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Key studies English (18) French All (18)

Key Study: Point-of-care C reactive protein to identify serious infection in acutely ill children presenting to hospital: prospective cohort study

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Verbakel JY, Lemiengre MB, De Burghgraeve T, De Sutter A, Aertgeerts B, Bulle...

This prospective study aimed to develop improved tools to assess children attending ambulatory hospital care, integrating clinical features with point-of-care C reactive protein (CRP).

Key Study: Clinical prediction models for young febrile infants at the emergency department: an international validation study

Visit

Vos-Kerkhof E, Gomez B, Milcent K, Steyerberg EW, Nijman RG, Smit FJ, Mintegi...

The objective of this study was to assess the diagnostic value of existing clinical prediction models in febrile young infants at risk for serious bacterial infections.

Key Study: Accuracy of Complete Blood Cell Counts to Identify Febrile Infants 60 Days or Younger With Invasive Bacterial Infections

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Cruz AT, Mahajan P, Bonsu BK, Bennett JE, Levine DA, Alpern ER, Nigrovic LE, ...

The objective of this study was to estimate the accuracy of individual complete blood cell count parameters to identify febrile infants with invasive bacterial infections.

Key Study: Clinical Pathway Effectiveness: Febrile Young Infant Clinical Pathway in a Pediatric Emergency Department

Visit

Murray AL, Alpern E, Lavelle J, Mollen C

The objective of this study was to evaluate the impact of a febrile young infant clinical pathway implemented in a large, urban children's hospital ED on the timeliness and consistency of care.

Key Study: The Yale Observation Scale Score and the Risk of Serious Bacterial Infections in Febrile Infants

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Nigrovic LE, Mahajan PV, Blumberg SM, Browne LR, Linakis JG, Ruddy RM, Bennet...

The objectives of this study were to assess the performance of the Yale Observation Scale score and unstructured clinician suspicion to identify febrile infants 60 days of age with and without serious bacterial infections.

Key Study: Lumbar Puncture for All Febrile Infants 29-56 Days Old: A Retrospective Cohort Reassessment Study

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Scarfone R, Murray A, Gala P, Balamuth F

The objectives of this study were to determine the incidence of bacterial meningitis among all febrile infants 29-56 days old undergoing a lumbar puncture in the emergency department of a tertiary care children's hospital and the number of low-risk febrile infants with bacterial meningitis to reassess the need for routine lumbar puncture in these infants.

Key Study: Prevalence of Concomitant Acute Bacterial Meningitis in Neonates with Febrile Urinary Tract Infection: A Retrospective Cross-Sectional Study

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Wallace SS, Brown DN, Cruz AT

The objective of this study was to describe the frequency of concomitant acute bacterial meningitis in neonates with febrile urinary tract infection.

Key Study: Initial Presentation of Neonatal Herpes Simplex Virus Infection

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Curfman AL, Glissmeyer EW, Ahmad FA, Korgenski EK, Blaschke AJ, Byington CL, ...

The objective of this study was to inform the decision to test and empirically treat for herpes simplex virus (HSV) by describing the initial clinical presentation and laboratory findings of infants with a confirmed diagnosis of neonatal HSV.

Key Study: Lack of Accuracy of Biomarkers and Physical Examination to Detect Bacterial Infection in Febrile Infants

Visit

Daz MG, Garca RP, Gamero DB, Gonzlez-Tom MI, Romero PC, Ferrer MM, Contreras JR

The aim of this study was to analyze the usefulness of physical examination, C-reactive protein, procalcitonin, white blood cell count, and absolute neutrophils counts for the diagnosis of invasive bacterial infections and potentially serious bacterial infections in infants younger than the age of 3 months presenting with fever without source to the emergency department.

Key Study: Validation of the "Step-by-Step" Approach in the Management of Young Febrile Infants

Visit

Gomez B, Mintegi S, Bressan S, Da Dalt L, Gervaix A, Lacroix L; European Grou...

The aim of this study was to prospectively validate a sequential approach to young febrile infants on the basis of clinical and laboratory parameters, and compare it with the Rochester criteria and the Lab-score.

Key Study: Use of Procalcitonin Assays to Predict Serious Bacterial Infection in Young Febrile Infants

Visit

Milcent K, Faesch S, Gras-Le Guen C, Dubos F, Poulalhon C, Badier I, Marc E, ...

The objective of this study was to assess the diagnostic characteristics of the procalcitonin assay for detecting serious bacterial infection and invasive bacterial infection in febrile infants aged 7 to 91 days.

Key Study: Value of white cell count in predicting serious bacterial infection in febrile children under 5 years of age

Visit

De S, Williams GJ, Hayen A, Macaskill P, McCaskill M, Isaacs D, Craig JC

The objective of this study was to evaluate the accuracy of leukocyte count for the detection of serious bacterial infections in febrile children.

Key Study: The changing epidemiology of serious bacterial infections in young infants

Visit

Greenhow TL, Hung YY, Herz AM, Losada E, Pantell RH

This study analyzed all cultures of blood, urine and cerebrospinal fluid obtained from full-term infants 1 week to 3 months of age, who presented during a 7-year period. Compared with earlier studies, urinary tract infections (UTIs) are now found significantly more often than bacteremia and meningitis with 92% of occult infections associated with UTIs. These data emphasize the importance of an urinalysis in febrile infants.

Key Study: Predicting severe bacterial infections in well-appearing febrile neonates: laboratory markers accuracy and duration of fever

Visit

Bressan S, Andreola B, Cattelan F, Zangardi T, Perilongo G, Da Dalt L

The objective of this study was to assess the diagnostic accuracy of white blood cell count, absolute neutrophil count, and C-reactive protein in detecting severe bacterial infections in well-appearing neonates with early onset fever without source and in relation to fever duration.

Key Study: Blood culture and bacteremia predictors in infants less than three months of age with fever without source

Visit

Gmez B, Mintegi S, Benito J, Egireun A, Garcia D, Astobiza E

The objectives of this study were (1) to assess the rate of bacteremia in febrile infants less than 3 months of age admitted to a pediatric emergency department at a tertiary hospital; (2) to describe the bacteria isolated; and (3) to analyze factors related to increased probability of having a positive blood culture.

Key Study: C-reactive protein as a marker of serious bacterial infections in hospitalized febrile infants

Visit

Bilavsky E, Yarden-Bilavsky H, Ashkenazi S, Amir J

The objective of this study was to determine the potential predictive power of C-reactive protein as a marker of serious bacterial infection in hospitalized febrile infants aged < or =3 months.

Key Study: Clinical and laboratory features of neonatal herpes simplex virus infection: a case-control study

Visit

Caviness AC, Demmler GJ, Selwyn BJ

The objective of this study was to determine the unique clinical and laboratory features of neonates with and without herpes simplex virus infection admitted to Texas Children's Hospital during a 14-year period.

Key Study: The effects of bundling on infant temperature

Visit

Grover G, Berkowitz CD, Lewis RJ, Thompson M, Berry L, Seidel J

The objective of this study was to determine whether bundling elevates rectal and/or skin temperature of young infants.

Key Study: Point-of-care C reactive protein to identify serious infection in acutely ill children presenting to hospital: prospective cohort study

Visit

Verbakel JY, Lemiengre MB, De Burghgraeve T, De Sutter A, Aertgeerts B, Bulle...

This prospective study aimed to develop improved tools to assess children attending ambulatory hospital care, integrating clinical features with point-of-care C reactive protein (CRP).

Key Study: Clinical prediction models for young febrile infants at the emergency department: an international validation study

Visit

Vos-Kerkhof E, Gomez B, Milcent K, Steyerberg EW, Nijman RG, Smit FJ, Mintegi...

The objective of this study was to assess the diagnostic value of existing clinical prediction models in febrile young infants at risk for serious bacterial infections.

Key Study: Accuracy of Complete Blood Cell Counts to Identify Febrile Infants 60 Days or Younger With Invasive Bacterial Infections

Visit

Cruz AT, Mahajan P, Bonsu BK, Bennett JE, Levine DA, Alpern ER, Nigrovic LE, ...

The objective of this study was to estimate the accuracy of individual complete blood cell count parameters to identify febrile infants with invasive bacterial infections.

Key Study: Clinical Pathway Effectiveness: Febrile Young Infant Clinical Pathway in a Pediatric Emergency Department

Visit

Murray AL, Alpern E, Lavelle J, Mollen C

The objective of this study was to evaluate the impact of a febrile young infant clinical pathway implemented in a large, urban children's hospital ED on the timeliness and consistency of care.

Key Study: The Yale Observation Scale Score and the Risk of Serious Bacterial Infections in Febrile Infants

Visit

Nigrovic LE, Mahajan PV, Blumberg SM, Browne LR, Linakis JG, Ruddy RM, Bennet...

The objectives of this study were to assess the performance of the Yale Observation Scale score and unstructured clinician suspicion to identify febrile infants 60 days of age with and without serious bacterial infections.

Key Study: Lumbar Puncture for All Febrile Infants 29-56 Days Old: A Retrospective Cohort Reassessment Study

Visit

Scarfone R, Murray A, Gala P, Balamuth F

The objectives of this study were to determine the incidence of bacterial meningitis among all febrile infants 29-56 days old undergoing a lumbar puncture in the emergency department of a tertiary care children's hospital and the number of low-risk febrile infants with bacterial meningitis to reassess the need for routine lumbar puncture in these infants.

Key Study: Prevalence of Concomitant Acute Bacterial Meningitis in Neonates with Febrile Urinary Tract Infection: A Retrospective Cross-Sectional Study

Visit

Wallace SS, Brown DN, Cruz AT

The objective of this study was to describe the frequency of concomitant acute bacterial meningitis in neonates with febrile urinary tract infection.

Key Study: Initial Presentation of Neonatal Herpes Simplex Virus Infection

Visit

Curfman AL, Glissmeyer EW, Ahmad FA, Korgenski EK, Blaschke AJ, Byington CL, ...

The objective of this study was to inform the decision to test and empirically treat for herpes simplex virus (HSV) by describing the initial clinical presentation and laboratory findings of infants with a confirmed diagnosis of neonatal HSV.

Key Study: Lack of Accuracy of Biomarkers and Physical Examination to Detect Bacterial Infection in Febrile Infants

Visit

Daz MG, Garca RP, Gamero DB, Gonzlez-Tom MI, Romero PC, Ferrer MM, Contreras JR

The aim of this study was to analyze the usefulness of physical examination, C-reactive protein, procalcitonin, white blood cell count, and absolute neutrophils counts for the diagnosis of invasive bacterial infections and potentially serious bacterial infections in infants younger than the age of 3 months presenting with fever without source to the emergency department.

Key Study: Validation of the "Step-by-Step" Approach in the Management of Young Febrile Infants

Visit

Gomez B, Mintegi S, Bressan S, Da Dalt L, Gervaix A, Lacroix L; European Grou...

The aim of this study was to prospectively validate a sequential approach to young febrile infants on the basis of clinical and laboratory parameters, and compare it with the Rochester criteria and the Lab-score.

Key Study: Use of Procalcitonin Assays to Predict Serious Bacterial Infection in Young Febrile Infants

Visit

Milcent K, Faesch S, Gras-Le Guen C, Dubos F, Poulalhon C, Badier I, Marc E, ...

The objective of this study was to assess the diagnostic characteristics of the procalcitonin assay for detecting serious bacterial infection and invasive bacterial infection in febrile infants aged 7 to 91 days.

Key Study: Value of white cell count in predicting serious bacterial infection in febrile children under 5 years of age

Visit

De S, Williams GJ, Hayen A, Macaskill P, McCaskill M, Isaacs D, Craig JC

The objective of this study was to evaluate the accuracy of leukocyte count for the detection of serious bacterial infections in febrile children.

Key Study: The changing epidemiology of serious bacterial infections in young infants

Visit

Greenhow TL, Hung YY, Herz AM, Losada E, Pantell RH

This study analyzed all cultures of blood, urine and cerebrospinal fluid obtained from full-term infants 1 week to 3 months of age, who presented during a 7-year period. Compared with earlier studies, urinary tract infections (UTIs) are now found significantly more often than bacteremia and meningitis with 92% of occult infections associated with UTIs. These data emphasize the importance of an urinalysis in febrile infants.

Key Study: Predicting severe bacterial infections in well-appearing febrile neonates: laboratory markers accuracy and duration of fever

Visit

Bressan S, Andreola B, Cattelan F, Zangardi T, Perilongo G, Da Dalt L

The objective of this study was to assess the diagnostic accuracy of white blood cell count, absolute neutrophil count, and C-reactive protein in detecting severe bacterial infections in well-appearing neonates with early onset fever without source and in relation to fever duration.

Key Study: Blood culture and bacteremia predictors in infants less than three months of age with fever without source

Visit

Gmez B, Mintegi S, Benito J, Egireun A, Garcia D, Astobiza E

The objectives of this study were (1) to assess the rate of bacteremia in febrile infants less than 3 months of age admitted to a pediatric emergency department at a tertiary hospital; (2) to describe the bacteria isolated; and (3) to analyze factors related to increased probability of having a positive blood culture.

Key Study: C-reactive protein as a marker of serious bacterial infections in hospitalized febrile infants

Visit

Bilavsky E, Yarden-Bilavsky H, Ashkenazi S, Amir J

The objective of this study was to determine the potential predictive power of C-reactive protein as a marker of serious bacterial infection in hospitalized febrile infants aged < or =3 months.

Key Study: Clinical and laboratory features of neonatal herpes simplex virus infection: a case-control study

Visit

Caviness AC, Demmler GJ, Selwyn BJ

The objective of this study was to determine the unique clinical and laboratory features of neonates with and without herpes simplex virus infection admitted to Texas Children's Hospital during a 14-year period.

Key Study: The effects of bundling on infant temperature

Visit

Grover G, Berkowitz CD, Lewis RJ, Thompson M, Berry L, Seidel J

The objective of this study was to determine whether bundling elevates rectal and/or skin temperature of young infants.