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Lyme Disease key studies

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Key study: Validation of a Clinical Prediction Rule to Distinguish Lyme Meningitis From Aseptic Meningitis

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Cohn KA,Thompson AD,Shah SS,Hines EM,Lyons TW,Welsh EJ,Nigrovic LE

Objective: The goal of this study was to test the performance of the Rule of 7's in a multicenter cohort of children with CSF pleocytosis.

Key study: Prospective Validation of a Clinical Prediction Model for Lyme Meningitis in Children

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Garro AC,Rutman M,Simonsen K,Jaeger JL,Chapin K,Lockhart G

Objective: A clinical prediction model was developed to distinguish Lyme meningitis from other causes of aseptic meningitis. Our objective was to prospectively validate this model.

Key study: Lyme neuroborreliosis in children: a prospective study of clinical features, prognosis, and outcome

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Skogman BH, Croner S, Nordwall M, Eknefelt M, Ernerudh J, Forsberg P

Objective: Evaluation of children with clinically suspected neuroborreliosis (NB) is difficult. With a prospective study design we wanted to characterize children with signs and symptoms indicative for NB, investigate clinical outcome and, if possible, identify factors of importance for recovery.

Key study: Prediction of Lyme Meningitis in Children From a Lyme DiseaseEndemic Region: A Logistic-Regression Model Using History, Physical, and Laboratory Findings

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Avery RA, Frank G, Glutting JJ, Eppes SC

Objective: To create a statistical model to predict LM versus AM in children based on history, physical, and laboratory findings during the initial presentation of meningitis.

Key study: Characterization of Lyme Meningitis and Comparison With Viral Meningitis in Children

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Eppes SC,Nelson DK,Lewis LL,Klein JD

Objective: The objectives of this study were to characterize Lyme meningitis (LM) in the pediatric population; to compare LM with viral meningitis (VM) with respect to epidemiology, history and physical examination, and laboratory data; and to provide means of early distinction of Lyme neuroborreliosis from other forms of aseptic meningitis.

Key study: Validation of a Clinical Prediction Rule to Distinguish Lyme Meningitis From Aseptic Meningitis

Visit

Cohn KA,Thompson AD,Shah SS,Hines EM,Lyons TW,Welsh EJ,Nigrovic LE

Objective: The goal of this study was to test the performance of the Rule of 7's in a multicenter cohort of children with CSF pleocytosis.

Key study: Prospective Validation of a Clinical Prediction Model for Lyme Meningitis in Children

Visit

Garro AC,Rutman M,Simonsen K,Jaeger JL,Chapin K,Lockhart G

Objective: A clinical prediction model was developed to distinguish Lyme meningitis from other causes of aseptic meningitis. Our objective was to prospectively validate this model.

Key study: Lyme neuroborreliosis in children: a prospective study of clinical features, prognosis, and outcome

Visit

Skogman BH, Croner S, Nordwall M, Eknefelt M, Ernerudh J, Forsberg P

Objective: Evaluation of children with clinically suspected neuroborreliosis (NB) is difficult. With a prospective study design we wanted to characterize children with signs and symptoms indicative for NB, investigate clinical outcome and, if possible, identify factors of importance for recovery.

Key study: Prediction of Lyme Meningitis in Children From a Lyme DiseaseEndemic Region: A Logistic-Regression Model Using History, Physical, and Laboratory Findings

Visit

Avery RA, Frank G, Glutting JJ, Eppes SC

Objective: To create a statistical model to predict LM versus AM in children based on history, physical, and laboratory findings during the initial presentation of meningitis.

Key study: Characterization of Lyme Meningitis and Comparison With Viral Meningitis in Children

Visit

Eppes SC,Nelson DK,Lewis LL,Klein JD

Objective: The objectives of this study were to characterize Lyme meningitis (LM) in the pediatric population; to compare LM with viral meningitis (VM) with respect to epidemiology, history and physical examination, and laboratory data; and to provide means of early distinction of Lyme neuroborreliosis from other forms of aseptic meningitis.