COVID19 key studies
Key study: Pointofcare lung ultrasound findings in the pediatric emergency clinic during the COVID19 pandemic.
Tre E, Korkmaz MF, Aksoy FD, et al.
Tre E, Korkmaz MF, Aksoy FD, et al.
Objective: To describe our experience concerning lung ultrasound (LUS) in the pediatric emergency clinic, and to investigate the diagnostic value of LUS in coronavirus disease-2019 (COVID-19).
Key study: Asymptomatic cases in a family cluster with SARS-CoV-2 infection
Wu X, Li T, Ou X, et al
Wu X, Li T, Ou X, et al
Objective: To report the findings from different types of clinical specimens collected from 82 infected individuals
Key study: SARS-CoV-2 Infection in Children.
Lu X, Zhang L, Du H, et al
Lu X, Zhang L, Du H, et al
Objective: In order to determine the spectrum of disease in children, we evaluated children infected with SARS-CoV-2 and treated at the Wuhan Childrens Hospital, the only center assigned by the central government for treating infected children under 16 years of age in Wuhan.
Key study: A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features
Jiehao C, Jing X, Daojiong L, et al
Jiehao C, Jing X, Daojiong L, et al
Objective: To report the clinical and epidemiological features in children with coronavirus diseases (COVID) in China.
Key study: Clinical features of paediatric patients with COVID-19: a report of two family clusters.
Ji L, Chao S, Wang Y, et al.
Ji L, Chao S, Wang Y, et al.
Objective: To retrospectively review two confirmed pediatric cases from two family clusters. Both clinical features and laboratory examination results of the children and their family members were described.
Key study: Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China.
Dong Y, Mo X, Hu Y, et al.
Dong Y, Mo X, Hu Y, et al.
Objective: This study examined the epidemiological characteristics and transmission patterns of 2143 pediatric patients with COVID-19, using a retrospective analytical approach.
Key study: Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China
Wei M, Yuan J, Liu Y, et al.,
Wei M, Yuan J, Liu Y, et al.,
Objective: For this retrospective study, authors identified all hospitalized infants diagnosed with COVID-19 infection between December 8, 2019, and February 6, 2020, in China and described demographic, epidemiologic, and clinical features.
Key study: Clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children
Hong H et al.,
Hong H et al.,
Objective: To describe the clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children
Key study: Report on the Epidemiological Features of Coronavirus Disease 2019 (COVID-19) Outbreak in the Republic of Korea from January 19 to March 2, 2020.
Korean Society of Infectious Diseases, Korean Society of Pediatric Infectious Diseases, Korean Society of Epidemiology, et al
Korean Society of Infectious Diseases, Korean Society of Pediatric Infectious...
Objective: This report summarizes the epidemiologic features and the snapshots of the outbreak in the Republic of Korea from January 19 and March 2, 2020.
Key study: Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single centers observational study.
Sun D, Li H, Lu X, et al.,
Sun D, Li H, Lu X, et al.,
Objective: To describe the clinical features of severe pediatric patients with COVID-19.
Key study: Clinical presentation and virological assessment of hospitalized cases of coronavirus disease 2019 in a travel-associated transmission cluster.
Woelfel R, Corman VM, Guggemos W, et al.,
Woelfel R, Corman VM, Guggemos W, et al.,
Objective: To study the viral load courses by RT-PCR in oro- and nasopharyngeal swabs, sputum, stool, blood, and urine in nine hospitalized cases. Infectious virus was detected by cell culture.
Key study: Acral cutaneous lesions in the time of COVID-19.
Recalcati S, Barbagallo T, Frasin LA, et al.
Recalcati S, Barbagallo T, Frasin LA, et al.
Objective: We report here on peculiar (perniosislike) skin lesions, unreported in the previous years, observed in young outpatients visited in our dermatologic unit in the last 4 weeks of COVID19 pandemic (MarchApril 2020).
Key study: Children with Covid-19 in pediatric emergency departments in Italy.
Parri N, Lenge M, Buonsenso D, Coronavirus Infection in Public Emergency Departments (CONFIDENCE) Research Group
Parri N, Lenge M, Buonsenso D, Coronavirus Infection in Public Emergency Depa...
Objective: The Coronavirus Infection in Pediatric Emergency Departments (CONFIDENCE) study involved a cohort of 100 Italian children younger than 18 years of age with Covid-19 confirmed by reverse-transcriptasepolymerase-chain-reaction testing of nasal or nasopharyngeal swabs who were assessed between March 3 and March 27 in 17 pediatric emergency departments. Here, we describe the results of the CONFIDENCE study and compare them with those from three cohorts in previously published analyses.
Key study: Chilblain-like lesions during COVID-19 epidemic: a preliminary study on 63 patients.
PiccoloV,NeriI, FilippeschiC, et al.
PiccoloV,NeriI, FilippeschiC, et al.
Objective: We have recently noticed an outbreak of chilblainlike lesions in Italy contemporarily to COVID19 epidemic. Due to the wellknown lockdownrelated difficulties to visit the patients, we created a Google form aimed to collect information about patients presenting with these singular clinical findings. An easy to access and quick tool was chosen by the investigators in order to permit the other colleagues to spend the least amount of time, given the severe health emergency.
Key study: The characteristics of household transmission of COVID-19.
Li W, Zhang B, Lu J, et al.
Li W, Zhang B, Lu J, et al.
Objective: Since December 2019, SARS-CoV-2 has extended to most parts of China with >80 000 cases and to at least 100 countries with >60 000 international cases as of 15 March 2020. Here we used a household cohort study to determine the features of household transmission of COVID-19.
Key study: Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases.
Casas CG, Catal A, Hernndez GC, et al.
Casas CG, Catal A, Hernndez GC, et al.
Objectives: To describe the cutaneous manifestations of COVID-19 disease and to relate them to other clinical findings.
Key study: Assessment of 135794 pediatric patients tested for severe scute respiratory syndrome coronavirus across the United States.
Bailey LC, Razzaghi H, Burrows EK, et al.
Bailey LC, Razzaghi H, Burrows EK, et al.
Objective: To describe testing for SARS-CoV-2 and the epidemiology of infected patients.
Key study: Baseline characteristics, management, and outcomes of 55,270 children and adolescents diagnosed with COVID-19 and 1,952,693 with influenza in France, Germany, Spain, South Korea and the United States: an international network cohort study.
Duarte-Salles T, Vizcaya D, Pistillo A, et al.
Duarte-Salles T, Vizcaya D, Pistillo A, et al.
Objectives To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children/adolescents diagnosed or hospitalized with COVID-19. Secondly, to describe health outcomes amongst children/adolescents diagnosed with previous seasonal influenza. Design International network cohort.
Key study: Cardiac abnormalities seen in pediatric patients during the SARS-CoV2 pandemic: an international experience.
Clark BC, Sanchez-de-Toledo J, Bautista-Rodriguez C, et al.
Clark BC, Sanchez-de-Toledo J, Bautista-Rodriguez C, et al.
Objective: To describe the cardiac manifestations found in an international cohort of 55 pediatric cases with multi-system inflammatory syndrome (MIS-C) during the SARS-CoV2 pandemic.
Key study: COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study.
Gtzinger F, Santiago-Garca B, Noguera-Julin A, et al.
Gtzinger F, Santiago-Garca B, Noguera-Julin A, et al.
Objective: This study aimed to capture key data on children and adolescents with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection across Europe to inform physicians and health-care service planning during the ongoing pandemic.
Key study: Severe acute respiratory syndrome coronavirus 2 clinical syndromes and predictors of disease severity in hospitalized children and youth.
Fernandes DM, Oliveira CR, Guerguis S, et al.
Fernandes DM, Oliveira CR, Guerguis S, et al.
Objective: To characterize the demographic and clinical features of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) syndromes and identify admission variables predictive of disease severity.
Key study: Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome.
Pereira MFB, Litvinov N, Farhat SCL, et al.
Pereira MFB, Litvinov N, Farhat SCL, et al.
Objectives: To assess the outcomes of pediatric patients with laboratory-confirmed coronavirus disease (COVID-19) with or without multisystem inflammatory syndrome in children (MIS-C).
Key study: A case series of pediatric croup with COVID-19.
Venn AMR, Schmidt JM, Mullan PC.
Venn AMR, Schmidt JM, Mullan PC.
Objective: We describe three previously healthy children, admitted from our emergency department (ED) to our free-standing children's hospital, as the first documented cases of croup as a manifestation of SARS-CoV-2 infection.
Key study: Anosmia and ageusia: not an uncommon presentation of COVID-19 infection in children and adolescents.
Mak PQ, Chung KS, Wong JS, Shek CC, Kwan MY.
Mak PQ, Chung KS, Wong JS, Shek CC, Kwan MY.
Objective: We report three cases of pediatric patients with COVID-19 infection who presented with anosmia and/or ageusia.
Summary: Emergency preparedness and response: multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19).
Centers for Disease Control and Prevention
Centers for Disease Control and Prevention
Objective: Providing 1) background information on several cases of a recently reported multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19); and 2) a case definition for this syndrome.
Key study: Characteristics and outcomes of children with Coronavirus disease 2019 (COVID-19) infection admitted to US and Canadian pediatric intensive care units.
Shekerdemian L, Mahmood N, Wolfe K, et al.
Shekerdemian L, Mahmood N, Wolfe K, et al.
Objective To provide an early description and characterization of COVID-19 infection in North American PICUs, focusing on mode of presentation, presence of comorbidities, severity of disease, therapeutic interventions, clinical trajectory, and early outcomes.
Summary: Coronavirus disease 2019 in children United States, February 12-April 2, 2020.
US Centers for Disease Control and Prevention
US Centers for Disease Control and Prevention
Objective: To describe COVID-19 in children and adolescents in the United States.
Key study: Pediatric critical care and COVID19.
Gonzlez-Dambrauskas S, Vsquez-Hoyos P, Camporesi A, et al.
Gonzlez-Dambrauskas S, Vsquez-Hoyos P, Camporesi A, et al.
Objective: We provide preliminary insights into our first 17 children from 10 PICUs in Chile, Colombia, Italy, Spain, and the United States.
Key study: Clinical characteristics of children with Coronavirus disease 2019 in Hubei, China.
Zheng F, Liao C, Fan Q, et al.
Zheng F, Liao C, Fan Q, et al.
Objective: The objective of this study is to describe the clinical characteristics of 25 hospitalized pediatric COVID-19.
Key study: Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding
Xu Y, Li X, Zhu B, et al.
Xu Y, Li X, Zhu B, et al.
Objective: We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA.
Key study: Pointofcare lung ultrasound findings in the pediatric emergency clinic during the COVID19 pandemic.
Tre E, Korkmaz MF, Aksoy FD, et al.
Tre E, Korkmaz MF, Aksoy FD, et al.
Objective: To describe our experience concerning lung ultrasound (LUS) in the pediatric emergency clinic, and to investigate the diagnostic value of LUS in coronavirus disease-2019 (COVID-19).
Key study: Asymptomatic cases in a family cluster with SARS-CoV-2 infection
Wu X, Li T, Ou X, et al
Wu X, Li T, Ou X, et al
Objective: To report the findings from different types of clinical specimens collected from 82 infected individuals
Key study: SARS-CoV-2 Infection in Children.
Lu X, Zhang L, Du H, et al
Lu X, Zhang L, Du H, et al
Objective: In order to determine the spectrum of disease in children, we evaluated children infected with SARS-CoV-2 and treated at the Wuhan Childrens Hospital, the only center assigned by the central government for treating infected children under 16 years of age in Wuhan.
Key study: A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features
Jiehao C, Jing X, Daojiong L, et al
Jiehao C, Jing X, Daojiong L, et al
Objective: To report the clinical and epidemiological features in children with coronavirus diseases (COVID) in China.
Key study: Clinical features of paediatric patients with COVID-19: a report of two family clusters.
Ji L, Chao S, Wang Y, et al.
Ji L, Chao S, Wang Y, et al.
Objective: To retrospectively review two confirmed pediatric cases from two family clusters. Both clinical features and laboratory examination results of the children and their family members were described.
Key study: Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China.
Dong Y, Mo X, Hu Y, et al.
Dong Y, Mo X, Hu Y, et al.
Objective: This study examined the epidemiological characteristics and transmission patterns of 2143 pediatric patients with COVID-19, using a retrospective analytical approach.
Key study: Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China
Wei M, Yuan J, Liu Y, et al.,
Wei M, Yuan J, Liu Y, et al.,
Objective: For this retrospective study, authors identified all hospitalized infants diagnosed with COVID-19 infection between December 8, 2019, and February 6, 2020, in China and described demographic, epidemiologic, and clinical features.
Key study: Clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children
Hong H et al.,
Hong H et al.,
Objective: To describe the clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children
Key study: Report on the Epidemiological Features of Coronavirus Disease 2019 (COVID-19) Outbreak in the Republic of Korea from January 19 to March 2, 2020.
Korean Society of Infectious Diseases, Korean Society of Pediatric Infectious Diseases, Korean Society of Epidemiology, et al
Korean Society of Infectious Diseases, Korean Society of Pediatric Infectious...
Objective: This report summarizes the epidemiologic features and the snapshots of the outbreak in the Republic of Korea from January 19 and March 2, 2020.
Key study: Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single centers observational study.
Sun D, Li H, Lu X, et al.,
Sun D, Li H, Lu X, et al.,
Objective: To describe the clinical features of severe pediatric patients with COVID-19.
Key study: Clinical presentation and virological assessment of hospitalized cases of coronavirus disease 2019 in a travel-associated transmission cluster.
Woelfel R, Corman VM, Guggemos W, et al.,
Woelfel R, Corman VM, Guggemos W, et al.,
Objective: To study the viral load courses by RT-PCR in oro- and nasopharyngeal swabs, sputum, stool, blood, and urine in nine hospitalized cases. Infectious virus was detected by cell culture.
Key study: Acral cutaneous lesions in the time of COVID-19.
Recalcati S, Barbagallo T, Frasin LA, et al.
Recalcati S, Barbagallo T, Frasin LA, et al.
Objective: We report here on peculiar (perniosislike) skin lesions, unreported in the previous years, observed in young outpatients visited in our dermatologic unit in the last 4 weeks of COVID19 pandemic (MarchApril 2020).
Key study: Children with Covid-19 in pediatric emergency departments in Italy.
Parri N, Lenge M, Buonsenso D, Coronavirus Infection in Public Emergency Departments (CONFIDENCE) Research Group
Parri N, Lenge M, Buonsenso D, Coronavirus Infection in Public Emergency Depa...
Objective: The Coronavirus Infection in Pediatric Emergency Departments (CONFIDENCE) study involved a cohort of 100 Italian children younger than 18 years of age with Covid-19 confirmed by reverse-transcriptasepolymerase-chain-reaction testing of nasal or nasopharyngeal swabs who were assessed between March 3 and March 27 in 17 pediatric emergency departments. Here, we describe the results of the CONFIDENCE study and compare them with those from three cohorts in previously published analyses.
Key study: Chilblain-like lesions during COVID-19 epidemic: a preliminary study on 63 patients.
PiccoloV,NeriI, FilippeschiC, et al.
PiccoloV,NeriI, FilippeschiC, et al.
Objective: We have recently noticed an outbreak of chilblainlike lesions in Italy contemporarily to COVID19 epidemic. Due to the wellknown lockdownrelated difficulties to visit the patients, we created a Google form aimed to collect information about patients presenting with these singular clinical findings. An easy to access and quick tool was chosen by the investigators in order to permit the other colleagues to spend the least amount of time, given the severe health emergency.
Key study: The characteristics of household transmission of COVID-19.
Li W, Zhang B, Lu J, et al.
Li W, Zhang B, Lu J, et al.
Objective: Since December 2019, SARS-CoV-2 has extended to most parts of China with >80 000 cases and to at least 100 countries with >60 000 international cases as of 15 March 2020. Here we used a household cohort study to determine the features of household transmission of COVID-19.
Key study: Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases.
Casas CG, Catal A, Hernndez GC, et al.
Casas CG, Catal A, Hernndez GC, et al.
Objectives: To describe the cutaneous manifestations of COVID-19 disease and to relate them to other clinical findings.
Key study: Assessment of 135794 pediatric patients tested for severe scute respiratory syndrome coronavirus across the United States.
Bailey LC, Razzaghi H, Burrows EK, et al.
Bailey LC, Razzaghi H, Burrows EK, et al.
Objective: To describe testing for SARS-CoV-2 and the epidemiology of infected patients.
Key study: Baseline characteristics, management, and outcomes of 55,270 children and adolescents diagnosed with COVID-19 and 1,952,693 with influenza in France, Germany, Spain, South Korea and the United States: an international network cohort study.
Duarte-Salles T, Vizcaya D, Pistillo A, et al.
Duarte-Salles T, Vizcaya D, Pistillo A, et al.
Objectives To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children/adolescents diagnosed or hospitalized with COVID-19. Secondly, to describe health outcomes amongst children/adolescents diagnosed with previous seasonal influenza. Design International network cohort.
Key study: Cardiac abnormalities seen in pediatric patients during the SARS-CoV2 pandemic: an international experience.
Clark BC, Sanchez-de-Toledo J, Bautista-Rodriguez C, et al.
Clark BC, Sanchez-de-Toledo J, Bautista-Rodriguez C, et al.
Objective: To describe the cardiac manifestations found in an international cohort of 55 pediatric cases with multi-system inflammatory syndrome (MIS-C) during the SARS-CoV2 pandemic.
Key study: COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study.
Gtzinger F, Santiago-Garca B, Noguera-Julin A, et al.
Gtzinger F, Santiago-Garca B, Noguera-Julin A, et al.
Objective: This study aimed to capture key data on children and adolescents with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection across Europe to inform physicians and health-care service planning during the ongoing pandemic.
Key study: Severe acute respiratory syndrome coronavirus 2 clinical syndromes and predictors of disease severity in hospitalized children and youth.
Fernandes DM, Oliveira CR, Guerguis S, et al.
Fernandes DM, Oliveira CR, Guerguis S, et al.
Objective: To characterize the demographic and clinical features of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) syndromes and identify admission variables predictive of disease severity.
Key study: Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome.
Pereira MFB, Litvinov N, Farhat SCL, et al.
Pereira MFB, Litvinov N, Farhat SCL, et al.
Objectives: To assess the outcomes of pediatric patients with laboratory-confirmed coronavirus disease (COVID-19) with or without multisystem inflammatory syndrome in children (MIS-C).
Key study: A case series of pediatric croup with COVID-19.
Venn AMR, Schmidt JM, Mullan PC.
Venn AMR, Schmidt JM, Mullan PC.
Objective: We describe three previously healthy children, admitted from our emergency department (ED) to our free-standing children's hospital, as the first documented cases of croup as a manifestation of SARS-CoV-2 infection.
Key study: Anosmia and ageusia: not an uncommon presentation of COVID-19 infection in children and adolescents.
Mak PQ, Chung KS, Wong JS, Shek CC, Kwan MY.
Mak PQ, Chung KS, Wong JS, Shek CC, Kwan MY.
Objective: We report three cases of pediatric patients with COVID-19 infection who presented with anosmia and/or ageusia.
Summary: Emergency preparedness and response: multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19).
Centers for Disease Control and Prevention
Centers for Disease Control and Prevention
Objective: Providing 1) background information on several cases of a recently reported multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19); and 2) a case definition for this syndrome.
Key study: Characteristics and outcomes of children with Coronavirus disease 2019 (COVID-19) infection admitted to US and Canadian pediatric intensive care units.
Shekerdemian L, Mahmood N, Wolfe K, et al.
Shekerdemian L, Mahmood N, Wolfe K, et al.
Objective To provide an early description and characterization of COVID-19 infection in North American PICUs, focusing on mode of presentation, presence of comorbidities, severity of disease, therapeutic interventions, clinical trajectory, and early outcomes.
Summary: Coronavirus disease 2019 in children United States, February 12-April 2, 2020.
US Centers for Disease Control and Prevention
US Centers for Disease Control and Prevention
Objective: To describe COVID-19 in children and adolescents in the United States.
Key study: Pediatric critical care and COVID19.
Gonzlez-Dambrauskas S, Vsquez-Hoyos P, Camporesi A, et al.
Gonzlez-Dambrauskas S, Vsquez-Hoyos P, Camporesi A, et al.
Objective: We provide preliminary insights into our first 17 children from 10 PICUs in Chile, Colombia, Italy, Spain, and the United States.
Key study: Clinical characteristics of children with Coronavirus disease 2019 in Hubei, China.
Zheng F, Liao C, Fan Q, et al.
Zheng F, Liao C, Fan Q, et al.
Objective: The objective of this study is to describe the clinical characteristics of 25 hospitalized pediatric COVID-19.
Key study: Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding
Xu Y, Li X, Zhu B, et al.
Xu Y, Li X, Zhu B, et al.
Objective: We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA.