effects of holding chambers (spacers) compared to nebulisers for the delivery of beta(2)-agonists for acute asthma. This review includes a total of 1897 children and 729 adults in 39 trials. Thirty-three trials were conducted in the emergency room and equivalent community settings, and six trials were on inpatients with acute asthma (207 children and 28 adults).

Cochrane Systematic Review: Combined inhaled anticholinergics and short-acting beta2-agonists for initial treatment of acute asthma in children (2013)

Cochrane Systematic Review: Combined inhaled anticholinergics and short-acting beta2-agonists for initial treatment of acute asthma in children (2013)

Visit

Griffiths, B, Ducharme, FM,

Griffiths, B, Ducharme, FM,

Objectives: To determine whether the addition of inhaled anticholinergics to SABAs provides clinical improvement and affects the incidence of adverse effects in children with acute asthma exacerbations.

Cochrane Systematic Review: Inhaled steroids for acute asthma following emergency department discharge (2012)

Cochrane Systematic Review: Inhaled steroids for acute asthma following emergency department discharge (2012)

Visit

Edmonds, ML, Milan, SJ, Brenner, BE, Camargo, CA Jr, Rowe, BH,

Edmonds, ML, Milan, SJ, Brenner, BE, Camargo, CA Jr, Rowe, BH,

Objectives: To determine the effectiveness of ICS on outcomes in the treatment of acute asthma following discharge from the ED. To quantify the effectiveness of ICS therapy on acute asthma following ED discharge, when used in addition to, or as a substitute for, systemic corticosteroids.

Cochrane Systematic Review: Ketamine for management of acute exacerbations of asthma in children (2012)

Cochrane Systematic Review: Ketamine for management of acute exacerbations of asthma in children (2012)

Visit

Jat, KR, Chawla, D,

Jat, KR, Chawla, D,

Objectives: To evaluate the efficacy of ketamine compared to placebo, no intervention or standard care for management of severe acute asthma in children who had not responded to standard therapy.

Cochrane Systematic Review: Interventions for educating children who are at risk of asthma-related emergency department attendance (2009)

Cochrane Systematic Review: Interventions for educating children who are at risk of asthma-related emergency department attendance (2009)

Visit

Boyd, M, Lasserson, TJ, McKean, MC, Gibson, PG, Ducharme, FM, Haby, M,

Boyd, M, Lasserson, TJ, McKean, MC, Gibson, PG, Ducharme, FM, Haby, M,

Objectives: To conduct a systematic review of the literature and update the previous review as to whether asthma education leads to improved health outcomes in children who have attended the emergency room for asthma.

Cochrane Systematic Review: Magnesium sulfate for treating exacerbations of acute asthma in the emergency department (2000)

Cochrane Systematic Review: Magnesium sulfate for treating exacerbations of acute asthma in the emergency department (2000)

Visit

Rowe, BH, Bretzlaff, JA, Bourdon, C, Bota, GW, Camargo, CA Jr,

Rowe, BH, Bretzlaff, JA, Bourdon, C, Bota, GW, Camargo, CA Jr,

Objectives: To examine the effect of additional intravenous magnesium sulfate in patients with acute asthma managed in the emergency department. Seven trials were included (5 adult, 2 pediatric).

Cochrane Systematic Review: Early emergency department treatment of acute asthma with systemic corticosteroids (2000)

Cochrane Systematic Review: Early emergency department treatment of acute asthma with systemic corticosteroids (2000)

Visit

Rowe, BH, Spooner, C, Ducharme, FM, Bretzlaff, JA, Bota, GW,

Rowe, BH, Spooner, C, Ducharme, FM, Bretzlaff, JA, Bota, GW,

Objectives: To determine the benefit of treating patients with acute asthma with systemic corticosteroids within an hour of presenting to the emergency department (ED).

Bacterial Meningitis English (10) French All (10)

Review: Emergency Medicine Myths: Computed Tomography of the Head Prior to Lumbar Puncture in Adults with Suspected Bacterial Meningitis - Due Diligence or Antiquated Practice?  (2017)

Review: Emergency Medicine Myths: Computed Tomography of the Head Prior to Lumbar Puncture in Adults with Suspected Bacterial Meningitis - Due Diligence or Antiquated Practice?

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April MD, Long B, Koyfman A

April MD, Long B, Koyfman A

Objective: To review the evidence regarding the utility of obtaining head CT prior to lumbar puncture in adults with suspected bacterial meningitis.

Review: Diagnosis and Treatment of Central Nervous System Infections in the Emergency Department  (2016)

Review: Diagnosis and Treatment of Central Nervous System Infections in the Emergency Department

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Dorsett M, Liang SY

Dorsett M, Liang SY

Objective: This review discusses the clinical signs and symptoms that should lead emergency physicians to consider CNS infection, paying particular attention to the sensitivity and specificity of different clinical findings at the bedside. Subsequently, the diagnostic workup and management of patients for whom there is high clinical suspicion for CNS infection is discussed.

Cochrane Systematic Review: Fluid therapy for acute bacterial meningitis  (2016)

Cochrane Systematic Review: Fluid therapy for acute bacterial meningitis

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Maconochie IK, Bhaumik S

Maconochie IK, Bhaumik S

Objective: To evaluate treatment of acute bacterial meningitis with differing volumes of initial fluid administration (up to 72 hours after first presentation) and the effects on death and neurological sequelae.

Cochrane Systematic Review: Corticosteroids for acute bacterial meningitis  (2015)

Cochrane Systematic Review: Corticosteroids for acute bacterial meningitis

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Brouwer MC, McIntyre P, Prasad K, Van de Beek D

Brouwer MC, McIntyre P, Prasad K, Van de Beek D

Objective: To examine the effect of adjuvant corticosteroid therapy versus placebo on mortality, hearing loss and neurological sequelae in people of all ages with acute bacterial meningitis.

Review: Early lumbar puncture in adult bacterial meningitis--rationale for revised guidelines  (2013)

Review: Early lumbar puncture in adult bacterial meningitis--rationale for revised guidelines

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Glimker M, Johansson B, Bell M, Ericsson M, Blckberg J, Brink M, Lindquist L, Sjlin J

Glimker M, Johansson B, Bell M, Ericsson M, Blckberg J, Brink M, Lindquist L,...

Objective: Revised Swedish guidelines regarding early lumbar puncture (LP) are presented, and the background documentation and reasons for omitting impaired consciousness, new onset seizures, and immunocompromised state as contraindications to LP are discussed.

Systematic Review: Does this child have bacterial meningitis? A systematic review of clinical prediction rules for children with suspected bacterial meningitis  (2013)

Systematic Review: Does this child have bacterial meningitis? A systematic review of clinical prediction rules for children with suspected bacterial meningitis

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Kulik DM, Uleryk EM, Maguire JL

Kulik DM, Uleryk EM, Maguire JL

Objective: Our aim was to systematically identify and review the quality and performance of published clinical prediction rules (CPRs) for children with suspected bacterial meningitis.

Systematic Review: Meta-analysis of bacterial meningitis score validation studies  (2012)

Systematic Review: Meta-analysis of bacterial meningitis score validation studies

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Nigrovic LE, Malley R, Kuppermann N

Nigrovic LE, Malley R, Kuppermann N

Objective: The study objective of the present work was to calculate the performance of the Bacterial Meningitis Score by performing a meta-analysis of all published validation studies.

Systematic Review: Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis  (2011)

Systematic Review: Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis

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Sakushima K, Hayashino Y, Kawaguchi T, Jackson JL, Fukuhara S

Sakushima K, Hayashino Y, Kawaguchi T, Jackson JL, Fukuhara S

Objective: Our study's purpose was to assess the utility of CSF lactate in differentiating bacterial meningitis from aseptic meningitis.

Systematic Review: Clinical features suggestive of meningitis in children: a systematic review of prospective data  (2010)

Systematic Review: Clinical features suggestive of meningitis in children: a systematic review of prospective data

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Curtis S, Stobart K, Vandermeer B, Simel DL, Klassen T

Curtis S, Stobart K, Vandermeer B, Simel DL, Klassen T

Objective: To seek evidence supporting accuracy of clinical features of pediatric bacterial meningitis.

Review: Lumbar puncture and brain herniation in acute bacterial meningitis: a review  (2007)

Review: Lumbar puncture and brain herniation in acute bacterial meningitis: a review

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Joffe AR

Joffe AR

Objective: There has been controversy regarding the risk of cerebral herniation caused by a lumbar puncture (LP) in acute bacterial meningitis (ABM). This review discusses in detail the issues involved in this controversy.

Review: Emergency Medicine Myths: Computed Tomography of the Head Prior to Lumbar Puncture in Adults with Suspected Bacterial Meningitis - Due Diligence or Antiquated Practice?  (2017)

Review: Emergency Medicine Myths: Computed Tomography of the Head Prior to Lumbar Puncture in Adults with Suspected Bacterial Meningitis - Due Diligence or Antiquated Practice?

Visit

April MD, Long B, Koyfman A

April MD, Long B, Koyfman A

Objective: To review the evidence regarding the utility of obtaining head CT prior to lumbar puncture in adults with suspected bacterial meningitis.

Review: Diagnosis and Treatment of Central Nervous System Infections in the Emergency Department  (2016)

Review: Diagnosis and Treatment of Central Nervous System Infections in the Emergency Department

Visit

Dorsett M, Liang SY

Dorsett M, Liang SY

Objective: This review discusses the clinical signs and symptoms that should lead emergency physicians to consider CNS infection, paying particular attention to the sensitivity and specificity of different clinical findings at the bedside. Subsequently, the diagnostic workup and management of patients for whom there is high clinical suspicion for CNS infection is discussed.

Cochrane Systematic Review: Fluid therapy for acute bacterial meningitis  (2016)

Cochrane Systematic Review: Fluid therapy for acute bacterial meningitis

Visit

Maconochie IK, Bhaumik S

Maconochie IK, Bhaumik S

Objective: To evaluate treatment of acute bacterial meningitis with differing volumes of initial fluid administration (up to 72 hours after first presentation) and the effects on death and neurological sequelae.

Cochrane Systematic Review: Corticosteroids for acute bacterial meningitis  (2015)

Cochrane Systematic Review: Corticosteroids for acute bacterial meningitis

Visit

Brouwer MC, McIntyre P, Prasad K, Van de Beek D

Brouwer MC, McIntyre P, Prasad K, Van de Beek D

Objective: To examine the effect of adjuvant corticosteroid therapy versus placebo on mortality, hearing loss and neurological sequelae in people of all ages with acute bacterial meningitis.

Review: Early lumbar puncture in adult bacterial meningitis--rationale for revised guidelines  (2013)

Review: Early lumbar puncture in adult bacterial meningitis--rationale for revised guidelines

Visit

Glimker M, Johansson B, Bell M, Ericsson M, Blckberg J, Brink M, Lindquist L, Sjlin J

Glimker M, Johansson B, Bell M, Ericsson M, Blckberg J, Brink M, Lindquist L,...

Objective: Revised Swedish guidelines regarding early lumbar puncture (LP) are presented, and the background documentation and reasons for omitting impaired consciousness, new onset seizures, and immunocompromised state as contraindications to LP are discussed.

Systematic Review: Does this child have bacterial meningitis? A systematic review of clinical prediction rules for children with suspected bacterial meningitis  (2013)

Systematic Review: Does this child have bacterial meningitis? A systematic review of clinical prediction rules for children with suspected bacterial meningitis

Visit

Kulik DM, Uleryk EM, Maguire JL

Kulik DM, Uleryk EM, Maguire JL

Objective: Our aim was to systematically identify and review the quality and performance of published clinical prediction rules (CPRs) for children with suspected bacterial meningitis.

Systematic Review: Meta-analysis of bacterial meningitis score validation studies  (2012)

Systematic Review: Meta-analysis of bacterial meningitis score validation studies

Visit

Nigrovic LE, Malley R, Kuppermann N

Nigrovic LE, Malley R, Kuppermann N

Objective: The study objective of the present work was to calculate the performance of the Bacterial Meningitis Score by performing a meta-analysis of all published validation studies.

Systematic Review: Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis  (2011)

Systematic Review: Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis

Visit

Sakushima K, Hayashino Y, Kawaguchi T, Jackson JL, Fukuhara S

Sakushima K, Hayashino Y, Kawaguchi T, Jackson JL, Fukuhara S

Objective: Our study's purpose was to assess the utility of CSF lactate in differentiating bacterial meningitis from aseptic meningitis.

Systematic Review: Clinical features suggestive of meningitis in children: a systematic review of prospective data  (2010)

Systematic Review: Clinical features suggestive of meningitis in children: a systematic review of prospective data

Visit

Curtis S, Stobart K, Vandermeer B, Simel DL, Klassen T

Curtis S, Stobart K, Vandermeer B, Simel DL, Klassen T

Objective: To seek evidence supporting accuracy of clinical features of pediatric bacterial meningitis.

Review: Lumbar puncture and brain herniation in acute bacterial meningitis: a review  (2007)

Review: Lumbar puncture and brain herniation in acute bacterial meningitis: a review

Visit

Joffe AR

Joffe AR

Objective: There has been controversy regarding the risk of cerebral herniation caused by a lumbar puncture (LP) in acute bacterial meningitis (ABM). This review discusses in detail the issues involved in this controversy.

Bronchiolitis English (16) French All (16)

Meta-analysis: Efficacy of salbutamol in the treatment of infants with bronchiolitis: a meta-analysis of 13 studies  (2020)

Meta-analysis: Efficacy of salbutamol in the treatment of infants with bronchiolitis: a meta-analysis of 13 studies

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Cai Z, Lin Y, Liang J

Cai Z, Lin Y, Liang J

Objective: To systematically evaluate the clinical efficacy of salbutamol treatment in infants with bronchiolitis.

Systematic review: High-flow nasal cannula therapy for children with bronchiolitis: a systematic review and meta-analysis  (2019)

Systematic review: High-flow nasal cannula therapy for children with bronchiolitis: a systematic review and meta-analysis

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Lin, J. Z., Y.; Xiong, L.; Liu, S.; Gong, C.; Dai, J.

Lin, J. Z., Y.; Xiong, L.; Liu, S.; Gong, C.; Dai, J.

Objective: To determine whether treatment with CNHD is more effective than other non-invasive forms of treatment in pediatric patients who require respiratory support.

Cochrane Systematic Review: Continuous positive airway pressure (CPAP) for acute bronchiolitis in children  (2019)

Cochrane Systematic Review: Continuous positive airway pressure (CPAP) for acute bronchiolitis in children

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KR Jat, JL Mathew

KR Jat, JL Mathew

Objective: To assess the efficacy and safety of CPAP compared to no or sham CPAP in infants and children under three years of age with acute bronchiolitis.

Meta-analysis: Association of diagnostic criteria with urinary tract infection prevalence in bronchiolitis: a systematic review and meta-analysis  (2019)

Meta-analysis: Association of diagnostic criteria with urinary tract infection prevalence in bronchiolitis: a systematic review and meta-analysis

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McDaniel C, Ralston S, Lucas B, Schroeder AR

McDaniel C, Ralston S, Lucas B, Schroeder AR

Objective: To conduct a systematic review and meta-analysis examining the prevalence of UTI in infants with bronchiolitis when positive UA results are incorporated into the UTI definition.

Meta-analysis: Hypertonic saline in bronchiolitis and type 1 error: a trial sequential analysis  (2018)

Meta-analysis: Hypertonic saline in bronchiolitis and type 1 error: a trial sequential analysis

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Harrison W, Angoulvant F, House S, Gajdos V, Ralston SL

Harrison W, Angoulvant F, House S, Gajdos V, Ralston SL

Objective: to use TSA to determine if the existing literature base is sufficient to draw firm conclusions about the effectiveness of HS in bronchiolitis.

Cochrane Systematic Review: Nebulised hypertonic saline solution for acute bronchiolitis in infants  (2017)

Cochrane Systematic Review: Nebulised hypertonic saline solution for acute bronchiolitis in infants

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Zhang L, Mendoza-Sassi RA, Wainwright C,Klassen TP

Zhang L, Mendoza-Sassi RA, Wainwright C,Klassen TP

Objective: to assess the effects of nebulizing hypertonic saline ( 3%) in infants with acute bronchiolitis.

Systematic Review: Nebulized hypertonic saline for acute bronchiolitis: A systematic review  (2015)

Systematic Review: Nebulized hypertonic saline for acute bronchiolitis: A systematic review

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Zhang L, Mendoza-Sassi RA, Klassen TP, Wainwright C.

Zhang L, Mendoza-Sassi RA, Klassen TP, Wainwright C.

Objective: The objective of this study was to assess the efficacy and safety of nebulized hypertonic saline (HS) in infants with acute bronchiolitis.

Cochrane Systematic Review: Heliox inhalation therapy for bronchiolitis in infants  (2015)

Cochrane Systematic Review: Heliox inhalation therapy for bronchiolitis in infants

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Liet JM, Ducruet T, Gupta V, Cambonie G

Liet JM, Ducruet T, Gupta V, Cambonie G

Objective: To assess heliox inhalation therapy in addition to standard medical care for acute bronchiolitis in infants with respiratory distress, as measured by clinical endpoints (in particular the rate of endotracheal intubation, the rate of emergency department discharge, the length of treatment for respiratory distress) and pulmonary function testing (mainly clinical respiratory scores).

Systematic Review: Antibiotics for bronchiolitis in children under two years of age  (2014)

Systematic Review: Antibiotics for bronchiolitis in children under two years of age

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Farley R, Spurling GK, Eriksson L, Del Mar CB

Farley R, Spurling GK, Eriksson L, Del Mar CB

Objective: to evaluate the effectiveness of antibiotics for bronchiolitis in children under two years of age compared to placebo or other interventions.

Systematic Review: Bronchodilators for bronchiolitis  (2014)

Systematic Review: Bronchodilators for bronchiolitis

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Gadomski AM, Scribani MB

Gadomski AM, Scribani MB

Objective: to assess the effects of bronchodilators on clinical outcomes in infants (0 to 12 months) with acute bronchiolitis.

Cochrane Systematic Review: Bronchodilators for bronchiolitis  (2014)

Cochrane Systematic Review: Bronchodilators for bronchiolitis

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Gadomski AM, Scribani MB

Gadomski AM, Scribani MB

Objective: To assess the effects of bronchodilators on clinical outcomes in infants (0 to 12 months) with acute bronchiolitis.

Systematic Review: Glucocorticoids for acute viral bronchiolitis in infants and young children  (2013)

Systematic Review: Glucocorticoids for acute viral bronchiolitis in infants and young children

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Fernandes RM, Bialy LM, Vandermeer B, Tjosvold L, Plint AC, Patel H, Johnson DW, Klassen TP, Hartling L

Fernandes RM, Bialy LM, Vandermeer B, Tjosvold L, Plint AC, Patel H, Johnson ...

Objective: to review the efficacy and safety of systemic and inhaled glucocorticoids in children with acute viral bronchiolitis.

Systematic Review: Nebulised hypertonic saline solution for acute bronchiolitis in infants  (2013)

Systematic Review: Nebulised hypertonic saline solution for acute bronchiolitis in infants

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Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP

Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP

Objective: to assess the effects of nebulised hypertonic ( 3%) saline solution in infants with acute viral bronchiolitis.

Cochrane Systematic Review: Glucocorticoids for acute viral bronchiolitis in infants and young children under two years of age  (2013)

Cochrane Systematic Review: Glucocorticoids for acute viral bronchiolitis in infants and young children under two years of age

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Fernandes RM, Bialy LM, Vandermeer B, Tjosvold L, Plint AC, Patel H, Johnson DW, Klassen TP, Hartling L

Fernandes RM, Bialy LM, Vandermeer B, Tjosvold L, Plint AC, Patel H, Johnson ...

Objective: To review the efficacy and safety of systemic and inhaled glucocorticoids in children with acute viral bronchiolitis.

Systematic Review: Epinephrine for bronchiolitis  (2011)

Systematic Review: Epinephrine for bronchiolitis

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Hartling L, Bialy LM, Vandermeer B, Tjosvold L, Johnson DW, Plint AC, Klassen TP, Patel H, Fernandes RM

Hartling L, Bialy LM, Vandermeer B, Tjosvold L, Johnson DW, Plint AC, Klassen...

Objective: to examine the efficacy and safety of epinephrine in children less than two with acute viral bronchiolitis.

Systematic Review: Steroids and bronchodilators for acute bronchiolitis in the first two years of life: systematic review and meta-analysis  (2011)

Systematic Review: Steroids and bronchodilators for acute bronchiolitis in the first two years of life: systematic review and meta-analysis

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Hartling L, Fernandes RM, Bialy L, Milne A, Johnson D, Plint A, Klassen TP, Vandermeer B

Hartling L, Fernandes RM, Bialy L, Milne A, Johnson D, Plint A, Klassen TP, V...

Objectives: to evaluate and compare the efficacy and safety of bronchodilators and steroids, alone or combined, for the acute management of bronchiolitis in children aged less than 2 years.

Meta-analysis: Efficacy of salbutamol in the treatment of infants with bronchiolitis: a meta-analysis of 13 studies  (2020)

Meta-analysis: Efficacy of salbutamol in the treatment of infants with bronchiolitis: a meta-analysis of 13 studies

Visit

Cai Z, Lin Y, Liang J

Cai Z, Lin Y, Liang J

Objective: To systematically evaluate the clinical efficacy of salbutamol treatment in infants with bronchiolitis.

Systematic review: High-flow nasal cannula therapy for children with bronchiolitis: a systematic review and meta-analysis  (2019)

Systematic review: High-flow nasal cannula therapy for children with bronchiolitis: a systematic review and meta-analysis

Visit

Lin, J. Z., Y.; Xiong, L.; Liu, S.; Gong, C.; Dai, J.

Lin, J. Z., Y.; Xiong, L.; Liu, S.; Gong, C.; Dai, J.

Objective: To determine whether treatment with CNHD is more effective than other non-invasive forms of treatment in pediatric patients who require respiratory support.

Cochrane Systematic Review: Continuous positive airway pressure (CPAP) for acute bronchiolitis in children  (2019)

Cochrane Systematic Review: Continuous positive airway pressure (CPAP) for acute bronchiolitis in children

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KR Jat, JL Mathew

KR Jat, JL Mathew

Objective: To assess the efficacy and safety of CPAP compared to no or sham CPAP in infants and children under three years of age with acute bronchiolitis.

Meta-analysis: Association of diagnostic criteria with urinary tract infection prevalence in bronchiolitis: a systematic review and meta-analysis  (2019)

Meta-analysis: Association of diagnostic criteria with urinary tract infection prevalence in bronchiolitis: a systematic review and meta-analysis

Visit

McDaniel C, Ralston S, Lucas B, Schroeder AR

McDaniel C, Ralston S, Lucas B, Schroeder AR

Objective: To conduct a systematic review and meta-analysis examining the prevalence of UTI in infants with bronchiolitis when positive UA results are incorporated into the UTI definition.

Meta-analysis: Hypertonic saline in bronchiolitis and type 1 error: a trial sequential analysis  (2018)

Meta-analysis: Hypertonic saline in bronchiolitis and type 1 error: a trial sequential analysis

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Harrison W, Angoulvant F, House S, Gajdos V, Ralston SL

Harrison W, Angoulvant F, House S, Gajdos V, Ralston SL

Objective: to use TSA to determine if the existing literature base is sufficient to draw firm conclusions about the effectiveness of HS in bronchiolitis.

Cochrane Systematic Review: Nebulised hypertonic saline solution for acute bronchiolitis in infants  (2017)

Cochrane Systematic Review: Nebulised hypertonic saline solution for acute bronchiolitis in infants

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Zhang L, Mendoza-Sassi RA, Wainwright C,Klassen TP

Zhang L, Mendoza-Sassi RA, Wainwright C,Klassen TP

Objective: to assess the effects of nebulizing hypertonic saline ( 3%) in infants with acute bronchiolitis.

Systematic Review: Nebulized hypertonic saline for acute bronchiolitis: A systematic review  (2015)

Systematic Review: Nebulized hypertonic saline for acute bronchiolitis: A systematic review

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Zhang L, Mendoza-Sassi RA, Klassen TP, Wainwright C.

Zhang L, Mendoza-Sassi RA, Klassen TP, Wainwright C.

Objective: The objective of this study was to assess the efficacy and safety of nebulized hypertonic saline (HS) in infants with acute bronchiolitis.

Cochrane Systematic Review: Heliox inhalation therapy for bronchiolitis in infants  (2015)

Cochrane Systematic Review: Heliox inhalation therapy for bronchiolitis in infants

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Liet JM, Ducruet T, Gupta V, Cambonie G

Liet JM, Ducruet T, Gupta V, Cambonie G

Objective: To assess heliox inhalation therapy in addition to standard medical care for acute bronchiolitis in infants with respiratory distress, as measured by clinical endpoints (in particular the rate of endotracheal intubation, the rate of emergency department discharge, the length of treatment for respiratory distress) and pulmonary function testing (mainly clinical respiratory scores).

Systematic Review: Antibiotics for bronchiolitis in children under two years of age  (2014)

Systematic Review: Antibiotics for bronchiolitis in children under two years of age

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Farley R, Spurling GK, Eriksson L, Del Mar CB

Farley R, Spurling GK, Eriksson L, Del Mar CB

Objective: to evaluate the effectiveness of antibiotics for bronchiolitis in children under two years of age compared to placebo or other interventions.

Systematic Review: Bronchodilators for bronchiolitis  (2014)

Systematic Review: Bronchodilators for bronchiolitis

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Gadomski AM, Scribani MB

Gadomski AM, Scribani MB

Objective: to assess the effects of bronchodilators on clinical outcomes in infants (0 to 12 months) with acute bronchiolitis.

Cochrane Systematic Review: Bronchodilators for bronchiolitis  (2014)

Cochrane Systematic Review: Bronchodilators for bronchiolitis

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Gadomski AM, Scribani MB

Gadomski AM, Scribani MB

Objective: To assess the effects of bronchodilators on clinical outcomes in infants (0 to 12 months) with acute bronchiolitis.

Systematic Review: Glucocorticoids for acute viral bronchiolitis in infants and young children  (2013)

Systematic Review: Glucocorticoids for acute viral bronchiolitis in infants and young children

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Fernandes RM, Bialy LM, Vandermeer B, Tjosvold L, Plint AC, Patel H, Johnson DW, Klassen TP, Hartling L

Fernandes RM, Bialy LM, Vandermeer B, Tjosvold L, Plint AC, Patel H, Johnson ...

Objective: to review the efficacy and safety of systemic and inhaled glucocorticoids in children with acute viral bronchiolitis.

Systematic Review: Nebulised hypertonic saline solution for acute bronchiolitis in infants  (2013)

Systematic Review: Nebulised hypertonic saline solution for acute bronchiolitis in infants

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Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP

Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP

Objective: to assess the effects of nebulised hypertonic ( 3%) saline solution in infants with acute viral bronchiolitis.

Cochrane Systematic Review: Glucocorticoids for acute viral bronchiolitis in infants and young children under two years of age  (2013)

Cochrane Systematic Review: Glucocorticoids for acute viral bronchiolitis in infants and young children under two years of age

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Fernandes RM, Bialy LM, Vandermeer B, Tjosvold L, Plint AC, Patel H, Johnson DW, Klassen TP, Hartling L

Fernandes RM, Bialy LM, Vandermeer B, Tjosvold L, Plint AC, Patel H, Johnson ...

Objective: To review the efficacy and safety of systemic and inhaled glucocorticoids in children with acute viral bronchiolitis.

Systematic Review: Epinephrine for bronchiolitis  (2011)

Systematic Review: Epinephrine for bronchiolitis

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Hartling L, Bialy LM, Vandermeer B, Tjosvold L, Johnson DW, Plint AC, Klassen TP, Patel H, Fernandes RM

Hartling L, Bialy LM, Vandermeer B, Tjosvold L, Johnson DW, Plint AC, Klassen...

Objective: to examine the efficacy and safety of epinephrine in children less than two with acute viral bronchiolitis.

Systematic Review: Steroids and bronchodilators for acute bronchiolitis in the first two years of life: systematic review and meta-analysis  (2011)

Systematic Review: Steroids and bronchodilators for acute bronchiolitis in the first two years of life: systematic review and meta-analysis

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Hartling L, Fernandes RM, Bialy L, Milne A, Johnson D, Plint A, Klassen TP, Vandermeer B

Hartling L, Fernandes RM, Bialy L, Milne A, Johnson D, Plint A, Klassen TP, V...

Objectives: to evaluate and compare the efficacy and safety of bronchodilators and steroids, alone or combined, for the acute management of bronchiolitis in children aged less than 2 years.

Burns English (12) French All (12)

Systematic Review: Comparative study of Silver Sulfadiazine with other materials for healing and infection prevention in burns: A systematic review and meta-analysis  (2018)

Systematic Review: Comparative study of Silver Sulfadiazine with other materials for healing and infection prevention in burns: A systematic review and meta-analysis

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Nmia HH, Carvalho VF, Isaac C, Souza F, Gemperli R, Paggiaro AO

Nmia HH, Carvalho VF, Isaac C, Souza F, Gemperli R, Paggiaro AO

Objective: The aim of this systematic review with meta-analysis was to compare the effect of Silver Sulfadiazine (SSD) with other new dressings, with or without silver, on healing and infection prevention in burns.

Review: Burn Care for Children  (2018)

Review: Burn Care for Children

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Sheridan RL

Sheridan RL

Objective: To provide an understanding of the practice of outpatient small burn care, and to present the concepts of inpatient burn care and long-term burn aftercare.

Review: Emergency management of burns: part 1  (2018)

Review: Emergency management of burns: part 1

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Stiles K

Stiles K

Objective: The aim of this article is to give an overview of burns trauma, and to describe the initial assessment and management of patients with these injuries in emergency departments (EDs). Part 1 of 2.

Review: Emergency management of burns: part 2  (2018)

Review: Emergency management of burns: part 2

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Stiles K

Stiles K

Objective: The aim of the two articles is to enhance emergency clinicians knowledge and confidence in burn management, and to build awareness of the life-changing implications of the initial clinical interventions in burn care. Part 2 of 2.

Review: Emergency Care of Pediatric Burns  (2018)

Review: Emergency Care of Pediatric Burns

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Strobel AM, Fey R

Strobel AM, Fey R

Objective: To review emergency care, management and prevention of pediatric burns.

Systematic Review: A systematic review and meta-analysis of clinical outcomes associated with nanocrystalline silver use compared to alternative silver delivery systems in the management of superficial and deep partial thickness burns  (2017)

Systematic Review: A systematic review and meta-analysis of clinical outcomes associated with nanocrystalline silver use compared to alternative silver delivery systems in the management of superficial and deep partial thickness burns

Visit

Nherera LM, Trueman P, Roberts CD, Berg L

Nherera LM, Trueman P, Roberts CD, Berg L

Objective: The purpose of this systematic review and meta-analysis was to assess the clinical effectiveness of nanocrystalline silver compared to alternative silver delivery systems (silver sulphadiazine [SSD] and silver nitrate) in adults and children with superficial and deep partial thickness burns.

Review: Pediatric burn resuscitation: past, present, and future  (2017)

Review: Pediatric burn resuscitation: past, present, and future

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Romanowski KS, Palmieri TL

Romanowski KS, Palmieri TL

Objective: To discuss the history of fluid resuscitation, current resuscitation practices, and future directions of resuscitation for the pediatric burn population.

Review: Pediatric Burn Resuscitation  (2016)

Review: Pediatric Burn Resuscitation

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Palmieri TL

Palmieri TL

Objective: The purpose of this article is to provide a foundation for initial assessment and management in burned children.

Review: Optimizing emergency management to reduce morbidity and mortality in pediatric burn patients  (2015)

Review: Optimizing emergency management to reduce morbidity and mortality in pediatric burn patients

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Haines E, Fairbrother H

Haines E, Fairbrother H

Objective: This article reviews methods for accurate classification and management of the full range of burns seen in pediatric patients.

Cochrane Systematic Review: Antibiotic prophylaxis for preventing burn wound infection  (2013)

Cochrane Systematic Review: Antibiotic prophylaxis for preventing burn wound infection

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Barajas-Nava LA, Lpez-Alcalde J, Roqu i Figuls M, Sol I, Bonfill Cosp X

Barajas-Nava LA, Lpez-Alcalde J, Roqu i Figuls M, Sol I, Bonfill Cosp X

Objective: To assess the effects of antibiotic prophylaxis on rates of burn wound infection.

Review: Use of Acticoat dressings in burns: what is the evidence?  (2010)

Review: Use of Acticoat dressings in burns: what is the evidence?

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Khundkar R, Malic C, Burge T

Khundkar R, Malic C, Burge T

Objective: To determine the level of evidence available in the literature in view of recent increased usage of Acticoat dressings in burns.

Review: Critical care of the burn patient: the first 48 hours  (2009)

Review: Critical care of the burn patient: the first 48 hours

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Latenser BA

Latenser BA

Objective: The goal of this concise review is to provide an overview of some of the most important resuscitation and monitoring issues and approaches that are unique to burn patients compared with the general intensive care unit population.

Systematic Review: Comparative study of Silver Sulfadiazine with other materials for healing and infection prevention in burns: A systematic review and meta-analysis  (2018)

Systematic Review: Comparative study of Silver Sulfadiazine with other materials for healing and infection prevention in burns: A systematic review and meta-analysis

Visit

Nmia HH, Carvalho VF, Isaac C, Souza F, Gemperli R, Paggiaro AO

Nmia HH, Carvalho VF, Isaac C, Souza F, Gemperli R, Paggiaro AO

Objective: The aim of this systematic review with meta-analysis was to compare the effect of Silver Sulfadiazine (SSD) with other new dressings, with or without silver, on healing and infection prevention in burns.

Review: Burn Care for Children  (2018)

Review: Burn Care for Children

Visit

Sheridan RL

Sheridan RL

Objective: To provide an understanding of the practice of outpatient small burn care, and to present the concepts of inpatient burn care and long-term burn aftercare.

Review: Emergency management of burns: part 1  (2018)

Review: Emergency management of burns: part 1

Visit

Stiles K

Stiles K

Objective: The aim of this article is to give an overview of burns trauma, and to describe the initial assessment and management of patients with these injuries in emergency departments (EDs). Part 1 of 2.

Review: Emergency management of burns: part 2  (2018)

Review: Emergency management of burns: part 2

Visit

Stiles K

Stiles K

Objective: The aim of the two articles is to enhance emergency clinicians knowledge and confidence in burn management, and to build awareness of the life-changing implications of the initial clinical interventions in burn care. Part 2 of 2.

Review: Emergency Care of Pediatric Burns  (2018)

Review: Emergency Care of Pediatric Burns

Visit

Strobel AM, Fey R

Strobel AM, Fey R

Objective: To review emergency care, management and prevention of pediatric burns.

Systematic Review: A systematic review and meta-analysis of clinical outcomes associated with nanocrystalline silver use compared to alternative silver delivery systems in the management of superficial and deep partial thickness burns  (2017)

Systematic Review: A systematic review and meta-analysis of clinical outcomes associated with nanocrystalline silver use compared to alternative silver delivery systems in the management of superficial and deep partial thickness burns

Visit

Nherera LM, Trueman P, Roberts CD, Berg L

Nherera LM, Trueman P, Roberts CD, Berg L

Objective: The purpose of this systematic review and meta-analysis was to assess the clinical effectiveness of nanocrystalline silver compared to alternative silver delivery systems (silver sulphadiazine [SSD] and silver nitrate) in adults and children with superficial and deep partial thickness burns.

Review: Pediatric burn resuscitation: past, present, and future  (2017)

Review: Pediatric burn resuscitation: past, present, and future

Visit

Romanowski KS, Palmieri TL

Romanowski KS, Palmieri TL

Objective: To discuss the history of fluid resuscitation, current resuscitation practices, and future directions of resuscitation for the pediatric burn population.

Review: Pediatric Burn Resuscitation  (2016)

Review: Pediatric Burn Resuscitation

Visit

Palmieri TL

Palmieri TL

Objective: The purpose of this article is to provide a foundation for initial assessment and management in burned children.

Review: Optimizing emergency management to reduce morbidity and mortality in pediatric burn patients  (2015)

Review: Optimizing emergency management to reduce morbidity and mortality in pediatric burn patients

Visit

Haines E, Fairbrother H

Haines E, Fairbrother H

Objective: This article reviews methods for accurate classification and management of the full range of burns seen in pediatric patients.

Cochrane Systematic Review: Antibiotic prophylaxis for preventing burn wound infection  (2013)

Cochrane Systematic Review: Antibiotic prophylaxis for preventing burn wound infection

Visit

Barajas-Nava LA, Lpez-Alcalde J, Roqu i Figuls M, Sol I, Bonfill Cosp X

Barajas-Nava LA, Lpez-Alcalde J, Roqu i Figuls M, Sol I, Bonfill Cosp X

Objective: To assess the effects of antibiotic prophylaxis on rates of burn wound infection.

Review: Use of Acticoat dressings in burns: what is the evidence?  (2010)

Review: Use of Acticoat dressings in burns: what is the evidence?

Visit

Khundkar R, Malic C, Burge T

Khundkar R, Malic C, Burge T

Objective: To determine the level of evidence available in the literature in view of recent increased usage of Acticoat dressings in burns.

Review: Critical care of the burn patient: the first 48 hours  (2009)

Review: Critical care of the burn patient: the first 48 hours

Visit

Latenser BA

Latenser BA

Objective: The goal of this concise review is to provide an overview of some of the most important resuscitation and monitoring issues and approaches that are unique to burn patients compared with the general intensive care unit population.

COVID19 English (9) French All (9)

Systematic review: Cardiovascular impact of COVID-19 with a focus on children: a systematic review.  (2020)

Systematic review: Cardiovascular impact of COVID-19 with a focus on children: a systematic review.

Visit

Rodriguez-Gonzalez M, Castellano-Martinez A, Cascales-Poyatos HM, Perez-Reviriego AA.

Rodriguez-Gonzalez M, Castellano-Martinez A, Cascales-Poyatos HM, Perez-Revir...

Aim: To summarize the current knowledge about the potential cardiovascular involvement in pediatric COVID-19 in order to give a perspective on how to take care of them during the current pandemic emergency.

Systematic review: Characteristics of pediatric multi-system inflammatory syndrome (PMIS) associated with COVID-19: a meta-analysis and insights into pathogenesis.  (2020)

Systematic review: Characteristics of pediatric multi-system inflammatory syndrome (PMIS) associated with COVID-19: a meta-analysis and insights into pathogenesis.

Visit

Zou H, Lu J, Liu J, et al.

Zou H, Lu J, Liu J, et al.

Objectives: There was an outbreak of pediatric multisystem inflammation syndrome (PMIS) was observed in multiple countries recently, and this syndrome was suspected to be associated with SARS-CoV-2 infection. At present, there is still no standardized diagnostic criteria and treatment regimen for PMIS, while the etiology and pathogenesis still remain unclear.

Systematic review: Clinical characteristics of COVID-19 in children: a systematic review.  (2020)

Systematic review: Clinical characteristics of COVID-19 in children: a systematic review.

Visit

Yasuhara J, Kuno T, Takagi H, Sumitomo N.

Yasuhara J, Kuno T, Takagi H, Sumitomo N.

Objective: Our aim was to investigate the clinical characteristics of COVID-19 in children.

Systematic review: Clinical manifestations of children with COVID-19: a systematic review.  (2020)

Systematic review: Clinical manifestations of children with COVID-19: a systematic review.

Visit

de Souza TH, Nadal JA, Nogueira RJN, Pereira RM, Brando MB

de Souza TH, Nadal JA, Nogueira RJN, Pereira RM, Brando MB

Objective: The aim of this study was to describe the clinical, laboratorial, and radiological characteristics of children with COVID-19.

Systematic review: COVID-19 in 7780 pediatric patients: a systematic review.  (2020)

Systematic review: COVID-19 in 7780 pediatric patients: a systematic review.

Visit

Hoang A, Chorath K, Moreira A, et al.

Hoang A, Chorath K, Moreira A, et al.

Objective: This review characterizes clinical symptoms, laboratory, and imaging findings, as well as therapies provided to confirmed pediatric cases of COVID-19.

Systematic review: Epidemiological and clinical characteristics of COVID-19 in children: a systematic review and meta-analysis.  (2020)

Systematic review: Epidemiological and clinical characteristics of COVID-19 in children: a systematic review and meta-analysis.

Visit

Li B, Zhang S, Zhang R, Chen X, Wang Y, Zhu C.

Li B, Zhang S, Zhang R, Chen X, Wang Y, Zhu C.

Objective: This systematic review with meta-analysis aimed to evaluate the epidemiological spectrum and clinical characteristics of children infected with SARS-CoV-2.

Systematic review: Multisystem inflammatory syndrome associated with COVID-19 from the pediatric emergency physician's point of view.  (2020)

Systematic review: Multisystem inflammatory syndrome associated with COVID-19 from the pediatric emergency physician's point of view.

Visit

Junior H, Sakano TMS, Rodrigues RM, et al.

Junior H, Sakano TMS, Rodrigues RM, et al.

Objective: Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease (COVID-19) is a rare and challenging diagnosis requiring early treatment. The diagnostic criteria involve clinical, laboratory, and complementary tests. This review aims to draw pediatrician attention to this diagnosis, suggesting early treatment strategies, and proposing a pediatric emergency care flowchart.

Systematic review: Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2: a systematic review.  (2020)

Systematic review: Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2: a systematic review.

Visit

Abrams JY, Godfred-Cato SE, Oster ME, et al.

Abrams JY, Godfred-Cato SE, Oster ME, et al.

Objective: To develop a more comprehensive description of multisystem inflammatory syndrome in children (MIS-C), a novel syndrome linked to severe acute respiratory syndrome coronavirus 2, by conducting a systematic analysis of studies from different settings that used various inclusion criteria.

Systematic review: Prevalence, clinical characteristics, and outcomes of pediatric COVID-19: a systematic review and meta-analysis.  (2020)

Systematic review: Prevalence, clinical characteristics, and outcomes of pediatric COVID-19: a systematic review and meta-analysis.

Visit

Badal S, Bajgain KT, Badal S, Thapa R, Bajgain BB, Santana MJ.

Badal S, Bajgain KT, Badal S, Thapa R, Bajgain BB, Santana MJ.

Introduction: The novel coronavirus pandemic is an ongoing challenge faced by the public and health care systems around the globe. Majority of information and evidence gathered so far regarding COVID-19 has been derived from data and studies in adult populations. Crucial information regarding the characterization, clinical symptomatology, sequelae, and overall outcomes in the pediatric population is lacking. As such, we aimed to conduct a comprehensive meta-analysis and systematic review to collect and analyze current evidence about COVID-19 in the pediatric population.

Systematic review: Cardiovascular impact of COVID-19 with a focus on children: a systematic review.  (2020)

Systematic review: Cardiovascular impact of COVID-19 with a focus on children: a systematic review.

Visit

Rodriguez-Gonzalez M, Castellano-Martinez A, Cascales-Poyatos HM, Perez-Reviriego AA.

Rodriguez-Gonzalez M, Castellano-Martinez A, Cascales-Poyatos HM, Perez-Revir...

Aim: To summarize the current knowledge about the potential cardiovascular involvement in pediatric COVID-19 in order to give a perspective on how to take care of them during the current pandemic emergency.

Systematic review: Characteristics of pediatric multi-system inflammatory syndrome (PMIS) associated with COVID-19: a meta-analysis and insights into pathogenesis.  (2020)

Systematic review: Characteristics of pediatric multi-system inflammatory syndrome (PMIS) associated with COVID-19: a meta-analysis and insights into pathogenesis.

Visit

Zou H, Lu J, Liu J, et al.

Zou H, Lu J, Liu J, et al.

Objectives: There was an outbreak of pediatric multisystem inflammation syndrome (PMIS) was observed in multiple countries recently, and this syndrome was suspected to be associated with SARS-CoV-2 infection. At present, there is still no standardized diagnostic criteria and treatment regimen for PMIS, while the etiology and pathogenesis still remain unclear.

Systematic review: Clinical characteristics of COVID-19 in children: a systematic review.  (2020)

Systematic review: Clinical characteristics of COVID-19 in children: a systematic review.

Visit

Yasuhara J, Kuno T, Takagi H, Sumitomo N.

Yasuhara J, Kuno T, Takagi H, Sumitomo N.

Objective: Our aim was to investigate the clinical characteristics of COVID-19 in children.

Systematic review: Clinical manifestations of children with COVID-19: a systematic review.  (2020)

Systematic review: Clinical manifestations of children with COVID-19: a systematic review.

Visit

de Souza TH, Nadal JA, Nogueira RJN, Pereira RM, Brando MB

de Souza TH, Nadal JA, Nogueira RJN, Pereira RM, Brando MB

Objective: The aim of this study was to describe the clinical, laboratorial, and radiological characteristics of children with COVID-19.

Systematic review: COVID-19 in 7780 pediatric patients: a systematic review.  (2020)

Systematic review: COVID-19 in 7780 pediatric patients: a systematic review.

Visit

Hoang A, Chorath K, Moreira A, et al.

Hoang A, Chorath K, Moreira A, et al.

Objective: This review characterizes clinical symptoms, laboratory, and imaging findings, as well as therapies provided to confirmed pediatric cases of COVID-19.

Systematic review: Epidemiological and clinical characteristics of COVID-19 in children: a systematic review and meta-analysis.  (2020)

Systematic review: Epidemiological and clinical characteristics of COVID-19 in children: a systematic review and meta-analysis.

Visit

Li B, Zhang S, Zhang R, Chen X, Wang Y, Zhu C.

Li B, Zhang S, Zhang R, Chen X, Wang Y, Zhu C.

Objective: This systematic review with meta-analysis aimed to evaluate the epidemiological spectrum and clinical characteristics of children infected with SARS-CoV-2.

Systematic review: Multisystem inflammatory syndrome associated with COVID-19 from the pediatric emergency physician's point of view.  (2020)

Systematic review: Multisystem inflammatory syndrome associated with COVID-19 from the pediatric emergency physician's point of view.

Visit

Junior H, Sakano TMS, Rodrigues RM, et al.

Junior H, Sakano TMS, Rodrigues RM, et al.

Objective: Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease (COVID-19) is a rare and challenging diagnosis requiring early treatment. The diagnostic criteria involve clinical, laboratory, and complementary tests. This review aims to draw pediatrician attention to this diagnosis, suggesting early treatment strategies, and proposing a pediatric emergency care flowchart.

Systematic review: Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2: a systematic review.  (2020)

Systematic review: Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2: a systematic review.

Visit

Abrams JY, Godfred-Cato SE, Oster ME, et al.

Abrams JY, Godfred-Cato SE, Oster ME, et al.

Objective: To develop a more comprehensive description of multisystem inflammatory syndrome in children (MIS-C), a novel syndrome linked to severe acute respiratory syndrome coronavirus 2, by conducting a systematic analysis of studies from different settings that used various inclusion criteria.

Systematic review: Prevalence, clinical characteristics, and outcomes of pediatric COVID-19: a systematic review and meta-analysis.  (2020)

Systematic review: Prevalence, clinical characteristics, and outcomes of pediatric COVID-19: a systematic review and meta-analysis.

Visit

Badal S, Bajgain KT, Badal S, Thapa R, Bajgain BB, Santana MJ.

Badal S, Bajgain KT, Badal S, Thapa R, Bajgain BB, Santana MJ.

Introduction: The novel coronavirus pandemic is an ongoing challenge faced by the public and health care systems around the globe. Majority of information and evidence gathered so far regarding COVID-19 has been derived from data and studies in adult populations. Crucial information regarding the characterization, clinical symptomatology, sequelae, and overall outcomes in the pediatric population is lacking. As such, we aimed to conduct a comprehensive meta-analysis and systematic review to collect and analyze current evidence about COVID-19 in the pediatric population.

Cannabis Intoxication English (2) French All (2)

Systematic Review: Unintentional Cannabis Ingestion in Children: A Systematic Review  (2017)

Systematic Review: Unintentional Cannabis Ingestion in Children: A Systematic Review

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Richards JRS, N. E.; Moulin, A. K.

Richards JRS, N. E.; Moulin, A. K.

To analyze published reports of unintentional cannabis ingestions in children to determine presenting signs and symptoms, route of exposure, treatment, and outcome.

Systematic Review: Cannabinoid Hyperemesis Syndrome: Diagnosis, Pathophysiology, and Treatmenta Systematic Review  (2017)

Systematic Review: Cannabinoid Hyperemesis Syndrome: Diagnosis, Pathophysiology, and Treatmenta Systematic Review

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Sorensen, C. J., DeSanto, K., Borgelt, L., Phillips, K. T., & Monte, A. A

Sorensen, C. J., DeSanto, K., Borgelt, L., Phillips, K. T., & Monte, A. A

To summarize the available evidence on CHS diagnosis, pathophysiology, and treatment.

Systematic Review: Unintentional Cannabis Ingestion in Children: A Systematic Review  (2017)

Systematic Review: Unintentional Cannabis Ingestion in Children: A Systematic Review

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Richards JRS, N. E.; Moulin, A. K.

Richards JRS, N. E.; Moulin, A. K.

To analyze published reports of unintentional cannabis ingestions in children to determine presenting signs and symptoms, route of exposure, treatment, and outcome.

Systematic Review: Cannabinoid Hyperemesis Syndrome: Diagnosis, Pathophysiology, and Treatmenta Systematic Review  (2017)

Systematic Review: Cannabinoid Hyperemesis Syndrome: Diagnosis, Pathophysiology, and Treatmenta Systematic Review

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Sorensen, C. J., DeSanto, K., Borgelt, L., Phillips, K. T., & Monte, A. A

Sorensen, C. J., DeSanto, K., Borgelt, L., Phillips, K. T., & Monte, A. A

To summarize the available evidence on CHS diagnosis, pathophysiology, and treatment.

Caring for Children with Developmental and Intellectual Disabilities English (9) French All (9)

Review: A Scoping Review of Targeted Interventions and Training to Facilitate Medical Encounters for School-Aged Patients with an Autism Spectrum Disorder  (2021)

Review: A Scoping Review of Targeted Interventions and Training to Facilitate Medical Encounters for School-Aged Patients with an Autism Spectrum Disorder

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Kouo JL, Kouo TS.

Kouo JL, Kouo TS.

Individuals with an autism spectrum disorder (ASD) have a greater number of healthcare provider interactions than individuals without ASD. The obstacles to patient-centered care for this population, which include inflexibility of hospital environments, limited resources, and inadequate training, has been documented. However, there is little knowledge on efforts to address such concerns. A scoping review was conducted and the systematic search of the literature resulted in 23 relevant studies. The predominant themes include the use of data collection instruments, application of evidence-based practices and resources, and training of providers. The results of this review have implications for practitioners and future research to adapt and improve upon the provision of medical care for individuals with ASD across the lifespan.

Review: Medical Encounters for Youth With Autism Spectrum Disorder: A Comprehensive Review of Environmental Considerations and Interventions  (2019)

Review: Medical Encounters for Youth With Autism Spectrum Disorder: A Comprehensive Review of Environmental Considerations and Interventions

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Straus J, Coburn S, Maskell S, Pappagianopoulos J, Cantrell K.

Straus J, Coburn S, Maskell S, Pappagianopoulos J, Cantrell K.

Approximately 1 in 59 youth are currently diagnosed with autism spectrum disorder (ASD), a neurodevelopmental disorder. In comparison to typically developing peers, youth with ASD encounter hospitalization at higher rates due to their heightened health care needs. While visiting the hospital is a stressor for youth with neurotypical needs, the experience contains unique challenges for those with ASD. This systematic literature review highlights research that considers the psychosocial impact of the hospital environment on the coping and adjustment of youth with ASD. Specifically, the review focuses on recommendations and interventions that may be used by health care professionals while supporting this population as they encounter the health care system. Ninety-six articles were identified as meeting inclusion and exclusion criteria. The findings suggest that practicing clinicians should implement a wide variety of interventions for youth with ASD including diversion techniques, comfort positions, and picture schedules. Although there are published evidence-based interventions for supporting youth with ASD in the hospital, most clinicians lack ASD-specific training. This article concludes with recommendations for future research.

Review: See-Hear-Feel-Speak: A Protocol for Improving Outcomes in Emergency Department Interactions With Patients With Autism Spectrum Disorder  (2019)

Review: See-Hear-Feel-Speak: A Protocol for Improving Outcomes in Emergency Department Interactions With Patients With Autism Spectrum Disorder

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Samet D, Luterman S.

Samet D, Luterman S.

The presentation of children and adolescents with autism in the emergency department (ED) poses a unique set of challenges to clinicians and their teams, which have not yet been met. Children and adolescents with autism spectrum disorder (ASD) are more likely than their age and ethnically matched counterparts to visit both pediatric and general EDs and are more likely to use it for primary care complaints and dental care and to present for psychiatric concerns including suicidality. Despite the higher relative frequency, individuals with ASD demonstrate lower patient satisfaction, lower healthcare self-efficacy, and higher odds of unmet healthcare needs related to physical health, mental health, health maintenance, and vaccination. This can be ameliorated by simple strategies regarding communication, sensory and environmental modification, and distraction. After performing a literature review of existing evidence-based recommendations via PubMed as well as resources from autism advocacy and self-advocacy groups, we compiled a 4-step system: "See-Hear-Feel-Speak" an approach conducive to learning with the goal of enabling clinicians and their teams to facilitate patient-centered encounters with pediatric patients with ASD. The protocol meets the practicality requirements defined by published research.

Review: Youth With Autism Spectrum Disorder in the Emergency Department  (2018)

Review: Youth With Autism Spectrum Disorder in the Emergency Department

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Lytle S, Hunt A, Moratschek S, Hall-Mennes M, Sajatovic M.

Lytle S, Hunt A, Moratschek S, Hall-Mennes M, Sajatovic M.

Youth (aged 0-17 years) with ASD were up to 30 times more likely to present to the ED than youth without ASD. Individuals with ASD who visited the ED were older, more likely to have public insurance, and more likely to have nonurgent ED visits. For youth with ASD, up to 13% of visits were for behavioral or psychiatric problems, whereas for youth without ASD less than 2% were for psychiatric problems. ASD youth were more likely to present for externalizing problems or psychotic symptoms. Youth with ASD were also likely to have repeat visits to the ED and more likely to be admitted to a psychiatric unit or medical floor than youth without ASD.

Review: Understanding and Improving Care for Individuals with Intellectual and Developmental Disabilities in the Emergency Department  (2014)

Review: Understanding and Improving Care for Individuals with Intellectual and Developmental Disabilities in the Emergency Department

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Lusky Y, Lake JK, Durbin J, Perry A, Bullock H, Morris S, Lee JS

Lusky Y, Lake JK, Durbin J, Perry A, Bullock H, Morris S, Lee JS

The aim of this review was to provide an overview of existing research on patterns and predictors of emergency department use among persons with intellectual and developmental disabilities, to summarize what is known about the care received and to describe interventions to improve emergency care.

Review: Management of agitation in individuals with autism spectrum disorders in the emergency department  (2014)

Review: Management of agitation in individuals with autism spectrum disorders in the emergency department

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McGonigle JJ, Venkat A, Beresford C, Campbell TP, Gabriels RL

McGonigle JJ, Venkat A, Beresford C, Campbell TP, Gabriels RL

This article describes the challenges that inidividuals with autism spectrum disorder face when receiving treatment in crisis and emergency settings.

Systematic Review: Children with autism spectrum disorder at a pediatric hospital: a systematic review of the literature  (2013)

Systematic Review: Children with autism spectrum disorder at a pediatric hospital: a systematic review of the literature

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Johnson NL, Rodriguez D

Johnson NL, Rodriguez D

This review describes the behaviors of hospitalized children with autism spectrum disorder that health care providers find challenging.

Review: Caring for the child with an autism spectrum disorder in the acute care setting  (2010)

Review: Caring for the child with an autism spectrum disorder in the acute care setting

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Scarpinato N, Bradley J, Kurbjun K, Bateman X, Holtzer B, Ely B

Scarpinato N, Bradley J, Kurbjun K, Bateman X, Holtzer B, Ely B

This article explores the challenges that patients with autism spectrum disorders face when hospitalized and provides assessment strategies and plan-of-care suggestions for nursing caregivers.

Review: Caring for children and adolescents with autism who require challenging procedures  (2002)

Review: Caring for children and adolescents with autism who require challenging procedures

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Souders MC, Freeman KG, DePaul D, Levy SE

Souders MC, Freeman KG, DePaul D, Levy SE

This review developed strategies for providing nursing care for children with autism or autistic spectrum disorders that incorporated theories and knowledge from disciplines of nursing, child development, psychology, applied behavior analysis, and pain management.

Review: A Scoping Review of Targeted Interventions and Training to Facilitate Medical Encounters for School-Aged Patients with an Autism Spectrum Disorder  (2021)

Review: A Scoping Review of Targeted Interventions and Training to Facilitate Medical Encounters for School-Aged Patients with an Autism Spectrum Disorder

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Kouo JL, Kouo TS.

Kouo JL, Kouo TS.

Individuals with an autism spectrum disorder (ASD) have a greater number of healthcare provider interactions than individuals without ASD. The obstacles to patient-centered care for this population, which include inflexibility of hospital environments, limited resources, and inadequate training, has been documented. However, there is little knowledge on efforts to address such concerns. A scoping review was conducted and the systematic search of the literature resulted in 23 relevant studies. The predominant themes include the use of data collection instruments, application of evidence-based practices and resources, and training of providers. The results of this review have implications for practitioners and future research to adapt and improve upon the provision of medical care for individuals with ASD across the lifespan.

Review: Medical Encounters for Youth With Autism Spectrum Disorder: A Comprehensive Review of Environmental Considerations and Interventions  (2019)

Review: Medical Encounters for Youth With Autism Spectrum Disorder: A Comprehensive Review of Environmental Considerations and Interventions

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Straus J, Coburn S, Maskell S, Pappagianopoulos J, Cantrell K.

Straus J, Coburn S, Maskell S, Pappagianopoulos J, Cantrell K.

Approximately 1 in 59 youth are currently diagnosed with autism spectrum disorder (ASD), a neurodevelopmental disorder. In comparison to typically developing peers, youth with ASD encounter hospitalization at higher rates due to their heightened health care needs. While visiting the hospital is a stressor for youth with neurotypical needs, the experience contains unique challenges for those with ASD. This systematic literature review highlights research that considers the psychosocial impact of the hospital environment on the coping and adjustment of youth with ASD. Specifically, the review focuses on recommendations and interventions that may be used by health care professionals while supporting this population as they encounter the health care system. Ninety-six articles were identified as meeting inclusion and exclusion criteria. The findings suggest that practicing clinicians should implement a wide variety of interventions for youth with ASD including diversion techniques, comfort positions, and picture schedules. Although there are published evidence-based interventions for supporting youth with ASD in the hospital, most clinicians lack ASD-specific training. This article concludes with recommendations for future research.

Review: See-Hear-Feel-Speak: A Protocol for Improving Outcomes in Emergency Department Interactions With Patients With Autism Spectrum Disorder  (2019)

Review: See-Hear-Feel-Speak: A Protocol for Improving Outcomes in Emergency Department Interactions With Patients With Autism Spectrum Disorder

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Samet D, Luterman S.

Samet D, Luterman S.

The presentation of children and adolescents with autism in the emergency department (ED) poses a unique set of challenges to clinicians and their teams, which have not yet been met. Children and adolescents with autism spectrum disorder (ASD) are more likely than their age and ethnically matched counterparts to visit both pediatric and general EDs and are more likely to use it for primary care complaints and dental care and to present for psychiatric concerns including suicidality. Despite the higher relative frequency, individuals with ASD demonstrate lower patient satisfaction, lower healthcare self-efficacy, and higher odds of unmet healthcare needs related to physical health, mental health, health maintenance, and vaccination. This can be ameliorated by simple strategies regarding communication, sensory and environmental modification, and distraction. After performing a literature review of existing evidence-based recommendations via PubMed as well as resources from autism advocacy and self-advocacy groups, we compiled a 4-step system: "See-Hear-Feel-Speak" an approach conducive to learning with the goal of enabling clinicians and their teams to facilitate patient-centered encounters with pediatric patients with ASD. The protocol meets the practicality requirements defined by published research.

Review: Youth With Autism Spectrum Disorder in the Emergency Department  (2018)

Review: Youth With Autism Spectrum Disorder in the Emergency Department

Visit

Lytle S, Hunt A, Moratschek S, Hall-Mennes M, Sajatovic M.

Lytle S, Hunt A, Moratschek S, Hall-Mennes M, Sajatovic M.

Youth (aged 0-17 years) with ASD were up to 30 times more likely to present to the ED than youth without ASD. Individuals with ASD who visited the ED were older, more likely to have public insurance, and more likely to have nonurgent ED visits. For youth with ASD, up to 13% of visits were for behavioral or psychiatric problems, whereas for youth without ASD less than 2% were for psychiatric problems. ASD youth were more likely to present for externalizing problems or psychotic symptoms. Youth with ASD were also likely to have repeat visits to the ED and more likely to be admitted to a psychiatric unit or medical floor than youth without ASD.

Review: Understanding and Improving Care for Individuals with Intellectual and Developmental Disabilities in the Emergency Department  (2014)

Review: Understanding and Improving Care for Individuals with Intellectual and Developmental Disabilities in the Emergency Department

Visit

Lusky Y, Lake JK, Durbin J, Perry A, Bullock H, Morris S, Lee JS

Lusky Y, Lake JK, Durbin J, Perry A, Bullock H, Morris S, Lee JS

The aim of this review was to provide an overview of existing research on patterns and predictors of emergency department use among persons with intellectual and developmental disabilities, to summarize what is known about the care received and to describe interventions to improve emergency care.

Review: Management of agitation in individuals with autism spectrum disorders in the emergency department  (2014)

Review: Management of agitation in individuals with autism spectrum disorders in the emergency department

Visit

McGonigle JJ, Venkat A, Beresford C, Campbell TP, Gabriels RL

McGonigle JJ, Venkat A, Beresford C, Campbell TP, Gabriels RL

This article describes the challenges that inidividuals with autism spectrum disorder face when receiving treatment in crisis and emergency settings.

Systematic Review: Children with autism spectrum disorder at a pediatric hospital: a systematic review of the literature  (2013)

Systematic Review: Children with autism spectrum disorder at a pediatric hospital: a systematic review of the literature

Visit

Johnson NL, Rodriguez D

Johnson NL, Rodriguez D

This review describes the behaviors of hospitalized children with autism spectrum disorder that health care providers find challenging.

Review: Caring for the child with an autism spectrum disorder in the acute care setting  (2010)

Review: Caring for the child with an autism spectrum disorder in the acute care setting

Visit

Scarpinato N, Bradley J, Kurbjun K, Bateman X, Holtzer B, Ely B

Scarpinato N, Bradley J, Kurbjun K, Bateman X, Holtzer B, Ely B

This article explores the challenges that patients with autism spectrum disorders face when hospitalized and provides assessment strategies and plan-of-care suggestions for nursing caregivers.

Review: Caring for children and adolescents with autism who require challenging procedures  (2002)

Review: Caring for children and adolescents with autism who require challenging procedures

Visit

Souders MC, Freeman KG, DePaul D, Levy SE

Souders MC, Freeman KG, DePaul D, Levy SE

This review developed strategies for providing nursing care for children with autism or autistic spectrum disorders that incorporated theories and knowledge from disciplines of nursing, child development, psychology, applied behavior analysis, and pain management.

Concussion English (14) French All (14)

Systematic review: Aerobic exercise for sport-related concussion: a systematic review and meta-analysis  (2020)

Systematic review: Aerobic exercise for sport-related concussion: a systematic review and meta-analysis

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Langevin P, Frmont P, Fait P, Dub MO, Bertrand-Charrette M, Roy JS.

Langevin P, Frmont P, Fait P, Dub MO, Bertrand-Charrette M, Roy JS.

The objective of this systematic review is to assess the effects of symptom-limited aerobic exercise programs compared with control interventions on symptom intensity in individuals with sports-related concussion.

Systematic review: Effectiveness of return to activity and return to school protocols for children postconcussion: a systematic review  (2020)

Systematic review: Effectiveness of return to activity and return to school protocols for children postconcussion: a systematic review

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DeMatteo C, Bednar ED, Randall S, Falla K.

DeMatteo C, Bednar ED, Randall S, Falla K.

Objective: To determine the effects of following return to activity (RTA) and return to school (RTS) protocols on clinical outcomes for children with concussion. The 12 subquestions of this review focus on the effectiveness of protocols, guidelines and recommendations, and the evidence supporting content of the protocols including rest, exercise and school accommodations.

Systematic review: Sleep disturbances after pediatric traumatic brain injury: a systematic review of prevalence, risk factors, and association with recovery  (2020)

Systematic review: Sleep disturbances after pediatric traumatic brain injury: a systematic review of prevalence, risk factors, and association with recovery

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Luther M, Poppert Cordts KM, Williams CN

Luther M, Poppert Cordts KM, Williams CN

Objectives: Sleep is vital for brain development and healing after injury, placing children with sleep-wake disturbances (SWD) after traumatic brain injury (TBI) at risk for worse outcomes. We conducted a systematic review to quantify SWD after pediatric TBI including prevalence, phenotypes, and risk factors. We also evaluated interventions for SWD and the association between SWD and other posttraumatic outcomes.

Systematic review: A systematic review of sleep-wake disturbances in childhood traumatic brain injury: relationship with fatigue, depression, and quality of life  (2019)

Systematic review: A systematic review of sleep-wake disturbances in childhood traumatic brain injury: relationship with fatigue, depression, and quality of life

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Botchway EN, Godfrey C, Anderson V, Catroppa C.

Botchway EN, Godfrey C, Anderson V, Catroppa C.

Objective: To systematically appraise the literature on the prevalence, types, and predictors of sleep-wake disturbances (SWD), and on the relationship between SWD, fatigue, depression, and quality of life in children and adolescents with traumatic brain injury (TBI).

Systematic review: Pediatric traumatic brain injury and antisocial behavior: are they linked? A systematic review  (2019)

Systematic review: Pediatric traumatic brain injury and antisocial behavior: are they linked? A systematic review

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Bellesi G, Barker ED, Brown L, Valmaggia L.

Bellesi G, Barker ED, Brown L, Valmaggia L.

This review aimed to explore systematically previous literature on the association between TBI before the age of 19 and severe behavioral problems such as violence, aggression and assault.

Systematic review: What factors must be considered in return to school following concussion and what strategies or accommodations should be followed? A systematic review  (2019)

Systematic review: What factors must be considered in return to school following concussion and what strategies or accommodations should be followed? A systematic review

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Purcell LK, Davis GA, Gioia GA.

Purcell LK, Davis GA, Gioia GA.

Objective: To evaluate the evidence regarding (1) factors affecting return to school (RTS) and (2) strategies/accommodations for RTS following a sport-related concussion (SRC) in children and adolescents.

Systematic review: A systematic review of criteria used to define recovery from sport-related concussion in youth athletes  (2018)

Systematic review: A systematic review of criteria used to define recovery from sport-related concussion in youth athletes

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Haider MN, Leddy JJ, Pavlesen S, et al.

Haider MN, Leddy JJ, Pavlesen S, et al.

Objective: The Concussion in Sport Group guidelines recommend a multifaceted approach to help clinicians make return to sport decisions. The purpose of this study was to identify the most common multifaceted measures used to define clinical recovery from sport-related concussion in young athletes (high school and/or college level) and to summarise existing knowledge of criteria used to make return to sport decisions.

Systematic review: A systematic review of neuroimaging findings in children and adolescents with sports-related concussion  (2018)

Systematic review: A systematic review of neuroimaging findings in children and adolescents with sports-related concussion

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Chamard E, Lichtenstein JD.

Chamard E, Lichtenstein JD.

The aim of this review is to systematically explore the literature on magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI), functional magnetic resonance imaging (fMRI), and cortical thickness following SRC in children and adolescents.

Systematic review: Chronic post-traumatic headache in children and adolescents: systematic review of prevalence and headache features  (2018)

Systematic review: Chronic post-traumatic headache in children and adolescents: systematic review of prevalence and headache features

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Shaw L, Morozova M, Abu-Arafeh I.

Shaw L, Morozova M, Abu-Arafeh I.

The aim of this systematic review is to determine the prevalence and clinical features of chronic post-traumatic headache (CPTH) in children and adolescents.

Systematic review: Diagnosis and management of mild traumatic brain injury in children: a systematic review  (2018)

Systematic review: Diagnosis and management of mild traumatic brain injury in children: a systematic review

Visit

Lumba-Brown A, Yeates KO, Sarmiento K, et al.

Lumba-Brown A, Yeates KO, Sarmiento K, et al.

Objective: To conduct a systematic review of the pediatric mTBI literature to serve as the foundation for an evidence-based guideline with clinical recommendations associated with the diagnosis and management of pediatric mTBI.

Systematic review: Imaging in pediatric concussion: a systematic review  (2018)

Systematic review: Imaging in pediatric concussion: a systematic review

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Schmidt J, Hayward KS, Brown KE, et al.

Schmidt J, Hayward KS, Brown KE, et al.

Objective: To investigate the differences in neuroimaging findings in children/youth with mTBI. Measures of behavior, symptoms, time since injury, and age at injury were also considered.

Systematic review: The age variable in childhood concussion management: a systematic review  (2018)

Systematic review: The age variable in childhood concussion management: a systematic review

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Moser RS, Davis GA, Schatz P.

Moser RS, Davis GA, Schatz P.

This paper reviews the research literature in an effort to shed light on the question, "At what age should young children be managed differently than adults or older adolescents?"

Systematic Review: Predictors of clinical recovery from concussion: a systematic review  (2017)

Systematic Review: Predictors of clinical recovery from concussion: a systematic review

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Iverson GL, Gardner AJ, Terry DP, Ponsford JL, Sills AK, Broshek DK, Solomon GS

Iverson GL, Gardner AJ, Terry DP, Ponsford JL, Sills AK, Broshek DK, Solomon GS

This is a systematic review of factors that might be associated with, or influence, clinical recovery from sport-related concussion

Systematic Review: Rest and treatment/rehabilitation following sport-related concussion: a systematic review  (2017)

Systematic Review: Rest and treatment/rehabilitation following sport-related concussion: a systematic review

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Schneider KJ, Leddy JJ, Guskiewicz KM, Seifert T, McCrea M, Silverberg ND, Feddermann-Demont N, Iverson GL, Hayden A, Makdissi M

Schneider KJ, Leddy JJ, Guskiewicz KM, Seifert T, McCrea M, Silverberg ND, Fe...

The objective of this systematic review was to evaluate the evidence regarding rest and active treatment/rehabilitation following sport-related concussion (SRC).

Systematic review: Aerobic exercise for sport-related concussion: a systematic review and meta-analysis  (2020)

Systematic review: Aerobic exercise for sport-related concussion: a systematic review and meta-analysis

Visit

Langevin P, Frmont P, Fait P, Dub MO, Bertrand-Charrette M, Roy JS.

Langevin P, Frmont P, Fait P, Dub MO, Bertrand-Charrette M, Roy JS.

The objective of this systematic review is to assess the effects of symptom-limited aerobic exercise programs compared with control interventions on symptom intensity in individuals with sports-related concussion.

Systematic review: Effectiveness of return to activity and return to school protocols for children postconcussion: a systematic review  (2020)

Systematic review: Effectiveness of return to activity and return to school protocols for children postconcussion: a systematic review

Visit

DeMatteo C, Bednar ED, Randall S, Falla K.

DeMatteo C, Bednar ED, Randall S, Falla K.

Objective: To determine the effects of following return to activity (RTA) and return to school (RTS) protocols on clinical outcomes for children with concussion. The 12 subquestions of this review focus on the effectiveness of protocols, guidelines and recommendations, and the evidence supporting content of the protocols including rest, exercise and school accommodations.

Systematic review: Sleep disturbances after pediatric traumatic brain injury: a systematic review of prevalence, risk factors, and association with recovery  (2020)

Systematic review: Sleep disturbances after pediatric traumatic brain injury: a systematic review of prevalence, risk factors, and association with recovery

Visit

Luther M, Poppert Cordts KM, Williams CN

Luther M, Poppert Cordts KM, Williams CN

Objectives: Sleep is vital for brain development and healing after injury, placing children with sleep-wake disturbances (SWD) after traumatic brain injury (TBI) at risk for worse outcomes. We conducted a systematic review to quantify SWD after pediatric TBI including prevalence, phenotypes, and risk factors. We also evaluated interventions for SWD and the association between SWD and other posttraumatic outcomes.

Systematic review: A systematic review of sleep-wake disturbances in childhood traumatic brain injury: relationship with fatigue, depression, and quality of life  (2019)

Systematic review: A systematic review of sleep-wake disturbances in childhood traumatic brain injury: relationship with fatigue, depression, and quality of life

Visit

Botchway EN, Godfrey C, Anderson V, Catroppa C.

Botchway EN, Godfrey C, Anderson V, Catroppa C.

Objective: To systematically appraise the literature on the prevalence, types, and predictors of sleep-wake disturbances (SWD), and on the relationship between SWD, fatigue, depression, and quality of life in children and adolescents with traumatic brain injury (TBI).

Systematic review: Pediatric traumatic brain injury and antisocial behavior: are they linked? A systematic review  (2019)

Systematic review: Pediatric traumatic brain injury and antisocial behavior: are they linked? A systematic review

Visit

Bellesi G, Barker ED, Brown L, Valmaggia L.

Bellesi G, Barker ED, Brown L, Valmaggia L.

This review aimed to explore systematically previous literature on the association between TBI before the age of 19 and severe behavioral problems such as violence, aggression and assault.

Systematic review: What factors must be considered in return to school following concussion and what strategies or accommodations should be followed? A systematic review  (2019)

Systematic review: What factors must be considered in return to school following concussion and what strategies or accommodations should be followed? A systematic review

Visit

Purcell LK, Davis GA, Gioia GA.

Purcell LK, Davis GA, Gioia GA.

Objective: To evaluate the evidence regarding (1) factors affecting return to school (RTS) and (2) strategies/accommodations for RTS following a sport-related concussion (SRC) in children and adolescents.

Systematic review: A systematic review of criteria used to define recovery from sport-related concussion in youth athletes  (2018)

Systematic review: A systematic review of criteria used to define recovery from sport-related concussion in youth athletes

Visit

Haider MN, Leddy JJ, Pavlesen S, et al.

Haider MN, Leddy JJ, Pavlesen S, et al.

Objective: The Concussion in Sport Group guidelines recommend a multifaceted approach to help clinicians make return to sport decisions. The purpose of this study was to identify the most common multifaceted measures used to define clinical recovery from sport-related concussion in young athletes (high school and/or college level) and to summarise existing knowledge of criteria used to make return to sport decisions.

Systematic review: A systematic review of neuroimaging findings in children and adolescents with sports-related concussion  (2018)

Systematic review: A systematic review of neuroimaging findings in children and adolescents with sports-related concussion

Visit

Chamard E, Lichtenstein JD.

Chamard E, Lichtenstein JD.

The aim of this review is to systematically explore the literature on magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI), functional magnetic resonance imaging (fMRI), and cortical thickness following SRC in children and adolescents.

Systematic review: Chronic post-traumatic headache in children and adolescents: systematic review of prevalence and headache features  (2018)

Systematic review: Chronic post-traumatic headache in children and adolescents: systematic review of prevalence and headache features

Visit

Shaw L, Morozova M, Abu-Arafeh I.

Shaw L, Morozova M, Abu-Arafeh I.

The aim of this systematic review is to determine the prevalence and clinical features of chronic post-traumatic headache (CPTH) in children and adolescents.

Systematic review: Diagnosis and management of mild traumatic brain injury in children: a systematic review  (2018)

Systematic review: Diagnosis and management of mild traumatic brain injury in children: a systematic review

Visit

Lumba-Brown A, Yeates KO, Sarmiento K, et al.

Lumba-Brown A, Yeates KO, Sarmiento K, et al.

Objective: To conduct a systematic review of the pediatric mTBI literature to serve as the foundation for an evidence-based guideline with clinical recommendations associated with the diagnosis and management of pediatric mTBI.

Systematic review: Imaging in pediatric concussion: a systematic review  (2018)

Systematic review: Imaging in pediatric concussion: a systematic review

Visit

Schmidt J, Hayward KS, Brown KE, et al.

Schmidt J, Hayward KS, Brown KE, et al.

Objective: To investigate the differences in neuroimaging findings in children/youth with mTBI. Measures of behavior, symptoms, time since injury, and age at injury were also considered.

Systematic review: The age variable in childhood concussion management: a systematic review  (2018)

Systematic review: The age variable in childhood concussion management: a systematic review

Visit

Moser RS, Davis GA, Schatz P.

Moser RS, Davis GA, Schatz P.

This paper reviews the research literature in an effort to shed light on the question, "At what age should young children be managed differently than adults or older adolescents?"

Systematic Review: Predictors of clinical recovery from concussion: a systematic review  (2017)

Systematic Review: Predictors of clinical recovery from concussion: a systematic review

Visit

Iverson GL, Gardner AJ, Terry DP, Ponsford JL, Sills AK, Broshek DK, Solomon GS

Iverson GL, Gardner AJ, Terry DP, Ponsford JL, Sills AK, Broshek DK, Solomon GS

This is a systematic review of factors that might be associated with, or influence, clinical recovery from sport-related concussion

Systematic Review: Rest and treatment/rehabilitation following sport-related concussion: a systematic review  (2017)

Systematic Review: Rest and treatment/rehabilitation following sport-related concussion: a systematic review

Visit

Schneider KJ, Leddy JJ, Guskiewicz KM, Seifert T, McCrea M, Silverberg ND, Feddermann-Demont N, Iverson GL, Hayden A, Makdissi M

Schneider KJ, Leddy JJ, Guskiewicz KM, Seifert T, McCrea M, Silverberg ND, Fe...

The objective of this systematic review was to evaluate the evidence regarding rest and active treatment/rehabilitation following sport-related concussion (SRC).

Congenital Heart Defect English (1) French All (1)

Systematic Review: Pulse oximetry screening for critical congenital heart defects in asymptomatic newborn babies: a systematic review and meta-analysis  (2012)

Systematic Review: Pulse oximetry screening for critical congenital heart defects in asymptomatic newborn babies: a systematic review and meta-analysis

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Thangaratinam S, Brown K, Zamora J, Khan KS, Ewer AK

Thangaratinam S, Brown K, Zamora J, Khan KS, Ewer AK

Objective: To assess the performance of pulse oximetry as a screening method for the detection of critical congenital heart defects in asymptomatic newborn babies.

Systematic Review: Pulse oximetry screening for critical congenital heart defects in asymptomatic newborn babies: a systematic review and meta-analysis  (2012)

Systematic Review: Pulse oximetry screening for critical congenital heart defects in asymptomatic newborn babies: a systematic review and meta-analysis

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Thangaratinam S, Brown K, Zamora J, Khan KS, Ewer AK

Thangaratinam S, Brown K, Zamora J, Khan KS, Ewer AK

Objective: To assess the performance of pulse oximetry as a screening method for the detection of critical congenital heart defects in asymptomatic newborn babies.

Constipation English (18) French All (18)

Systematic Review: When Poorly Conducted Systematic Reviews and Meta-analyses can Mislead: a critical appraisal and update of systematic reviews and meta-analyses examining the effects of probiotics in the treatment of functional constipation in children  (2019)

Systematic Review: When Poorly Conducted Systematic Reviews and Meta-analyses can Mislead: a critical appraisal and update of systematic reviews and meta-analyses examining the effects of probiotics in the treatment of functional constipation in children

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Harris RG,Neale EP,Ferreira I

Harris RG,Neale EP,Ferreira I

The aim of this study was to critically review and update the evidence in this field by mapping all the steps involved against those reported in previous reviews, in an attempt to understand the nature of their conflicting results.

Systematic Review: Use Of Fibers in Childhood Constipation Treatment: systematic review with meta-analysis  (2018)

Systematic Review: Use Of Fibers in Childhood Constipation Treatment: systematic review with meta-analysis

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Piccoli de Mello P,Eifer DA,Daniel de Mello E

Piccoli de Mello P,Eifer DA,Daniel de Mello E

To gather current evidence on the use of fiber for constipation treatment in pediatric patients.

Systematic Review: The Role of Fiber in the Treatment of Functional Gastrointestinal Disorders in Children  (2018)

Systematic Review: The Role of Fiber in the Treatment of Functional Gastrointestinal Disorders in Children

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Cara Hannah Axelrod,Miguel Saps

Cara Hannah Axelrod,Miguel Saps

We reviewed the available evidence on the role of fiber in the treatment of Functional Constipation (FC) and Irritable Bowel Syndrome (IBS) in children.

Systematic Review: Systematic Review and Meta-analysis of the Effect of Probiotic Supplementation on Functional Constipation in Children  (2018)

Systematic Review: Systematic Review and Meta-analysis of the Effect of Probiotic Supplementation on Functional Constipation in Children

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Jin L,Deng L,Wu W,Wang Z,Shao W,Liu J

Jin L,Deng L,Wu W,Wang Z,Shao W,Liu J

To evaluate the effect of probiotic supplementation on functional constipation in children.

Systematic Review: Effectiveness of Probiotics in Children with Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review  (2018)

Systematic Review: Effectiveness of Probiotics in Children with Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review

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Wegh CAM,Benninga MA,Tabbers MM

Wegh CAM,Benninga MA,Tabbers MM

The objective of this study was to investigate the effect of probiotics on functional abdominal pain disorders (FAPD) and functional constipation (FC).

Systematic Review: Positive Effect of Probiotics on Constipation in Children: A Systematic Review and Meta-Analysis of Six Randomized Controlled Trials  (2017)

Systematic Review: Positive Effect of Probiotics on Constipation in Children: A Systematic Review and Meta-Analysis of Six Randomized Controlled Trials

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Huang R,Hu J

Huang R,Hu J

This study reviewed the existing literatures of 6 Randomized Control Trials (RCTs) to ascertain some baseline understanding and available information for the effects of probiotics on stool frequency and consistency in children with constipation.

Systematic Review: Probiotics for Functional Constipation in Children  (2017)

Systematic Review: Probiotics for Functional Constipation in Children

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Katarzyna Wojtyniak, Hania Szajewska

Katarzyna Wojtyniak, Hania Szajewska

We updated our 2010 systematic review on the efficacy of probiotics in the treatment of constipation in children.

Cochrane Systematic Review: Osmotic and Stimulant Laxatives for the Management of Childhood Constipation  (2016)

Cochrane Systematic Review: Osmotic and Stimulant Laxatives for the Management of Childhood Constipation

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Gordon M, MacDonald JK, Parker CE, Akobeng AK, Thomas AG

Gordon M, MacDonald JK, Parker CE, Akobeng AK, Thomas AG

The objective of this systematic review was to evaluate the efficacy and safety of osmotic and stimulant laxatives used to treat functional childhood constipation.

Systematic Review: Is There A Role for Pre-, Pro- and Synbiotics in the Treatment of Functional Constipation in Children?  (2016)

Systematic Review: Is There A Role for Pre-, Pro- and Synbiotics in the Treatment of Functional Constipation in Children?

Visit

Koppen IJ, Benninga MA, Tabbers MM

Koppen IJ, Benninga MA, Tabbers MM

The objective of this systematic review was to investigate the efficacy and safety of pre-, pro- and synbiotics in the treatment of pediatric functional constipation.

Review: Management of Functional Constipation in Children: Therapy in Practice  (2015)

Review: Management of Functional Constipation in Children: Therapy in Practice

Visit

Koppen IJ, Lammers LA, Benninga MA, Tabbers MM

Koppen IJ, Lammers LA, Benninga MA, Tabbers MM

This review discusses the evaluation and management of functional constipation in the pediatric population and provides a summary of drug treatment options.

Systematic Review: Constipation in Children: Fibre and Probiotics  (2015)

Systematic Review: Constipation in Children: Fibre and Probiotics

Visit

Tabbers MM, Benninga MA

Tabbers MM, Benninga MA

This systematic review aimed to answer the following clinical questions: What are the effects of fibre for children with chronic constipation? What are the effects of probiotics for children with chronic constipation?

Review: Irritable Bowel Syndrome in Children: Pathogenesis, Diagnosis and Evidence-Based Treatment  (2014)

Review: Irritable Bowel Syndrome in Children: Pathogenesis, Diagnosis and Evidence-Based Treatment

Visit

Sandhu BK, Paul SP

Sandhu BK, Paul SP

This review covers the description, etiology, diagnosis and management of irritable bowel syndrome in children.

Systematic Review: Value of Abdominal Radiography, Colonic Transit Time, and Rectal Ultrasound Scanning in the Diagnosis of Idiopathic Constipation in Children: a systematic review  (2012)

Systematic Review: Value of Abdominal Radiography, Colonic Transit Time, and Rectal Ultrasound Scanning in the Diagnosis of Idiopathic Constipation in Children: a systematic review

Visit

Berger MY,Tabbers MM,Kurver MJ,Boluyt N,Benninga MA

Berger MY,Tabbers MM,Kurver MJ,Boluyt N,Benninga MA

To perform a systematic review evaluating the value of abdominal radiography, colonic transit time (CTT), and rectal ultrasound scanning in the diagnosis of idiopathic constipation in children.

Cochrane Systematic Review: Behavioural and cognitive interventions with or without other treatments for the management of faecal incontinence in children  (2011)

Cochrane Systematic Review: Behavioural and cognitive interventions with or without other treatments for the management of faecal incontinence in children

Visit

Brazzelli M, Griffiths PV, Cody JD, Tappin D

Brazzelli M, Griffiths PV, Cody JD, Tappin D

The objective of this systematic review was to assess the effects of behavioural and/or cognitive interventions for the management of faecal incontinence in children.

Systematic Review: Nonpharmacologic treatments for childhood constipation: systematic review  (2011)

Systematic Review: Nonpharmacologic treatments for childhood constipation: systematic review

Visit

Tabbers MM, Boluyt N, Berger MY, Benninga MA

Tabbers MM, Boluyt N, Berger MY, Benninga MA

The objectives of this systematic review were to summarize the evidence and assess the reported quality of studies concerning nonpharmacologic treatments for childhood constipation, including fiber, fluid, physical movement, prebiotics, probiotics, behavioral therapy, multidisciplinary treatment, and forms of alternative medicine.

Systematic Review: Constipation in children  (2010)

Systematic Review: Constipation in children

Visit

Tabbers MM, Boluyt N, Berger MY, Benninga MA

Tabbers MM, Boluyt N, Berger MY, Benninga MA

This systematic review aimed to answer the following clinical questions: What are the effects of treatments for children with chronic constipation? What are the effects of treatments for clearing the bowel in children with faecal impaction?

Systematic Review: Currently recommended treatments of childhood constipation are not evidence based: a systematic literature review on the effect of laxative treatment and dietary measures  (2009)

Systematic Review: Currently recommended treatments of childhood constipation are not evidence based: a systematic literature review on the effect of laxative treatment and dietary measures

Visit

Pijpers MA, Tabbers MM, Benninga MA, Berger MY

Pijpers MA, Tabbers MM, Benninga MA, Berger MY

The objective of this systematic review was to investigate and summarise the quantity and quality of the current evidence for the effect of laxatives and dietary measures on functional childhood constipation.

Systematic Review: Diagnostic value of abdominal radiography in constipatedchildren: asystematic review.  (2005)

Systematic Review: Diagnostic value of abdominal radiography in constipatedchildren: asystematic review.

Visit

Reuchlin-Vroklage LM,Bierma-Zeinstra S,Benninga MA,Berger MY

Reuchlin-Vroklage LM,Bierma-Zeinstra S,Benninga MA,Berger MY

To describe and to assess the evidence from observational, controlled studies concerning the association between abdominal radiography and symptoms and signs related to constipation in children.

Systematic Review: When Poorly Conducted Systematic Reviews and Meta-analyses can Mislead: a critical appraisal and update of systematic reviews and meta-analyses examining the effects of probiotics in the treatment of functional constipation in children  (2019)

Systematic Review: When Poorly Conducted Systematic Reviews and Meta-analyses can Mislead: a critical appraisal and update of systematic reviews and meta-analyses examining the effects of probiotics in the treatment of functional constipation in children

Visit

Harris RG,Neale EP,Ferreira I

Harris RG,Neale EP,Ferreira I

The aim of this study was to critically review and update the evidence in this field by mapping all the steps involved against those reported in previous reviews, in an attempt to understand the nature of their conflicting results.

Systematic Review: Use Of Fibers in Childhood Constipation Treatment: systematic review with meta-analysis  (2018)

Systematic Review: Use Of Fibers in Childhood Constipation Treatment: systematic review with meta-analysis

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Piccoli de Mello P,Eifer DA,Daniel de Mello E

Piccoli de Mello P,Eifer DA,Daniel de Mello E

To gather current evidence on the use of fiber for constipation treatment in pediatric patients.

Systematic Review: The Role of Fiber in the Treatment of Functional Gastrointestinal Disorders in Children  (2018)

Systematic Review: The Role of Fiber in the Treatment of Functional Gastrointestinal Disorders in Children

Visit

Cara Hannah Axelrod,Miguel Saps

Cara Hannah Axelrod,Miguel Saps

We reviewed the available evidence on the role of fiber in the treatment of Functional Constipation (FC) and Irritable Bowel Syndrome (IBS) in children.

Systematic Review: Systematic Review and Meta-analysis of the Effect of Probiotic Supplementation on Functional Constipation in Children  (2018)

Systematic Review: Systematic Review and Meta-analysis of the Effect of Probiotic Supplementation on Functional Constipation in Children

Visit

Jin L,Deng L,Wu W,Wang Z,Shao W,Liu J

Jin L,Deng L,Wu W,Wang Z,Shao W,Liu J

To evaluate the effect of probiotic supplementation on functional constipation in children.

Systematic Review: Effectiveness of Probiotics in Children with Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review  (2018)

Systematic Review: Effectiveness of Probiotics in Children with Functional Abdominal Pain Disorders and Functional Constipation: A Systematic Review

Visit

Wegh CAM,Benninga MA,Tabbers MM

Wegh CAM,Benninga MA,Tabbers MM

The objective of this study was to investigate the effect of probiotics on functional abdominal pain disorders (FAPD) and functional constipation (FC).

Systematic Review: Positive Effect of Probiotics on Constipation in Children: A Systematic Review and Meta-Analysis of Six Randomized Controlled Trials  (2017)

Systematic Review: Positive Effect of Probiotics on Constipation in Children: A Systematic Review and Meta-Analysis of Six Randomized Controlled Trials

Visit

Huang R,Hu J

Huang R,Hu J

This study reviewed the existing literatures of 6 Randomized Control Trials (RCTs) to ascertain some baseline understanding and available information for the effects of probiotics on stool frequency and consistency in children with constipation.

Systematic Review: Probiotics for Functional Constipation in Children  (2017)

Systematic Review: Probiotics for Functional Constipation in Children

Visit

Katarzyna Wojtyniak, Hania Szajewska

Katarzyna Wojtyniak, Hania Szajewska

We updated our 2010 systematic review on the efficacy of probiotics in the treatment of constipation in children.

Cochrane Systematic Review: Osmotic and Stimulant Laxatives for the Management of Childhood Constipation  (2016)

Cochrane Systematic Review: Osmotic and Stimulant Laxatives for the Management of Childhood Constipation

Visit

Gordon M, MacDonald JK, Parker CE, Akobeng AK, Thomas AG

Gordon M, MacDonald JK, Parker CE, Akobeng AK, Thomas AG

The objective of this systematic review was to evaluate the efficacy and safety of osmotic and stimulant laxatives used to treat functional childhood constipation.

Systematic Review: Is There A Role for Pre-, Pro- and Synbiotics in the Treatment of Functional Constipation in Children?  (2016)

Systematic Review: Is There A Role for Pre-, Pro- and Synbiotics in the Treatment of Functional Constipation in Children?

Visit

Koppen IJ, Benninga MA, Tabbers MM

Koppen IJ, Benninga MA, Tabbers MM

The objective of this systematic review was to investigate the efficacy and safety of pre-, pro- and synbiotics in the treatment of pediatric functional constipation.

Review: Management of Functional Constipation in Children: Therapy in Practice  (2015)

Review: Management of Functional Constipation in Children: Therapy in Practice

Visit

Koppen IJ, Lammers LA, Benninga MA, Tabbers MM

Koppen IJ, Lammers LA, Benninga MA, Tabbers MM

This review discusses the evaluation and management of functional constipation in the pediatric population and provides a summary of drug treatment options.

Systematic Review: Constipation in Children: Fibre and Probiotics  (2015)

Systematic Review: Constipation in Children: Fibre and Probiotics

Visit

Tabbers MM, Benninga MA

Tabbers MM, Benninga MA

This systematic review aimed to answer the following clinical questions: What are the effects of fibre for children with chronic constipation? What are the effects of probiotics for children with chronic constipation?

Review: Irritable Bowel Syndrome in Children: Pathogenesis, Diagnosis and Evidence-Based Treatment  (2014)

Review: Irritable Bowel Syndrome in Children: Pathogenesis, Diagnosis and Evidence-Based Treatment

Visit

Sandhu BK, Paul SP

Sandhu BK, Paul SP

This review covers the description, etiology, diagnosis and management of irritable bowel syndrome in children.

Systematic Review: Value of Abdominal Radiography, Colonic Transit Time, and Rectal Ultrasound Scanning in the Diagnosis of Idiopathic Constipation in Children: a systematic review  (2012)

Systematic Review: Value of Abdominal Radiography, Colonic Transit Time, and Rectal Ultrasound Scanning in the Diagnosis of Idiopathic Constipation in Children: a systematic review

Visit

Berger MY,Tabbers MM,Kurver MJ,Boluyt N,Benninga MA

Berger MY,Tabbers MM,Kurver MJ,Boluyt N,Benninga MA

To perform a systematic review evaluating the value of abdominal radiography, colonic transit time (CTT), and rectal ultrasound scanning in the diagnosis of idiopathic constipation in children.

Cochrane Systematic Review: Behavioural and cognitive interventions with or without other treatments for the management of faecal incontinence in children  (2011)

Cochrane Systematic Review: Behavioural and cognitive interventions with or without other treatments for the management of faecal incontinence in children

Visit

Brazzelli M, Griffiths PV, Cody JD, Tappin D

Brazzelli M, Griffiths PV, Cody JD, Tappin D

The objective of this systematic review was to assess the effects of behavioural and/or cognitive interventions for the management of faecal incontinence in children.

Systematic Review: Nonpharmacologic treatments for childhood constipation: systematic review  (2011)

Systematic Review: Nonpharmacologic treatments for childhood constipation: systematic review

Visit

Tabbers MM, Boluyt N, Berger MY, Benninga MA

Tabbers MM, Boluyt N, Berger MY, Benninga MA

The objectives of this systematic review were to summarize the evidence and assess the reported quality of studies concerning nonpharmacologic treatments for childhood constipation, including fiber, fluid, physical movement, prebiotics, probiotics, behavioral therapy, multidisciplinary treatment, and forms of alternative medicine.

Systematic Review: Constipation in children  (2010)

Systematic Review: Constipation in children

Visit

Tabbers MM, Boluyt N, Berger MY, Benninga MA

Tabbers MM, Boluyt N, Berger MY, Benninga MA

This systematic review aimed to answer the following clinical questions: What are the effects of treatments for children with chronic constipation? What are the effects of treatments for clearing the bowel in children with faecal impaction?

Systematic Review: Currently recommended treatments of childhood constipation are not evidence based: a systematic literature review on the effect of laxative treatment and dietary measures  (2009)

Systematic Review: Currently recommended treatments of childhood constipation are not evidence based: a systematic literature review on the effect of laxative treatment and dietary measures

Visit

Pijpers MA, Tabbers MM, Benninga MA, Berger MY

Pijpers MA, Tabbers MM, Benninga MA, Berger MY

The objective of this systematic review was to investigate and summarise the quantity and quality of the current evidence for the effect of laxatives and dietary measures on functional childhood constipation.

Systematic Review: Diagnostic value of abdominal radiography in constipatedchildren: asystematic review.  (2005)

Systematic Review: Diagnostic value of abdominal radiography in constipatedchildren: asystematic review.

Visit

Reuchlin-Vroklage LM,Bierma-Zeinstra S,Benninga MA,Berger MY

Reuchlin-Vroklage LM,Bierma-Zeinstra S,Benninga MA,Berger MY

To describe and to assess the evidence from observational, controlled studies concerning the association between abdominal radiography and symptoms and signs related to constipation in children.

Croup English (5) French All (5)

Cochrane Systematic Review: Glucocorticoids for croup in children  (2018)

Cochrane Systematic Review: Glucocorticoids for croup in children

Visit

Gates A, Gates M, Vandermeer B, Johnson C, Hartling L, Johnson DW, Klassen TP,

Gates A, Gates M, Vandermeer B, Johnson C, Hartling L, Johnson DW, Klassen TP,

Objective: To examine the effects of glucocorticoids for the treatment of croup in children aged 0 to 18 years. Published: 2018.

Cochrane Systematic Review: Heliox for croup in children  (2018)

Cochrane Systematic Review: Heliox for croup in children

Visit

Moraa I, Sturman N, McGuire TM, van Driel ML,

Moraa I, Sturman N, McGuire TM, van Driel ML,

Objective: To examine the effect of heliox compared to oxygen or other active interventions, placebo, or no treatment, on relieving signs and symptoms in children with croup as determined by a croup score and rates of admission and intubation.

Cochrane Systematic Review: Nebulized epinephrine for croup in children  (2013)

Cochrane Systematic Review: Nebulized epinephrine for croup in children

Visit

Bjornson, C, Russell, K, Vandermeer, B, Klassen, TP, Johnson, DW,

Bjornson, C, Russell, K, Vandermeer, B, Klassen, TP, Johnson, DW,

Objective: To assess the efficacy (measured by croup scores, rate of intubation and health care utilization such as rate of hospitalization) and safety (frequency and severity of side effects) of nebulized epinephrine versus placebo in children with croup, evaluated in an emergency department (ED) or hospital setting.

Review: Croup in children  (2013)

Review: Croup in children

Visit

Bjornson CL, Johnson DW,

Bjornson CL, Johnson DW,

Objective:This review will address the diagnosis and management of croup in children, specifically focusing on clinical assessment of disease severity to guide management decisions.

Cochrane Systematic Review: Humidified air inhalation for treating croup  (2006)

Cochrane Systematic Review: Humidified air inhalation for treating croup

Visit

Moore, M, Little, P,

Moore, M, Little, P,

Objective: To assess the efficacy of humidified air in the treatment of croup.

Cochrane Systematic Review: Glucocorticoids for croup in children  (2018)

Cochrane Systematic Review: Glucocorticoids for croup in children

Visit

Gates A, Gates M, Vandermeer B, Johnson C, Hartling L, Johnson DW, Klassen TP,

Gates A, Gates M, Vandermeer B, Johnson C, Hartling L, Johnson DW, Klassen TP,

Objective: To examine the effects of glucocorticoids for the treatment of croup in children aged 0 to 18 years. Published: 2018.

Cochrane Systematic Review: Heliox for croup in children  (2018)

Cochrane Systematic Review: Heliox for croup in children

Visit

Moraa I, Sturman N, McGuire TM, van Driel ML,

Moraa I, Sturman N, McGuire TM, van Driel ML,

Objective: To examine the effect of heliox compared to oxygen or other active interventions, placebo, or no treatment, on relieving signs and symptoms in children with croup as determined by a croup score and rates of admission and intubation.

Cochrane Systematic Review: Nebulized epinephrine for croup in children  (2013)

Cochrane Systematic Review: Nebulized epinephrine for croup in children

Visit

Bjornson, C, Russell, K, Vandermeer, B, Klassen, TP, Johnson, DW,

Bjornson, C, Russell, K, Vandermeer, B, Klassen, TP, Johnson, DW,

Objective: To assess the efficacy (measured by croup scores, rate of intubation and health care utilization such as rate of hospitalization) and safety (frequency and severity of side effects) of nebulized epinephrine versus placebo in children with croup, evaluated in an emergency department (ED) or hospital setting.

Review: Croup in children  (2013)

Review: Croup in children

Visit

Bjornson CL, Johnson DW,

Bjornson CL, Johnson DW,

Objective:This review will address the diagnosis and management of croup in children, specifically focusing on clinical assessment of disease severity to guide management decisions.

Cochrane Systematic Review: Humidified air inhalation for treating croup  (2006)

Cochrane Systematic Review: Humidified air inhalation for treating croup

Visit

Moore, M, Little, P,

Moore, M, Little, P,

Objective: To assess the efficacy of humidified air in the treatment of croup.

Diabetic ketoacidosis English (9) French All (9)

Application of bench studies at the bedside to improve outcomes in the management of severe diabetic ketoacidosis in children-a narrative review.  (2021)

Application of bench studies at the bedside to improve outcomes in the management of severe diabetic ketoacidosis in children-a narrative review.

Visit

Ravikumar N, Bansal A.

Ravikumar N, Bansal A.

In this review, we address a few key issues and the challenges faced in the management of severe diabetic ketoacidosis (DKA) in children, highlighting the existing standard of care, supported by evidence and bench studies.

Update and harmonisation of guidance for the management of diabetic ketoacidosis in children and young people in the UK  (2021)

Update and harmonisation of guidance for the management of diabetic ketoacidosis in children and young people in the UK

Visit

Rugg-Gunn CE, Deakin M, Hawcutt DB.

Rugg-Gunn CE, Deakin M, Hawcutt DB.

Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes mellitus. Careful and timely intervention is required to optimise glycaemic control and reduce the risk of mortality and devastating complications. Of these, cerebral oedema is the leading cause of death, with a mortality rate of approximately 25%. This article highlights the recent updates to UK fluid therapy guidelines for DKA and provides clinical context for the benefit of paediatricians and junior doctors in light of this new guidance.

Diabetic ketoacidosis in patients with SARS-CoV-2: a systematic review and meta-analysis.  (2021)

Diabetic ketoacidosis in patients with SARS-CoV-2: a systematic review and meta-analysis.

Visit

Alhumaid S, Al Mutair A, Al Alawi Z, Rabaan AA, Alomari MA, Al Salman SA, et al.

Alhumaid S, Al Mutair A, Al Alawi Z, Rabaan AA, Alomari MA, Al Salman SA, et al.

To re-evaluate the association of SARS-CoV-2 and development of DKA and analyse the demographic and biochemical parameters and the clinical outcomes in COVID-19 patients with DKA. DKA is not uncommon in SARS-CoV-2 patients with diabetes mellitus and results in a mortality rate of 25.9%. Mortality key determinants in DKA patients with SARS-CoV-2 infection are individuals with pre-existing diabetes mellitus type 2, older age [ 60 years old], male gender, BMI 30, blood glucose level > 1000 mg/dl, and anion gap 30 mEq/l.

Effectiveness of ketoacidosis prevention campaigns at diagnosis of type 1 diabetes in children: A systematic review and meta-analysis.  (2021)

Effectiveness of ketoacidosis prevention campaigns at diagnosis of type 1 diabetes in children: A systematic review and meta-analysis.

Visit

Cherubini V, Marino M, Carle F, Zagaroli L, Bowers R, Gesuita R.

Cherubini V, Marino M, Carle F, Zagaroli L, Bowers R, Gesuita R.

To determine if diabetes awareness campaigns are an effective intervention to reduce diabetes ketoacidosis at diagnosis of type 1 diabetes in children and youth. This review demonstrated that DKA awareness campaigns are effective to reduce DKA among children and adolescents with type 1 diabetes and the core components that explain why these campaigns are effective.

Management of Diabetic Ketoacidosis in Children and Adolescents with Type 1 Diabetes Mellitus  (2020)

Management of Diabetic Ketoacidosis in Children and Adolescents with Type 1 Diabetes Mellitus

Visit

Castellanos L, Tuffaha M, Koren D, Levitsky LL.

Castellanos L, Tuffaha M, Koren D, Levitsky LL.

Diabetic ketoacidosis (DKA) is the end result of insulin deficiency in type 1 diabetes mellitus (T1D). Loss of insulin production leads to profound catabolism with increased gluconeogenesis, glycogenolysis, lipolysis, and muscle proteolysis causing hyperglycemia and osmotic diuresis. High levels of counter-regulatory hormones lead to enhanced ketogenesis and the release of 'ketone bodies' into the circulation, which dissociate to release hydrogen ions and cause an overwhelming acidosis. Dehydration, hyperglycemia, and ketoacidosis are the hallmarks of this condition. Treatment is effective repletion of insulin, fluids and electrolytes. Newer approaches to early diagnosis, treatment, and prevention may diminish the risk of DKA and its childhood complications including cerebral edema. However, the potential for some technical and pharmacologic advances in the management of T1D to increase DKA events must be recognized.

Fluid management in children with diabetic ketoacidosis  (2020)

Fluid management in children with diabetic ketoacidosis

Visit

McGregor S, Metzger DL, Amed S, Goldman RD.

McGregor S, Metzger DL, Amed S, Goldman RD.

Previous research has indicated that rapid rehydration in children with type 1 diabetes who present with diabetic ketoacidosis could result in cerebral edema. I have been treating patients with diabetic ketoacidosis with gradual fluid replacement. With the risk of cerebral injury in these patients, should I continue management with slow fluid rehydration?

Fluid treatment for children with diabetic ketoacidosis: How do the results of the pediatric emergency care applied research network Fluid Therapies Under Investigation in Diabetic Ketoacidosis (FLUID) Trial change our perspective?  (2019)

Fluid treatment for children with diabetic ketoacidosis: How do the results of the pediatric emergency care applied research network Fluid Therapies Under Investigation in Diabetic Ketoacidosis (FLUID) Trial change our perspective?

Visit

Glaser N, Kuppermann N.

Glaser N, Kuppermann N.

The optimal fluid treatment protocol for children with diabetic ketoacidosis (DKA) has long been a subject of controversy. Until recently, there was no high-quality evidence from randomized clinical trials to support an optimal guideline, and recommendations were mainly based on theoretical considerations. As a consequence, fluid treatment protocols for children with DKA vary between institutions (and countries). In June 2018, the results from the Fluid Therapies Under Investigation in DKA Trial conducted in the Pediatric Emergency Care Applied Research Network were published. This large, factorial-designed randomized controlled trial assessed neurological outcomes of 1387 children with DKA who were treated with one of four fluid protocols that varied in infusion rate and sodium content. In this commentary, we review and discuss the results of this new study and the implications for clinical care of DKA in children.

Systematic Review: Bicarbonate in diabetic ketoacidosis  (2011)

Systematic Review: Bicarbonate in diabetic ketoacidosis

Visit

Chua HR, Schneider A, and Bellomo R

Chua HR, Schneider A, and Bellomo R

Objective: This study was designed to examine the efficacy and risk of bicarbonate administration in the emergent treatment of severe acidemia in diabetic ketoacidosis (DKA).

Systematic Review: Factors associated with the presence of diabetic ketoacidosis at diagnosis of diabetes in children and young adults  (2011)

Systematic Review: Factors associated with the presence of diabetic ketoacidosis at diagnosis of diabetes in children and young adults

Visit

Usher-Smith JA, Thompson MJ, Sharp SJ, and Walter FM

Usher-Smith JA, Thompson MJ, Sharp SJ, and Walter FM

Objective: To identify the factors associated with diabetic ketoacidosis at diagnosis of type 1 diabetes in children and young adults.

Application of bench studies at the bedside to improve outcomes in the management of severe diabetic ketoacidosis in children-a narrative review.  (2021)

Application of bench studies at the bedside to improve outcomes in the management of severe diabetic ketoacidosis in children-a narrative review.

Visit

Ravikumar N, Bansal A.

Ravikumar N, Bansal A.

In this review, we address a few key issues and the challenges faced in the management of severe diabetic ketoacidosis (DKA) in children, highlighting the existing standard of care, supported by evidence and bench studies.

Update and harmonisation of guidance for the management of diabetic ketoacidosis in children and young people in the UK  (2021)

Update and harmonisation of guidance for the management of diabetic ketoacidosis in children and young people in the UK

Visit

Rugg-Gunn CE, Deakin M, Hawcutt DB.

Rugg-Gunn CE, Deakin M, Hawcutt DB.

Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes mellitus. Careful and timely intervention is required to optimise glycaemic control and reduce the risk of mortality and devastating complications. Of these, cerebral oedema is the leading cause of death, with a mortality rate of approximately 25%. This article highlights the recent updates to UK fluid therapy guidelines for DKA and provides clinical context for the benefit of paediatricians and junior doctors in light of this new guidance.

Diabetic ketoacidosis in patients with SARS-CoV-2: a systematic review and meta-analysis.  (2021)

Diabetic ketoacidosis in patients with SARS-CoV-2: a systematic review and meta-analysis.

Visit

Alhumaid S, Al Mutair A, Al Alawi Z, Rabaan AA, Alomari MA, Al Salman SA, et al.

Alhumaid S, Al Mutair A, Al Alawi Z, Rabaan AA, Alomari MA, Al Salman SA, et al.

To re-evaluate the association of SARS-CoV-2 and development of DKA and analyse the demographic and biochemical parameters and the clinical outcomes in COVID-19 patients with DKA. DKA is not uncommon in SARS-CoV-2 patients with diabetes mellitus and results in a mortality rate of 25.9%. Mortality key determinants in DKA patients with SARS-CoV-2 infection are individuals with pre-existing diabetes mellitus type 2, older age [ 60 years old], male gender, BMI 30, blood glucose level > 1000 mg/dl, and anion gap 30 mEq/l.

Effectiveness of ketoacidosis prevention campaigns at diagnosis of type 1 diabetes in children: A systematic review and meta-analysis.  (2021)

Effectiveness of ketoacidosis prevention campaigns at diagnosis of type 1 diabetes in children: A systematic review and meta-analysis.

Visit

Cherubini V, Marino M, Carle F, Zagaroli L, Bowers R, Gesuita R.

Cherubini V, Marino M, Carle F, Zagaroli L, Bowers R, Gesuita R.

To determine if diabetes awareness campaigns are an effective intervention to reduce diabetes ketoacidosis at diagnosis of type 1 diabetes in children and youth. This review demonstrated that DKA awareness campaigns are effective to reduce DKA among children and adolescents with type 1 diabetes and the core components that explain why these campaigns are effective.

Management of Diabetic Ketoacidosis in Children and Adolescents with Type 1 Diabetes Mellitus  (2020)

Management of Diabetic Ketoacidosis in Children and Adolescents with Type 1 Diabetes Mellitus

Visit

Castellanos L, Tuffaha M, Koren D, Levitsky LL.

Castellanos L, Tuffaha M, Koren D, Levitsky LL.

Diabetic ketoacidosis (DKA) is the end result of insulin deficiency in type 1 diabetes mellitus (T1D). Loss of insulin production leads to profound catabolism with increased gluconeogenesis, glycogenolysis, lipolysis, and muscle proteolysis causing hyperglycemia and osmotic diuresis. High levels of counter-regulatory hormones lead to enhanced ketogenesis and the release of 'ketone bodies' into the circulation, which dissociate to release hydrogen ions and cause an overwhelming acidosis. Dehydration, hyperglycemia, and ketoacidosis are the hallmarks of this condition. Treatment is effective repletion of insulin, fluids and electrolytes. Newer approaches to early diagnosis, treatment, and prevention may diminish the risk of DKA and its childhood complications including cerebral edema. However, the potential for some technical and pharmacologic advances in the management of T1D to increase DKA events must be recognized.

Fluid management in children with diabetic ketoacidosis  (2020)

Fluid management in children with diabetic ketoacidosis

Visit

McGregor S, Metzger DL, Amed S, Goldman RD.

McGregor S, Metzger DL, Amed S, Goldman RD.

Previous research has indicated that rapid rehydration in children with type 1 diabetes who present with diabetic ketoacidosis could result in cerebral edema. I have been treating patients with diabetic ketoacidosis with gradual fluid replacement. With the risk of cerebral injury in these patients, should I continue management with slow fluid rehydration?

Fluid treatment for children with diabetic ketoacidosis: How do the results of the pediatric emergency care applied research network Fluid Therapies Under Investigation in Diabetic Ketoacidosis (FLUID) Trial change our perspective?  (2019)

Fluid treatment for children with diabetic ketoacidosis: How do the results of the pediatric emergency care applied research network Fluid Therapies Under Investigation in Diabetic Ketoacidosis (FLUID) Trial change our perspective?

Visit

Glaser N, Kuppermann N.

Glaser N, Kuppermann N.

The optimal fluid treatment protocol for children with diabetic ketoacidosis (DKA) has long been a subject of controversy. Until recently, there was no high-quality evidence from randomized clinical trials to support an optimal guideline, and recommendations were mainly based on theoretical considerations. As a consequence, fluid treatment protocols for children with DKA vary between institutions (and countries). In June 2018, the results from the Fluid Therapies Under Investigation in DKA Trial conducted in the Pediatric Emergency Care Applied Research Network were published. This large, factorial-designed randomized controlled trial assessed neurological outcomes of 1387 children with DKA who were treated with one of four fluid protocols that varied in infusion rate and sodium content. In this commentary, we review and discuss the results of this new study and the implications for clinical care of DKA in children.

Systematic Review: Bicarbonate in diabetic ketoacidosis  (2011)

Systematic Review: Bicarbonate in diabetic ketoacidosis

Visit

Chua HR, Schneider A, and Bellomo R

Chua HR, Schneider A, and Bellomo R

Objective: This study was designed to examine the efficacy and risk of bicarbonate administration in the emergent treatment of severe acidemia in diabetic ketoacidosis (DKA).

Systematic Review: Factors associated with the presence of diabetic ketoacidosis at diagnosis of diabetes in children and young adults  (2011)

Systematic Review: Factors associated with the presence of diabetic ketoacidosis at diagnosis of diabetes in children and young adults

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Usher-Smith JA, Thompson MJ, Sharp SJ, and Walter FM

Usher-Smith JA, Thompson MJ, Sharp SJ, and Walter FM

Objective: To identify the factors associated with diabetic ketoacidosis at diagnosis of type 1 diabetes in children and young adults.

Febrile Status Epilepticus English (3) French All (3)

Review: Febrile seizures: emergency medicine perspective  (2015)

Review: Febrile seizures: emergency medicine perspective

Visit

Kimia AA, Bachur RG, Torres A, Harper MB

Kimia AA, Bachur RG, Torres A, Harper MB

This review describes current evidence on the evaluation of febrile seizures in the acute setting, the need for further outpatient assessment, and predictors regarding long-term outcomes of these patients

Review: Management of febrile convulsion in children  (2015)

Review: Management of febrile convulsion in children

Visit

Paul SP, Rogers E, Wilkinson R, Paul B

Paul SP, Rogers E, Wilkinson R, Paul B

This article discusses the aetiology, clinical presentation, diagnosis and management of children with febrile convulsion, and best practice for care in EDs.

Systematic Review: Risk of bacterial meningitis in young children with a first seizure in the context of fever: a systematic review and meta-analysis  (2013)

Systematic Review: Risk of bacterial meningitis in young children with a first seizure in the context of fever: a systematic review and meta-analysis

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Najaf-Zadeh A, Dubos F, Hue V, Pruvost I, Bennour A, Martinot A

Najaf-Zadeh A, Dubos F, Hue V, Pruvost I, Bennour A, Martinot A

This systematic review assesses the risk of bacterial meningitis among various subgroups of young children with a first seizure in the context of fever, and the utility of routine lumbar puncture in children with an apparent first febrile seizure.

Review: Febrile seizures: emergency medicine perspective  (2015)

Review: Febrile seizures: emergency medicine perspective

Visit

Kimia AA, Bachur RG, Torres A, Harper MB

Kimia AA, Bachur RG, Torres A, Harper MB

This review describes current evidence on the evaluation of febrile seizures in the acute setting, the need for further outpatient assessment, and predictors regarding long-term outcomes of these patients

Review: Management of febrile convulsion in children  (2015)

Review: Management of febrile convulsion in children

Visit

Paul SP, Rogers E, Wilkinson R, Paul B

Paul SP, Rogers E, Wilkinson R, Paul B

This article discusses the aetiology, clinical presentation, diagnosis and management of children with febrile convulsion, and best practice for care in EDs.

Systematic Review: Risk of bacterial meningitis in young children with a first seizure in the context of fever: a systematic review and meta-analysis  (2013)

Systematic Review: Risk of bacterial meningitis in young children with a first seizure in the context of fever: a systematic review and meta-analysis

Visit

Najaf-Zadeh A, Dubos F, Hue V, Pruvost I, Bennour A, Martinot A

Najaf-Zadeh A, Dubos F, Hue V, Pruvost I, Bennour A, Martinot A

This systematic review assesses the risk of bacterial meningitis among various subgroups of young children with a first seizure in the context of fever, and the utility of routine lumbar puncture in children with an apparent first febrile seizure.

Fever English (28) French All (28)

Analysis of Nurses' and Physicians' Attitudes, Knowledge, and Perceptions toward Fever in Children: A Systematic Review with Meta-Analysis.  (2021)

Analysis of Nurses' and Physicians' Attitudes, Knowledge, and Perceptions toward Fever in Children: A Systematic Review with Meta-Analysis.

Visit

Vicens-Blanes F, Mir-Bonet R, Molina-Mula J.

Vicens-Blanes F, Mir-Bonet R, Molina-Mula J.

To investigate whether doctors' and nurses' knowledge, perceptions, and attitudes toward fever influence how this sign is managed. Furthermore, it intends to evaluate whether educational programs increase knowledge and change attitudes and/or perceptions of nurses about children's fever.

Symptomatic fever management in children: A systematic review of national and international guidelines.  (2021)

Symptomatic fever management in children: A systematic review of national and international guidelines.

Visit

Green C, Krafft H, Guyatt G, Martin D.

Green C, Krafft H, Guyatt G, Martin D.

Divergent attitudes towards fever have led to a high level of inconsistency in approaches to its management. In an attempt to overcome this, clinical practice guidelines (CPGs) for the symptomatic management of fever in children have been produced by several healthcare organizations. To date, a comprehensive assessment of the evidence level of the recommendations made in these CPGs has not been carried out.

Predictors of disease severity in children presenting from the community with febrile illnesses: a systematic review of prognostic studies  (2021)

Predictors of disease severity in children presenting from the community with febrile illnesses: a systematic review of prognostic studies

Visit

Chandna A, Tan R, Carter M, Van Den Bruel A, Verbakel J, Koshiaris C, et al

Chandna A, Tan R, Carter M, Van Den Bruel A, Verbakel J, Koshiaris C, et al

Early identification of children at risk of severe febrile illness can optimise referral, admission and treatment decisions, particularly in resource-limited settings. We aimed to identify prognostic clinical and laboratory factors that predict progression to severe disease in febrile children presenting from the community.

Hyperpyrexia and high fever as a predictor for serious bacterial infection (SBI) in children-a systematic review.  (2020)

Hyperpyrexia and high fever as a predictor for serious bacterial infection (SBI) in children-a systematic review.

Visit

Rosenfeld-Yehoshua N, Barkan S, Abu-Kishk I, Booch M, Suhami R, Kozer E.

Rosenfeld-Yehoshua N, Barkan S, Abu-Kishk I, Booch M, Suhami R, Kozer E.

It is not clear if children with high fever are at increased risk for serious bacterial infection (SBI). Our aim was to systematically review if children suffering from high fever are at high risk for SBI.

Prescribing Controversies: An Updated Review and Meta-Analysis on Combined/Alternating Use of Ibuprofen and Paracetamol in Febrile Children.  (2019)

Prescribing Controversies: An Updated Review and Meta-Analysis on Combined/Alternating Use of Ibuprofen and Paracetamol in Febrile Children.

Visit

Trippella G, Ciarci M, de Martino M, Chiappini E.

Trippella G, Ciarci M, de Martino M, Chiappini E.

To compare the efficacy and safety of combined or alternating use of ibuprofen and paracetamol in children.

Educational interventions on fever management in children: A scoping review  (2019)

Educational interventions on fever management in children: A scoping review

Visit

Arias D, Chen TF, Moles RJ.

Arias D, Chen TF, Moles RJ.

To collect and examine peer-reviewed literature for active educational interventions aimed at improving fever management in children and profile them based on: who provided the training, training location, how the intervention was delivered, outcomes of training, and how it was measured.

Fever in under 5s: assessment and initial management.  (2019)

Fever in under 5s: assessment and initial management.

Visit

National Institute for Health and Care Excellence (NICE)

National Institute for Health and Care Excellence (NICE)

This guideline covers the assessment and early management of fever with no obvious cause in children aged under 5. It aims to improve clinical assessment and help healthcare professionals diagnose serious illness among young children who present with fever in primary and secondary care. This guideline should be read in conjunction with the NICE guidelines on sepsis, neonatal infection, meningitis (bacterial) and meningococcal septicaemia in under 16s, urinary tract infection in under 16s, diarrhoea and vomiting caused by gastroenteritis in under 5s and antimicrobial prescribing for common infections.

Review: During the Emergency Department Evaluation of a Well-Appearing Neonate with Fever, Should Empiric Acyclovir Be Initiated?  (2018)

Review: During the Emergency Department Evaluation of a Well-Appearing Neonate with Fever, Should Empiric Acyclovir Be Initiated?

Visit

Bruno E, Pillus D, Cheng D, Vilke G, Pokrajac N

Bruno E, Pillus D, Cheng D, Vilke G, Pokrajac N

This review aimed to identify when to initiate testing and treatment for herpes simplex virus infection.

Review: Facing the ongoing challenge of the febrile young infant  (2017)

Review: Facing the ongoing challenge of the febrile young infant

Visit

DePorre AG, Aronson PL, McCulloh RJ

DePorre AG, Aronson PL, McCulloh RJ

The authors highlight the historical context of febrile infant management, review important definitions and terminology, discuss the most clinically relevant viral and bacterial causes of fever in the young infant, describe current risk stratification tools guiding medicaldecision making, and outline research and clinical practice improvement priorities for improving the management of the febrile young infant.

Review: Management of the Febrile Young Infant: Update for the 21st Century  (2017)

Review: Management of the Febrile Young Infant: Update for the 21st Century

Visit

Woll C, Neuman MI, Aronson PL

Woll C, Neuman MI, Aronson PL

Newer laboratory investigations such as C-reactive protein and procalcitonin have favorable test characteristics compared with traditional laboratory studies such as a white blood cell count. These novel biomarkers have not gained widespread acceptance because of lack of robust prospectively collected data, varying thresholds to define positivity, and differing inclusion criteria across studies. However, C-reactive protein and procalcitonin, when combined with other patient characteristics in the step-by-step approach, have a high sensitivity for detection of serious bacterial infection.

Fever in Children: Pearls and Pitfalls.  (2017)

Fever in Children: Pearls and Pitfalls.

Visit

Barbi E, Marzuillo P, Neri E, Naviglio S, Krauss BS.

Barbi E, Marzuillo P, Neri E, Naviglio S, Krauss BS.

Fever in children is a common concern for parents and one of the most frequent presenting complaints in emergency department visits, often involving non-pediatric emergency physicians. Although the incidence of serious infections has decreased after the introduction of conjugate vaccines, fever remains a major cause of laboratory investigation and hospital admissions. Furthermore, antipyretics are the most common medications administered to children. We review the epidemiology and measurement of fever, the meaning of fever and associated clinical signs in children of different ages and under special conditions, including fever in children with cognitive impairment, recurrent fevers, and fever of unknown origin.

Systematic Review: Meta-analysis to Determine Risk for Serious Bacterial Infection in Febrile Outpatient Neonates With RSV Infection  (2016)

Systematic Review: Meta-analysis to Determine Risk for Serious Bacterial Infection in Febrile Outpatient Neonates With RSV Infection

Visit

Bonadio W, Huang F, Nateson S, Okpalaji C, Kodsi A, Sokolovsky S, Homel P

Bonadio W, Huang F, Nateson S, Okpalaji C, Kodsi A, Sokolovsky S, Homel P

This study aimed to analyze a large group of febrile neonates 28 days or younger who received outpatient sepsis evaluation and nasopharyngeal aspirate antigen testing (NPAT) for respiratory syncytial viral (RSV) infection to determine whether there is a clinically significant association between viral study results and risk for serious bacterial infection (SBI: bacterial meningitis, bacteremia, urinary tract infection, bacterial enteritis).

Drivers for inappropriate fever management in children: a systematic review.  (2016)

Drivers for inappropriate fever management in children: a systematic review.

Visit

Kelly M, McCarthy S, O'Sullivan R, Shiely F, Larkin P, Brenner M, Sahm LJ.

Kelly M, McCarthy S, O'Sullivan R, Shiely F, Larkin P, Brenner M, Sahm LJ.

The aim of this review was to synthesise qualitative and quantitative evidence on the knowledge, attitudes and beliefs of parents regarding fever and febrile illness in children.

Evaluation and Management of Febrile Children: A Review.  (2016)

Evaluation and Management of Febrile Children: A Review.

Visit

Cioffredi LA, Jhaveri R.

Cioffredi LA, Jhaveri R.

Management of febrile children is an intrinsic aspect of pediatric practice. Febrile children account for 15% of emergency department visits and outcomes range from the presence of serious bacterial infection to benign self-limited illness.

Systematic Review: Diagnostic utility of biomarkers for neonatal sepsis--a systematic review  (2015)

Systematic Review: Diagnostic utility of biomarkers for neonatal sepsis--a systematic review

Visit

Hedegaard SS, Wisborg K, Hvas AM

Hedegaard SS, Wisborg K, Hvas AM

The objective of the study was to systematically evaluate existing evidence of the diagnostic utility of biomarkers for prediction of sepsis in neonates.

Review: Neonatal Herpes Simplex Virus Infection  (2015)

Review: Neonatal Herpes Simplex Virus Infection

Visit

James SH, Kimberlin DW

James SH, Kimberlin DW

This review describes diagnostic and therapeutic advances for infants with herpes simplex virus 1 (HSV-1) and 2 (HSV-2).

Systematic Review: Use of serum procalcitonin in evaluation of febrile infants: a meta-analysis of 2317 patients  (2014)

Systematic Review: Use of serum procalcitonin in evaluation of febrile infants: a meta-analysis of 2317 patients

Visit

England JT, Del Vecchio MT, Aronoff SC

England JT, Del Vecchio MT, Aronoff SC

The objectives of this systematic review and meta-analysis were to determine: 1) the ability of serum procalcitonin concentrations to identify febrile infants < 91 days of age at high and low risk for serious bacterial infections, and 2) to compare its utility with available clinical prediction rules.

Combined and alternating paracetamol and ibuprofen therapy for febrile children.  (2013)

Combined and alternating paracetamol and ibuprofen therapy for febrile children.

Visit

Wong T, Stang AS, Ganshorn H, Hartling L, Maconochie IK, Thomsen AM, Johnson DW.

Wong T, Stang AS, Ganshorn H, Hartling L, Maconochie IK, Thomsen AM, Johnson DW.

To assess the effects and side effects of combining paracetamol and ibuprofen, or alternating them on consecutive treatments, compared with monotherapy for treating fever in children.

Risk stratification and management of the febrile young child.  (2013)

Risk stratification and management of the febrile young child.

Visit

Ishimine P.

Ishimine P.

Febrile young children present frequently to the emergency department. While most febrile children recover uneventfully, certain subgroups are at higher risk of serious infection. Febrile neonates require extensive diagnostic testing, antibiotic therapy, and hospital admission. Diagnostic testing can be utilized in older patients to identify children at low risk and high risk for serious infection. This information may assist in determining the treatment and disposition of these febrile children.

Evaluation of child with fever without source: review of literature and update  (2013)

Evaluation of child with fever without source: review of literature and update

Visit

Arora R, Mahajan P.

Arora R, Mahajan P.

Fever is one of the most common reasons for a visit to the primary care provider or the emergency department. Traditionally, clinicians have used various risk-stratification strategies to identify serious bacterial infections (SBI) without an obvious source in febrile children, because missed bacterial infections in such children can result in meningitis, sepsis, and death; therefore, early and accurate identification of SBIs is critical. Infants aged less than 60 to 90 days are at greatest risk of SBI. The epidemiology of SBI continues to evolve, especially after the successful introduction of conjugate vaccines against Streptococcus pneumoniae and Haemophilus influenzae.

Systematic Review: Diagnosis and management of febrile infants (0-3 months)  (2012)

Systematic Review: Diagnosis and management of febrile infants (0-3 months)

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Hui C, Neto G, Tsertsvadze A, Yazdi F, Tricco AC, Tsouros S, Skidmore B, Daniel R

Hui C, Neto G, Tsertsvadze A, Yazdi F, Tricco AC, Tsouros S, Skidmore B, Dani...

Objectives: To review the evidence for diagnostic accuracy of screening for serious bacterial illness (SBI) and invasive herpes simplex virus (HSV) infection in febrile infants 3 months or younger; ascertain harms and benefits of various management strategies; compare prevalence of SBI and HSV between different clinical settings; determine how well the presence of viral infection predicts against SBI; and review evidence on parental compliance to return for followup assessments (infants less than 6 months).

Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care.  (2012)

Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care.

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Thompson M, Van den Bruel A, Verbakel J, Lakhanpaul M, Haj-Hassan T, Stevens R, et al

Thompson M, Van den Bruel A, Verbakel J, Lakhanpaul M, Haj-Hassan T, Stevens ...

We systematically identified clinical features and laboratory tests which identify serious infection in children attending the ED and primary care. We also identified clinical prediction rules and validated those using existing data sets.

Review: Management of the non-toxic-appearing acutely febrile child: a 21st century approach  (2011)

Review: Management of the non-toxic-appearing acutely febrile child: a 21st century approach

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Jhaveri R, Byington CL, Klein JO, Shapiro ED

Jhaveri R, Byington CL, Klein JO, Shapiro ED

This review discusses challenges and new approaches to assessment and management of febrile children with suspected serious bacterial infections.

Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review  (2011)

Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review

Visit

Van den Bruel A, Thompson MJ, Haj-Hassan T, Stevens R, Moll H, Lakhanpaul M, Mant D.

Van den Bruel A, Thompson MJ, Haj-Hassan T, Stevens R, Moll H, Lakhanpaul M, ...

To collate all available evidence on the diagnostic value of laboratory tests for the diagnosis of serious infections in febrile children in ambulatory settings.

Systematic Review: Systematic review of the diagnostic accuracy of C-reactive protein to detect bacterial infection in nonhospitalized infants and children with fever  (2008)

Systematic Review: Systematic review of the diagnostic accuracy of C-reactive protein to detect bacterial infection in nonhospitalized infants and children with fever

Visit

Sanders S, Barnett A, Correa-Velez I, Coulthard M, Doust J

Sanders S, Barnett A, Correa-Velez I, Coulthard M, Doust J

The objective of this systematic review was to determine the accuracy of C-reactive protein (CRP) for diagnosing serious bacterial and bacterial infections in infants and children presenting with fever.

Management of childhood fever by parents: literature review.  (2006)

Management of childhood fever by parents: literature review.

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Walsh A, Edwards H.

Walsh A, Edwards H.

This paper reports a review which draws together findings from studies targeting parents' temperature-taking, antipyretic administration, attitudes, practices and information-seeking behaviours.

Evaluation and management of infants and young children with fever.  (2001)

Evaluation and management of infants and young children with fever.

Visit

Luszczak M.

Luszczak M.

A practice guideline for the management of febrile infants and children younger than three years of age sparked controversy when it was published in 1993. Surveys indicate that many office-based physicians do not agree with recommendations for venipuncture and bladder catheterization in nontoxic febrile children, and that many employ watchful waiting rather than empiric antibiotic therapy. Surveys of parents note a preference for less testing and treatment.

Systematic Review: Temperature measured at the axilla compared with rectum in children and young people: systematic review  (2000)

Systematic Review: Temperature measured at the axilla compared with rectum in children and young people: systematic review

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Craig JV, Lancaster GA, Williamson PR, Smyth RL

Craig JV, Lancaster GA, Williamson PR, Smyth RL

The objective of this systematic review was to evaluate the agreement between temperature measured at the axilla and rectum in children and young people.

Analysis of Nurses' and Physicians' Attitudes, Knowledge, and Perceptions toward Fever in Children: A Systematic Review with Meta-Analysis.  (2021)

Analysis of Nurses' and Physicians' Attitudes, Knowledge, and Perceptions toward Fever in Children: A Systematic Review with Meta-Analysis.

Visit

Vicens-Blanes F, Mir-Bonet R, Molina-Mula J.

Vicens-Blanes F, Mir-Bonet R, Molina-Mula J.

To investigate whether doctors' and nurses' knowledge, perceptions, and attitudes toward fever influence how this sign is managed. Furthermore, it intends to evaluate whether educational programs increase knowledge and change attitudes and/or perceptions of nurses about children's fever.

Symptomatic fever management in children: A systematic review of national and international guidelines.  (2021)

Symptomatic fever management in children: A systematic review of national and international guidelines.

Visit

Green C, Krafft H, Guyatt G, Martin D.

Green C, Krafft H, Guyatt G, Martin D.

Divergent attitudes towards fever have led to a high level of inconsistency in approaches to its management. In an attempt to overcome this, clinical practice guidelines (CPGs) for the symptomatic management of fever in children have been produced by several healthcare organizations. To date, a comprehensive assessment of the evidence level of the recommendations made in these CPGs has not been carried out.

Predictors of disease severity in children presenting from the community with febrile illnesses: a systematic review of prognostic studies  (2021)

Predictors of disease severity in children presenting from the community with febrile illnesses: a systematic review of prognostic studies

Visit

Chandna A, Tan R, Carter M, Van Den Bruel A, Verbakel J, Koshiaris C, et al

Chandna A, Tan R, Carter M, Van Den Bruel A, Verbakel J, Koshiaris C, et al

Early identification of children at risk of severe febrile illness can optimise referral, admission and treatment decisions, particularly in resource-limited settings. We aimed to identify prognostic clinical and laboratory factors that predict progression to severe disease in febrile children presenting from the community.

Hyperpyrexia and high fever as a predictor for serious bacterial infection (SBI) in children-a systematic review.  (2020)

Hyperpyrexia and high fever as a predictor for serious bacterial infection (SBI) in children-a systematic review.

Visit

Rosenfeld-Yehoshua N, Barkan S, Abu-Kishk I, Booch M, Suhami R, Kozer E.

Rosenfeld-Yehoshua N, Barkan S, Abu-Kishk I, Booch M, Suhami R, Kozer E.

It is not clear if children with high fever are at increased risk for serious bacterial infection (SBI). Our aim was to systematically review if children suffering from high fever are at high risk for SBI.

Prescribing Controversies: An Updated Review and Meta-Analysis on Combined/Alternating Use of Ibuprofen and Paracetamol in Febrile Children.  (2019)

Prescribing Controversies: An Updated Review and Meta-Analysis on Combined/Alternating Use of Ibuprofen and Paracetamol in Febrile Children.

Visit

Trippella G, Ciarci M, de Martino M, Chiappini E.

Trippella G, Ciarci M, de Martino M, Chiappini E.

To compare the efficacy and safety of combined or alternating use of ibuprofen and paracetamol in children.

Educational interventions on fever management in children: A scoping review  (2019)

Educational interventions on fever management in children: A scoping review

Visit

Arias D, Chen TF, Moles RJ.

Arias D, Chen TF, Moles RJ.

To collect and examine peer-reviewed literature for active educational interventions aimed at improving fever management in children and profile them based on: who provided the training, training location, how the intervention was delivered, outcomes of training, and how it was measured.

Fever in under 5s: assessment and initial management.  (2019)

Fever in under 5s: assessment and initial management.

Visit

National Institute for Health and Care Excellence (NICE)

National Institute for Health and Care Excellence (NICE)

This guideline covers the assessment and early management of fever with no obvious cause in children aged under 5. It aims to improve clinical assessment and help healthcare professionals diagnose serious illness among young children who present with fever in primary and secondary care. This guideline should be read in conjunction with the NICE guidelines on sepsis, neonatal infection, meningitis (bacterial) and meningococcal septicaemia in under 16s, urinary tract infection in under 16s, diarrhoea and vomiting caused by gastroenteritis in under 5s and antimicrobial prescribing for common infections.

Review: During the Emergency Department Evaluation of a Well-Appearing Neonate with Fever, Should Empiric Acyclovir Be Initiated?  (2018)

Review: During the Emergency Department Evaluation of a Well-Appearing Neonate with Fever, Should Empiric Acyclovir Be Initiated?

Visit

Bruno E, Pillus D, Cheng D, Vilke G, Pokrajac N

Bruno E, Pillus D, Cheng D, Vilke G, Pokrajac N

This review aimed to identify when to initiate testing and treatment for herpes simplex virus infection.

Review: Facing the ongoing challenge of the febrile young infant  (2017)

Review: Facing the ongoing challenge of the febrile young infant

Visit

DePorre AG, Aronson PL, McCulloh RJ

DePorre AG, Aronson PL, McCulloh RJ

The authors highlight the historical context of febrile infant management, review important definitions and terminology, discuss the most clinically relevant viral and bacterial causes of fever in the young infant, describe current risk stratification tools guiding medicaldecision making, and outline research and clinical practice improvement priorities for improving the management of the febrile young infant.

Review: Management of the Febrile Young Infant: Update for the 21st Century  (2017)

Review: Management of the Febrile Young Infant: Update for the 21st Century

Visit

Woll C, Neuman MI, Aronson PL

Woll C, Neuman MI, Aronson PL

Newer laboratory investigations such as C-reactive protein and procalcitonin have favorable test characteristics compared with traditional laboratory studies such as a white blood cell count. These novel biomarkers have not gained widespread acceptance because of lack of robust prospectively collected data, varying thresholds to define positivity, and differing inclusion criteria across studies. However, C-reactive protein and procalcitonin, when combined with other patient characteristics in the step-by-step approach, have a high sensitivity for detection of serious bacterial infection.

Fever in Children: Pearls and Pitfalls.  (2017)

Fever in Children: Pearls and Pitfalls.

Visit

Barbi E, Marzuillo P, Neri E, Naviglio S, Krauss BS.

Barbi E, Marzuillo P, Neri E, Naviglio S, Krauss BS.

Fever in children is a common concern for parents and one of the most frequent presenting complaints in emergency department visits, often involving non-pediatric emergency physicians. Although the incidence of serious infections has decreased after the introduction of conjugate vaccines, fever remains a major cause of laboratory investigation and hospital admissions. Furthermore, antipyretics are the most common medications administered to children. We review the epidemiology and measurement of fever, the meaning of fever and associated clinical signs in children of different ages and under special conditions, including fever in children with cognitive impairment, recurrent fevers, and fever of unknown origin.

Systematic Review: Meta-analysis to Determine Risk for Serious Bacterial Infection in Febrile Outpatient Neonates With RSV Infection  (2016)

Systematic Review: Meta-analysis to Determine Risk for Serious Bacterial Infection in Febrile Outpatient Neonates With RSV Infection

Visit

Bonadio W, Huang F, Nateson S, Okpalaji C, Kodsi A, Sokolovsky S, Homel P

Bonadio W, Huang F, Nateson S, Okpalaji C, Kodsi A, Sokolovsky S, Homel P

This study aimed to analyze a large group of febrile neonates 28 days or younger who received outpatient sepsis evaluation and nasopharyngeal aspirate antigen testing (NPAT) for respiratory syncytial viral (RSV) infection to determine whether there is a clinically significant association between viral study results and risk for serious bacterial infection (SBI: bacterial meningitis, bacteremia, urinary tract infection, bacterial enteritis).

Drivers for inappropriate fever management in children: a systematic review.  (2016)

Drivers for inappropriate fever management in children: a systematic review.

Visit

Kelly M, McCarthy S, O'Sullivan R, Shiely F, Larkin P, Brenner M, Sahm LJ.

Kelly M, McCarthy S, O'Sullivan R, Shiely F, Larkin P, Brenner M, Sahm LJ.

The aim of this review was to synthesise qualitative and quantitative evidence on the knowledge, attitudes and beliefs of parents regarding fever and febrile illness in children.

Evaluation and Management of Febrile Children: A Review.  (2016)

Evaluation and Management of Febrile Children: A Review.

Visit

Cioffredi LA, Jhaveri R.

Cioffredi LA, Jhaveri R.

Management of febrile children is an intrinsic aspect of pediatric practice. Febrile children account for 15% of emergency department visits and outcomes range from the presence of serious bacterial infection to benign self-limited illness.

Systematic Review: Diagnostic utility of biomarkers for neonatal sepsis--a systematic review  (2015)

Systematic Review: Diagnostic utility of biomarkers for neonatal sepsis--a systematic review

Visit

Hedegaard SS, Wisborg K, Hvas AM

Hedegaard SS, Wisborg K, Hvas AM

The objective of the study was to systematically evaluate existing evidence of the diagnostic utility of biomarkers for prediction of sepsis in neonates.

Review: Neonatal Herpes Simplex Virus Infection  (2015)

Review: Neonatal Herpes Simplex Virus Infection

Visit

James SH, Kimberlin DW

James SH, Kimberlin DW

This review describes diagnostic and therapeutic advances for infants with herpes simplex virus 1 (HSV-1) and 2 (HSV-2).

Systematic Review: Use of serum procalcitonin in evaluation of febrile infants: a meta-analysis of 2317 patients  (2014)

Systematic Review: Use of serum procalcitonin in evaluation of febrile infants: a meta-analysis of 2317 patients

Visit

England JT, Del Vecchio MT, Aronoff SC

England JT, Del Vecchio MT, Aronoff SC

The objectives of this systematic review and meta-analysis were to determine: 1) the ability of serum procalcitonin concentrations to identify febrile infants < 91 days of age at high and low risk for serious bacterial infections, and 2) to compare its utility with available clinical prediction rules.

Combined and alternating paracetamol and ibuprofen therapy for febrile children.  (2013)

Combined and alternating paracetamol and ibuprofen therapy for febrile children.

Visit

Wong T, Stang AS, Ganshorn H, Hartling L, Maconochie IK, Thomsen AM, Johnson DW.

Wong T, Stang AS, Ganshorn H, Hartling L, Maconochie IK, Thomsen AM, Johnson DW.

To assess the effects and side effects of combining paracetamol and ibuprofen, or alternating them on consecutive treatments, compared with monotherapy for treating fever in children.

Risk stratification and management of the febrile young child.  (2013)

Risk stratification and management of the febrile young child.

Visit

Ishimine P.

Ishimine P.

Febrile young children present frequently to the emergency department. While most febrile children recover uneventfully, certain subgroups are at higher risk of serious infection. Febrile neonates require extensive diagnostic testing, antibiotic therapy, and hospital admission. Diagnostic testing can be utilized in older patients to identify children at low risk and high risk for serious infection. This information may assist in determining the treatment and disposition of these febrile children.

Evaluation of child with fever without source: review of literature and update  (2013)

Evaluation of child with fever without source: review of literature and update

Visit

Arora R, Mahajan P.

Arora R, Mahajan P.

Fever is one of the most common reasons for a visit to the primary care provider or the emergency department. Traditionally, clinicians have used various risk-stratification strategies to identify serious bacterial infections (SBI) without an obvious source in febrile children, because missed bacterial infections in such children can result in meningitis, sepsis, and death; therefore, early and accurate identification of SBIs is critical. Infants aged less than 60 to 90 days are at greatest risk of SBI. The epidemiology of SBI continues to evolve, especially after the successful introduction of conjugate vaccines against Streptococcus pneumoniae and Haemophilus influenzae.

Systematic Review: Diagnosis and management of febrile infants (0-3 months)  (2012)

Systematic Review: Diagnosis and management of febrile infants (0-3 months)

Visit

Hui C, Neto G, Tsertsvadze A, Yazdi F, Tricco AC, Tsouros S, Skidmore B, Daniel R

Hui C, Neto G, Tsertsvadze A, Yazdi F, Tricco AC, Tsouros S, Skidmore B, Dani...

Objectives: To review the evidence for diagnostic accuracy of screening for serious bacterial illness (SBI) and invasive herpes simplex virus (HSV) infection in febrile infants 3 months or younger; ascertain harms and benefits of various management strategies; compare prevalence of SBI and HSV between different clinical settings; determine how well the presence of viral infection predicts against SBI; and review evidence on parental compliance to return for followup assessments (infants less than 6 months).

Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care.  (2012)

Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care.

Visit

Thompson M, Van den Bruel A, Verbakel J, Lakhanpaul M, Haj-Hassan T, Stevens R, et al

Thompson M, Van den Bruel A, Verbakel J, Lakhanpaul M, Haj-Hassan T, Stevens ...

We systematically identified clinical features and laboratory tests which identify serious infection in children attending the ED and primary care. We also identified clinical prediction rules and validated those using existing data sets.

Review: Management of the non-toxic-appearing acutely febrile child: a 21st century approach  (2011)

Review: Management of the non-toxic-appearing acutely febrile child: a 21st century approach

Visit

Jhaveri R, Byington CL, Klein JO, Shapiro ED

Jhaveri R, Byington CL, Klein JO, Shapiro ED

This review discusses challenges and new approaches to assessment and management of febrile children with suspected serious bacterial infections.

Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review  (2011)

Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review

Visit

Van den Bruel A, Thompson MJ, Haj-Hassan T, Stevens R, Moll H, Lakhanpaul M, Mant D.

Van den Bruel A, Thompson MJ, Haj-Hassan T, Stevens R, Moll H, Lakhanpaul M, ...

To collate all available evidence on the diagnostic value of laboratory tests for the diagnosis of serious infections in febrile children in ambulatory settings.

Systematic Review: Systematic review of the diagnostic accuracy of C-reactive protein to detect bacterial infection in nonhospitalized infants and children with fever  (2008)

Systematic Review: Systematic review of the diagnostic accuracy of C-reactive protein to detect bacterial infection in nonhospitalized infants and children with fever

Visit

Sanders S, Barnett A, Correa-Velez I, Coulthard M, Doust J

Sanders S, Barnett A, Correa-Velez I, Coulthard M, Doust J

The objective of this systematic review was to determine the accuracy of C-reactive protein (CRP) for diagnosing serious bacterial and bacterial infections in infants and children presenting with fever.

Management of childhood fever by parents: literature review.  (2006)

Management of childhood fever by parents: literature review.

Visit

Walsh A, Edwards H.

Walsh A, Edwards H.

This paper reports a review which draws together findings from studies targeting parents' temperature-taking, antipyretic administration, attitudes, practices and information-seeking behaviours.

Evaluation and management of infants and young children with fever.  (2001)

Evaluation and management of infants and young children with fever.

Visit

Luszczak M.

Luszczak M.

A practice guideline for the management of febrile infants and children younger than three years of age sparked controversy when it was published in 1993. Surveys indicate that many office-based physicians do not agree with recommendations for venipuncture and bladder catheterization in nontoxic febrile children, and that many employ watchful waiting rather than empiric antibiotic therapy. Surveys of parents note a preference for less testing and treatment.

Systematic Review: Temperature measured at the axilla compared with rectum in children and young people: systematic review  (2000)

Systematic Review: Temperature measured at the axilla compared with rectum in children and young people: systematic review

Visit

Craig JV, Lancaster GA, Williamson PR, Smyth RL

Craig JV, Lancaster GA, Williamson PR, Smyth RL

The objective of this systematic review was to evaluate the agreement between temperature measured at the axilla and rectum in children and young people.

Fever 3 months to 12 years English (17) French All (17)

Analysis of Nurses' and Physicians' Attitudes, Knowledge, and Perceptions toward Fever in Children: A Systematic Review with Meta-Analysis.  (2021)

Analysis of Nurses' and Physicians' Attitudes, Knowledge, and Perceptions toward Fever in Children: A Systematic Review with Meta-Analysis.

Visit

Vicens-Blanes F, Mir-Bonet R, Molina-Mula J.

Vicens-Blanes F, Mir-Bonet R, Molina-Mula J.

To investigate whether doctors' and nurses' knowledge, perceptions, and attitudes toward fever influence how this sign is managed. Furthermore, it intends to evaluate whether educational programs increase knowledge and change attitudes and/or perceptions of nurses about children's fever.

Symptomatic fever management in children: A systematic review of national and international guidelines.  (2021)

Symptomatic fever management in children: A systematic review of national and international guidelines.

Visit

Green C, Krafft H, Guyatt G, Martin D.

Green C, Krafft H, Guyatt G, Martin D.

Divergent attitudes towards fever have led to a high level of inconsistency in approaches to its management. In an attempt to overcome this, clinical practice guidelines (CPGs) for the symptomatic management of fever in children have been produced by several healthcare organizations. To date, a comprehensive assessment of the evidence level of the recommendations made in these CPGs has not been carried out.

Predictors of disease severity in children presenting from the community with febrile illnesses: a systematic review of prognostic studies  (2021)

Predictors of disease severity in children presenting from the community with febrile illnesses: a systematic review of prognostic studies

Visit

Chandna A, Tan R, Carter M, Van Den Bruel A, Verbakel J, Koshiaris C, et al

Chandna A, Tan R, Carter M, Van Den Bruel A, Verbakel J, Koshiaris C, et al

Early identification of children at risk of severe febrile illness can optimise referral, admission and treatment decisions, particularly in resource-limited settings. We aimed to identify prognostic clinical and laboratory factors that predict progression to severe disease in febrile children presenting from the community.

Hyperpyrexia and high fever as a predictor for serious bacterial infection (SBI) in children-a systematic review.  (2020)

Hyperpyrexia and high fever as a predictor for serious bacterial infection (SBI) in children-a systematic review.

Visit

Rosenfeld-Yehoshua N, Barkan S, Abu-Kishk I, Booch M, Suhami R, Kozer E.

Rosenfeld-Yehoshua N, Barkan S, Abu-Kishk I, Booch M, Suhami R, Kozer E.

It is not clear if children with high fever are at increased risk for serious bacterial infection (SBI). Our aim was to systematically review if children suffering from high fever are at high risk for SBI.

Prescribing Controversies: An Updated Review and Meta-Analysis on Combined/Alternating Use of Ibuprofen and Paracetamol in Febrile Children.  (2019)

Prescribing Controversies: An Updated Review and Meta-Analysis on Combined/Alternating Use of Ibuprofen and Paracetamol in Febrile Children.

Visit

Trippella G, Ciarci M, de Martino M, Chiappini E.

Trippella G, Ciarci M, de Martino M, Chiappini E.

To compare the efficacy and safety of combined or alternating use of ibuprofen and paracetamol in children.

Educational interventions on fever management in children: A scoping review  (2019)

Educational interventions on fever management in children: A scoping review

Visit

Arias D, Chen TF, Moles RJ.

Arias D, Chen TF, Moles RJ.

To collect and examine peer-reviewed literature for active educational interventions aimed at improving fever management in children and profile them based on: who provided the training, training location, how the intervention was delivered, outcomes of training, and how it was measured.

Fever in under 5s: assessment and initial management.  (2019)

Fever in under 5s: assessment and initial management.

Visit

National Institute for Health and Care Excellence (NICE)

National Institute for Health and Care Excellence (NICE)

This guideline covers the assessment and early management of fever with no obvious cause in children aged under 5. It aims to improve clinical assessment and help healthcare professionals diagnose serious illness among young children who present with fever in primary and secondary care. This guideline should be read in conjunction with the NICE guidelines on sepsis, neonatal infection, meningitis (bacterial) and meningococcal septicaemia in under 16s, urinary tract infection in under 16s, diarrhoea and vomiting caused by gastroenteritis in under 5s and antimicrobial prescribing for common infections.

Fever in Children: Pearls and Pitfalls.  (2017)

Fever in Children: Pearls and Pitfalls.

Visit

Barbi E, Marzuillo P, Neri E, Naviglio S, Krauss BS.

Barbi E, Marzuillo P, Neri E, Naviglio S, Krauss BS.

Fever in children is a common concern for parents and one of the most frequent presenting complaints in emergency department visits, often involving non-pediatric emergency physicians. Although the incidence of serious infections has decreased after the introduction of conjugate vaccines, fever remains a major cause of laboratory investigation and hospital admissions. Furthermore, antipyretics are the most common medications administered to children. We review the epidemiology and measurement of fever, the meaning of fever and associated clinical signs in children of different ages and under special conditions, including fever in children with cognitive impairment, recurrent fevers, and fever of unknown origin.

Drivers for inappropriate fever management in children: a systematic review.  (2016)

Drivers for inappropriate fever management in children: a systematic review.

Visit

Kelly M, McCarthy S, O'Sullivan R, Shiely F, Larkin P, Brenner M, Sahm LJ.

Kelly M, McCarthy S, O'Sullivan R, Shiely F, Larkin P, Brenner M, Sahm LJ.

The aim of this review was to synthesise qualitative and quantitative evidence on the knowledge, attitudes and beliefs of parents regarding fever and febrile illness in children.

Evaluation and Management of Febrile Children: A Review.  (2016)

Evaluation and Management of Febrile Children: A Review.

Visit

Cioffredi LA, Jhaveri R.

Cioffredi LA, Jhaveri R.

Management of febrile children is an intrinsic aspect of pediatric practice. Febrile children account for 15% of emergency department visits and outcomes range from the presence of serious bacterial infection to benign self-limited illness.

Combined and alternating paracetamol and ibuprofen therapy for febrile children.  (2013)

Combined and alternating paracetamol and ibuprofen therapy for febrile children.

Visit

Wong T, Stang AS, Ganshorn H, Hartling L, Maconochie IK, Thomsen AM, Johnson DW.

Wong T, Stang AS, Ganshorn H, Hartling L, Maconochie IK, Thomsen AM, Johnson DW.

To assess the effects and side effects of combining paracetamol and ibuprofen, or alternating them on consecutive treatments, compared with monotherapy for treating fever in children.

Risk stratification and management of the febrile young child.  (2013)

Risk stratification and management of the febrile young child.

Visit

Ishimine P.

Ishimine P.

Febrile young children present frequently to the emergency department. While most febrile children recover uneventfully, certain subgroups are at higher risk of serious infection. Febrile neonates require extensive diagnostic testing, antibiotic therapy, and hospital admission. Diagnostic testing can be utilized in older patients to identify children at low risk and high risk for serious infection. This information may assist in determining the treatment and disposition of these febrile children.

Evaluation of child with fever without source: review of literature and update  (2013)

Evaluation of child with fever without source: review of literature and update

Visit

Arora R, Mahajan P.

Arora R, Mahajan P.

Fever is one of the most common reasons for a visit to the primary care provider or the emergency department. Traditionally, clinicians have used various risk-stratification strategies to identify serious bacterial infections (SBI) without an obvious source in febrile children, because missed bacterial infections in such children can result in meningitis, sepsis, and death; therefore, early and accurate identification of SBIs is critical. Infants aged less than 60 to 90 days are at greatest risk of SBI. The epidemiology of SBI continues to evolve, especially after the successful introduction of conjugate vaccines against Streptococcus pneumoniae and Haemophilus influenzae.

Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care.  (2012)

Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care.

Visit

Thompson M, Van den Bruel A, Verbakel J, Lakhanpaul M, Haj-Hassan T, Stevens R, et al

Thompson M, Van den Bruel A, Verbakel J, Lakhanpaul M, Haj-Hassan T, Stevens ...

We systematically identified clinical features and laboratory tests which identify serious infection in children attending the ED and primary care. We also identified clinical prediction rules and validated those using existing data sets.

Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review  (2011)

Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review

Visit

Van den Bruel A, Thompson MJ, Haj-Hassan T, Stevens R, Moll H, Lakhanpaul M, Mant D.

Van den Bruel A, Thompson MJ, Haj-Hassan T, Stevens R, Moll H, Lakhanpaul M, ...

To collate all available evidence on the diagnostic value of laboratory tests for the diagnosis of serious infections in febrile children in ambulatory settings.

Management of childhood fever by parents: literature review.  (2006)

Management of childhood fever by parents: literature review.

Visit

Walsh A, Edwards H.

Walsh A, Edwards H.

This paper reports a review which draws together findings from studies targeting parents' temperature-taking, antipyretic administration, attitudes, practices and information-seeking behaviours.

Evaluation and management of infants and young children with fever.  (2001)

Evaluation and management of infants and young children with fever.

Visit

Luszczak M.

Luszczak M.

A practice guideline for the management of febrile infants and children younger than three years of age sparked controversy when it was published in 1993. Surveys indicate that many office-based physicians do not agree with recommendations for venipuncture and bladder catheterization in nontoxic febrile children, and that many employ watchful waiting rather than empiric antibiotic therapy. Surveys of parents note a preference for less testing and treatment.

Analysis of Nurses' and Physicians' Attitudes, Knowledge, and Perceptions toward Fever in Children: A Systematic Review with Meta-Analysis.  (2021)

Analysis of Nurses' and Physicians' Attitudes, Knowledge, and Perceptions toward Fever in Children: A Systematic Review with Meta-Analysis.

Visit

Vicens-Blanes F, Mir-Bonet R, Molina-Mula J.

Vicens-Blanes F, Mir-Bonet R, Molina-Mula J.

To investigate whether doctors' and nurses' knowledge, perceptions, and attitudes toward fever influence how this sign is managed. Furthermore, it intends to evaluate whether educational programs increase knowledge and change attitudes and/or perceptions of nurses about children's fever.

Symptomatic fever management in children: A systematic review of national and international guidelines.  (2021)

Symptomatic fever management in children: A systematic review of national and international guidelines.

Visit

Green C, Krafft H, Guyatt G, Martin D.

Green C, Krafft H, Guyatt G, Martin D.

Divergent attitudes towards fever have led to a high level of inconsistency in approaches to its management. In an attempt to overcome this, clinical practice guidelines (CPGs) for the symptomatic management of fever in children have been produced by several healthcare organizations. To date, a comprehensive assessment of the evidence level of the recommendations made in these CPGs has not been carried out.

Predictors of disease severity in children presenting from the community with febrile illnesses: a systematic review of prognostic studies  (2021)

Predictors of disease severity in children presenting from the community with febrile illnesses: a systematic review of prognostic studies

Visit

Chandna A, Tan R, Carter M, Van Den Bruel A, Verbakel J, Koshiaris C, et al

Chandna A, Tan R, Carter M, Van Den Bruel A, Verbakel J, Koshiaris C, et al

Early identification of children at risk of severe febrile illness can optimise referral, admission and treatment decisions, particularly in resource-limited settings. We aimed to identify prognostic clinical and laboratory factors that predict progression to severe disease in febrile children presenting from the community.

Hyperpyrexia and high fever as a predictor for serious bacterial infection (SBI) in children-a systematic review.  (2020)

Hyperpyrexia and high fever as a predictor for serious bacterial infection (SBI) in children-a systematic review.

Visit

Rosenfeld-Yehoshua N, Barkan S, Abu-Kishk I, Booch M, Suhami R, Kozer E.

Rosenfeld-Yehoshua N, Barkan S, Abu-Kishk I, Booch M, Suhami R, Kozer E.

It is not clear if children with high fever are at increased risk for serious bacterial infection (SBI). Our aim was to systematically review if children suffering from high fever are at high risk for SBI.

Prescribing Controversies: An Updated Review and Meta-Analysis on Combined/Alternating Use of Ibuprofen and Paracetamol in Febrile Children.  (2019)

Prescribing Controversies: An Updated Review and Meta-Analysis on Combined/Alternating Use of Ibuprofen and Paracetamol in Febrile Children.

Visit

Trippella G, Ciarci M, de Martino M, Chiappini E.

Trippella G, Ciarci M, de Martino M, Chiappini E.

To compare the efficacy and safety of combined or alternating use of ibuprofen and paracetamol in children.

Educational interventions on fever management in children: A scoping review  (2019)

Educational interventions on fever management in children: A scoping review

Visit

Arias D, Chen TF, Moles RJ.

Arias D, Chen TF, Moles RJ.

To collect and examine peer-reviewed literature for active educational interventions aimed at improving fever management in children and profile them based on: who provided the training, training location, how the intervention was delivered, outcomes of training, and how it was measured.

Fever in under 5s: assessment and initial management.  (2019)

Fever in under 5s: assessment and initial management.

Visit

National Institute for Health and Care Excellence (NICE)

National Institute for Health and Care Excellence (NICE)

This guideline covers the assessment and early management of fever with no obvious cause in children aged under 5. It aims to improve clinical assessment and help healthcare professionals diagnose serious illness among young children who present with fever in primary and secondary care. This guideline should be read in conjunction with the NICE guidelines on sepsis, neonatal infection, meningitis (bacterial) and meningococcal septicaemia in under 16s, urinary tract infection in under 16s, diarrhoea and vomiting caused by gastroenteritis in under 5s and antimicrobial prescribing for common infections.

Fever in Children: Pearls and Pitfalls.  (2017)

Fever in Children: Pearls and Pitfalls.

Visit

Barbi E, Marzuillo P, Neri E, Naviglio S, Krauss BS.

Barbi E, Marzuillo P, Neri E, Naviglio S, Krauss BS.

Fever in children is a common concern for parents and one of the most frequent presenting complaints in emergency department visits, often involving non-pediatric emergency physicians. Although the incidence of serious infections has decreased after the introduction of conjugate vaccines, fever remains a major cause of laboratory investigation and hospital admissions. Furthermore, antipyretics are the most common medications administered to children. We review the epidemiology and measurement of fever, the meaning of fever and associated clinical signs in children of different ages and under special conditions, including fever in children with cognitive impairment, recurrent fevers, and fever of unknown origin.

Drivers for inappropriate fever management in children: a systematic review.  (2016)

Drivers for inappropriate fever management in children: a systematic review.

Visit

Kelly M, McCarthy S, O'Sullivan R, Shiely F, Larkin P, Brenner M, Sahm LJ.

Kelly M, McCarthy S, O'Sullivan R, Shiely F, Larkin P, Brenner M, Sahm LJ.

The aim of this review was to synthesise qualitative and quantitative evidence on the knowledge, attitudes and beliefs of parents regarding fever and febrile illness in children.

Evaluation and Management of Febrile Children: A Review.  (2016)

Evaluation and Management of Febrile Children: A Review.

Visit

Cioffredi LA, Jhaveri R.

Cioffredi LA, Jhaveri R.

Management of febrile children is an intrinsic aspect of pediatric practice. Febrile children account for 15% of emergency department visits and outcomes range from the presence of serious bacterial infection to benign self-limited illness.

Combined and alternating paracetamol and ibuprofen therapy for febrile children.  (2013)

Combined and alternating paracetamol and ibuprofen therapy for febrile children.

Visit

Wong T, Stang AS, Ganshorn H, Hartling L, Maconochie IK, Thomsen AM, Johnson DW.

Wong T, Stang AS, Ganshorn H, Hartling L, Maconochie IK, Thomsen AM, Johnson DW.

To assess the effects and side effects of combining paracetamol and ibuprofen, or alternating them on consecutive treatments, compared with monotherapy for treating fever in children.

Risk stratification and management of the febrile young child.  (2013)

Risk stratification and management of the febrile young child.

Visit

Ishimine P.

Ishimine P.

Febrile young children present frequently to the emergency department. While most febrile children recover uneventfully, certain subgroups are at higher risk of serious infection. Febrile neonates require extensive diagnostic testing, antibiotic therapy, and hospital admission. Diagnostic testing can be utilized in older patients to identify children at low risk and high risk for serious infection. This information may assist in determining the treatment and disposition of these febrile children.

Evaluation of child with fever without source: review of literature and update  (2013)

Evaluation of child with fever without source: review of literature and update

Visit

Arora R, Mahajan P.

Arora R, Mahajan P.

Fever is one of the most common reasons for a visit to the primary care provider or the emergency department. Traditionally, clinicians have used various risk-stratification strategies to identify serious bacterial infections (SBI) without an obvious source in febrile children, because missed bacterial infections in such children can result in meningitis, sepsis, and death; therefore, early and accurate identification of SBIs is critical. Infants aged less than 60 to 90 days are at greatest risk of SBI. The epidemiology of SBI continues to evolve, especially after the successful introduction of conjugate vaccines against Streptococcus pneumoniae and Haemophilus influenzae.

Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care.  (2012)

Systematic review and validation of prediction rules for identifying children with serious infections in emergency departments and urgent-access primary care.

Visit

Thompson M, Van den Bruel A, Verbakel J, Lakhanpaul M, Haj-Hassan T, Stevens R, et al

Thompson M, Van den Bruel A, Verbakel J, Lakhanpaul M, Haj-Hassan T, Stevens ...

We systematically identified clinical features and laboratory tests which identify serious infection in children attending the ED and primary care. We also identified clinical prediction rules and validated those using existing data sets.

Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review  (2011)

Diagnostic value of laboratory tests in identifying serious infections in febrile children: systematic review

Visit

Van den Bruel A, Thompson MJ, Haj-Hassan T, Stevens R, Moll H, Lakhanpaul M, Mant D.

Van den Bruel A, Thompson MJ, Haj-Hassan T, Stevens R, Moll H, Lakhanpaul M, ...

To collate all available evidence on the diagnostic value of laboratory tests for the diagnosis of serious infections in febrile children in ambulatory settings.

Management of childhood fever by parents: literature review.  (2006)

Management of childhood fever by parents: literature review.

Visit

Walsh A, Edwards H.

Walsh A, Edwards H.

This paper reports a review which draws together findings from studies targeting parents' temperature-taking, antipyretic administration, attitudes, practices and information-seeking behaviours.

Evaluation and management of infants and young children with fever.  (2001)

Evaluation and management of infants and young children with fever.

Visit

Luszczak M.

Luszczak M.

A practice guideline for the management of febrile infants and children younger than three years of age sparked controversy when it was published in 1993. Surveys indicate that many office-based physicians do not agree with recommendations for venipuncture and bladder catheterization in nontoxic febrile children, and that many employ watchful waiting rather than empiric antibiotic therapy. Surveys of parents note a preference for less testing and treatment.

Fever in Young Infants English (11) French All (11)

Review: During the Emergency Department Evaluation of a Well-Appearing Neonate with Fever, Should Empiric Acyclovir Be Initiated?  (2018)

Review: During the Emergency Department Evaluation of a Well-Appearing Neonate with Fever, Should Empiric Acyclovir Be Initiated?

Visit

Bruno E, Pillus D, Cheng D, Vilke G, Pokrajac N

Bruno E, Pillus D, Cheng D, Vilke G, Pokrajac N

This review aimed to identify when to initiate testing and treatment for herpes simplex virus infection.

Review: Facing the ongoing challenge of the febrile young infant  (2017)

Review: Facing the ongoing challenge of the febrile young infant

Visit

DePorre AG, Aronson PL, McCulloh RJ

DePorre AG, Aronson PL, McCulloh RJ

The authors highlight the historical context of febrile infant management, review important definitions and terminology, discuss the most clinically relevant viral and bacterial causes of fever in the young infant, describe current risk stratification tools guiding medicaldecision making, and outline research and clinical practice improvement priorities for improving the management of the febrile young infant.

Review: Management of the Febrile Young Infant: Update for the 21st Century  (2017)

Review: Management of the Febrile Young Infant: Update for the 21st Century

Visit

Woll C, Neuman MI, Aronson PL

Woll C, Neuman MI, Aronson PL

Newer laboratory investigations such as C-reactive protein and procalcitonin have favorable test characteristics compared with traditional laboratory studies such as a white blood cell count. These novel biomarkers have not gained widespread acceptance because of lack of robust prospectively collected data, varying thresholds to define positivity, and differing inclusion criteria across studies. However, C-reactive protein and procalcitonin, when combined with other patient characteristics in the step-by-step approach, have a high sensitivity for detection of serious bacterial infection.

Systematic Review: Meta-analysis to Determine Risk for Serious Bacterial Infection in Febrile Outpatient Neonates With RSV Infection  (2016)

Systematic Review: Meta-analysis to Determine Risk for Serious Bacterial Infection in Febrile Outpatient Neonates With RSV Infection

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Bonadio W, Huang F, Nateson S, Okpalaji C, Kodsi A, Sokolovsky S, Homel P

Bonadio W, Huang F, Nateson S, Okpalaji C, Kodsi A, Sokolovsky S, Homel P

This study aimed to analyze a large group of febrile neonates 28 days or younger who received outpatient sepsis evaluation and nasopharyngeal aspirate antigen testing (NPAT) for respiratory syncytial viral (RSV) infection to determine whether there is a clinically significant association between viral study results and risk for serious bacterial infection (SBI: bacterial meningitis, bacteremia, urinary tract infection, bacterial enteritis).

Systematic Review: Diagnostic utility of biomarkers for neonatal sepsis--a systematic review  (2015)

Systematic Review: Diagnostic utility of biomarkers for neonatal sepsis--a systematic review

Visit

Hedegaard SS, Wisborg K, Hvas AM

Hedegaard SS, Wisborg K, Hvas AM

The objective of the study was to systematically evaluate existing evidence of the diagnostic utility of biomarkers for prediction of sepsis in neonates.

Review: Neonatal Herpes Simplex Virus Infection  (2015)

Review: Neonatal Herpes Simplex Virus Infection

Visit

James SH, Kimberlin DW

James SH, Kimberlin DW

This review describes diagnostic and therapeutic advances for infants with herpes simplex virus 1 (HSV-1) and 2 (HSV-2).

Systematic Review: Use of serum procalcitonin in evaluation of febrile infants: a meta-analysis of 2317 patients  (2014)

Systematic Review: Use of serum procalcitonin in evaluation of febrile infants: a meta-analysis of 2317 patients

Visit

England JT, Del Vecchio MT, Aronoff SC

England JT, Del Vecchio MT, Aronoff SC

The objectives of this systematic review and meta-analysis were to determine: 1) the ability of serum procalcitonin concentrations to identify febrile infants < 91 days of age at high and low risk for serious bacterial infections, and 2) to compare its utility with available clinical prediction rules.

Systematic Review: Diagnosis and management of febrile infants (0-3 months)  (2012)

Systematic Review: Diagnosis and management of febrile infants (0-3 months)

Visit

Hui C, Neto G, Tsertsvadze A, Yazdi F, Tricco AC, Tsouros S, Skidmore B, Daniel R

Hui C, Neto G, Tsertsvadze A, Yazdi F, Tricco AC, Tsouros S, Skidmore B, Dani...

Objectives: To review the evidence for diagnostic accuracy of screening for serious bacterial illness (SBI) and invasive herpes simplex virus (HSV) infection in febrile infants 3 months or younger; ascertain harms and benefits of various management strategies; compare prevalence of SBI and HSV between different clinical settings; determine how well the presence of viral infection predicts against SBI; and review evidence on parental compliance to return for followup assessments (infants less than 6 months).

Review: Management of the non-toxic-appearing acutely febrile child: a 21st century approach  (2011)

Review: Management of the non-toxic-appearing acutely febrile child: a 21st century approach

Visit

Jhaveri R, Byington CL, Klein JO, Shapiro ED

Jhaveri R, Byington CL, Klein JO, Shapiro ED

This review discusses challenges and new approaches to assessment and management of febrile children with suspected serious bacterial infections.

Systematic Review: Systematic review of the diagnostic accuracy of C-reactive protein to detect bacterial infection in nonhospitalized infants and children with fever  (2008)

Systematic Review: Systematic review of the diagnostic accuracy of C-reactive protein to detect bacterial infection in nonhospitalized infants and children with fever

Visit

Sanders S, Barnett A, Correa-Velez I, Coulthard M, Doust J

Sanders S, Barnett A, Correa-Velez I, Coulthard M, Doust J

The objective of this systematic review was to determine the accuracy of C-reactive protein (CRP) for diagnosing serious bacterial and bacterial infections in infants and children presenting with fever.

Systematic Review: Temperature measured at the axilla compared with rectum in children and young people: systematic review  (2000)

Systematic Review: Temperature measured at the axilla compared with rectum in children and young people: systematic review

Visit

Craig JV, Lancaster GA, Williamson PR, Smyth RL

Craig JV, Lancaster GA, Williamson PR, Smyth RL

The objective of this systematic review was to evaluate the agreement between temperature measured at the axilla and rectum in children and young people.

Review: During the Emergency Department Evaluation of a Well-Appearing Neonate with Fever, Should Empiric Acyclovir Be Initiated?  (2018)

Review: During the Emergency Department Evaluation of a Well-Appearing Neonate with Fever, Should Empiric Acyclovir Be Initiated?

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Bruno E, Pillus D, Cheng D, Vilke G, Pokrajac N

Bruno E, Pillus D, Cheng D, Vilke G, Pokrajac N

This review aimed to identify when to initiate testing and treatment for herpes simplex virus infection.

Review: Facing the ongoing challenge of the febrile young infant  (2017)

Review: Facing the ongoing challenge of the febrile young infant

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DePorre AG, Aronson PL, McCulloh RJ

DePorre AG, Aronson PL, McCulloh RJ

The authors highlight the historical context of febrile infant management, review important definitions and terminology, discuss the most clinically relevant viral and bacterial causes of fever in the young infant, describe current risk stratification tools guiding medicaldecision making, and outline research and clinical practice improvement priorities for improving the management of the febrile young infant.

Review: Management of the Febrile Young Infant: Update for the 21st Century  (2017)

Review: Management of the Febrile Young Infant: Update for the 21st Century

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Woll C, Neuman MI, Aronson PL

Woll C, Neuman MI, Aronson PL

Newer laboratory investigations such as C-reactive protein and procalcitonin have favorable test characteristics compared with traditional laboratory studies such as a white blood cell count. These novel biomarkers have not gained widespread acceptance because of lack of robust prospectively collected data, varying thresholds to define positivity, and differing inclusion criteria across studies. However, C-reactive protein and procalcitonin, when combined with other patient characteristics in the step-by-step approach, have a high sensitivity for detection of serious bacterial infection.

Systematic Review: Meta-analysis to Determine Risk for Serious Bacterial Infection in Febrile Outpatient Neonates With RSV Infection  (2016)

Systematic Review: Meta-analysis to Determine Risk for Serious Bacterial Infection in Febrile Outpatient Neonates With RSV Infection

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Bonadio W, Huang F, Nateson S, Okpalaji C, Kodsi A, Sokolovsky S, Homel P

Bonadio W, Huang F, Nateson S, Okpalaji C, Kodsi A, Sokolovsky S, Homel P

This study aimed to analyze a large group of febrile neonates 28 days or younger who received outpatient sepsis evaluation and nasopharyngeal aspirate antigen testing (NPAT) for respiratory syncytial viral (RSV) infection to determine whether there is a clinically significant association between viral study results and risk for serious bacterial infection (SBI: bacterial meningitis, bacteremia, urinary tract infection, bacterial enteritis).

Systematic Review: Diagnostic utility of biomarkers for neonatal sepsis--a systematic review  (2015)

Systematic Review: Diagnostic utility of biomarkers for neonatal sepsis--a systematic review

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Hedegaard SS, Wisborg K, Hvas AM

Hedegaard SS, Wisborg K, Hvas AM

The objective of the study was to systematically evaluate existing evidence of the diagnostic utility of biomarkers for prediction of sepsis in neonates.

Review: Neonatal Herpes Simplex Virus Infection  (2015)

Review: Neonatal Herpes Simplex Virus Infection

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James SH, Kimberlin DW

James SH, Kimberlin DW

This review describes diagnostic and therapeutic advances for infants with herpes simplex virus 1 (HSV-1) and 2 (HSV-2).

Systematic Review: Use of serum procalcitonin in evaluation of febrile infants: a meta-analysis of 2317 patients  (2014)

Systematic Review: Use of serum procalcitonin in evaluation of febrile infants: a meta-analysis of 2317 patients

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England JT, Del Vecchio MT, Aronoff SC

England JT, Del Vecchio MT, Aronoff SC

The objectives of this systematic review and meta-analysis were to determine: 1) the ability of serum procalcitonin concentrations to identify febrile infants < 91 days of age at high and low risk for serious bacterial infections, and 2) to compare its utility with available clinical prediction rules.

Systematic Review: Diagnosis and management of febrile infants (0-3 months)  (2012)

Systematic Review: Diagnosis and management of febrile infants (0-3 months)

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Hui C, Neto G, Tsertsvadze A, Yazdi F, Tricco AC, Tsouros S, Skidmore B, Daniel R

Hui C, Neto G, Tsertsvadze A, Yazdi F, Tricco AC, Tsouros S, Skidmore B, Dani...

Objectives: To review the evidence for diagnostic accuracy of screening for serious bacterial illness (SBI) and invasive herpes simplex virus (HSV) infection in febrile infants 3 months or younger; ascertain harms and benefits of various management strategies; compare prevalence of SBI and HSV between different clinical settings; determine how well the presence of viral infection predicts against SBI; and review evidence on parental compliance to return for followup assessments (infants less than 6 months).

Review: Management of the non-toxic-appearing acutely febrile child: a 21st century approach  (2011)

Review: Management of the non-toxic-appearing acutely febrile child: a 21st century approach

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Jhaveri R, Byington CL, Klein JO, Shapiro ED

Jhaveri R, Byington CL, Klein JO, Shapiro ED

This review discusses challenges and new approaches to assessment and management of febrile children with suspected serious bacterial infections.

Systematic Review: Systematic review of the diagnostic accuracy of C-reactive protein to detect bacterial infection in nonhospitalized infants and children with fever  (2008)

Systematic Review: Systematic review of the diagnostic accuracy of C-reactive protein to detect bacterial infection in nonhospitalized infants and children with fever