Urinary Tract Infections key studies
Key Study: Development and Validation of a Calculator for Estimating the Probability of Urinary Tract Infection in Young Febrile Children
Shaikh N, Hoberman A, Hum SW, Alberty A, Muniz G, Kurs-Lasky M, Landsittel D, Shope T
Shaikh N, Hoberman A, Hum SW, Alberty A, Muniz G, Kurs-Lasky M, Landsittel D,...
The objective of this study is to develop and test a calculator (UTICalc) that can first estimate the probability of urinary tract infection based on clinical variables and then update that probability based on laboratory results.
The objective of this study is to develop and test a calculator (UTICalc) that can first estimate the probability of urinary tract infection based on clinical variables and then update that probability based on laboratory results.
Key Study: Accuracy of the Urinalysis for Urinary Tract Infections in Febrile Infants 60 Days and Younger
Tzimenatos L, Mahajan P, Dayan PS, Vitale M, Linakis JG, Blumberg S, Borgialli D, Ruddy RM, Van Buren J, Ramilo O, Kuppermann N; Pediatric Emergency Care App...
Tzimenatos L, Mahajan P, Dayan PS, Vitale M, Linakis JG, Blumberg S, Borgiall...
This study evaluated the test characteristics of the urinalysis for diagnosing urinary tract infections, with and without associated bacteremia, in young febrile infants.
This study evaluated the test characteristics of the urinalysis for diagnosing urinary tract infections, with and without associated bacteremia, in young febrile infants.
Key Study: Delayed treatment of the first febrile urinary tract infection in early childhood increased the risk of renal scarring
Karavanaki KA, Soldatou A, Koufadaki AM, Tsentidis C, Haliotis FA, Stefanidis CJ
Karavanaki KA, Soldatou A, Koufadaki AM, Tsentidis C, Haliotis FA, Stefanidis CJ
This study evaluated the controversial relationship between the duration of fever before treatment initiation for a febrile urinary tract infection, with renal scarring based on dimercaptosuccinic acid scintigraphy (DMSA) findings.
This study evaluated the controversial relationship between the duration of fever before treatment initiation for a febrile urinary tract infection, with renal scarring based on dimercaptosuccinic acid scintigraphy (DMSA) findings.
Key Study: Testing for Urinary Tract Infection in the Influenza/Respiratory Syncytial Virus-Positive Febrile Infant Aged 2 to 12 Months
Schlechter Salinas AK, Hains DS, Jones T, Harrell C, Meredith M
Schlechter Salinas AK, Hains DS, Jones T, Harrell C, Meredith M
This study assessed the prevalence of urinary tract infection (UTI) in febrile RSV/influenza positive infants aged 2 to 12 months presenting to the emergency department. We also examined whether the 2011 American Academy of Pediatrics UTI clinical practice guidelines could be used to identify patients at lower risk of UTI.
This study assessed the prevalence of urinary tract infection (UTI) in febrile RSV/influenza positive infants aged 2 to 12 months presenting to the emergency department. We also examined whether the 2011 American Academy of Pediatrics UTI clinical practice guidelines could be used to identify patients at lower risk of UTI.
Key Study: The Diagnosis of Urinary Tract infection in Young children (DUTY): a diagnostic prospective observational study to derive and validate a clinical algorithm for the diagnosis of urinary tract infection in children presenting to primary care
Hay AD, Birnie K, Busby J, Delaney B, Downing H, Dudley J, Durbaba S, Fletcher M, Harman K, Hollingworth W, Hood K, Howe R, Lawton M, Lisles C, Little P, Mac...
Hay AD, Birnie K, Busby J, Delaney B, Downing H, Dudley J, Durbaba S, Fletche...
The objective of this study was to develop algorithms to accurately identify pre-school children in whom urine should be obtained; assess whether or not dipstick urinalysis provides additional diagnostic information; and model algorithm cost-effectiveness.
The objective of this study was to develop algorithms to accurately identify pre-school children in whom urine should be obtained; assess whether or not dipstick urinalysis provides additional diagnostic information; and model algorithm cost-effectiveness.
Key Study: Improving the Diagnosis and Treatment of Urinary Tract Infection in Young Children in Primary Care: Results from the DUTY Prospective Diagnostic Cohort Stud
Hay AD, Sterne JA, Hood K, Little P, Delaney B, Hollingworth W, Wootton M, Howe R, MacGowan A, Lawton M, Busby J, Pickles T, Birnie K, O'Brien K, Waldron CA,...
Hay AD, Sterne JA, Hood K, Little P, Delaney B, Hollingworth W, Wootton M, Ho...
Up to 50% of urinary tract infections (UTIs) in young children are missed in primary care. Urine culture is essential for diagnosis, but urine collection is often difficult. The aim of this study was to derive and internally validate a 2-step clinical rule using (1) symptoms and signs to select children for urine collection; and (2) symptoms, signs, and dipstick testing to guide antibiotic treatment.
Up to 50% of urinary tract infections (UTIs) in young children are missed in primary care. Urine culture is essential for diagnosis, but urine collection is often difficult. The aim of this study was to derive and internally validate a 2-step clinical rule using (1) symptoms and signs to select children for urine collection; and (2) symptoms, signs, and dipstick testing to guide antibiotic treatment.
Key Study: Predictors of Antimicrobial Resistance among Pathogens Causing Urinary Tract Infection in Children
Shaikh N, Hoberman A, Keren R, Ivanova A, Gotman N, Chesney RW, Carpenter MA, Moxey-Mims M, Wald ER
Shaikh N, Hoberman A, Keren R, Ivanova A, Gotman N, Chesney RW, Carpenter MA,...
The objective of this study was to determine which children with urinary tract infection are likely to have pathogens resistant to narrow-spectrum antimicrobials.
The objective of this study was to determine which children with urinary tract infection are likely to have pathogens resistant to narrow-spectrum antimicrobials.
Key Study: Early Antibiotic Treatment for Pediatric Febrile Urinary Tract Infection and Renal Scarring
Shaikh N, Mattoo TK, Keren R, Ivanova A, Cui G, Moxey-Mims M, Majd M, Ziessman HA, Hoberman A
Shaikh N, Mattoo TK, Keren R, Ivanova A, Cui G, Moxey-Mims M, Majd M, Ziessma...
The objective of this study was to determine whether delay in the initiation of antimicrobial therapy for febrile urinary tract infections is associated with the occurrence and severity of renal scarring.
The objective of this study was to determine whether delay in the initiation of antimicrobial therapy for febrile urinary tract infections is associated with the occurrence and severity of renal scarring.
Key Study: Pathogens causing urinary tract infections in infants: a European overview by the ESCAPE study group
Alberici I, Bayazit AK, Drozdz D, Emre S, Fischbach M, Harambat J, Jankauskiene A, Litwin M, Mir S, Morello W, Peco-Antic A, Sallay P, Sever L, Simonetti GD,...
Alberici I, Bayazit AK, Drozdz D, Emre S, Fischbach M, Harambat J, Jankauskie...
The objective of this study was to determine the pathogens in positive urine cultures from hospitalized and non-hospitalized infants under 24 months of age.
The objective of this study was to determine the pathogens in positive urine cultures from hospitalized and non-hospitalized infants under 24 months of age.
Key Study: Accuracy of a new clean-catch technique for diagnosis of urinary tract infection in infants younger than 90 days of age
Herreros ML, Tagarro A, Garca-Pose A, Snchez A, Caete A, Gili P
Herreros ML, Tagarro A, Garca-Pose A, Snchez A, Caete A, Gili P
The objective of this study was to evaluate the accuracy of diagnosing urinary tract infections using a new, recently described, standardized clean-catch collection technique.
The objective of this study was to evaluate the accuracy of diagnosing urinary tract infections using a new, recently described, standardized clean-catch collection technique.
Key Study: Diagnostic accuracy of the urinalysis for urinary tract infection in infants <3 months of age
Schroeder AR, Chang PW, Shen MW, Biondi EA, Greenhow TL
Schroeder AR, Chang PW, Shen MW, Biondi EA, Greenhow TL
The purpose of this study was to determine the accuracy (sensitivity and specificity) of urinalysis for diagnosing urinary tract infection in infants <3 months of age.
The purpose of this study was to determine the accuracy (sensitivity and specificity) of urinalysis for diagnosing urinary tract infection in infants <3 months of age.
Key Study: Does prompt treatment of urinary tract infection in preschool children prevent renal scarring: mixed retrospective and prospective audits
Coulthard MG, Lambert HJ, Vernon SJ, Hunter EW, Keir MJ, Matthews JN
Coulthard MG, Lambert HJ, Vernon SJ, Hunter EW, Keir MJ, Matthews JN
The objective of this study was to test whether active management of urinary tract infections in young children by general practitioners can reduce kidney scarring rates.
The objective of this study was to test whether active management of urinary tract infections in young children by general practitioners can reduce kidney scarring rates.
Key Study: Outpatient management of young febrile infants with urinary tract infections
Schnadower D, Kuppermann N, Macias CG, Freedman SB, Agrawal D, Mao J, Dayan PS, American Academy of Pediatrics Pediatric Emergency Medicine Collaborative Res...
Schnadower D, Kuppermann N, Macias CG, Freedman SB, Agrawal D, Mao J, Dayan P...
This study aimed to determine the variation in patient disposition for young febrile infants who present to emergency departments with urinary tract infections and clinical factors independently associated with outpatient management.
This study aimed to determine the variation in patient disposition for young febrile infants who present to emergency departments with urinary tract infections and clinical factors independently associated with outpatient management.
Key Study: Reliability of the urinalysis for predicting urinary tract infections in young febrile children
Bachur R, Harper MB
Bachur R, Harper MB
The objectives of this study were to determine how the sensitivity of the standard urinalysis as a screening test for urinary tract infection varies with age, and to determine the clinical situation that necessitates the collection of a urine culture regardless of the urinalysis result.
The objectives of this study were to determine how the sensitivity of the standard urinalysis as a screening test for urinary tract infection varies with age, and to determine the clinical situation that necessitates the collection of a urine culture regardless of the urinalysis result.
Key Study: Screening for urinary tract infection in infants in the emergency department: which test is best?
Shaw KN, McGowan KL, Gorelick MH, Schwartz JS
Shaw KN, McGowan KL, Gorelick MH, Schwartz JS
The objective of this study wa to compare rapid tests and screening strategies for detecting urinary tract infection in infants.
The objective of this study wa to compare rapid tests and screening strategies for detecting urinary tract infection in infants.
Key Study: Is urine culture necessary to rule out urinary tract infection in young febrile children?
Hoberman A, Wald ER, Reynolds EA, Penchansky L, Charron M
Hoberman A, Wald ER, Reynolds EA, Penchansky L, Charron M
The objective of this study was to determine whether the absence of pyuria on the enhanced urinalysis can be used to eliminate the diagnosis of urinary tract infection, avoiding the need for urine culture and sparing large health care expenditures.
The objective of this study was to determine whether the absence of pyuria on the enhanced urinalysis can be used to eliminate the diagnosis of urinary tract infection, avoiding the need for urine culture and sparing large health care expenditures.
Key Study: Development and Validation of a Calculator for Estimating the Probability of Urinary Tract Infection in Young Febrile Children
Shaikh N, Hoberman A, Hum SW, Alberty A, Muniz G, Kurs-Lasky M, Landsittel D, Shope T
Shaikh N, Hoberman A, Hum SW, Alberty A, Muniz G, Kurs-Lasky M, Landsittel D,...
The objective of this study is to develop and test a calculator (UTICalc) that can first estimate the probability of urinary tract infection based on clinical variables and then update that probability based on laboratory results.
The objective of this study is to develop and test a calculator (UTICalc) that can first estimate the probability of urinary tract infection based on clinical variables and then update that probability based on laboratory results.
Key Study: Accuracy of the Urinalysis for Urinary Tract Infections in Febrile Infants 60 Days and Younger
Tzimenatos L, Mahajan P, Dayan PS, Vitale M, Linakis JG, Blumberg S, Borgialli D, Ruddy RM, Van Buren J, Ramilo O, Kuppermann N; Pediatric Emergency Care App...
Tzimenatos L, Mahajan P, Dayan PS, Vitale M, Linakis JG, Blumberg S, Borgiall...
This study evaluated the test characteristics of the urinalysis for diagnosing urinary tract infections, with and without associated bacteremia, in young febrile infants.
This study evaluated the test characteristics of the urinalysis for diagnosing urinary tract infections, with and without associated bacteremia, in young febrile infants.
Key Study: Delayed treatment of the first febrile urinary tract infection in early childhood increased the risk of renal scarring
Karavanaki KA, Soldatou A, Koufadaki AM, Tsentidis C, Haliotis FA, Stefanidis CJ
Karavanaki KA, Soldatou A, Koufadaki AM, Tsentidis C, Haliotis FA, Stefanidis CJ
This study evaluated the controversial relationship between the duration of fever before treatment initiation for a febrile urinary tract infection, with renal scarring based on dimercaptosuccinic acid scintigraphy (DMSA) findings.
This study evaluated the controversial relationship between the duration of fever before treatment initiation for a febrile urinary tract infection, with renal scarring based on dimercaptosuccinic acid scintigraphy (DMSA) findings.
Key Study: Testing for Urinary Tract Infection in the Influenza/Respiratory Syncytial Virus-Positive Febrile Infant Aged 2 to 12 Months
Schlechter Salinas AK, Hains DS, Jones T, Harrell C, Meredith M
Schlechter Salinas AK, Hains DS, Jones T, Harrell C, Meredith M
This study assessed the prevalence of urinary tract infection (UTI) in febrile RSV/influenza positive infants aged 2 to 12 months presenting to the emergency department. We also examined whether the 2011 American Academy of Pediatrics UTI clinical practice guidelines could be used to identify patients at lower risk of UTI.
This study assessed the prevalence of urinary tract infection (UTI) in febrile RSV/influenza positive infants aged 2 to 12 months presenting to the emergency department. We also examined whether the 2011 American Academy of Pediatrics UTI clinical practice guidelines could be used to identify patients at lower risk of UTI.
Key Study: The Diagnosis of Urinary Tract infection in Young children (DUTY): a diagnostic prospective observational study to derive and validate a clinical algorithm for the diagnosis of urinary tract infection in children presenting to primary care
Hay AD, Birnie K, Busby J, Delaney B, Downing H, Dudley J, Durbaba S, Fletcher M, Harman K, Hollingworth W, Hood K, Howe R, Lawton M, Lisles C, Little P, Mac...
Hay AD, Birnie K, Busby J, Delaney B, Downing H, Dudley J, Durbaba S, Fletche...
The objective of this study was to develop algorithms to accurately identify pre-school children in whom urine should be obtained; assess whether or not dipstick urinalysis provides additional diagnostic information; and model algorithm cost-effectiveness.
The objective of this study was to develop algorithms to accurately identify pre-school children in whom urine should be obtained; assess whether or not dipstick urinalysis provides additional diagnostic information; and model algorithm cost-effectiveness.
Key Study: Improving the Diagnosis and Treatment of Urinary Tract Infection in Young Children in Primary Care: Results from the DUTY Prospective Diagnostic Cohort Stud
Hay AD, Sterne JA, Hood K, Little P, Delaney B, Hollingworth W, Wootton M, Howe R, MacGowan A, Lawton M, Busby J, Pickles T, Birnie K, O'Brien K, Waldron CA,...
Hay AD, Sterne JA, Hood K, Little P, Delaney B, Hollingworth W, Wootton M, Ho...
Up to 50% of urinary tract infections (UTIs) in young children are missed in primary care. Urine culture is essential for diagnosis, but urine collection is often difficult. The aim of this study was to derive and internally validate a 2-step clinical rule using (1) symptoms and signs to select children for urine collection; and (2) symptoms, signs, and dipstick testing to guide antibiotic treatment.
Up to 50% of urinary tract infections (UTIs) in young children are missed in primary care. Urine culture is essential for diagnosis, but urine collection is often difficult. The aim of this study was to derive and internally validate a 2-step clinical rule using (1) symptoms and signs to select children for urine collection; and (2) symptoms, signs, and dipstick testing to guide antibiotic treatment.
Key Study: Predictors of Antimicrobial Resistance among Pathogens Causing Urinary Tract Infection in Children
Shaikh N, Hoberman A, Keren R, Ivanova A, Gotman N, Chesney RW, Carpenter MA, Moxey-Mims M, Wald ER
Shaikh N, Hoberman A, Keren R, Ivanova A, Gotman N, Chesney RW, Carpenter MA,...
The objective of this study was to determine which children with urinary tract infection are likely to have pathogens resistant to narrow-spectrum antimicrobials.
The objective of this study was to determine which children with urinary tract infection are likely to have pathogens resistant to narrow-spectrum antimicrobials.
Key Study: Early Antibiotic Treatment for Pediatric Febrile Urinary Tract Infection and Renal Scarring
Shaikh N, Mattoo TK, Keren R, Ivanova A, Cui G, Moxey-Mims M, Majd M, Ziessman HA, Hoberman A
Shaikh N, Mattoo TK, Keren R, Ivanova A, Cui G, Moxey-Mims M, Majd M, Ziessma...
The objective of this study was to determine whether delay in the initiation of antimicrobial therapy for febrile urinary tract infections is associated with the occurrence and severity of renal scarring.
The objective of this study was to determine whether delay in the initiation of antimicrobial therapy for febrile urinary tract infections is associated with the occurrence and severity of renal scarring.
Key Study: Pathogens causing urinary tract infections in infants: a European overview by the ESCAPE study group
Alberici I, Bayazit AK, Drozdz D, Emre S, Fischbach M, Harambat J, Jankauskiene A, Litwin M, Mir S, Morello W, Peco-Antic A, Sallay P, Sever L, Simonetti GD,...
Alberici I, Bayazit AK, Drozdz D, Emre S, Fischbach M, Harambat J, Jankauskie...
The objective of this study was to determine the pathogens in positive urine cultures from hospitalized and non-hospitalized infants under 24 months of age.
The objective of this study was to determine the pathogens in positive urine cultures from hospitalized and non-hospitalized infants under 24 months of age.
Key Study: Accuracy of a new clean-catch technique for diagnosis of urinary tract infection in infants younger than 90 days of age
Herreros ML, Tagarro A, Garca-Pose A, Snchez A, Caete A, Gili P
Herreros ML, Tagarro A, Garca-Pose A, Snchez A, Caete A, Gili P
The objective of this study was to evaluate the accuracy of diagnosing urinary tract infections using a new, recently described, standardized clean-catch collection technique.
The objective of this study was to evaluate the accuracy of diagnosing urinary tract infections using a new, recently described, standardized clean-catch collection technique.
Key Study: Diagnostic accuracy of the urinalysis for urinary tract infection in infants <3 months of age
Schroeder AR, Chang PW, Shen MW, Biondi EA, Greenhow TL
Schroeder AR, Chang PW, Shen MW, Biondi EA, Greenhow TL
The purpose of this study was to determine the accuracy (sensitivity and specificity) of urinalysis for diagnosing urinary tract infection in infants <3 months of age.
The purpose of this study was to determine the accuracy (sensitivity and specificity) of urinalysis for diagnosing urinary tract infection in infants <3 months of age.
Key Study: Does prompt treatment of urinary tract infection in preschool children prevent renal scarring: mixed retrospective and prospective audits
Coulthard MG, Lambert HJ, Vernon SJ, Hunter EW, Keir MJ, Matthews JN
Coulthard MG, Lambert HJ, Vernon SJ, Hunter EW, Keir MJ, Matthews JN
The objective of this study was to test whether active management of urinary tract infections in young children by general practitioners can reduce kidney scarring rates.
The objective of this study was to test whether active management of urinary tract infections in young children by general practitioners can reduce kidney scarring rates.
Key Study: Outpatient management of young febrile infants with urinary tract infections
Schnadower D, Kuppermann N, Macias CG, Freedman SB, Agrawal D, Mao J, Dayan PS, American Academy of Pediatrics Pediatric Emergency Medicine Collaborative Res...
Schnadower D, Kuppermann N, Macias CG, Freedman SB, Agrawal D, Mao J, Dayan P...
This study aimed to determine the variation in patient disposition for young febrile infants who present to emergency departments with urinary tract infections and clinical factors independently associated with outpatient management.
This study aimed to determine the variation in patient disposition for young febrile infants who present to emergency departments with urinary tract infections and clinical factors independently associated with outpatient management.
Key Study: Reliability of the urinalysis for predicting urinary tract infections in young febrile children
Bachur R, Harper MB
Bachur R, Harper MB
The objectives of this study were to determine how the sensitivity of the standard urinalysis as a screening test for urinary tract infection varies with age, and to determine the clinical situation that necessitates the collection of a urine culture regardless of the urinalysis result.
The objectives of this study were to determine how the sensitivity of the standard urinalysis as a screening test for urinary tract infection varies with age, and to determine the clinical situation that necessitates the collection of a urine culture regardless of the urinalysis result.
Key Study: Screening for urinary tract infection in infants in the emergency department: which test is best?
Shaw KN, McGowan KL, Gorelick MH, Schwartz JS
Shaw KN, McGowan KL, Gorelick MH, Schwartz JS
The objective of this study wa to compare rapid tests and screening strategies for detecting urinary tract infection in infants.
The objective of this study wa to compare rapid tests and screening strategies for detecting urinary tract infection in infants.
Key Study: Is urine culture necessary to rule out urinary tract infection in young febrile children?
Hoberman A, Wald ER, Reynolds EA, Penchansky L, Charron M
Hoberman A, Wald ER, Reynolds EA, Penchansky L, Charron M
The objective of this study was to determine whether the absence of pyuria on the enhanced urinalysis can be used to eliminate the diagnosis of urinary tract infection, avoiding the need for urine culture and sparing large health care expenditures.
The objective of this study was to determine whether the absence of pyuria on the enhanced urinalysis can be used to eliminate the diagnosis of urinary tract infection, avoiding the need for urine culture and sparing large health care expenditures.