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BROWSE EVIDENCE REPOSITORY

 

Key studies English (16) French All (16)

Key Study: Development and Validation of a Calculator for Estimating the Probability of Urinary Tract Infection in Young Febrile Children

Visit

Shaikh N, Hoberman A, Hum SW, Alberty A, Muniz G, Kurs-Lasky M, Landsittel D,...

The objective of this study is to develop and test a calculator (UTICalc) that can first estimate the probability of urinary tract infection based on clinical variables and then update that probability based on laboratory results.

Key Study: Accuracy of the Urinalysis for Urinary Tract Infections in Febrile Infants 60 Days and Younger

Visit

Tzimenatos L, Mahajan P, Dayan PS, Vitale M, Linakis JG, Blumberg S, Borgiall...

This study evaluated the test characteristics of the urinalysis for diagnosing urinary tract infections, with and without associated bacteremia, in young febrile infants.

Key Study: Delayed treatment of the first febrile urinary tract infection in early childhood increased the risk of renal scarring

Visit

Karavanaki KA, Soldatou A, Koufadaki AM, Tsentidis C, Haliotis FA, Stefanidis CJ

This study evaluated the controversial relationship between the duration of fever before treatment initiation for a febrile urinary tract infection, with renal scarring based on dimercaptosuccinic acid scintigraphy (DMSA) findings.

Key Study: Testing for Urinary Tract Infection in the Influenza/Respiratory Syncytial Virus-Positive Febrile Infant Aged 2 to 12 Months

Visit

Schlechter Salinas AK, Hains DS, Jones T, Harrell C, Meredith M

This study assessed the prevalence of urinary tract infection (UTI) in febrile RSV/influenza positive infants aged 2 to 12 months presenting to the emergency department. We also examined whether the 2011 American Academy of Pediatrics UTI clinical practice guidelines could be used to identify patients at lower risk of UTI.

Key Study: The Diagnosis of Urinary Tract infection in Young children (DUTY): a diagnostic prospective observational study to derive and validate a clinical algorithm for the diagnosis of urinary tract infection in children presenting to primary care

Visit

Hay AD, Birnie K, Busby J, Delaney B, Downing H, Dudley J, Durbaba S, Fletche...

The objective of this study was to develop algorithms to accurately identify pre-school children in whom urine should be obtained; assess whether or not dipstick urinalysis provides additional diagnostic information; and model algorithm cost-effectiveness.

Key Study: Improving the Diagnosis and Treatment of Urinary Tract Infection in Young Children in Primary Care: Results from the DUTY Prospective Diagnostic Cohort Stud

Visit

Hay AD, Sterne JA, Hood K, Little P, Delaney B, Hollingworth W, Wootton M, Ho...

Up to 50% of urinary tract infections (UTIs) in young children are missed in primary care. Urine culture is essential for diagnosis, but urine collection is often difficult. The aim of this study was to derive and internally validate a 2-step clinical rule using (1) symptoms and signs to select children for urine collection; and (2) symptoms, signs, and dipstick testing to guide antibiotic treatment.

Key Study: Predictors of Antimicrobial Resistance among Pathogens Causing Urinary Tract Infection in Children

Visit

Shaikh N, Hoberman A, Keren R, Ivanova A, Gotman N, Chesney RW, Carpenter MA,...

The objective of this study was to determine which children with urinary tract infection are likely to have pathogens resistant to narrow-spectrum antimicrobials.

Key Study: Early Antibiotic Treatment for Pediatric Febrile Urinary Tract Infection and Renal Scarring

Visit

Shaikh N, Mattoo TK, Keren R, Ivanova A, Cui G, Moxey-Mims M, Majd M, Ziessma...

The objective of this study was to determine whether delay in the initiation of antimicrobial therapy for febrile urinary tract infections is associated with the occurrence and severity of renal scarring.

Key Study: Pathogens causing urinary tract infections in infants: a European overview by the ESCAPE study group

Visit

Alberici I, Bayazit AK, Drozdz D, Emre S, Fischbach M, Harambat J, Jankauskie...

The objective of this study was to determine the pathogens in positive urine cultures from hospitalized and non-hospitalized infants under 24 months of age.

Key Study: Accuracy of a new clean-catch technique for diagnosis of urinary tract infection in infants younger than 90 days of age

Visit

Herreros ML, Tagarro A, Garca-Pose A, Snchez A, Caete A, Gili P

The objective of this study was to evaluate the accuracy of diagnosing urinary tract infections using a new, recently described, standardized clean-catch collection technique.

Key Study: Diagnostic accuracy of the urinalysis for urinary tract infection in infants <3 months of age

Visit

Schroeder AR, Chang PW, Shen MW, Biondi EA, Greenhow TL

The purpose of this study was to determine the accuracy (sensitivity and specificity) of urinalysis for diagnosing urinary tract infection in infants <3 months of age.

Key Study: Does prompt treatment of urinary tract infection in preschool children prevent renal scarring: mixed retrospective and prospective audits

Visit

Coulthard MG, Lambert HJ, Vernon SJ, Hunter EW, Keir MJ, Matthews JN

The objective of this study was to test whether active management of urinary tract infections in young children by general practitioners can reduce kidney scarring rates.

Key Study: Outpatient management of young febrile infants with urinary tract infections

Visit

Schnadower D, Kuppermann N, Macias CG, Freedman SB, Agrawal D, Mao J, Dayan P...

This study aimed to determine the variation in patient disposition for young febrile infants who present to emergency departments with urinary tract infections and clinical factors independently associated with outpatient management.

Key Study: Reliability of the urinalysis for predicting urinary tract infections in young febrile children

Visit

Bachur R, Harper MB

The objectives of this study were to determine how the sensitivity of the standard urinalysis as a screening test for urinary tract infection varies with age, and to determine the clinical situation that necessitates the collection of a urine culture regardless of the urinalysis result.

Key Study: Screening for urinary tract infection in infants in the emergency department: which test is best?

Visit

Shaw KN, McGowan KL, Gorelick MH, Schwartz JS

The objective of this study wa to compare rapid tests and screening strategies for detecting urinary tract infection in infants.

Key Study: Is urine culture necessary to rule out urinary tract infection in young febrile children?

Visit

Hoberman A, Wald ER, Reynolds EA, Penchansky L, Charron M

The objective of this study was to determine whether the absence of pyuria on the enhanced urinalysis can be used to eliminate the diagnosis of urinary tract infection, avoiding the need for urine culture and sparing large health care expenditures.

Key Study: Development and Validation of a Calculator for Estimating the Probability of Urinary Tract Infection in Young Febrile Children

Visit

Shaikh N, Hoberman A, Hum SW, Alberty A, Muniz G, Kurs-Lasky M, Landsittel D,...

The objective of this study is to develop and test a calculator (UTICalc) that can first estimate the probability of urinary tract infection based on clinical variables and then update that probability based on laboratory results.

Key Study: Accuracy of the Urinalysis for Urinary Tract Infections in Febrile Infants 60 Days and Younger

Visit

Tzimenatos L, Mahajan P, Dayan PS, Vitale M, Linakis JG, Blumberg S, Borgiall...

This study evaluated the test characteristics of the urinalysis for diagnosing urinary tract infections, with and without associated bacteremia, in young febrile infants.

Key Study: Delayed treatment of the first febrile urinary tract infection in early childhood increased the risk of renal scarring

Visit

Karavanaki KA, Soldatou A, Koufadaki AM, Tsentidis C, Haliotis FA, Stefanidis CJ

This study evaluated the controversial relationship between the duration of fever before treatment initiation for a febrile urinary tract infection, with renal scarring based on dimercaptosuccinic acid scintigraphy (DMSA) findings.

Key Study: Testing for Urinary Tract Infection in the Influenza/Respiratory Syncytial Virus-Positive Febrile Infant Aged 2 to 12 Months

Visit

Schlechter Salinas AK, Hains DS, Jones T, Harrell C, Meredith M

This study assessed the prevalence of urinary tract infection (UTI) in febrile RSV/influenza positive infants aged 2 to 12 months presenting to the emergency department. We also examined whether the 2011 American Academy of Pediatrics UTI clinical practice guidelines could be used to identify patients at lower risk of UTI.

Key Study: The Diagnosis of Urinary Tract infection in Young children (DUTY): a diagnostic prospective observational study to derive and validate a clinical algorithm for the diagnosis of urinary tract infection in children presenting to primary care

Visit

Hay AD, Birnie K, Busby J, Delaney B, Downing H, Dudley J, Durbaba S, Fletche...

The objective of this study was to develop algorithms to accurately identify pre-school children in whom urine should be obtained; assess whether or not dipstick urinalysis provides additional diagnostic information; and model algorithm cost-effectiveness.

Key Study: Improving the Diagnosis and Treatment of Urinary Tract Infection in Young Children in Primary Care: Results from the DUTY Prospective Diagnostic Cohort Stud

Visit

Hay AD, Sterne JA, Hood K, Little P, Delaney B, Hollingworth W, Wootton M, Ho...

Up to 50% of urinary tract infections (UTIs) in young children are missed in primary care. Urine culture is essential for diagnosis, but urine collection is often difficult. The aim of this study was to derive and internally validate a 2-step clinical rule using (1) symptoms and signs to select children for urine collection; and (2) symptoms, signs, and dipstick testing to guide antibiotic treatment.

Key Study: Predictors of Antimicrobial Resistance among Pathogens Causing Urinary Tract Infection in Children

Visit

Shaikh N, Hoberman A, Keren R, Ivanova A, Gotman N, Chesney RW, Carpenter MA,...

The objective of this study was to determine which children with urinary tract infection are likely to have pathogens resistant to narrow-spectrum antimicrobials.

Key Study: Early Antibiotic Treatment for Pediatric Febrile Urinary Tract Infection and Renal Scarring

Visit

Shaikh N, Mattoo TK, Keren R, Ivanova A, Cui G, Moxey-Mims M, Majd M, Ziessma...

The objective of this study was to determine whether delay in the initiation of antimicrobial therapy for febrile urinary tract infections is associated with the occurrence and severity of renal scarring.

Key Study: Pathogens causing urinary tract infections in infants: a European overview by the ESCAPE study group

Visit

Alberici I, Bayazit AK, Drozdz D, Emre S, Fischbach M, Harambat J, Jankauskie...

The objective of this study was to determine the pathogens in positive urine cultures from hospitalized and non-hospitalized infants under 24 months of age.

Key Study: Accuracy of a new clean-catch technique for diagnosis of urinary tract infection in infants younger than 90 days of age

Visit

Herreros ML, Tagarro A, Garca-Pose A, Snchez A, Caete A, Gili P

The objective of this study was to evaluate the accuracy of diagnosing urinary tract infections using a new, recently described, standardized clean-catch collection technique.

Key Study: Diagnostic accuracy of the urinalysis for urinary tract infection in infants <3 months of age

Visit

Schroeder AR, Chang PW, Shen MW, Biondi EA, Greenhow TL

The purpose of this study was to determine the accuracy (sensitivity and specificity) of urinalysis for diagnosing urinary tract infection in infants <3 months of age.

Key Study: Does prompt treatment of urinary tract infection in preschool children prevent renal scarring: mixed retrospective and prospective audits

Visit

Coulthard MG, Lambert HJ, Vernon SJ, Hunter EW, Keir MJ, Matthews JN

The objective of this study was to test whether active management of urinary tract infections in young children by general practitioners can reduce kidney scarring rates.

Key Study: Outpatient management of young febrile infants with urinary tract infections

Visit

Schnadower D, Kuppermann N, Macias CG, Freedman SB, Agrawal D, Mao J, Dayan P...

This study aimed to determine the variation in patient disposition for young febrile infants who present to emergency departments with urinary tract infections and clinical factors independently associated with outpatient management.

Key Study: Reliability of the urinalysis for predicting urinary tract infections in young febrile children

Visit

Bachur R, Harper MB

The objectives of this study were to determine how the sensitivity of the standard urinalysis as a screening test for urinary tract infection varies with age, and to determine the clinical situation that necessitates the collection of a urine culture regardless of the urinalysis result.

Key Study: Screening for urinary tract infection in infants in the emergency department: which test is best?

Visit

Shaw KN, McGowan KL, Gorelick MH, Schwartz JS

The objective of this study wa to compare rapid tests and screening strategies for detecting urinary tract infection in infants.

Key Study: Is urine culture necessary to rule out urinary tract infection in young febrile children?

Visit

Hoberman A, Wald ER, Reynolds EA, Penchansky L, Charron M

The objective of this study was to determine whether the absence of pyuria on the enhanced urinalysis can be used to eliminate the diagnosis of urinary tract infection, avoiding the need for urine culture and sparing large health care expenditures.