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Gastroenteritis is a common disease, usually of viral origin that inflames both the stomach and small intestine. It is characterized by fever, diarrhea and vomiting.

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Key studies English (22) French All (22)

Key Study: Assessing Dehydration Employing End-Tidal Carbon Dioxide in Children With Vomiting and Diarrhea

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Freedman SB, Johnson DW, Nettel-Aguirre A, Mikrogianakis A, Williamson-Urquha...

This study evaluated whether end-tidal carbon dioxide predicts weight change in children with vomiting and/or diarrhea.

Key Study: Oral Ondansetron Administration to Nondehydrated Children With Diarrhea and Associated Vomiting in Emergency Departments in Pakistan: A Randomized Controlled Trial

Visit

Freedman SB, Soofi SB, Willan AR, Williamson-Urquhart S, Ali N, Xie J, Dawoud...

Objective: To determine whether single-dose oral ondansetron administration to children with vomiting as a result of acute gastroenteritis without dehydration reduces administration of intravenous fluid rehydration.

Key Study: Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis

Visit

Freedman SB, Williamson-Urquhart S, Farion KJ, Gouin S, Willan AR, Poonai N, ...

Objective: To determine whether the use of probiotics improves outcomes in children with gastroenteritis.

Key Study: Efficacy of an Oral Rehydration Solution Enriched with Lactobacillus reuteri DSM 17938 and Zinc in the Management of Acute Diarrhoea in Infants: A Randomized, Double-Blind, Placebo-Controlled Trial

Visit

Maragkoudaki M, Chouliaras G, Moutafi A, Thomas A, Orfanakou A, Papadopoulou A

Objective: to assess the efficacy of an oral rehydration solution enriched with Lactobacillus reuteri DSM 17938 and zinc in well-nourished, non-hospitalized infants with acute diarrhoea.

Key Study: Lactobacillus rhamnosus GG versus Placebo for Acute Gastroenteritis in Children

Visit

Schnadower D, Tarr PI, Casper TC, Gorelick MH, Dean JM, O'Connell KJ, Mahajan...

This study evaluated outcomes for children with acute gastroenteritis who received Lactobacillus rhamnosus GG versus placebo.

Key Study: Performance of Stool Testing Recommendations for Acute Gastroenteritis when Used to Identify Children with Nine Potential Bacterial Enteropathogens

Visit

Tarr GAM, Chui L, Lee BE, Pang XL, Ali S, Nettel-Aguirre A, Vanderkooi OG, Be...

This study evaluated six leading gastroenteritis guidelines for stool testing recommendations.

Key Study: Identification of Enteric Viruses in Oral Swabs from Children with Acute Gastroenteritis

Visit

Zhuo R, Parsons BD, Lee BE, Drews SJ, Chui L, Louie M, Crago B, Freedman SB, ...

This study evaluated if oral swabs are a suitable alternative specimen to stools for identifying enteric viruses from children with acute gastroenteritis.

Key Study: Province-Wide Review of Pediatric Shiga Toxin-Producing Escherichia coli Case Management

Visit

Freedman SB, Eltorki M, Chui L, Xie J, Feng S, MacDonald J, Dixon A, Ali S, L...

Objective: To identify the gaps in the care of children infected with Shiga toxin-producing Escherichia coli, this study sought to quantitate care received and management timelines.

Key Study: Enteropathogen detection in children with diarrhoea, or vomiting, or both, comparing rectal flocked swabs with stool specimens: an outpatient cohort study

Visit

Freedman SB, Xie J, Nettel-Aguirre A, Lee B, Chui L, Pang XL, Zhuo R, Parsons...

Objective: to compare the enteropathogen yields of rectal swabs and stool specimens in children with diarrhoea or vomiting, or both.

Key Study: Implementation of clinical decision support in young children with acute gastroenteritis: a randomized controlled trial at the emergency department

Visit

Geurts D, de Vos-Kerkhof E, Polinder S, Steyerberg E, van der Lei J, Moll H, ...

Objectives: To evaluate feasibility of a nurse-guided clinical decision support system for rehydration treatment in children with AGE, and the impact on diagnostics, treatment, and costs compared with usual care by attending physician.

Key Study: High genetic variability of norovirus leads to diagnostic test challenges

Visit

Zhuo R, Cho J, Qiu Y, Parsons BD, Lee BE, Chui L, Freedman SB, Pang X; Albert...

Objectives: To characterize the cases of discordant norovirus genogroup II (NoV GII) results between Gastrointestinal Pathogen Panel (GPP) and Gastroenteritis Virus Panel (GVP), and determine the sensitivity of the two assays for specific NoV GII genotypes.

Key Study: A randomized trial of Plasma-Lyte A and 0.9 % sodium chloride in acute pediatric gastroenteritis

Visit

Allen CH, Goldman RD, Bhatt S, Simon HK, Gorelick MH, Spandorfer PR, Spiro DM...

Objective: To compare the efficacy and safety of Plasma-Lyte A (PLA) versus 0.9 % sodium chloride (NaCl) intravenous (IV) fluid replacement in children with moderate to severe dehydration secondary to acute gastroenteritis.

Key Study: Evaluating the Impact of Clinical Decision Tools in Pediatric Acute Gastroenteritis: A Population-based Cohort Study

Visit

Bahm A, Freedman SB, Guan J, Guttmann A

This study sought to determine if the following tools - 1) pathways/order sets, 2) medical directives for oral rehydration therapy (ORT) or ondansetron, and 3) printed discharge instructions - are associated with acute gastroenteritis admission and emergency department revisits.

Key Study: Effect of Dilute Apple Juice and Preferred Fluids vs Electrolyte Maintenance Solution on Treatment Failure Among Children With Mild Gastroenteritis: A Randomized Clinical Trial

Visit

Freedman SB, Willan AR, Boutis K, Schuh S

Objective: To determine if oral hydration with dilute apple juice/preferred fluids is noninferior to electrolyte maintenance solution in children with mild gastroenteritis.

Key Study: Oral Ondansetron versus Domperidone for Acute Gastroenteritis in Pediatric Emergency Departments: Multicenter Double Blind Randomized Controlled Trial

Visit

Marchetti F, Bonati M, Maestro A, Zanon D, Rovere F, Arrighini A, Barbi E, Be...

Objective: To evaluate whether a single oral dose of ondansetron vs domperidone or placebo improves outcomes in children with gastroenteritis.

Key Study: Should all acutely ill children in primary care be tested with point-of-care CRP: a cluster randomised trial

Visit

Verbakel JY, Lemiengre MB, De Burghgraeve T, De Sutter A, Aertgeerts B, Shink...

Objective: To determine whether C-reactive protein (CRP) testing should be offered to all acutely ill children in primary care or restricted to those identified as at risk on clinical assessment.

Key Study: Cost-effectiveness of point-of-care testing for dehydration in the pediatric ED

Visit

Whitney RE, Santucci K, Hsiao A, Chen L

Objective: To examine the cost-effectiveness of using point-of-care electrolyte testing vs traditional serum chemistry testing in the pediatric emergency department for children with acute gastroenteritis.

Key Study: Emergency Department Treatment of Children With Diarrhea Who Attend Day Care: A Randomized Multidose Trial of a Lactobacillus helveticus and Lactobacillus rhamnosus Combination Probiotic

Visit

Freedman SB, Sherman PM, Willan A, Johnson D, Gouin S, Schuh S; Pediatric Eme...

This study evaluated the rates of day care absenteeism of children with gastroenteritis treated with probiotics.

Key Study: Impact of increasing ondansetron use on clinical outcomes in children with gastroenteritis

Visit

Freedman SB, Hall M, Shah SS, Kharbanda AB, Aronson PL, Florin TA, Mistry RD,...

The objective of this retrospective study is to determine whether increasing emergency department ondansetron use results in a reduction in intravenous rehydration rates in children with gastroenteritis.

Key Study: Emergency department revisits in children with gastroenteritis

Visit

Freedman SB, Thull-Freedman JD, Rumantir M, Atenafu EG, Stephens D

The aim of the study is to determine whether intravenous fluid administration to children with gastroenteritis is independently associated with a reduction in unscheduled emergency department (ED) revisits within 7 days.

Key Study: Oral ondansetron for gastroenteritis in a pediatric emergency department

Visit

Freedman SB, Adler M, Seshadri R, Powell EC

The aim of this trial is to determine whether a single dose of ondansetron would improve outcomes in children with gastroenteritis.

Key Study: Oral versus intravenous rehydration of moderately dehydrated children: a randomized, controlled trial

Visit

Spandorfer PR, Alessandrini EA, Joffe MD, Localio R, Shaw KN

The objective of this trial is to test the hypothesis that the failure rate of oral rehydration therapy would be not be >5% greater than the failure rate of intravenous fluid therapy for moderately dehydrated children.

Key Study: Assessing Dehydration Employing End-Tidal Carbon Dioxide in Children With Vomiting and Diarrhea

Visit

Freedman SB, Johnson DW, Nettel-Aguirre A, Mikrogianakis A, Williamson-Urquha...

This study evaluated whether end-tidal carbon dioxide predicts weight change in children with vomiting and/or diarrhea.

Key Study: Oral Ondansetron Administration to Nondehydrated Children With Diarrhea and Associated Vomiting in Emergency Departments in Pakistan: A Randomized Controlled Trial

Visit

Freedman SB, Soofi SB, Willan AR, Williamson-Urquhart S, Ali N, Xie J, Dawoud...

Objective: To determine whether single-dose oral ondansetron administration to children with vomiting as a result of acute gastroenteritis without dehydration reduces administration of intravenous fluid rehydration.

Key Study: Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis

Visit

Freedman SB, Williamson-Urquhart S, Farion KJ, Gouin S, Willan AR, Poonai N, ...

Objective: To determine whether the use of probiotics improves outcomes in children with gastroenteritis.

Key Study: Efficacy of an Oral Rehydration Solution Enriched with Lactobacillus reuteri DSM 17938 and Zinc in the Management of Acute Diarrhoea in Infants: A Randomized, Double-Blind, Placebo-Controlled Trial

Visit

Maragkoudaki M, Chouliaras G, Moutafi A, Thomas A, Orfanakou A, Papadopoulou A

Objective: to assess the efficacy of an oral rehydration solution enriched with Lactobacillus reuteri DSM 17938 and zinc in well-nourished, non-hospitalized infants with acute diarrhoea.

Key Study: Lactobacillus rhamnosus GG versus Placebo for Acute Gastroenteritis in Children

Visit

Schnadower D, Tarr PI, Casper TC, Gorelick MH, Dean JM, O'Connell KJ, Mahajan...

This study evaluated outcomes for children with acute gastroenteritis who received Lactobacillus rhamnosus GG versus placebo.

Key Study: Performance of Stool Testing Recommendations for Acute Gastroenteritis when Used to Identify Children with Nine Potential Bacterial Enteropathogens

Visit

Tarr GAM, Chui L, Lee BE, Pang XL, Ali S, Nettel-Aguirre A, Vanderkooi OG, Be...

This study evaluated six leading gastroenteritis guidelines for stool testing recommendations.

Key Study: Identification of Enteric Viruses in Oral Swabs from Children with Acute Gastroenteritis

Visit

Zhuo R, Parsons BD, Lee BE, Drews SJ, Chui L, Louie M, Crago B, Freedman SB, ...

This study evaluated if oral swabs are a suitable alternative specimen to stools for identifying enteric viruses from children with acute gastroenteritis.

Key Study: Province-Wide Review of Pediatric Shiga Toxin-Producing Escherichia coli Case Management

Visit

Freedman SB, Eltorki M, Chui L, Xie J, Feng S, MacDonald J, Dixon A, Ali S, L...

Objective: To identify the gaps in the care of children infected with Shiga toxin-producing Escherichia coli, this study sought to quantitate care received and management timelines.

Key Study: Enteropathogen detection in children with diarrhoea, or vomiting, or both, comparing rectal flocked swabs with stool specimens: an outpatient cohort study

Visit

Freedman SB, Xie J, Nettel-Aguirre A, Lee B, Chui L, Pang XL, Zhuo R, Parsons...

Objective: to compare the enteropathogen yields of rectal swabs and stool specimens in children with diarrhoea or vomiting, or both.

Key Study: Implementation of clinical decision support in young children with acute gastroenteritis: a randomized controlled trial at the emergency department

Visit

Geurts D, de Vos-Kerkhof E, Polinder S, Steyerberg E, van der Lei J, Moll H, ...

Objectives: To evaluate feasibility of a nurse-guided clinical decision support system for rehydration treatment in children with AGE, and the impact on diagnostics, treatment, and costs compared with usual care by attending physician.

Key Study: High genetic variability of norovirus leads to diagnostic test challenges

Visit

Zhuo R, Cho J, Qiu Y, Parsons BD, Lee BE, Chui L, Freedman SB, Pang X; Albert...

Objectives: To characterize the cases of discordant norovirus genogroup II (NoV GII) results between Gastrointestinal Pathogen Panel (GPP) and Gastroenteritis Virus Panel (GVP), and determine the sensitivity of the two assays for specific NoV GII genotypes.

Key Study: A randomized trial of Plasma-Lyte A and 0.9 % sodium chloride in acute pediatric gastroenteritis

Visit

Allen CH, Goldman RD, Bhatt S, Simon HK, Gorelick MH, Spandorfer PR, Spiro DM...

Objective: To compare the efficacy and safety of Plasma-Lyte A (PLA) versus 0.9 % sodium chloride (NaCl) intravenous (IV) fluid replacement in children with moderate to severe dehydration secondary to acute gastroenteritis.

Key Study: Evaluating the Impact of Clinical Decision Tools in Pediatric Acute Gastroenteritis: A Population-based Cohort Study

Visit

Bahm A, Freedman SB, Guan J, Guttmann A

This study sought to determine if the following tools - 1) pathways/order sets, 2) medical directives for oral rehydration therapy (ORT) or ondansetron, and 3) printed discharge instructions - are associated with acute gastroenteritis admission and emergency department revisits.

Key Study: Effect of Dilute Apple Juice and Preferred Fluids vs Electrolyte Maintenance Solution on Treatment Failure Among Children With Mild Gastroenteritis: A Randomized Clinical Trial

Visit

Freedman SB, Willan AR, Boutis K, Schuh S

Objective: To determine if oral hydration with dilute apple juice/preferred fluids is noninferior to electrolyte maintenance solution in children with mild gastroenteritis.

Key Study: Oral Ondansetron versus Domperidone for Acute Gastroenteritis in Pediatric Emergency Departments: Multicenter Double Blind Randomized Controlled Trial

Visit

Marchetti F, Bonati M, Maestro A, Zanon D, Rovere F, Arrighini A, Barbi E, Be...

Objective: To evaluate whether a single oral dose of ondansetron vs domperidone or placebo improves outcomes in children with gastroenteritis.

Key Study: Should all acutely ill children in primary care be tested with point-of-care CRP: a cluster randomised trial

Visit

Verbakel JY, Lemiengre MB, De Burghgraeve T, De Sutter A, Aertgeerts B, Shink...

Objective: To determine whether C-reactive protein (CRP) testing should be offered to all acutely ill children in primary care or restricted to those identified as at risk on clinical assessment.

Key Study: Cost-effectiveness of point-of-care testing for dehydration in the pediatric ED

Visit

Whitney RE, Santucci K, Hsiao A, Chen L

Objective: To examine the cost-effectiveness of using point-of-care electrolyte testing vs traditional serum chemistry testing in the pediatric emergency department for children with acute gastroenteritis.

Key Study: Emergency Department Treatment of Children With Diarrhea Who Attend Day Care: A Randomized Multidose Trial of a Lactobacillus helveticus and Lactobacillus rhamnosus Combination Probiotic

Visit

Freedman SB, Sherman PM, Willan A, Johnson D, Gouin S, Schuh S; Pediatric Eme...

This study evaluated the rates of day care absenteeism of children with gastroenteritis treated with probiotics.

Key Study: Impact of increasing ondansetron use on clinical outcomes in children with gastroenteritis

Visit

Freedman SB, Hall M, Shah SS, Kharbanda AB, Aronson PL, Florin TA, Mistry RD,...

The objective of this retrospective study is to determine whether increasing emergency department ondansetron use results in a reduction in intravenous rehydration rates in children with gastroenteritis.

Key Study: Emergency department revisits in children with gastroenteritis

Visit

Freedman SB, Thull-Freedman JD, Rumantir M, Atenafu EG, Stephens D

The aim of the study is to determine whether intravenous fluid administration to children with gastroenteritis is independently associated with a reduction in unscheduled emergency department (ED) revisits within 7 days.

Key Study: Oral ondansetron for gastroenteritis in a pediatric emergency department

Visit

Freedman SB, Adler M, Seshadri R, Powell EC

The aim of this trial is to determine whether a single dose of ondansetron would improve outcomes in children with gastroenteritis.

Key Study: Oral versus intravenous rehydration of moderately dehydrated children: a randomized, controlled trial

Visit

Spandorfer PR, Alessandrini EA, Joffe MD, Localio R, Shaw KN

The objective of this trial is to test the hypothesis that the failure rate of oral rehydration therapy would be not be >5% greater than the failure rate of intravenous fluid therapy for moderately dehydrated children.

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