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Acute Otitis Media English (10) French All (10)

Key Study: Invasive bacterial Infections in afebrile infants diagnosed with acute otitis media

Visit

Son H McLaren 1, Andrea T Cruz 2, Kenneth Yen, et al. Pediatrics

Objective: to determine the prevalence of invasive bacterial infections (IBIs) and adverse events in afebrile infants with acute otitis media (AOM).

Key study: Acute otitis media in children presenting to the emergency department: Is it diagnosed and managed appropriately?

Visit

Niroshan Balasundaram, Dung Phan, Daniel Mazzoni, Elliot Duong, Amy Sweeny, C...

Objective: To describe the diagnostic and management practice in children with acute otitis media (AOM) presenting to the emergency department (ED) and compare diagnosis and management against existing guidelines.

Key study: Diagnostic Accuracy, Prescription Behavior, and Watchful Waiting Efficacy for Pediatric Acute Otitis Media

Visit

Brinker DL Jr, MacGeorge EL, Hackman N

Objective: To assess the implications and recommendations to improve antibiotic stewardship through watchful waiting as an alternative to immediate antibiotic treatment in children with AOM.

Key Study: Anaesthetic-analgesic ear drops to reduce antibiotic consumption in children with acute otitis media: the CEDAR RCT

Download

Hay, A.D. et al.

Objective: The Childrens Ear Pain Study (CEDAR) investigated whether or not providing anaestheticanalgesic ear drops reduced antibiotic consumption in children with AOM. Secondary objectives included pain control and cost-effectiveness.

Key study: Optimising pain management in children with acute otitis media through a primary care-based multifaceted educational intervention: study protocol for a cluster randomised controlled trial

Visit

van Uum RT, Venekamp RP, Sjoukes A, van de Pol AC, de Wit GA, Schilder AGM, D...

Objective: We have developed a primary care-based multifaceted educational intervention to optimise pain management in children with AOM, and we trial its clinical and cost effectiveness.

Key study: Shortened Antimicrobial Treatment for Acute Otitis Media in Young Children

Visit

Hoberman A, Paradise JL, Rockette HE, Kearney DH, Bhatnagar S, Shope TR, Mart...

Objective: Given methodologic limitations in available publications, we undertook the current trial involving children 6 to 23 months of age to determine whether limiting antimicrobial treatment to 5 days rather than using the standard 10-day regimen would afford equivalent outcomes and whether doing so also for subsequent episodes would lead to a reduction in the overall use of antimicrobial treatment, with a resulting reduction in the development of antimicrobial resistance.

Key study: Use of symptoms and risk factors to predict acute otitis media in infants

Visit

McCormick DP, Jennings K, Ede LC, Alvarez-Fernandez P, Patel J, Chonmaitree T

Objective: The purpose of this study was to evaluate the usefulness of symptoms and other risk factors in predicting the presence of AOM in infants.

Key study: Symptomatic and asymptomatic respiratory viral infections in the first year of life: association with acute otitis media development

Visit

Chonmaitree T, Alvarez-Fernandez P, Jennings K, Trujillo R, Marom T, Loeffelh...

Objective: This study determined the epidemiologic characteristics and etiology of asymptomatic upper respiratory tract infection in the first year of life and the association with acute otitis media complication.

Key study: Treatment of acute otitis media in children under 2 years of age

Visit

Hoberman A, Paradise JL, Rockette HE, Shaikh N, Wald ER, Kearney DH, Colborn ...

Objective: We undertook this clinical trial to determine the extent to which antimicrobial treatment affects the course of both symptoms and signs of acute otitis media, irrespective of the apparent severity of the disease, among children 6 to 23 months of age in whom the diagnosis of acute otitis media is quite certain.

Key study: A placebo-controlled trial of antimicrobial treatment for acute otitis media

Visit

Thtinen PA, Laine MK, Huovinen P, Jalava J, Ruuskanen O, Ruohola A

Objective: We conducted a randomized, double-blind, placebo-controlled study of the efficacy of antimicrobial therapy in the age group with the highest incidence of acute otitis media. Our aim was to assess the efficacy of antimicrobial treatment for acute otitis media when strict diagnostic criteria are used and the antimicrobial coverage and dosage of the active treatment are adequate.

Key Study: Invasive bacterial Infections in afebrile infants diagnosed with acute otitis media

Visit

Son H McLaren 1, Andrea T Cruz 2, Kenneth Yen, et al. Pediatrics

Objective: to determine the prevalence of invasive bacterial infections (IBIs) and adverse events in afebrile infants with acute otitis media (AOM).

Key study: Acute otitis media in children presenting to the emergency department: Is it diagnosed and managed appropriately?

Visit

Niroshan Balasundaram, Dung Phan, Daniel Mazzoni, Elliot Duong, Amy Sweeny, C...

Objective: To describe the diagnostic and management practice in children with acute otitis media (AOM) presenting to the emergency department (ED) and compare diagnosis and management against existing guidelines.

Key study: Diagnostic Accuracy, Prescription Behavior, and Watchful Waiting Efficacy for Pediatric Acute Otitis Media

Visit

Brinker DL Jr, MacGeorge EL, Hackman N

Objective: To assess the implications and recommendations to improve antibiotic stewardship through watchful waiting as an alternative to immediate antibiotic treatment in children with AOM.

Key Study: Anaesthetic-analgesic ear drops to reduce antibiotic consumption in children with acute otitis media: the CEDAR RCT

Download

Hay, A.D. et al.

Objective: The Childrens Ear Pain Study (CEDAR) investigated whether or not providing anaestheticanalgesic ear drops reduced antibiotic consumption in children with AOM. Secondary objectives included pain control and cost-effectiveness.

Key study: Optimising pain management in children with acute otitis media through a primary care-based multifaceted educational intervention: study protocol for a cluster randomised controlled trial

Visit

van Uum RT, Venekamp RP, Sjoukes A, van de Pol AC, de Wit GA, Schilder AGM, D...

Objective: We have developed a primary care-based multifaceted educational intervention to optimise pain management in children with AOM, and we trial its clinical and cost effectiveness.

Key study: Shortened Antimicrobial Treatment for Acute Otitis Media in Young Children

Visit

Hoberman A, Paradise JL, Rockette HE, Kearney DH, Bhatnagar S, Shope TR, Mart...

Objective: Given methodologic limitations in available publications, we undertook the current trial involving children 6 to 23 months of age to determine whether limiting antimicrobial treatment to 5 days rather than using the standard 10-day regimen would afford equivalent outcomes and whether doing so also for subsequent episodes would lead to a reduction in the overall use of antimicrobial treatment, with a resulting reduction in the development of antimicrobial resistance.

Key study: Use of symptoms and risk factors to predict acute otitis media in infants

Visit

McCormick DP, Jennings K, Ede LC, Alvarez-Fernandez P, Patel J, Chonmaitree T

Objective: The purpose of this study was to evaluate the usefulness of symptoms and other risk factors in predicting the presence of AOM in infants.

Key study: Symptomatic and asymptomatic respiratory viral infections in the first year of life: association with acute otitis media development

Visit

Chonmaitree T, Alvarez-Fernandez P, Jennings K, Trujillo R, Marom T, Loeffelh...

Objective: This study determined the epidemiologic characteristics and etiology of asymptomatic upper respiratory tract infection in the first year of life and the association with acute otitis media complication.

Key study: Treatment of acute otitis media in children under 2 years of age

Visit

Hoberman A, Paradise JL, Rockette HE, Shaikh N, Wald ER, Kearney DH, Colborn ...

Objective: We undertook this clinical trial to determine the extent to which antimicrobial treatment affects the course of both symptoms and signs of acute otitis media, irrespective of the apparent severity of the disease, among children 6 to 23 months of age in whom the diagnosis of acute otitis media is quite certain.

Key study: A placebo-controlled trial of antimicrobial treatment for acute otitis media

Visit

Thtinen PA, Laine MK, Huovinen P, Jalava J, Ruuskanen O, Ruohola A

Objective: We conducted a randomized, double-blind, placebo-controlled study of the efficacy of antimicrobial therapy in the age group with the highest incidence of acute otitis media. Our aim was to assess the efficacy of antimicrobial treatment for acute otitis media when strict diagnostic criteria are used and the antimicrobial coverage and dosage of the active treatment are adequate.

Anaphylaxis English (11) French All (11)

Key Study: Biphasic Reactions in Emergency Department Anaphylaxis Patients: A Prospective Cohort Study

Visit

Liu X, Lee S, Lohse CM, Hardy CT, Campbell RL.

To evaluate biphasic reaction rates and associated risk factors.

Key Study: Simulation of Health and Economic Benefits of Extended Observation of Resolved Anaphylaxis

Visit

Shaker M, Wallace D, Golden DBK, Oppenheimer J, Greenhawt M

What is the cost-effectiveness of 1 hour vs 6 to 24 hours of medical observation for biphasic anaphylaxis?

Key Study: An economic evaluation of immediate vs non-immediate activation of emergency medical services after epinephrine use for peanut-induced anaphylaxis

Visit

Shaker M, Kanaoka T, Feenan L, Greenhawt M.

To evaluate the cost-effectiveness of this strategy, vs a watchful waiting approach before activating emergency medical services (EMS).

Key Study: Epinephrine Use for Anaphylaxis - A Multi-Incident Analysis

Visit

Institute for Safe Medication Practices Canada

This multi-incident analysis was conducted to identify factors contributing to errors when epinephrine was used for the treatment of anaphylaxis and to suggest strategies to prevent or minimize potential harm when epinephrine is used for this indication.

Key Study: The Risk of Recurrent Anaphylaxis

Visit

O'Keefe A, Clarke A, St Pierre Y, Mill J, Asai Y, Eisman H, La Vieille S, Ali...

factors contributing to errors when epinephrine was

Key Study: Lacerations and Embedded Needles Caused by Epinephrine Autoinjector Use in Children

Visit

Brown JC, Tuuri RE, Akhter S, Guerra LD, Goodman IS, Myers SR, Nozicka C, Man...

used for the treatment of anaphylaxis and to suggest

Key Study: Embedded Needles Caused by Epinephrine Autoinjector Use in Children

Visit

Dreborg S, Wen X, Kim L, Tsai G, Nevis I, Potts R, Chiu J, Dominic A, Kim H

strategies to prevent or minimize potential harm

Key Study: Increasing visits for anaphylaxis and the benefits of early epinephrine administration: A 4-year study at a pediatric emergency department in Montreal, Canada

Visit

Hochstadter E, Clarke A, De Schryver S, LaVieille S, Alizadehfar R, Joseph L,...

when epinephrine is used for this indication.

Key Study: Epidemiology and clinical predictors of biphasic reactions in children with anaphylaxis

Visit

Alqurashi W, Stiell I, Chan K, Neto G, Alsadoon A, Wells G

The objective of this study was to investigate the incidence and clinical predictors of biphasic reactions in children presenting to the emergency department (ED) with anaphylaxis.

Key Study: Early treatment of food-induced anaphylaxis with epinephrine is associated with a lower risk of hospitalization

Visit

Fleming JT, Clark S, Camargo CA Jr, Rudders SA

The objective of this study was to identify factors associated with early epinephrine treatment for FIA and to specifically examine the association between early epinephrine treatment and hospitalization.

Key Study: Patients' ability to treat anaphylaxis using adrenaline autoinjectors: a randomized controlled trial

Visit

Umasunthar T, Procktor A, Hodes M, Smith JG, Gore C, Cox HE, Marrs T, Hanna H...

Previous work has shown patients commonly misuse adrenaline autoinjectors (AAI). It is unclear whether this is due to inadequate training, or poor device design. We undertook a prospective randomized controlled trial to evaluate ability to administer adrenaline using different AAI devices.

Key Study: Biphasic Reactions in Emergency Department Anaphylaxis Patients: A Prospective Cohort Study

Visit

Liu X, Lee S, Lohse CM, Hardy CT, Campbell RL.

To evaluate biphasic reaction rates and associated risk factors.

Key Study: Simulation of Health and Economic Benefits of Extended Observation of Resolved Anaphylaxis

Visit

Shaker M, Wallace D, Golden DBK, Oppenheimer J, Greenhawt M

What is the cost-effectiveness of 1 hour vs 6 to 24 hours of medical observation for biphasic anaphylaxis?

Key Study: An economic evaluation of immediate vs non-immediate activation of emergency medical services after epinephrine use for peanut-induced anaphylaxis

Visit

Shaker M, Kanaoka T, Feenan L, Greenhawt M.

To evaluate the cost-effectiveness of this strategy, vs a watchful waiting approach before activating emergency medical services (EMS).

Key Study: Epinephrine Use for Anaphylaxis - A Multi-Incident Analysis

Visit

Institute for Safe Medication Practices Canada

This multi-incident analysis was conducted to identify factors contributing to errors when epinephrine was used for the treatment of anaphylaxis and to suggest strategies to prevent or minimize potential harm when epinephrine is used for this indication.

Key Study: The Risk of Recurrent Anaphylaxis

Visit

O'Keefe A, Clarke A, St Pierre Y, Mill J, Asai Y, Eisman H, La Vieille S, Ali...

factors contributing to errors when epinephrine was

Key Study: Lacerations and Embedded Needles Caused by Epinephrine Autoinjector Use in Children

Visit

Brown JC, Tuuri RE, Akhter S, Guerra LD, Goodman IS, Myers SR, Nozicka C, Man...

used for the treatment of anaphylaxis and to suggest

Key Study: Embedded Needles Caused by Epinephrine Autoinjector Use in Children

Visit

Dreborg S, Wen X, Kim L, Tsai G, Nevis I, Potts R, Chiu J, Dominic A, Kim H

strategies to prevent or minimize potential harm

Key Study: Increasing visits for anaphylaxis and the benefits of early epinephrine administration: A 4-year study at a pediatric emergency department in Montreal, Canada

Visit

Hochstadter E, Clarke A, De Schryver S, LaVieille S, Alizadehfar R, Joseph L,...

when epinephrine is used for this indication.

Key Study: Epidemiology and clinical predictors of biphasic reactions in children with anaphylaxis

Visit

Alqurashi W, Stiell I, Chan K, Neto G, Alsadoon A, Wells G

The objective of this study was to investigate the incidence and clinical predictors of biphasic reactions in children presenting to the emergency department (ED) with anaphylaxis.

Key Study: Early treatment of food-induced anaphylaxis with epinephrine is associated with a lower risk of hospitalization

Visit

Fleming JT, Clark S, Camargo CA Jr, Rudders SA

The objective of this study was to identify factors associated with early epinephrine treatment for FIA and to specifically examine the association between early epinephrine treatment and hospitalization.

Key Study: Patients' ability to treat anaphylaxis using adrenaline autoinjectors: a randomized controlled trial

Visit

Umasunthar T, Procktor A, Hodes M, Smith JG, Gore C, Cox HE, Marrs T, Hanna H...

Previous work has shown patients commonly misuse adrenaline autoinjectors (AAI). It is unclear whether this is due to inadequate training, or poor device design. We undertook a prospective randomized controlled trial to evaluate ability to administer adrenaline using different AAI devices.

Asthma English (2) French All (2)

Key Study: The Pediatric Respiratory Assessment Measure: a valid clinical score for assessing acute asthma severity from toddlers to teenagers (2008)

Visit

Ducharme, FM, Chalut, D, Plotnick, L, Savdie, C, Kudirka, D, Zhang, X, Meng, ...

To determine the performance characteristics of the Preschool Respiratory Assessment Measure (PRAM) in preschool and school-aged children with acute asthma.

Key Study: The Preschool Respiratory Assessment Measure (PRAM): a responsive index of acute asthma severity (2000)

Visit

Chalut DS, Ducharme FM, Davis GM

To elaborate and validate a Preschool Respiratory Assessment Measure (PRAM) that would accurately reflect the severity of airway obstruction and the response to treatment in young patients with asthma.

Key Study: The Pediatric Respiratory Assessment Measure: a valid clinical score for assessing acute asthma severity from toddlers to teenagers (2008)

Visit

Ducharme, FM, Chalut, D, Plotnick, L, Savdie, C, Kudirka, D, Zhang, X, Meng, ...

To determine the performance characteristics of the Preschool Respiratory Assessment Measure (PRAM) in preschool and school-aged children with acute asthma.

Key Study: The Preschool Respiratory Assessment Measure (PRAM): a responsive index of acute asthma severity (2000)

Visit

Chalut DS, Ducharme FM, Davis GM

To elaborate and validate a Preschool Respiratory Assessment Measure (PRAM) that would accurately reflect the severity of airway obstruction and the response to treatment in young patients with asthma.

Bacterial Meningitis English (11) French All (11)

Key study: Cranial CT, Lumbar Puncture, and Clinical Deterioration in Bacterial Meningitis: A Nationwide Cohort Study

Visit

Costerus JM, Brouwer MC, Sprengers MES, Roosendaal SD, van der Ende A, van de...

Objective: In 2006, we started a prospective cohort study to identify and characterize host genetic traits and bacterial genetic factors controlling occurrence and outcome of bacterial meningitis (MeninGene). Here, we report data from this study, focusing on complications of LP in adults with community-acquired bacterial meningitis and the role of cranial CT prior to LP.

Key study: Lumbar Puncture Performed Promptly or After Neuroimaging in Acute Bacterial Meningitis in Adults: A Prospective National Cohort Study Evaluating Different Guidelines

Visit

Glimker M, Sjlin J, kesson S, Naucler P

Objective: The aim was to evaluate the effect on outcome of adherence to European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), and Swedish guidelines regarding neuroimaging before LP.

Key study: Cranial Imaging Before Lumbar Puncture in Adults With Community-Acquired Meningitis: Clinical Utility and Adherence to the Infectious Diseases Society of America Guidelines

Visit

Salazar L, Hasbun R

Objective: The main objectives of this study were to identify the adherence of clinicians to IDSA guidelines regarding cranial imaging in patients with CAM, to evaluate the clinical and prognostic differences between those patients with and without an indication for cranial imaging, and to assess the clinical impact in management in those with abnormal intracranial findings with or without altered mental status as their sole indication for imaging.

Key study: Adult bacterial meningitis: earlier treatment and improved outcome following guideline revision promoting prompt lumbar puncture

Visit

Glimker M, Johansson B, Grindborg , Bottai M, Lindquist L, Sjlin J

Objective: Despite guideline emphasis on early treatment, performing CT prior to LP implies a risk of delayed treatment and unfavorable outcome. Therefore, Swedish guidelines were revised in 2009, deleting impaired mental status as a contraindication for LP without prior CT scan. The aim of the present study was to evaluate the guideline revision.

Key study: Prevalence and predictors of bacterial meningitis in young infants with Fever without a source

Visit

Martinez E, Mintegi S, Vilar B, Martinez MJ, Lopez A, Catediano E, Gomez B

Objective: Our objectives were to analyze the prevalence and microbiology of bacterial meningitis in this group and its prevalence in relation to clinical and laboratory risk factors.

Key study: Outcomes of invasive meningococcal disease in adults and children in Canada between 2002 and 2011: a prospective cohort study

Visit

Sadarangani M, Scheifele DW, Halperin SA, Vaudry W, Le Saux N, Tsang R, Betti...

Objective: The objectives of this study were to describe the outcomes following invasive meningococcal disease (IMD) in a prospective cohort of children and adults, and to identify specific risk factors for death and development of neurological and nonneurological complications.

Key study: Distinguishing between bacterial and aseptic meningitis in children: European comparison of two clinical decision rules

Visit

Dubos F, Korczowski B, Aygun DA, Martinot A, Prat C, Galetto-Lacour A, Casado...

Objective: To compare the performance of two of these CDRs for children: the Bacterial Meningitis Score (BMS) and the Meningitest.

Key study: Clinical prediction rule for identifying children with cerebrospinal fluid pleocytosis at very low risk of bacterial meningitis

Visit

Nigrovic LE, Kuppermann N, Macias CG, Cannavino CR, Moro-Sutherland DM, Schem...

Objective: To validate the Bacterial Meningitis Score in the era of widespread pneumococcal conjugate vaccination.

Key study: Lumbar puncture in pediatric bacterial meningitis: defining the time interval for recovery of cerebrospinal fluid pathogens after parenteral antibiotic pretreatment

Visit

Kanegaye JT, Soliemanzadeh P, Bradley JS

Objective: We conducted a retrospective review of children with bacterial meningitis to describe the rate at which parenteral antibiotic pretreatment sterilizes CSF cultures.

Key study: Cerebrospinal fluid findings in aseptic versus bacterial meningitis

Visit

Negrini B, Kelleher KJ, Wald ER

Objective: To assess 1) the characteristics of the CSF differential in aseptic versus bacterial meningitis, 2) the influence of duration of illness on the CSF differential, and 3) the role of the CSF differential in discriminating between aseptic versus bacterial meningitis.

Key study: A comparison of ceftriaxone and cefuroxime for the treatment of bacterial meningitis in children

Visit

Schaad UB, Suter S, Gianella-Borradori A, Pfenninger J, Auckenthaler R, Berna...

Objective: To compare ceftriaxone with cefuroxime for the treatment of meningitis, we conducted a study in which 106 children with acute bacterial meningitis were randomly assigned to receive either ceftriaxone (100 mg per kilogram of body weight per day, administered intravenously once daily; n = 53) or cefuroxime (240 mg per kilogram per day, administered intravenously in four equal doses; n = 53).

Key study: Cranial CT, Lumbar Puncture, and Clinical Deterioration in Bacterial Meningitis: A Nationwide Cohort Study

Visit

Costerus JM, Brouwer MC, Sprengers MES, Roosendaal SD, van der Ende A, van de...

Objective: In 2006, we started a prospective cohort study to identify and characterize host genetic traits and bacterial genetic factors controlling occurrence and outcome of bacterial meningitis (MeninGene). Here, we report data from this study, focusing on complications of LP in adults with community-acquired bacterial meningitis and the role of cranial CT prior to LP.

Key study: Lumbar Puncture Performed Promptly or After Neuroimaging in Acute Bacterial Meningitis in Adults: A Prospective National Cohort Study Evaluating Different Guidelines

Visit

Glimker M, Sjlin J, kesson S, Naucler P

Objective: The aim was to evaluate the effect on outcome of adherence to European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), and Swedish guidelines regarding neuroimaging before LP.

Key study: Cranial Imaging Before Lumbar Puncture in Adults With Community-Acquired Meningitis: Clinical Utility and Adherence to the Infectious Diseases Society of America Guidelines

Visit

Salazar L, Hasbun R

Objective: The main objectives of this study were to identify the adherence of clinicians to IDSA guidelines regarding cranial imaging in patients with CAM, to evaluate the clinical and prognostic differences between those patients with and without an indication for cranial imaging, and to assess the clinical impact in management in those with abnormal intracranial findings with or without altered mental status as their sole indication for imaging.

Key study: Adult bacterial meningitis: earlier treatment and improved outcome following guideline revision promoting prompt lumbar puncture

Visit

Glimker M, Johansson B, Grindborg , Bottai M, Lindquist L, Sjlin J

Objective: Despite guideline emphasis on early treatment, performing CT prior to LP implies a risk of delayed treatment and unfavorable outcome. Therefore, Swedish guidelines were revised in 2009, deleting impaired mental status as a contraindication for LP without prior CT scan. The aim of the present study was to evaluate the guideline revision.

Key study: Prevalence and predictors of bacterial meningitis in young infants with Fever without a source

Visit

Martinez E, Mintegi S, Vilar B, Martinez MJ, Lopez A, Catediano E, Gomez B

Objective: Our objectives were to analyze the prevalence and microbiology of bacterial meningitis in this group and its prevalence in relation to clinical and laboratory risk factors.

Key study: Outcomes of invasive meningococcal disease in adults and children in Canada between 2002 and 2011: a prospective cohort study

Visit

Sadarangani M, Scheifele DW, Halperin SA, Vaudry W, Le Saux N, Tsang R, Betti...

Objective: The objectives of this study were to describe the outcomes following invasive meningococcal disease (IMD) in a prospective cohort of children and adults, and to identify specific risk factors for death and development of neurological and nonneurological complications.

Key study: Distinguishing between bacterial and aseptic meningitis in children: European comparison of two clinical decision rules

Visit

Dubos F, Korczowski B, Aygun DA, Martinot A, Prat C, Galetto-Lacour A, Casado...

Objective: To compare the performance of two of these CDRs for children: the Bacterial Meningitis Score (BMS) and the Meningitest.

Key study: Clinical prediction rule for identifying children with cerebrospinal fluid pleocytosis at very low risk of bacterial meningitis

Visit

Nigrovic LE, Kuppermann N, Macias CG, Cannavino CR, Moro-Sutherland DM, Schem...

Objective: To validate the Bacterial Meningitis Score in the era of widespread pneumococcal conjugate vaccination.

Key study: Lumbar puncture in pediatric bacterial meningitis: defining the time interval for recovery of cerebrospinal fluid pathogens after parenteral antibiotic pretreatment

Visit

Kanegaye JT, Soliemanzadeh P, Bradley JS

Objective: We conducted a retrospective review of children with bacterial meningitis to describe the rate at which parenteral antibiotic pretreatment sterilizes CSF cultures.

Key study: Cerebrospinal fluid findings in aseptic versus bacterial meningitis

Visit

Negrini B, Kelleher KJ, Wald ER

Objective: To assess 1) the characteristics of the CSF differential in aseptic versus bacterial meningitis, 2) the influence of duration of illness on the CSF differential, and 3) the role of the CSF differential in discriminating between aseptic versus bacterial meningitis.

Key study: A comparison of ceftriaxone and cefuroxime for the treatment of bacterial meningitis in children

Visit

Schaad UB, Suter S, Gianella-Borradori A, Pfenninger J, Auckenthaler R, Berna...

Objective: To compare ceftriaxone with cefuroxime for the treatment of meningitis, we conducted a study in which 106 children with acute bacterial meningitis were randomly assigned to receive either ceftriaxone (100 mg per kilogram of body weight per day, administered intravenously once daily; n = 53) or cefuroxime (240 mg per kilogram per day, administered intravenously in four equal doses; n = 53).

Bronchiolitis English (24) French All (24)

Key Study: Association of Fluid Overload with Clinical Outcomes in Critically Ill Children with Bronchiolitis: Bronquiolitis en la Unidad de Cuidados Intensivos Pediatricos (BRUCIP) Study*

Visit

Flores-Gonzalez, J. C. V., C. M.; Yun Castilla, C.; Mayordomo-Colunga, J.; Qu...

Objective: To our knowledge, few studies have examined the impact of fluid balance on clinical outcome in severe bronchiolitis. Our aim was to determine whether fluid overload was associated with adverse clinical outcomes in critically ill children with severe bronchiolitis.

Key Study: [Does heliox administered by low-flow nasal cannula improve respiratory distress in infants with respiratory syncytial virus acute bronchiolitis? A randomized controlled trial]

Visit

Seliem, W and Sultan, AM

Objective: To evaluate whether the use of heliox (79:21) delivered through a low flow nasal cannula would improve respiratory distress in infants with acute bronchiolitis caused by respiratory syncytial virus.

Key Study: Chest radiography in children hospitalized with bronchiolitis

Visit

Wrotek A, Czajkowska M, Jackowska T

Objective: to evaluate the use of CR in children with bronchiolitis due to a lower respiratory tract infection (RSV-RTI) with respiratory syncytial virus (RSV) and the influence of CR on patient treatment during the 2010-2017 seasons.

Key Study: A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis

Visit

Franklin, D. B., F. E.; Schlapbach, L. J.; Oakley, E.; Craig, S.; Neutze, J.;...

Objective: To assess efficacy of high-flow oxygen therapy through a nasal cannula in settings other than intensive care units (ICUs).

Key Study: Heliox delivered by high flow nasal cannula improves oxygenation in infants with respiratory syncytial virus acute bronchiolitis

Visit

Seliem, W. S., A. M.

Objective: to evaluate the hypothesis that use of heliox would result in improvement of gas exchange when used with high flow nasal cannula in infants with RSV acute bronchiolitis.

Key Study: Predicting escalated care in infants with bronchiolitis

Visit

Freire

Objective: to identify predictors of "escalated care" in bronchiolitis.

Key Study: Predictors of critical care and mortality in bronchiolitis after emergency department discharge

Visit

Schuh S, Kwong J, Holder L, Graves E, Macdonald E, Finkelstein Y

Objectives:To identify the epidemiologic predictors and stratify the risk of critical care unit (CCU) admission or death in bronchiolitis following emergency department discharge. This information has not yet been explored.

Key Study: Lung ultrasound for the diagnosis of pneumonia in children with acute bronchiolitis

Visit

Biagi C, Pierantoni L, Baldazzi M, Greco L, Dormi A, Dondi A, Faldella G, Lan...

Objective: to assess the diagnostic accuracy and reliability of LUS for the detection of pneumonia in hospitalized children with bronchiolitis and to evaluate the agreement between LUS and CXR in diagnosing pneumonia in these patients.

Key Study: High-flow warm humidified oxygen versus standard low-flow nasal cannula oxygen for moderate bronchiolitis (HFWHO RCT): An open, phase 4, randomised controlled trial

Visit

Kepreotes E, Whitehead B, Attia J, Oldmeadow C, Collison A, Searles A, Goddar...

Objectives: Bronchiolitis is the most common lung infection in infants and treatment focuses on management of respiratory distress and hypoxia. High-flow warm humidified oxygen (HFWHO) is increasingly used, but has not been rigorously studied in randomised trials. This study aimed to examine whether HFWHO provided enhanced respiratory support, thereby shortening time to weaning off oxygen

Key Study: Effect of nebulized hypertonic saline treatment in emergenc departments on hospitalization rate for acute bronchiolitis: a randomized clinical trial

Visit

Angoulvant F, Belletre X, Milcent K, et al

Objective: To examine whether HS nebulization treatment would decrease the hospital admission rate among infants with a first episode of acute bronchiolitis.

Key Study: High flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: a multicenter randomized controlled trial (TRAMONTANE study)

Visit

Milsi C, Essouri S, Pouyau R, Liet JM, Afanetti M, Portefaix A, Baleine J,Dur...

Objective: To assess oxygen delivery via high flow nasal cannula (HFNC).

Key Study: Effect of oxygen desaturations on subsequent medical visits in infants discharged from the emergency department with bronchiolitis

Visit

Principi T, Coates AL, Parkin PC, Stephens D, DaSilva Z, Schuh S

Objective: To examine whether there is a difference in the proportion of unscheduled medical visits within 72 hours of emergency department discharge in infants with bronchiolitis who have oxygen desaturations to lower than 90% for at least 1 minute during home oximetry monitoring vs those without desaturations.

Key Study: Nasal irrigation with saline solution significantly improves oxygen saturation in infants with bronchiolitis

Visit

Schreiber S, Ronfani L, Ghirardo S, Minen F, Taddio A, Jaber M, Rizzello E, B...

Objective: To compare nasal irrigation using either isotonic 0.9% sodium chloride or hypertonic 3% sodium chloride with simple supportive care in infants with bronchiolitis.

Key Study: Use of intermittent vs continuous pulse oximetry for nonhypoxemic infants and young children hospitalized for bronchiolitis: a randomized controlled trial

Visit

McCulloh R, Koster M, Ralston S, Johnson M, Hill V, Koehn K, Weddle G, Alvers...

Objective: To determine the effect of intermittent vs continuous pulse oximetry monitoring on hospital length of stay among nonhypoxemic infants and young children hospitalized for bronchiolitis.

Key Study: Epinephrine Improves the Efficacy of Nebulized Hypertonic Saline in Moderate Bronchiolitis: A Randomised Clinical Trial

Visit

Flores-Gonzlez JC, Matamala-Morillo MA, Rodrguez-Campoy P, Prez-Guerrero JJ, ...

Objective: To evaluate the efficacy of nebulized epinephrine in 3% hypertonic saline.

Key Study: Bronchiolitis of Infancy Discharge Study (BIDS): a multicentre, parallel-group, double-blind, randomised controlled, equivalence trial with economic evaluation

Visit

Cunningham S, Rodriguez A, Boyd KA, McIntosh E, Lewis SC, BIDS Collaborators ...

Objective: To compare the American Academy of Pediatrics guideline target of SpO2 90% with the Scottish Intercollegiate Guidelines Network target of SpO2 94%.

Key Study: Nebulised hypertonic saline (3%) among children with mild to moderately severe bronchiolitis--a double blind randomized controlled trial

Visit

Khanal A, Sharma A, Basnet S, Sharma PR, Gami FC

Objective: To Assess the efficacy of nebulised hypertonic saline (HS) (3%) among children with mild to moderately severe bronchiolitis.

Key Study: Effect of oximetry on hospitalization in bronchiolitis: a randomized clinical trial

Visit

Schuh S, Freedman S, Coates A, Allen U, Parkin P, Stephens D, Ungar W, DaSilv...

Objective: To examine if infants with bronchiolitis whose displayed oximetry measurements have been artificially elevated 3 percentage points above true values experience hospitalization rates at least 15% lower compared with infants with true values displayed.

Key Study: Nasogastric hydration vs intravenous hydration for infants with bronchiolitis: a randomised trial

Visit

Oakley Ed, Borland M, () Babl F

Objective: to assess whether intravenous hydration or nasogastric hydration is better for treatment of infants.

Key Study: Epinephrine and dexamethasone in children with bronchiolitis

Visit

Plint AC, Johnson DW, Patel H, Wiebe N, Correll R, Brant R, Mitton C, Gouin S...

This randomized, double-blind, placebo-controlled, clinical trial with a factorial design at multiple sites was undertaken to determine whether treatment with nebulized epinephrine, a short course of oral dexamethasone, or both resulted in a clinically important decrease in hospital admissions among infants with bronchiolitis who were seen in the emergency department.

Key Study: A cost-effectiveness analysis of omitting radiography in diagnosis of acute bronchiolitis

Visit

Yong JHE, Schuh S, Rashidi R, Vanderby S, Lau R, Laporte A, Nauenberg E, Unga...

Objective:To carry out a cost-effectiveness analysis of omitting chest radiography in the diagnosis of infant bronchiolitis.

Key Study: A multicenter, randomized, controlled trial of dexamethasone for bronchiolitis

Visit

Corneli HM, Zorc JJ, Mahajan P, Shaw KN, Holubkov R, Reeves SD, Ruddy RM, Mal...

The goal of this study was to determine the effectiveness of a single dose of oral dexamethasone in infants with moderate-to-severe bronchiolitis.

Key Study: Evaluation of the utility of radiography in acute bronchiolitis

Visit

Schuh S, Lalani A, Allen U, Manson D, Babyn P, Stephens D, MacPhee S, Mokansk...

Objectives: to determine the proportion of radiographs inconsistent with bronchiolitis in children with typical presentation of bronchiolitis and to compare rates of intended antibiotic therapy before radiography versus those given antibiotics after radiography.

Key Study: Risk of serious bacterial infection in young febrile infants with respiratory syncytial virus infections

Visit

Levine DA, Platt SL, Dayan PS, Macias CG, Zorc JJ, Krief W, Schor J, Bank D, ...

Objective: to determine the risk of SBI in young febrile infants who are infected with RSV compared with those without RSV infections.

Key Study: Association of Fluid Overload with Clinical Outcomes in Critically Ill Children with Bronchiolitis: Bronquiolitis en la Unidad de Cuidados Intensivos Pediatricos (BRUCIP) Study*

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Flores-Gonzalez, J. C. V., C. M.; Yun Castilla, C.; Mayordomo-Colunga, J.; Qu...

Objective: To our knowledge, few studies have examined the impact of fluid balance on clinical outcome in severe bronchiolitis. Our aim was to determine whether fluid overload was associated with adverse clinical outcomes in critically ill children with severe bronchiolitis.

Key Study: [Does heliox administered by low-flow nasal cannula improve respiratory distress in infants with respiratory syncytial virus acute bronchiolitis? A randomized controlled trial]

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Seliem, W and Sultan, AM

Objective: To evaluate whether the use of heliox (79:21) delivered through a low flow nasal cannula would improve respiratory distress in infants with acute bronchiolitis caused by respiratory syncytial virus.

Key Study: Chest radiography in children hospitalized with bronchiolitis

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Wrotek A, Czajkowska M, Jackowska T

Objective: to evaluate the use of CR in children with bronchiolitis due to a lower respiratory tract infection (RSV-RTI) with respiratory syncytial virus (RSV) and the influence of CR on patient treatment during the 2010-2017 seasons.

Key Study: A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis

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Franklin, D. B., F. E.; Schlapbach, L. J.; Oakley, E.; Craig, S.; Neutze, J.;...

Objective: To assess efficacy of high-flow oxygen therapy through a nasal cannula in settings other than intensive care units (ICUs).

Key Study: Heliox delivered by high flow nasal cannula improves oxygenation in infants with respiratory syncytial virus acute bronchiolitis

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Seliem, W. S., A. M.

Objective: to evaluate the hypothesis that use of heliox would result in improvement of gas exchange when used with high flow nasal cannula in infants with RSV acute bronchiolitis.

Key Study: Predicting escalated care in infants with bronchiolitis

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Freire

Objective: to identify predictors of "escalated care" in bronchiolitis.

Key Study: Predictors of critical care and mortality in bronchiolitis after emergency department discharge

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Schuh S, Kwong J, Holder L, Graves E, Macdonald E, Finkelstein Y

Objectives:To identify the epidemiologic predictors and stratify the risk of critical care unit (CCU) admission or death in bronchiolitis following emergency department discharge. This information has not yet been explored.

Key Study: Lung ultrasound for the diagnosis of pneumonia in children with acute bronchiolitis

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Biagi C, Pierantoni L, Baldazzi M, Greco L, Dormi A, Dondi A, Faldella G, Lan...

Objective: to assess the diagnostic accuracy and reliability of LUS for the detection of pneumonia in hospitalized children with bronchiolitis and to evaluate the agreement between LUS and CXR in diagnosing pneumonia in these patients.

Key Study: High-flow warm humidified oxygen versus standard low-flow nasal cannula oxygen for moderate bronchiolitis (HFWHO RCT): An open, phase 4, randomised controlled trial

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Kepreotes E, Whitehead B, Attia J, Oldmeadow C, Collison A, Searles A, Goddar...

Objectives: Bronchiolitis is the most common lung infection in infants and treatment focuses on management of respiratory distress and hypoxia. High-flow warm humidified oxygen (HFWHO) is increasingly used, but has not been rigorously studied in randomised trials. This study aimed to examine whether HFWHO provided enhanced respiratory support, thereby shortening time to weaning off oxygen

Key Study: Effect of nebulized hypertonic saline treatment in emergenc departments on hospitalization rate for acute bronchiolitis: a randomized clinical trial

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Angoulvant F, Belletre X, Milcent K, et al

Objective: To examine whether HS nebulization treatment would decrease the hospital admission rate among infants with a first episode of acute bronchiolitis.

Key Study: High flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: a multicenter randomized controlled trial (TRAMONTANE study)

Visit

Milsi C, Essouri S, Pouyau R, Liet JM, Afanetti M, Portefaix A, Baleine J,Dur...

Objective: To assess oxygen delivery via high flow nasal cannula (HFNC).

Key Study: Effect of oxygen desaturations on subsequent medical visits in infants discharged from the emergency department with bronchiolitis

Visit

Principi T, Coates AL, Parkin PC, Stephens D, DaSilva Z, Schuh S

Objective: To examine whether there is a difference in the proportion of unscheduled medical visits within 72 hours of emergency department discharge in infants with bronchiolitis who have oxygen desaturations to lower than 90% for at least 1 minute during home oximetry monitoring vs those without desaturations.

Key Study: Nasal irrigation with saline solution significantly improves oxygen saturation in infants with bronchiolitis

Visit

Schreiber S, Ronfani L, Ghirardo S, Minen F, Taddio A, Jaber M, Rizzello E, B...

Objective: To compare nasal irrigation using either isotonic 0.9% sodium chloride or hypertonic 3% sodium chloride with simple supportive care in infants with bronchiolitis.

Key Study: Use of intermittent vs continuous pulse oximetry for nonhypoxemic infants and young children hospitalized for bronchiolitis: a randomized controlled trial

Visit

McCulloh R, Koster M, Ralston S, Johnson M, Hill V, Koehn K, Weddle G, Alvers...

Objective: To determine the effect of intermittent vs continuous pulse oximetry monitoring on hospital length of stay among nonhypoxemic infants and young children hospitalized for bronchiolitis.

Key Study: Epinephrine Improves the Efficacy of Nebulized Hypertonic Saline in Moderate Bronchiolitis: A Randomised Clinical Trial

Visit

Flores-Gonzlez JC, Matamala-Morillo MA, Rodrguez-Campoy P, Prez-Guerrero JJ, ...

Objective: To evaluate the efficacy of nebulized epinephrine in 3% hypertonic saline.

Key Study: Bronchiolitis of Infancy Discharge Study (BIDS): a multicentre, parallel-group, double-blind, randomised controlled, equivalence trial with economic evaluation

Visit

Cunningham S, Rodriguez A, Boyd KA, McIntosh E, Lewis SC, BIDS Collaborators ...

Objective: To compare the American Academy of Pediatrics guideline target of SpO2 90% with the Scottish Intercollegiate Guidelines Network target of SpO2 94%.

Key Study: Nebulised hypertonic saline (3%) among children with mild to moderately severe bronchiolitis--a double blind randomized controlled trial

Visit

Khanal A, Sharma A, Basnet S, Sharma PR, Gami FC

Objective: To Assess the efficacy of nebulised hypertonic saline (HS) (3%) among children with mild to moderately severe bronchiolitis.

Key Study: Effect of oximetry on hospitalization in bronchiolitis: a randomized clinical trial

Visit

Schuh S, Freedman S, Coates A, Allen U, Parkin P, Stephens D, Ungar W, DaSilv...

Objective: To examine if infants with bronchiolitis whose displayed oximetry measurements have been artificially elevated 3 percentage points above true values experience hospitalization rates at least 15% lower compared with infants with true values displayed.

Key Study: Nasogastric hydration vs intravenous hydration for infants with bronchiolitis: a randomised trial

Visit

Oakley Ed, Borland M, () Babl F

Objective: to assess whether intravenous hydration or nasogastric hydration is better for treatment of infants.

Key Study: Epinephrine and dexamethasone in children with bronchiolitis

Visit

Plint AC, Johnson DW, Patel H, Wiebe N, Correll R, Brant R, Mitton C, Gouin S...

This randomized, double-blind, placebo-controlled, clinical trial with a factorial design at multiple sites was undertaken to determine whether treatment with nebulized epinephrine, a short course of oral dexamethasone, or both resulted in a clinically important decrease in hospital admissions among infants with bronchiolitis who were seen in the emergency department.

Key Study: A cost-effectiveness analysis of omitting radiography in diagnosis of acute bronchiolitis

Visit

Yong JHE, Schuh S, Rashidi R, Vanderby S, Lau R, Laporte A, Nauenberg E, Unga...

Objective:To carry out a cost-effectiveness analysis of omitting chest radiography in the diagnosis of infant bronchiolitis.

Key Study: A multicenter, randomized, controlled trial of dexamethasone for bronchiolitis

Visit

Corneli HM, Zorc JJ, Mahajan P, Shaw KN, Holubkov R, Reeves SD, Ruddy RM, Mal...

The goal of this study was to determine the effectiveness of a single dose of oral dexamethasone in infants with moderate-to-severe bronchiolitis.

Key Study: Evaluation of the utility of radiography in acute bronchiolitis

Visit

Schuh S, Lalani A, Allen U, Manson D, Babyn P, Stephens D, MacPhee S, Mokansk...

Objectives: to determine the proportion of radiographs inconsistent with bronchiolitis in children with typical presentation of bronchiolitis and to compare rates of intended antibiotic therapy before radiography versus those given antibiotics after radiography.

Key Study: Risk of serious bacterial infection in young febrile infants with respiratory syncytial virus infections

Visit

Levine DA, Platt SL, Dayan PS, Macias CG, Zorc JJ, Krief W, Schor J, Bank D, ...

Objective: to determine the risk of SBI in young febrile infants who are infected with RSV compared with those without RSV infections.

Burns English (5) French All (5)

Key study: Delayed Healing Associated with Silver Sulfadiazine Use for Partial Thickness Scald Burns in Children

Visit

Raymond SL, Zecevic A, Larson SD, Ruzic A, Islam S

Objective: The purpose of this study was to compare outcomes of three different dressings for pediatric partial-thickness scald burns.

Key study: Effectiveness of aspiration or deroofing for blister management in patients with burns: A prospective randomized controlled trial

Visit

Ro HS, Shin JY, Sabbagh MD, Roh SG, Chang SC, Lee NH

Objective: To determine which treatment is the best option when encountering blisters while treating burn patients.

Key study: A Randomized Controlled Study of Silver-Based Burns Dressing in a Pediatric Emergency Department

Visit

Brown M, Dalziel SR, Herd E, Johnson K, Wong She R, Shepherd M

Objective: This study sought to determine whether silver sodium carboxymethyl cellulose dressing is a superior treatment to nanocrystalline silver-coated polyethylene dressing in pediatric patients with partial thickness burns.

Key study: Randomized controlled trial of three burns dressings for partial thickness burns in children

Visit

Gee Kee EL, Kimble RM, Cuttle L, Khan A, Stockton KA

Objective: This study compared the effects of three silver dressing combinations on small to medium size acute partial thickness burns in children, focusing on re-epithelialization time, pain and distress during dressing changes.

Key study: Discrepancy in Initial Pediatric Burn Estimates and Its Impact on Fluid Resuscitation

Visit

Goverman J, Bittner EA, Friedstat JS, Moore M, Nozari A, Ibrahim AE, Sarhane ...

Objective: To evaluate the differences between initial TBSA estimates and its impact on fluid resuscitation at an American Burn Associationverified pediatric burn center.

Key study: Delayed Healing Associated with Silver Sulfadiazine Use for Partial Thickness Scald Burns in Children

Visit

Raymond SL, Zecevic A, Larson SD, Ruzic A, Islam S

Objective: The purpose of this study was to compare outcomes of three different dressings for pediatric partial-thickness scald burns.

Key study: Effectiveness of aspiration or deroofing for blister management in patients with burns: A prospective randomized controlled trial

Visit

Ro HS, Shin JY, Sabbagh MD, Roh SG, Chang SC, Lee NH

Objective: To determine which treatment is the best option when encountering blisters while treating burn patients.

Key study: A Randomized Controlled Study of Silver-Based Burns Dressing in a Pediatric Emergency Department

Visit

Brown M, Dalziel SR, Herd E, Johnson K, Wong She R, Shepherd M

Objective: This study sought to determine whether silver sodium carboxymethyl cellulose dressing is a superior treatment to nanocrystalline silver-coated polyethylene dressing in pediatric patients with partial thickness burns.

Key study: Randomized controlled trial of three burns dressings for partial thickness burns in children

Visit

Gee Kee EL, Kimble RM, Cuttle L, Khan A, Stockton KA

Objective: This study compared the effects of three silver dressing combinations on small to medium size acute partial thickness burns in children, focusing on re-epithelialization time, pain and distress during dressing changes.

Key study: Discrepancy in Initial Pediatric Burn Estimates and Its Impact on Fluid Resuscitation

Visit

Goverman J, Bittner EA, Friedstat JS, Moore M, Nozari A, Ibrahim AE, Sarhane ...

Objective: To evaluate the differences between initial TBSA estimates and its impact on fluid resuscitation at an American Burn Associationverified pediatric burn center.

COVID19 English (30) French All (30)

Key study: Pointofcare lung ultrasound findings in the pediatric emergency clinic during the COVID19 pandemic.

Visit

Tre E, Korkmaz MF, Aksoy FD, et al.

Objective: To describe our experience concerning lung ultrasound (LUS) in the pediatric emergency clinic, and to investigate the diagnostic value of LUS in coronavirus disease-2019 (COVID-19).

Key study: Asymptomatic cases in a family cluster with SARS-CoV-2 infection

Visit

Wu X, Li T, Ou X, et al

Objective: To report the findings from different types of clinical specimens collected from 82 infected individuals

Key study: SARS-CoV-2 Infection in Children.

Visit

Lu X, Zhang L, Du H, et al

Objective: In order to determine the spectrum of disease in children, we evaluated children infected with SARS-CoV-2 and treated at the Wuhan Childrens Hospital, the only center assigned by the central government for treating infected children under 16 years of age in Wuhan.

Key study: A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features

Visit

Jiehao C, Jing X, Daojiong L, et al

Objective: To report the clinical and epidemiological features in children with coronavirus diseases (COVID) in China.

Key study: Clinical features of paediatric patients with COVID-19: a report of two family clusters.

Visit

Ji L, Chao S, Wang Y, et al.

Objective: To retrospectively review two confirmed pediatric cases from two family clusters. Both clinical features and laboratory examination results of the children and their family members were described.

Key study: Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China.

Visit

Dong Y, Mo X, Hu Y, et al.

Objective: This study examined the epidemiological characteristics and transmission patterns of 2143 pediatric patients with COVID-19, using a retrospective analytical approach.

Key study: Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China

Visit

Wei M, Yuan J, Liu Y, et al.,

Objective: For this retrospective study, authors identified all hospitalized infants diagnosed with COVID-19 infection between December 8, 2019, and February 6, 2020, in China and described demographic, epidemiologic, and clinical features.

Key study: Clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children

Visit

Hong H et al.,

Objective: To describe the clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children

Key study: Report on the Epidemiological Features of Coronavirus Disease 2019 (COVID-19) Outbreak in the Republic of Korea from January 19 to March 2, 2020.

Visit

Korean Society of Infectious Diseases, Korean Society of Pediatric Infectious...

Objective: This report summarizes the epidemiologic features and the snapshots of the outbreak in the Republic of Korea from January 19 and March 2, 2020.

Key study: Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single centers observational study.

Visit

Sun D, Li H, Lu X, et al.,

Objective: To describe the clinical features of severe pediatric patients with COVID-19.

Key study: Clinical presentation and virological assessment of hospitalized cases of coronavirus disease 2019 in a travel-associated transmission cluster.

Visit

Woelfel R, Corman VM, Guggemos W, et al.,

Objective: To study the viral load courses by RT-PCR in oro- and nasopharyngeal swabs, sputum, stool, blood, and urine in nine hospitalized cases. Infectious virus was detected by cell culture.

Key study: Acral cutaneous lesions in the time of COVID-19.

Visit

Recalcati S, Barbagallo T, Frasin LA, et al.

Objective: We report here on peculiar (perniosislike) skin lesions, unreported in the previous years, observed in young outpatients visited in our dermatologic unit in the last 4 weeks of COVID19 pandemic (MarchApril 2020).

Key study: Children with Covid-19 in pediatric emergency departments in Italy.

Visit

Parri N, Lenge M, Buonsenso D, Coronavirus Infection in Public Emergency Depa...

Objective: The Coronavirus Infection in Pediatric Emergency Departments (CONFIDENCE) study involved a cohort of 100 Italian children younger than 18 years of age with Covid-19 confirmed by reverse-transcriptasepolymerase-chain-reaction testing of nasal or nasopharyngeal swabs who were assessed between March 3 and March 27 in 17 pediatric emergency departments. Here, we describe the results of the CONFIDENCE study and compare them with those from three cohorts in previously published analyses.

Key study: Chilblain-like lesions during COVID-19 epidemic: a preliminary study on 63 patients.

Visit

PiccoloV,NeriI, FilippeschiC, et al.

Objective: We have recently noticed an outbreak of chilblainlike lesions in Italy contemporarily to COVID19 epidemic. Due to the wellknown lockdownrelated difficulties to visit the patients, we created a Google form aimed to collect information about patients presenting with these singular clinical findings. An easy to access and quick tool was chosen by the investigators in order to permit the other colleagues to spend the least amount of time, given the severe health emergency.

Key study: The characteristics of household transmission of COVID-19.

Visit

Li W, Zhang B, Lu J, et al.

Objective: Since December 2019, SARS-CoV-2 has extended to most parts of China with >80 000 cases and to at least 100 countries with >60 000 international cases as of 15 March 2020. Here we used a household cohort study to determine the features of household transmission of COVID-19.

Key study: Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases.

Visit

Casas CG, Catal A, Hernndez GC, et al.

Objectives: To describe the cutaneous manifestations of COVID-19 disease and to relate them to other clinical findings.

Key study: Assessment of 135794 pediatric patients tested for severe scute respiratory syndrome coronavirus across the United States.

Visit

Bailey LC, Razzaghi H, Burrows EK, et al.

Objective: To describe testing for SARS-CoV-2 and the epidemiology of infected patients.

Key study: Baseline characteristics, management, and outcomes of 55,270 children and adolescents diagnosed with COVID-19 and 1,952,693 with influenza in France, Germany, Spain, South Korea and the United States: an international network cohort study.

Visit

Duarte-Salles T, Vizcaya D, Pistillo A, et al.

Objectives To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children/adolescents diagnosed or hospitalized with COVID-19. Secondly, to describe health outcomes amongst children/adolescents diagnosed with previous seasonal influenza. Design International network cohort.

Key study: Cardiac abnormalities seen in pediatric patients during the SARS-CoV2 pandemic: an international experience.

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Clark BC, Sanchez-de-Toledo J, Bautista-Rodriguez C, et al.

Objective: To describe the cardiac manifestations found in an international cohort of 55 pediatric cases with multi-system inflammatory syndrome (MIS-C) during the SARS-CoV2 pandemic.

Key study: COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study.

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Gtzinger F, Santiago-Garca B, Noguera-Julin A, et al.

Objective: This study aimed to capture key data on children and adolescents with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection across Europe to inform physicians and health-care service planning during the ongoing pandemic.

Key study: Severe acute respiratory syndrome coronavirus 2 clinical syndromes and predictors of disease severity in hospitalized children and youth.

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Fernandes DM, Oliveira CR, Guerguis S, et al.

Objective: To characterize the demographic and clinical features of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) syndromes and identify admission variables predictive of disease severity.

Key study: Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome.

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Pereira MFB, Litvinov N, Farhat SCL, et al.

Objectives: To assess the outcomes of pediatric patients with laboratory-confirmed coronavirus disease (COVID-19) with or without multisystem inflammatory syndrome in children (MIS-C).

Key study: A case series of pediatric croup with COVID-19.

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Venn AMR, Schmidt JM, Mullan PC.

Objective: We describe three previously healthy children, admitted from our emergency department (ED) to our free-standing children's hospital, as the first documented cases of croup as a manifestation of SARS-CoV-2 infection.

Key study: Anosmia and ageusia: not an uncommon presentation of COVID-19 infection in children and adolescents.

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Mak PQ, Chung KS, Wong JS, Shek CC, Kwan MY.

Objective: We report three cases of pediatric patients with COVID-19 infection who presented with anosmia and/or ageusia.

Summary: Emergency preparedness and response: multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19).

Visit

Centers for Disease Control and Prevention

Objective: Providing 1) background information on several cases of a recently reported multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19); and 2) a case definition for this syndrome.

Key study: Characteristics and outcomes of children with Coronavirus disease 2019 (COVID-19) infection admitted to US and Canadian pediatric intensive care units.

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Shekerdemian L, Mahmood N, Wolfe K, et al.

Objective To provide an early description and characterization of COVID-19 infection in North American PICUs, focusing on mode of presentation, presence of comorbidities, severity of disease, therapeutic interventions, clinical trajectory, and early outcomes.

Summary: Coronavirus disease 2019 in children United States, February 12-April 2, 2020.

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US Centers for Disease Control and Prevention

Objective: To describe COVID-19 in children and adolescents in the United States.

Key study: Pediatric critical care and COVID19.

Visit

Gonzlez-Dambrauskas S, Vsquez-Hoyos P, Camporesi A, et al.

Objective: We provide preliminary insights into our first 17 children from 10 PICUs in Chile, Colombia, Italy, Spain, and the United States.

Key study: Clinical characteristics of children with Coronavirus disease 2019 in Hubei, China.

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Zheng F, Liao C, Fan Q, et al.

Objective: The objective of this study is to describe the clinical characteristics of 25 hospitalized pediatric COVID-19.

Key study: Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding

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Xu Y, Li X, Zhu B, et al.

Objective: We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA.

Key study: Pointofcare lung ultrasound findings in the pediatric emergency clinic during the COVID19 pandemic.

Visit

Tre E, Korkmaz MF, Aksoy FD, et al.

Objective: To describe our experience concerning lung ultrasound (LUS) in the pediatric emergency clinic, and to investigate the diagnostic value of LUS in coronavirus disease-2019 (COVID-19).

Key study: Asymptomatic cases in a family cluster with SARS-CoV-2 infection

Visit

Wu X, Li T, Ou X, et al

Objective: To report the findings from different types of clinical specimens collected from 82 infected individuals

Key study: SARS-CoV-2 Infection in Children.

Visit

Lu X, Zhang L, Du H, et al

Objective: In order to determine the spectrum of disease in children, we evaluated children infected with SARS-CoV-2 and treated at the Wuhan Childrens Hospital, the only center assigned by the central government for treating infected children under 16 years of age in Wuhan.

Key study: A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features

Visit

Jiehao C, Jing X, Daojiong L, et al

Objective: To report the clinical and epidemiological features in children with coronavirus diseases (COVID) in China.

Key study: Clinical features of paediatric patients with COVID-19: a report of two family clusters.

Visit

Ji L, Chao S, Wang Y, et al.

Objective: To retrospectively review two confirmed pediatric cases from two family clusters. Both clinical features and laboratory examination results of the children and their family members were described.

Key study: Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China.

Visit

Dong Y, Mo X, Hu Y, et al.

Objective: This study examined the epidemiological characteristics and transmission patterns of 2143 pediatric patients with COVID-19, using a retrospective analytical approach.

Key study: Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China

Visit

Wei M, Yuan J, Liu Y, et al.,

Objective: For this retrospective study, authors identified all hospitalized infants diagnosed with COVID-19 infection between December 8, 2019, and February 6, 2020, in China and described demographic, epidemiologic, and clinical features.

Key study: Clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children

Visit

Hong H et al.,

Objective: To describe the clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children

Key study: Report on the Epidemiological Features of Coronavirus Disease 2019 (COVID-19) Outbreak in the Republic of Korea from January 19 to March 2, 2020.

Visit

Korean Society of Infectious Diseases, Korean Society of Pediatric Infectious...

Objective: This report summarizes the epidemiologic features and the snapshots of the outbreak in the Republic of Korea from January 19 and March 2, 2020.

Key study: Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single centers observational study.

Visit

Sun D, Li H, Lu X, et al.,

Objective: To describe the clinical features of severe pediatric patients with COVID-19.

Key study: Clinical presentation and virological assessment of hospitalized cases of coronavirus disease 2019 in a travel-associated transmission cluster.

Visit

Woelfel R, Corman VM, Guggemos W, et al.,

Objective: To study the viral load courses by RT-PCR in oro- and nasopharyngeal swabs, sputum, stool, blood, and urine in nine hospitalized cases. Infectious virus was detected by cell culture.

Key study: Acral cutaneous lesions in the time of COVID-19.

Visit

Recalcati S, Barbagallo T, Frasin LA, et al.

Objective: We report here on peculiar (perniosislike) skin lesions, unreported in the previous years, observed in young outpatients visited in our dermatologic unit in the last 4 weeks of COVID19 pandemic (MarchApril 2020).

Key study: Children with Covid-19 in pediatric emergency departments in Italy.

Visit

Parri N, Lenge M, Buonsenso D, Coronavirus Infection in Public Emergency Depa...

Objective: The Coronavirus Infection in Pediatric Emergency Departments (CONFIDENCE) study involved a cohort of 100 Italian children younger than 18 years of age with Covid-19 confirmed by reverse-transcriptasepolymerase-chain-reaction testing of nasal or nasopharyngeal swabs who were assessed between March 3 and March 27 in 17 pediatric emergency departments. Here, we describe the results of the CONFIDENCE study and compare them with those from three cohorts in previously published analyses.

Key study: Chilblain-like lesions during COVID-19 epidemic: a preliminary study on 63 patients.

Visit

PiccoloV,NeriI, FilippeschiC, et al.

Objective: We have recently noticed an outbreak of chilblainlike lesions in Italy contemporarily to COVID19 epidemic. Due to the wellknown lockdownrelated difficulties to visit the patients, we created a Google form aimed to collect information about patients presenting with these singular clinical findings. An easy to access and quick tool was chosen by the investigators in order to permit the other colleagues to spend the least amount of time, given the severe health emergency.

Key study: The characteristics of household transmission of COVID-19.

Visit

Li W, Zhang B, Lu J, et al.

Objective: Since December 2019, SARS-CoV-2 has extended to most parts of China with >80 000 cases and to at least 100 countries with >60 000 international cases as of 15 March 2020. Here we used a household cohort study to determine the features of household transmission of COVID-19.

Key study: Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases.

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Casas CG, Catal A, Hernndez GC, et al.

Objectives: To describe the cutaneous manifestations of COVID-19 disease and to relate them to other clinical findings.

Key study: Assessment of 135794 pediatric patients tested for severe scute respiratory syndrome coronavirus across the United States.

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Bailey LC, Razzaghi H, Burrows EK, et al.

Objective: To describe testing for SARS-CoV-2 and the epidemiology of infected patients.

Key study: Baseline characteristics, management, and outcomes of 55,270 children and adolescents diagnosed with COVID-19 and 1,952,693 with influenza in France, Germany, Spain, South Korea and the United States: an international network cohort study.

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Duarte-Salles T, Vizcaya D, Pistillo A, et al.

Objectives To characterize the demographics, comorbidities, symptoms, in-hospital treatments, and health outcomes among children/adolescents diagnosed or hospitalized with COVID-19. Secondly, to describe health outcomes amongst children/adolescents diagnosed with previous seasonal influenza. Design International network cohort.

Key study: Cardiac abnormalities seen in pediatric patients during the SARS-CoV2 pandemic: an international experience.

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Clark BC, Sanchez-de-Toledo J, Bautista-Rodriguez C, et al.

Objective: To describe the cardiac manifestations found in an international cohort of 55 pediatric cases with multi-system inflammatory syndrome (MIS-C) during the SARS-CoV2 pandemic.

Key study: COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study.

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Gtzinger F, Santiago-Garca B, Noguera-Julin A, et al.

Objective: This study aimed to capture key data on children and adolescents with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection across Europe to inform physicians and health-care service planning during the ongoing pandemic.

Key study: Severe acute respiratory syndrome coronavirus 2 clinical syndromes and predictors of disease severity in hospitalized children and youth.

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Fernandes DM, Oliveira CR, Guerguis S, et al.

Objective: To characterize the demographic and clinical features of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) syndromes and identify admission variables predictive of disease severity.

Key study: Severe clinical spectrum with high mortality in pediatric patients with COVID-19 and multisystem inflammatory syndrome.

Visit

Pereira MFB, Litvinov N, Farhat SCL, et al.

Objectives: To assess the outcomes of pediatric patients with laboratory-confirmed coronavirus disease (COVID-19) with or without multisystem inflammatory syndrome in children (MIS-C).

Key study: A case series of pediatric croup with COVID-19.

Visit

Venn AMR, Schmidt JM, Mullan PC.

Objective: We describe three previously healthy children, admitted from our emergency department (ED) to our free-standing children's hospital, as the first documented cases of croup as a manifestation of SARS-CoV-2 infection.

Key study: Anosmia and ageusia: not an uncommon presentation of COVID-19 infection in children and adolescents.

Visit

Mak PQ, Chung KS, Wong JS, Shek CC, Kwan MY.

Objective: We report three cases of pediatric patients with COVID-19 infection who presented with anosmia and/or ageusia.

Summary: Emergency preparedness and response: multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19).

Visit

Centers for Disease Control and Prevention

Objective: Providing 1) background information on several cases of a recently reported multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 (COVID-19); and 2) a case definition for this syndrome.

Key study: Characteristics and outcomes of children with Coronavirus disease 2019 (COVID-19) infection admitted to US and Canadian pediatric intensive care units.

Visit

Shekerdemian L, Mahmood N, Wolfe K, et al.

Objective To provide an early description and characterization of COVID-19 infection in North American PICUs, focusing on mode of presentation, presence of comorbidities, severity of disease, therapeutic interventions, clinical trajectory, and early outcomes.

Summary: Coronavirus disease 2019 in children United States, February 12-April 2, 2020.

Visit

US Centers for Disease Control and Prevention

Objective: To describe COVID-19 in children and adolescents in the United States.

Key study: Pediatric critical care and COVID19.

Visit

Gonzlez-Dambrauskas S, Vsquez-Hoyos P, Camporesi A, et al.

Objective: We provide preliminary insights into our first 17 children from 10 PICUs in Chile, Colombia, Italy, Spain, and the United States.

Key study: Clinical characteristics of children with Coronavirus disease 2019 in Hubei, China.

Visit

Zheng F, Liao C, Fan Q, et al.

Objective: The objective of this study is to describe the clinical characteristics of 25 hospitalized pediatric COVID-19.

Key study: Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding

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Xu Y, Li X, Zhu B, et al.

Objective: We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA.

Cannabis Intoxication English (32) French All (32)

Key Study: Increased Testing and Health Care Costs for Pediatric Cannabis Exposures

Visit

Bashqoy FH, J. W.; Reiter, P. D.; Wang, G. S.; Borgelt, L. M.

This study aimed to evaluate the process of identifying marijuana exposure in a children's hospital emergency department and compare the cost of diagnostic testing and procedures.

Key Study: Acute cannabis toxicity

Visit

Noble MJH, K.; Hendrickson, R. G.

We describe the clinical effects of, and products associated with, acute exposures to cannabis during the early legalization period of recreational cannabis in Oregon and Alaska.

Key Study: A 21st Century Problem: Cannabis Toxicity in a 13-Month-Old Child

Visit

Levene RJP-C, Elza; Wolfram, Sigrid

We report the case of a 13-month-old female presenting with self-limiting altered mental status and lethargy, with a subsequent diagnosis of tetrahydrocannabinol exposure on confirmatory urine gas chromatography-mass spectrometry.

Key Study: Synthetic Cannabinoid Exposure in Adolescents Presenting for Emergency Care

Visit

Gilley MB, J.; Calello, D. P.; Wax, P.; Finkelstein, Y.; Toxicology Investiga...

The objective of this study was to characterize the clinical picture and management of synthetic cannabinoid exposure in a cohort of adolescents.

Key Study: Marijuana Misadventures in Children: Exploration of a Dose-Response Relationship and Summary of Clinical Effects and Outcomes

Visit

Heizer JWB, L. M.; Bashqoy, F.; Wang, G. S.; Reiter, P. D.

This study aimed to explore a dose-response relationship of delta-9-tetrahydrocannabinol (THC) in THC-nave children after unintentional acute exposure and compare clinical outcomes with non-nave children.

Key Study: Cannabis Intoxication Case Series: The Dangers of Edibles Containing Tetrahydrocannabinol

Visit

Vo KTH, H.; Li, K.; Ho, R. Y.; Wu, A. H. B.; Lynch, K. L.; Smollin, C. G.

Cannabis and its principal active constituent, 9-tetrahydrocannabinol (THC), are increasingly available as edibles resembling commercially available food products. In this case series, we describe a population of predominantly pediatric patients who were inadvertently exposed to a THC-containing product in San Francisco.

Key Study: Intoxicacin por cannabis en menores de 3 aos

Visit

Pinedo-Painous IG-R, Roser; Valls-Lafon, Anna; Muoz-Santanach, David; Martnez...

We present a retrospective, descriptive study of patients aged 3 years or younger who were treated for cannabis poisoning in a pediatric emergency department between 2012 and 2017.

Key Study: Longitudinal associations of social cognition and substance use in childhood and early adolescence: findings from the Avon Longitudinal Study of Parents and Children

Visit

Fluharty, M. E., Heron, J., & Munaf, M. R

We investigated both directions of association within an adolescent birth cohort: the association of social cognition with subsequent substance use, and the association of early substance use with subsequent social cognition

Key Study: Unintentional Cannabis Intoxication in Toddlers

Visit

Claudet IM, S.; Labadie, M.; Manin, C.; Michard-Lenoir, A. P.; Eyer, D.; Dufo...

We sought to evaluate the French national trend of admissions for unintentional cannabis intoxication in children over an 11-year period (20042014).

Key Study: A 10-year review of cannabis exposure in children under 3-years of age: do we need a more global approach?

Visit

Claudet, I., Le Breton, M., Brhin, C., & Franchitto, N

We carried out a retrospective cohort study of children admitted to a pediatric emergency department due to unintentional cannabis exposure over a 10-year period from 2004 to 2014.

Key Study: Drug Misuse in Adolescents Presenting to the Emergency Department

Visit

Finkelstein YG, G.; Hutson, J. R.; Armstrong, J.; Baum, C. R.; Wax, P.; Brent...

Drug misuse is a disturbing, common practice among youth. One in 4 American adolescents reports consuming prescription medications without a clinical indication. We sought to explore current trends of drug misuse in adolescents.

Key Study: Acute intoxication caused by synthetic cannabinoids 5F-ADB and MMB-2201: A case series

Visit

Barcelo BP, S.; Lopez-Corominas, V.; Gomila, I.; Yates, C.; Busardo, F. P.; P...

Here, we report five cases of acute intoxication by synthetic cannabinoids 5F-ADB and MMB-2201 with analytical confirmation

Key Study: Detecting biomarkers of secondhand marijuana smoke in young children

Visit

Wilson, K. M., Torok, M. R., Wei, B., Wang, L., Robinson, M., Sosnoff, C. S.,...

We studied children ages 1 mo to 2 y hospitalized with bronchiolitis in Colorado from 2013 to 2015.

Key Study: Unintentional Pediatric Exposures to Marijuana in Colorado, 2009-2015

Visit

George SamWang,MD1,2; Marie-ClaireLe Lait,MS2; Sara J.Deakyne,MPH3; et al

To compare the incidence of pediatric marijuana exposures evaluated at a children's hospital and regional poison center (RPC) in Colorado before and after recreational marijuana legalization and to compare population rate trends of RPC cases for marijuana exposures with the rest of the United States.

Key Study: Marijuana exposure among children younger than siz years in the United States

Visit

Onders B, Casavant MJ, Spiller HA, Chounthirath T, Smith GA

This study investigates marijuana exposures among children <6 years old in the United States using data from the National Poison Data System.

Key Study: Synthetic Cannabinoid Exposure

Visit

Adair AG, Spencer C.; Greeley, Christopher S.; Coleman, Ryan D.; Shekerdemian...

We present 2 cases of actual or highly suspected synthetic cannabinoid exposure in 2 pediatric patients to demonstrate the wide range of symptoms that can be present in these patients.

Key Study: Treat plays trick on a 3-year-old boy

Visit

Thuy Trang JNC, Arthur K.

Presents a case study of a 3 year old with acute cannabis intoxication.

Key Study: Changes in Cannabis Potency Over the Last 2 Decades (19952014): Analysis of Current Data in the United States

Visit

ElSohly, M. A., Mehmedic, Z., Foster, S., Gon, C., Chandra, S., & Church,...

This report examines the concentration of cannabinoids in illicit cannabis products seized by the U.S. Drug Enforcement Administration over the last 2 decades, with particular emphasis on (9)-tetrahydrocannabinol and cannabidiol.

Key Study: Non-Smoker Exposure to Secondhand Cannabis Smoke. I. Urine Screening and Confirmation Results

Visit

Cone, E. J., Bigelow, G. E., Herrmann, E. S., Mitchell, J. M., LoDico, C., Fl...

A systematic study was conducted of smoke exposure on drug-free participants.

Key Study: Non-smoker exposure to secondhand cannabis smoke II: Effect of room ventilation on the physiological, subjective, and behavioral/cognitive effects.

Visit

Herrmann, E. S., Cone, E. J., Mitchell, J. M., Bigelow, G. E., LoDico, C., Fl...

This report examines the concentration of cannabinoids in illicit cannabis products seized by the U.S. Drug Enforcement Administration over the last 2 decades, with particular emphasis on (9)-tetrahydrocannabinol and cannabidiol.

Key Study: Nonsmoker Exposure to Secondhand Cannabis Smoke. III. Oral Fluid and Blood Drug Concentrations and Corresponding Subjective Effects

Visit

Cone, E. J., Bigelow, G. E., Herrmann, E. S., Mitchell, J. M., LoDico, C., Fl...

The study was designed to produce extreme cannabis smoke exposure conditions tolerable to drug-free nonsmokers

Key Study: Accidental pediatric ingestions of medical marijuana: a 4-year poison center experience

Visit

Lovecchio, F., & Heise, C. W

A study of incidental pediatric cannabis consumption over a 4-year period.

Key Study: A cannabinoid-intoxicated child treated with dexmedetomidine: a case report

Visit

Cipriani, F., Mancino, A., Pulitan, S. M., Piastra, M., & Conti, G.

To our knowledge, this is the first reported case of dexmedetomidine use to support a cannabis intoxicated patient.

Key Study: The Impact of Marijuana Policies on Youth: Clinical, Research, and Legal Update

Visit

Ammerman, S., Ryan, S., Adelman, W. P., & THE COMMITTEE ON SUBSTANCE ABUS...

This technical report updates the 2004 American Academy of Pediatrics technical report on the legalization of marijuana

Key Study: Dangerous Relationships: Asthma and Substance Abuse

Visit

Caponnetto, P., Auditore, R., Russo, C., Alamo, A., Campagna, D., Demma, S., ...

The review emphasizes the importance for clinicians to be alert to the possibility of this substance as a precipitating factor for acute asthma.

Key Study: The Pharmacologic and Clinical Effects of Medical Cannabis

Visit

Borgelt, L. M., Franson, K. L., Nussbaum, A. M., & Wang, G. S.

This article will describe the pharmacology of cannabis, effects of various dosage formulations, therapeutics benefits and risks of cannabis for pain and muscle spasm, and safety concerns of medical cannabis use.

Key Study: Acute intoxication caused by a synthetic cannabinoid in two adolescents

Visit

Heath TSB, Z.; Thompson, A. J.; Tecklenburg, F. W.

In this report, we describe two adolescent patients admitted after they inhaled K2, resulting in loss of consciousness, tachycardia, and diffuse pain.

Key Study: Drug use and screening in pediatric trauma

Visit

Martin KLV, K. N.; Girotti, M. J.; Stewart, T. C.; Parry, N. G.

This article will describe the pharmacology of cannabis, effects of various dosage formulations, therapeutics benefits and risks of cannabis for pain and muscle spasm, and safety concerns of medical cannabis use.

Key Study: Sensitivity and Specificity of Urinary Cannabinoid Detection With Two Immunoassays After Controlled Oral Administration of Cannabinoids to Humans.

Visit

Grauwiler, S. B., Drewe, J., & Scholer, A.

This study aims to describe trends in substance use and screening in the Canadian pediatric trauma population.

Key Study: Ataxia and shaking in a 2-year-old girl: acute marijuana intoxication presenting as seizure.

Visit

Bonkowsky, J. L., Sarco, D., & Pomeroy, S. L

This is a case study of a young girl experiencing cannabis usage.

Key Study: Urine drug screens in overdose patients do not contribute to immediate clinical management

Visit

Montague REG, R. F.; Lewis, J. H.; Shenfield, G. M.

A prospective study assessed whether routine urine drug screens might alter the management of overdose patients.

Key Study: Substance abuse in adolescent trauma

Visit

Loiselle JMB, M. D.; Templeton, J. M., Jr.; Schwartz, G.; Drott, H.

To determine if there is a significant prevalence of drug or alcohol use among adolescents evaluated for significant acute trauma.

Key Study: Increased Testing and Health Care Costs for Pediatric Cannabis Exposures

Visit

Bashqoy FH, J. W.; Reiter, P. D.; Wang, G. S.; Borgelt, L. M.

This study aimed to evaluate the process of identifying marijuana exposure in a children's hospital emergency department and compare the cost of diagnostic testing and procedures.

Key Study: Acute cannabis toxicity

Visit

Noble MJH, K.; Hendrickson, R. G.

We describe the clinical effects of, and products associated with, acute exposures to cannabis during the early legalization period of recreational cannabis in Oregon and Alaska.

Key Study: A 21st Century Problem: Cannabis Toxicity in a 13-Month-Old Child

Visit

Levene RJP-C, Elza; Wolfram, Sigrid

We report the case of a 13-month-old female presenting with self-limiting altered mental status and lethargy, with a subsequent diagnosis of tetrahydrocannabinol exposure on confirmatory urine gas chromatography-mass spectrometry.

Key Study: Synthetic Cannabinoid Exposure in Adolescents Presenting for Emergency Care

Visit

Gilley MB, J.; Calello, D. P.; Wax, P.; Finkelstein, Y.; Toxicology Investiga...

The objective of this study was to characterize the clinical picture and management of synthetic cannabinoid exposure in a cohort of adolescents.

Key Study: Marijuana Misadventures in Children: Exploration of a Dose-Response Relationship and Summary of Clinical Effects and Outcomes

Visit

Heizer JWB, L. M.; Bashqoy, F.; Wang, G. S.; Reiter, P. D.

This study aimed to explore a dose-response relationship of delta-9-tetrahydrocannabinol (THC) in THC-nave children after unintentional acute exposure and compare clinical outcomes with non-nave children.

Key Study: Cannabis Intoxication Case Series: The Dangers of Edibles Containing Tetrahydrocannabinol

Visit

Vo KTH, H.; Li, K.; Ho, R. Y.; Wu, A. H. B.; Lynch, K. L.; Smollin, C. G.

Cannabis and its principal active constituent, 9-tetrahydrocannabinol (THC), are increasingly available as edibles resembling commercially available food products. In this case series, we describe a population of predominantly pediatric patients who were inadvertently exposed to a THC-containing product in San Francisco.

Key Study: Intoxicacin por cannabis en menores de 3 aos

Visit

Pinedo-Painous IG-R, Roser; Valls-Lafon, Anna; Muoz-Santanach, David; Martnez...

We present a retrospective, descriptive study of patients aged 3 years or younger who were treated for cannabis poisoning in a pediatric emergency department between 2012 and 2017.

Key Study: Longitudinal associations of social cognition and substance use in childhood and early adolescence: findings from the Avon Longitudinal Study of Parents and Children

Visit

Fluharty, M. E., Heron, J., & Munaf, M. R

We investigated both directions of association within an adolescent birth cohort: the association of social cognition with subsequent substance use, and the association of early substance use with subsequent social cognition

Key Study: Unintentional Cannabis Intoxication in Toddlers

Visit

Claudet IM, S.; Labadie, M.; Manin, C.; Michard-Lenoir, A. P.; Eyer, D.; Dufo...

We sought to evaluate the French national trend of admissions for unintentional cannabis intoxication in children over an 11-year period (20042014).

Key Study: A 10-year review of cannabis exposure in children under 3-years of age: do we need a more global approach?

Visit

Claudet, I., Le Breton, M., Brhin, C., & Franchitto, N

We carried out a retrospective cohort study of children admitted to a pediatric emergency department due to unintentional cannabis exposure over a 10-year period from 2004 to 2014.

Key Study: Drug Misuse in Adolescents Presenting to the Emergency Department

Visit

Finkelstein YG, G.; Hutson, J. R.; Armstrong, J.; Baum, C. R.; Wax, P.; Brent...

Drug misuse is a disturbing, common practice among youth. One in 4 American adolescents reports consuming prescription medications without a clinical indication. We sought to explore current trends of drug misuse in adolescents.

Key Study: Acute intoxication caused by synthetic cannabinoids 5F-ADB and MMB-2201: A case series

Visit

Barcelo BP, S.; Lopez-Corominas, V.; Gomila, I.; Yates, C.; Busardo, F. P.; P...

Here, we report five cases of acute intoxication by synthetic cannabinoids 5F-ADB and MMB-2201 with analytical confirmation

Key Study: Detecting biomarkers of secondhand marijuana smoke in young children

Visit

Wilson, K. M., Torok, M. R., Wei, B., Wang, L., Robinson, M., Sosnoff, C. S.,...

We studied children ages 1 mo to 2 y hospitalized with bronchiolitis in Colorado from 2013 to 2015.

Key Study: Unintentional Pediatric Exposures to Marijuana in Colorado, 2009-2015

Visit

George SamWang,MD1,2; Marie-ClaireLe Lait,MS2; Sara J.Deakyne,MPH3; et al

To compare the incidence of pediatric marijuana exposures evaluated at a children's hospital and regional poison center (RPC) in Colorado before and after recreational marijuana legalization and to compare population rate trends of RPC cases for marijuana exposures with the rest of the United States.

Key Study: Marijuana exposure among children younger than siz years in the United States

Visit

Onders B, Casavant MJ, Spiller HA, Chounthirath T, Smith GA

This study investigates marijuana exposures among children <6 years old in the United States using data from the National Poison Data System.

Key Study: Synthetic Cannabinoid Exposure

Visit

Adair AG, Spencer C.; Greeley, Christopher S.; Coleman, Ryan D.; Shekerdemian...

We present 2 cases of actual or highly suspected synthetic cannabinoid exposure in 2 pediatric patients to demonstrate the wide range of symptoms that can be present in these patients.

Key Study: Treat plays trick on a 3-year-old boy

Visit

Thuy Trang JNC, Arthur K.

Presents a case study of a 3 year old with acute cannabis intoxication.

Key Study: Changes in Cannabis Potency Over the Last 2 Decades (19952014): Analysis of Current Data in the United States

Visit

ElSohly, M. A., Mehmedic, Z., Foster, S., Gon, C., Chandra, S., & Church,...

This report examines the concentration of cannabinoids in illicit cannabis products seized by the U.S. Drug Enforcement Administration over the last 2 decades, with particular emphasis on (9)-tetrahydrocannabinol and cannabidiol.

Key Study: Non-Smoker Exposure to Secondhand Cannabis Smoke. I. Urine Screening and Confirmation Results

Visit

Cone, E. J., Bigelow, G. E., Herrmann, E. S., Mitchell, J. M., LoDico, C., Fl...

A systematic study was conducted of smoke exposure on drug-free participants.

Key Study: Non-smoker exposure to secondhand cannabis smoke II: Effect of room ventilation on the physiological, subjective, and behavioral/cognitive effects.

Visit

Herrmann, E. S., Cone, E. J., Mitchell, J. M., Bigelow, G. E., LoDico, C., Fl...

This report examines the concentration of cannabinoids in illicit cannabis products seized by the U.S. Drug Enforcement Administration over the last 2 decades, with particular emphasis on (9)-tetrahydrocannabinol and cannabidiol.

Key Study: Nonsmoker Exposure to Secondhand Cannabis Smoke. III. Oral Fluid and Blood Drug Concentrations and Corresponding Subjective Effects

Visit

Cone, E. J., Bigelow, G. E., Herrmann, E. S., Mitchell, J. M., LoDico, C., Fl...

The study was designed to produce extreme cannabis smoke exposure conditions tolerable to drug-free nonsmokers

Key Study: Accidental pediatric ingestions of medical marijuana: a 4-year poison center experience

Visit

Lovecchio, F., & Heise, C. W

A study of incidental pediatric cannabis consumption over a 4-year period.

Key Study: A cannabinoid-intoxicated child treated with dexmedetomidine: a case report

Visit

Cipriani, F., Mancino, A., Pulitan, S. M., Piastra, M., & Conti, G.

To our knowledge, this is the first reported case of dexmedetomidine use to support a cannabis intoxicated patient.

Key Study: The Impact of Marijuana Policies on Youth: Clinical, Research, and Legal Update

Visit

Ammerman, S., Ryan, S., Adelman, W. P., & THE COMMITTEE ON SUBSTANCE ABUS...

This technical report updates the 2004 American Academy of Pediatrics technical report on the legalization of marijuana

Key Study: Dangerous Relationships: Asthma and Substance Abuse

Visit

Caponnetto, P., Auditore, R., Russo, C., Alamo, A., Campagna, D., Demma, S., ...

The review emphasizes the importance for clinicians to be alert to the possibility of this substance as a precipitating factor for acute asthma.

Key Study: The Pharmacologic and Clinical Effects of Medical Cannabis

Visit

Borgelt, L. M., Franson, K. L., Nussbaum, A. M., & Wang, G. S.

This article will describe the pharmacology of cannabis, effects of various dosage formulations, therapeutics benefits and risks of cannabis for pain and muscle spasm, and safety concerns of medical cannabis use.

Key Study: Acute intoxication caused by a synthetic cannabinoid in two adolescents

Visit

Heath TSB, Z.; Thompson, A. J.; Tecklenburg, F. W.

In this report, we describe two adolescent patients admitted after they inhaled K2, resulting in loss of consciousness, tachycardia, and diffuse pain.

Key Study: Drug use and screening in pediatric trauma

Visit

Martin KLV, K. N.; Girotti, M. J.; Stewart, T. C.; Parry, N. G.

This article will describe the pharmacology of cannabis, effects of various dosage formulations, therapeutics benefits and risks of cannabis for pain and muscle spasm, and safety concerns of medical cannabis use.

Key Study: Sensitivity and Specificity of Urinary Cannabinoid Detection With Two Immunoassays After Controlled Oral Administration of Cannabinoids to Humans.

Visit

Grauwiler, S. B., Drewe, J., & Scholer, A.

This study aims to describe trends in substance use and screening in the Canadian pediatric trauma population.

Key Study: Ataxia and shaking in a 2-year-old girl: acute marijuana intoxication presenting as seizure.

Visit

Bonkowsky, J. L., Sarco, D., & Pomeroy, S. L

This is a case study of a young girl experiencing cannabis usage.

Key Study: Urine drug screens in overdose patients do not contribute to immediate clinical management

Visit

Montague REG, R. F.; Lewis, J. H.; Shenfield, G. M.

A prospective study assessed whether routine urine drug screens might alter the management of overdose patients.

Key Study: Substance abuse in adolescent trauma

Visit

Loiselle JMB, M. D.; Templeton, J. M., Jr.; Schwartz, G.; Drott, H.

To determine if there is a significant prevalence of drug or alcohol use among adolescents evaluated for significant acute trauma.

Concussion English (45) French All (45)

Key study: Association between ondansetron use and symptom persistence in children with concussions: A 5P substudy

Visit

Gravel J, Boutis K, Tang K, et al.

Ondansetron is increasingly administered to children suffering from concussion-associated nausea/vomiting. We examined the association between ondansetron administration and post-concussion symptoms in children at 1 week and 1 month following the concussion.

Key study: Association of time since injury to the first clinic visit with recovery following concussion

Visit

Kontos AP, Jorgensen-Wagers K, Trbovich AM, et al.

To investigate the association of time since injury with initiation of clinical care on recovery time following concussion.

Key study: Characteristics of concussion in elementary school-aged children: implications for clinical management

Visit

Master CL, Curry AE, Pfeiffer MR, et al.

To comprehensively characterize the clinical presentation and course of care for concussion among 5- to 11-year-old children, identifying preinjury and injury factors potentially influencing clinical outcomes.

Key study: Characteristics of diagnosed concussions in children aged 0 to 4 years presenting to a large pediatric healthcare network

Visit

Podolak OE, Chaudhary S, Haarbauer-Krupa J, et al.

The aim of the study was to comprehensively describe the natural history of concussion in early childhood between 0 and 4 years.

Key study: Concussion Guidelines Step 2: evidence for subtype classification

Visit

Lumba-Brown A, Teramoto M, Bloom OJ, et al.

Objective: To use evidence-based methodology to characterize the 5 concussion subtypes and 2 associated conditions and report their prevalence in acute concussion patients as compared to baseline or controls within 3 d of injury.

Key study: Concussion-symptom rating correlation between pediatric patients and their parents

Visit

Patsimas T, Howell DR, Potter MN, Potter MN, Provance AJ, Kirkwood MW, Wilson JC

To examine patient-parent correlations and agreement on concussion-symptom ratings, to identify differences in patient-parent symptom reporting between children (8-12 years of age) and adolescents (13-18 years of age), and to evaluate the correlation between patient and parent initial symptom-severity ratings with symptom duration and return-to-play time.

Key study: Continuing play, symptom severity, and symptom duration after concussion in youth athletes

Visit

Howell DR, O'Brien MJ, Fraser J, Meehan WP.

Objective: To determine whether continuing to play after a concussion is associated with higher symptom burden or prolonged symptom duration.

Key study: Delayed symptom onset following pediatric sport-related concussion

Visit

Olson A, Ellis MJ, Selci E, Russell K.

Objective: (1) To examine the prevalence of delayed symptom onset (DSO) among pediatric sport-related concussion (SRC) patients as well as the effect of symptom onset on initial symptom severity, length of recovery, and development of delayed recovery; (2) to evaluate the impact of symptom onset on sideline management.

Key study: Early versus delayed emergency department presentation following mild traumatic nrain injury and the presence of symptom at 1, 4 and 12 weeks in children

Visit

Gravel J, Ledoux AA, Tang K, et al.

We evaluated the association between timing of presentation and postconcussive symptoms (PCS) at 1, 4 and 12 weeks after injury.

Key study: Effect of cognitive and physical rest on persistent postconcussive symptoms following a pediatric head injury

Visit

Root JM, Sady MD, Gai J, Vaughan CG, Madati PJ

To evaluate the effect of cognitive and physical rest on persistent postconcussive symptoms in a pediatric population.

Key study: Participation in physical activity at time of presentation to a specialty concussion clinic is associated with shorter time to recovery

Visit

Coslick AM, Chin KE, Kalb LG, Slomine BS, Suskauer SJ.

To determine if level of physical activity at presentation to a rehabilitation-based concussion specialty clinic predicted days from injury to recovery.

Key study: Pediatric minor head injury imaging practices: results from an ESPR survey

Visit

Argyropoulou MI, Alexiou GA, Xydis VG, et al.

Objective: Computed tomography (CT) for minor head injury exposes a large number of children to ionizing radiation, with an associated increased lifetime risk of malignancy. To study imaging practices for children with minor head injury and the level of awareness of radiologists of the current clinical decision rules for minor traumatic brain injury (TBI).

Key study: Reliability of the visio-vestibular examination for concussion among providers in a pediatric emergency department

Visit

Corwin DJ, Arbogast KB, Swann C, et al.

Our objective was to determine the inter-rater (IRR) and test-retest reliability (TRR) of the VVE in a pediatric ED.

Key study: Trajectories and predictors of clinician-determined recovery after child concussion

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Anderson V, Davis GA, Takagi M, et al.

We mapped concussion recovery to 3 months post-injury and explored non-modifiable (e.g., age, sex, pre-injury factors, injury mechanism, acute PCS) and modifiable (post-acute child symptoms) predictors of persisting symptoms in order to identify opportunities for early intervention.

Key study: Use of the sport concussion assessment tools in the emergency department to predict persistent post-concussive symptoms in children

Visit

Bressan S, Clarke CJ, Anderson V, et al.

We aim to assess the predictive value of the main SCAT3/ChildSCAT3 components for PPCS when applied in the ED.

Key study: A longitudinal investigation of sleep and daytime wakefulness in children and youth with concussion

Visit

Wiseman-Hakes C, Gosselin N, Sharma B, Langer L, Gagnon I.

In this study, we investigated the trajectory of sleep and daytime sleepiness in a prospective cohort of 40 children and youth (6-18 years old) with concussion, 40 age-and sex-matched healthy children and youth, and 40 with upper-extremity orthopedic injury.

Key study: Admission of pediatric concussion injury patients: is it necessary?

Visit

Lindholm EB, DCruz R, Fajardo R, et al.

The purpose of this study was to determine if pediatric patients evaluated in the emergency department (ED) for concussion with a negative head CT scan require routine hospital admission.

Key study: Concussion symptom profiles among child, adolescent, and young adult athletes

Visit

Howell DR, Kriz P, Mannix RC, Kirchberg T, Master C L, Meehan WP

(1) To examine how age influences initial symptom presentation following concussion; and (2) to determine whether specific symptom profiles are associated with duration of postconcussion symptoms, and whether they vary by age group.

Key study: Delayed presentations to emergency departments of children with head injury: A PREDICT Study

Visit

Borland ML, Dalziel SR, Phillips N, et al.

Objective: Existing clinical decision rules guide management for head-injured children presenting 24 hours or sooner after injury, even though some may present greater than 24 hours afterward. We seek to determine the prevalence of traumatic brain injuries for patients presenting to emergency departments greater than 24 hours after injury and identify symptoms and signs to guide management.

Key study: Derivation and initial validation of clinical phenotypes of children presenting with concussion acutely in the emergency department: latent class analysis of a multi-center, prospective cohort, observational study

Visit

Yeates KO, Tang K, Barrowman N, et al.

This study used latent class analysis (LCA) to identify discernible phenotypes among children with acute concussion and examine the association between phenotypes and persistent post-concussive symptoms (PPCS) at 4 and 12 weeks post-injury. We conducted LCA of variables representing pre-injury history, clinical presentation, and parent symptom ratings, derived from a prospective cohort, observational study that recruited participants from August 2013 until June 2015 at nine pediatric emergency departments within the Pediatric Emergency Research Canada network.

Key study: Early subthreshold aerobic exercise for sport-related concussion: a randomized clinical trial

Visit

Leddy JJ, Haider MN, Ellis MJ, et al.

To assess the effectiveness of subsymptom threshold aerobic exercise vs a placebo-like stretching program prescribed to adolescents in the acute phase of recovery from SRC.

Key study: Insomnia in adolescents with slow recovery from concussion

Visit

Brooks BL, Sayers PQ, Virani S, Rajaram AA, Tomfohr-Madsen L.

This study examined: 1) some of the psychometric properties of the Insomnia Severity Index (ISI), 2) the prevalence and severity of insomnia symptoms, and 3) associations between insomnia symptoms and clinical measures of post-concussion symptoms, mental health symptoms, and cognitive tests in adolescents with slow recovery from concussion.

Key study: Low-value diagnostic imaging use in the pediatric emergency department in the United States and Canada

Visit

Cohen E, Rodean J, Diong C, et al.

Objective To compare overall and low-value use of diagnostic imaging across pediatric ED visits in Ontario, Canada, and the United States.

Key study: Natural progression of symptom change and recovery from concussion in a pediatric population

Visit

Ledoux AA, Tang K, Yeates KO, et al.

Objectives: To describe the natural progression of symptom change by age group (5-7, 8-12, and 13-18 years) and sex, as well as to develop centile curves to inform families about children after injury recovery.

Key study: Persistent vestibular-ocular impairment following concussion in adolescents

Visit

Sinnott AM, Elbin RJ, Collins MW, Reeves VL, Holland CL, Kontos AP.

Objectives: The current study investigated the role of persistent vestibular-ocular symptoms and impairment following sport-related concussion on recovery time and clinical outcomes among adolescents.

Key study: Physical activity after mild traumatic brain injury: what are the relationships with fatigue and sleep quality?

Visit

van Markus-Doornbosch F, Peeters E, van der Pas S, Vlieland TV, Meesters J.

To determine self-reported physical activity (PA) levels and relationships with fatigue and sleep quality in adolescents and young adults after mild traumatic brain injury (mTBI).

Key study: Practice patterns in pharmacological and non-pharmacological therapies for children with mild traumatic brain injury: a survey of 15 canadian and United States centers

Visit

Mannix R, Zemek R, Yeates KO, et al.

Given the lack of evidence regarding effective pharmacological and non-pharmacological interventions for pediatric mild traumatic brain injury (mTBI) and the resultant lack of treatment recommendations reflected in consensus guidelines, variation in the management of pediatric mTBI is to be expected. We therefore surveyed practitioners across 15 centers in the United States and Canada who care for children with pediatric mTBI to evaluate common-practice variation in the management of pediatric mTBI.

Key study: Quality of life and symptom burden 1 month after concussion in children and adolescents

Visit

Howell DR, Wilson JC, Kirkwood MW, Grubenhoff JA.

We conducted a prospective study of children and adolescents (n = 176; mean age = 13.0 2.7 years; 38% female) assessed acutely post-concussion and again 30 days later. We investigated the association between symptom burden and quality of life (QOL) outcomes, as well as the effect of age on QOL.

Key study: Reduction of computed tomography use for pediatric closed head injury evaluation at a nonpediatric community emergency department

Visit

Puffenbarger MS, Ahmad FA, Argent M, Gu H, Samson C, Quayle KS, Saito JM.

The purpose of this study was to determine if implementation of a Pediatric Emergency Care Applied Research Network (PECARN)-based Closed Head Injury Assessment Tool could safely decrease computed tomography (CT) use for pediatric head injury evaluation at a nonpediatric community emergency department (ED).

Key study: Risk factors for prolonged symptoms of mild traumatic brain injury: a pediatric sports concussion clinic cohort

Visit

Fehr SD, Nelson LD, Scharer KR, et al.

To examine predictors of prolonged symptom duration from mild traumatic brain injury (mTBI) in a pediatric sports medicine specialty clinic cohort as these predictors may be distinct in this population.

Key study: Trouble falling asleep after concussion is associated with higher symptom burden among children and adolescents

Visit

Howell DR, Oldham JR, Brilliant AN, Meehan WP.

Our objective was to identify factors associated with trouble falling asleep postconcussion.

Key study: Use of the vestibular and oculomotor examination for concussion in a pediatric emergency department

Visit

Corwin DJ, Propert KJ, Zorc JJ, Zonfrillo MR, Wiebe DJ.

We aimed to measure rates of exam performance after implementation of training and support tools in a pediatric emergency department.

Key study: What comes first: return to school or return to activity for youth after concussion? Maybe we dont have to choose.

Visit

DeMatteo CA, Randall S, Lin CA, Claridge EA.

This study investigates recovery trajectories of children/youth while following RTA and RTS protocols simultaneously, with the following objectives: (1) to compare rates and patterns of progression through the stages of both protocols; (2) to evaluate symptom trajectories of youth post-concussion while progressing through stages of RTS and RTA; and (3) to propose a new model for concussion management in youth that involves the integration of Return to Activity and Return to School protocols.

Key study: Characterizing hospitalizations for pediatric concussion and trends in care

Visit

Rhine T, Byczkowski T, Altaye M, Wade SL, Babcock L.

Objective: Delineate a cohort of children admitted for concussion, describe care practices received, examine factors associated with prolonged length of stay (LOS) or emergency department (ED) readmission, and investigate changes in care over time.

Key study: Identifying persistent postconcussion symptom risk in a pediatric sports medicine clinic

Visit

Howell DR, Zemek R, Brilliant AN, Mannix RC, Master CL, Meehan WP.

To determine if the Predicting Persistent Post-concussive Problems in Pediatrics (5P) clinical risk score, an emergency department (ED)derived and validated tool, is associated with developing PPCS when obtained in a primary care sports concussion setting.

Key study: MRI in mild pediatric traumatic brain injury: diagnostic overkill or useful tool?

Visit

Cohrs, G., Huhndorf, M., Niemczyk, N. et al.

Magnetic resonance imaging (MRI) is a sensitive imaging tool which lacks the burden of ionizing radiation. It is not established as primary diagnostic tool in traumatic brain injury (TBI). The purpose of this study was to evaluate the usefulness of MRI as initial imaging modality in the emergency management of mild pediatric TBI.

Key study: No association between metoclopramide treatment in ED and reduced risk of post-concussion headache

Visit

Bresee N, Aglipay M, Dubrovsky AS, et al.

There is a lack of definitive pediatric literature on effective pharmacotherapy for persistent post-concussion headache symptoms. This study assessed whether acute metoclopramide treatment in the Emergency Department (ED) was associated with a reduction in persistent headache in children at 1- and 4-weeks post-concussion.

Key study: Resumption of physical activity within 7 days of a concussion was associated with lower rates of persistent postconcussive symptoms (PPCS)

Visit

Kanani AN, Hartshorn S.

A planned secondary analysis of nine pediatric emergency departments of return to physical activity within 7 days postinjury (ranging from light exercise to a full return to competitive sports).

Key study: The diagnosis of concussion in pediatric emergency departments: a prospective multicenter study

Visit

Boutis K, Gravel J, Freedman SB, et al.

Objectives: We compared the frequency of persistent concussion symptoms in children who were provided the diagnosis of concussion by an emergency physician versus those who met Berlin/Zurich international criteria for this diagnosis. We also determined the clinical variables independently associated with a physician-diagnosed concussion.

Key study: Vision and vestibular system dysfunction predicts prolonged concussion recovery in children

Visit

Master CL, Master SR, Wiebe DJ, et al.

Objective: Up to one-third of children with concussion have prolonged symptoms lasting beyond 4 weeks. Vision and vestibular dysfunction is common after concussion. It is unknown whether such dysfunction predicts prolonged recovery. We sought to determine which vision or vestibular problems predict prolonged recovery in children.

Key study: Symptom-guided emergency department discharge instructions for children with concussion

Visit

Brooks TM, Smith MM, Silvis RM, et al.

Objectives: The objective was to evaluate the use and utility of a novel set of emergency department discharge instructions (DIs) for concussion based on a child's ongoing symptoms: symptom-guided DIs (symptom DIs). Differences in clinical outcomes were also assessed.

Key study: The Child Sport Concussion Assessment Tool 5th Edition (Child SCAT5): Background and rationale

Visit

Davis GA, Purcell L, Schneider KJ, et al.

This article presents the Child Sport Concussion Assessment Tool 5th Edition (Child SCAT5). The Sport Concussion Assessment Tool was introduced in 2004, following the 2nd International Conference on Concussion in Sport in Prague, Czech Republic.

Key Study: Clinical risk score for persistent postconcussion symptoms among children with acute concussion in the ED

Visit

Zemek R, Barrowman N, Freedman SB, Gravel J, Gagnon I, McGahern C, Aglipay M,...

Objective: To derive and validate a clinical risk score for persistent postconcussion symptoms among children presenting to the emergency department.

Key study: Association between early participation in physical activity following acute concussion and persistent postconcussive symptoms in children and adolescents

Visit

Grool AM, Aglipay M, Momoli F, et al.

To investigate the association between participation in physical activity within 7 days postinjury and incidence of persistent postconcussive symptoms (PPCS).

Key Study: Comparison of PECARN, CATCH, and CHALICE rules for children with minor head injury: a prospective cohort study

Visit

Easter JS, Bakes K, Dhaliwal J, Miller M, Caruso E, Haukoos JS

Objective: To evaluate the diagnostic accuracy of clinical decision rules and physician judgment for identifying clinically important traumatic brain injuries in children with minor head injuries presenting to the emergency department.

Key study: Association between ondansetron use and symptom persistence in children with concussions: A 5P substudy

Visit

Gravel J, Boutis K, Tang K, et al.

Ondansetron is increasingly administered to children suffering from concussion-associated nausea/vomiting. We examined the association between ondansetron administration and post-concussion symptoms in children at 1 week and 1 month following the concussion.

Key study: Association of time since injury to the first clinic visit with recovery following concussion

Visit

Kontos AP, Jorgensen-Wagers K, Trbovich AM, et al.

To investigate the association of time since injury with initiation of clinical care on recovery time following concussion.

Key study: Characteristics of concussion in elementary school-aged children: implications for clinical management

Visit

Master CL, Curry AE, Pfeiffer MR, et al.

To comprehensively characterize the clinical presentation and course of care for concussion among 5- to 11-year-old children, identifying preinjury and injury factors potentially influencing clinical outcomes.

Key study: Characteristics of diagnosed concussions in children aged 0 to 4 years presenting to a large pediatric healthcare network

Visit

Podolak OE, Chaudhary S, Haarbauer-Krupa J, et al.

The aim of the study was to comprehensively describe the natural history of concussion in early childhood between 0 and 4 years.

Key study: Concussion Guidelines Step 2: evidence for subtype classification

Visit

Lumba-Brown A, Teramoto M, Bloom OJ, et al.

Objective: To use evidence-based methodology to characterize the 5 concussion subtypes and 2 associated conditions and report their prevalence in acute concussion patients as compared to baseline or controls within 3 d of injury.

Key study: Concussion-symptom rating correlation between pediatric patients and their parents

Visit

Patsimas T, Howell DR, Potter MN, Potter MN, Provance AJ, Kirkwood MW, Wilson JC

To examine patient-parent correlations and agreement on concussion-symptom ratings, to identify differences in patient-parent symptom reporting between children (8-12 years of age) and adolescents (13-18 years of age), and to evaluate the correlation between patient and parent initial symptom-severity ratings with symptom duration and return-to-play time.

Key study: Continuing play, symptom severity, and symptom duration after concussion in youth athletes

Visit

Howell DR, O'Brien MJ, Fraser J, Meehan WP.

Objective: To determine whether continuing to play after a concussion is associated with higher symptom burden or prolonged symptom duration.

Key study: Delayed symptom onset following pediatric sport-related concussion

Visit

Olson A, Ellis MJ, Selci E, Russell K.

Objective: (1) To examine the prevalence of delayed symptom onset (DSO) among pediatric sport-related concussion (SRC) patients as well as the effect of symptom onset on initial symptom severity, length of recovery, and development of delayed recovery; (2) to evaluate the impact of symptom onset on sideline management.

Key study: Early versus delayed emergency department presentation following mild traumatic nrain injury and the presence of symptom at 1, 4 and 12 weeks in children

Visit

Gravel J, Ledoux AA, Tang K, et al.

We evaluated the association between timing of presentation and postconcussive symptoms (PCS) at 1, 4 and 12 weeks after injury.

Key study: Effect of cognitive and physical rest on persistent postconcussive symptoms following a pediatric head injury

Visit

Root JM, Sady MD, Gai J, Vaughan CG, Madati PJ

To evaluate the effect of cognitive and physical rest on persistent postconcussive symptoms in a pediatric population.

Key study: Participation in physical activity at time of presentation to a specialty concussion clinic is associated with shorter time to recovery

Visit

Coslick AM, Chin KE, Kalb LG, Slomine BS, Suskauer SJ.

To determine if level of physical activity at presentation to a rehabilitation-based concussion specialty clinic predicted days from injury to recovery.

Key study: Pediatric minor head injury imaging practices: results from an ESPR survey

Visit

Argyropoulou MI, Alexiou GA, Xydis VG, et al.

Objective: Computed tomography (CT) for minor head injury exposes a large number of children to ionizing radiation, with an associated increased lifetime risk of malignancy. To study imaging practices for children with minor head injury and the level of awareness of radiologists of the current clinical decision rules for minor traumatic brain injury (TBI).

Key study: Reliability of the visio-vestibular examination for concussion among providers in a pediatric emergency department

Visit

Corwin DJ, Arbogast KB, Swann C, et al.

Our objective was to determine the inter-rater (IRR) and test-retest reliability (TRR) of the VVE in a pediatric ED.

Key study: Trajectories and predictors of clinician-determined recovery after child concussion

Visit

Anderson V, Davis GA, Takagi M, et al.

We mapped concussion recovery to 3 months post-injury and explored non-modifiable (e.g., age, sex, pre-injury factors, injury mechanism, acute PCS) and modifiable (post-acute child symptoms) predictors of persisting symptoms in order to identify opportunities for early intervention.

Key study: Use of the sport concussion assessment tools in the emergency department to predict persistent post-concussive symptoms in children

Visit

Bressan S, Clarke CJ, Anderson V, et al.

We aim to assess the predictive value of the main SCAT3/ChildSCAT3 components for PPCS when applied in the ED.

Key study: A longitudinal investigation of sleep and daytime wakefulness in children and youth with concussion

Visit

Wiseman-Hakes C, Gosselin N, Sharma B, Langer L, Gagnon I.

In this study, we investigated the trajectory of sleep and daytime sleepiness in a prospective cohort of 40 children and youth (6-18 years old) with concussion, 40 age-and sex-matched healthy children and youth, and 40 with upper-extremity orthopedic injury.

Key study: Admission of pediatric concussion injury patients: is it necessary?

Visit

Lindholm EB, DCruz R, Fajardo R, et al.

The purpose of this study was to determine if pediatric patients evaluated in the emergency department (ED) for concussion with a negative head CT scan require routine hospital admission.

Key study: Concussion symptom profiles among child, adolescent, and young adult athletes

Visit

Howell DR, Kriz P, Mannix RC, Kirchberg T, Master C L, Meehan WP

(1) To examine how age influences initial symptom presentation following concussion; and (2) to determine whether specific symptom profiles are associated with duration of postconcussion symptoms, and whether they vary by age group.

Key study: Delayed presentations to emergency departments of children with head injury: A PREDICT Study

Visit

Borland ML, Dalziel SR, Phillips N, et al.

Objective: Existing clinical decision rules guide management for head-injured children presenting 24 hours or sooner after injury, even though some may present greater than 24 hours afterward. We seek to determine the prevalence of traumatic brain injuries for patients presenting to emergency departments greater than 24 hours after injury and identify symptoms and signs to guide management.

Key study: Derivation and initial validation of clinical phenotypes of children presenting with concussion acutely in the emergency department: latent class analysis of a multi-center, prospective cohort, observational study

Visit

Yeates KO, Tang K, Barrowman N, et al.

This study used latent class analysis (LCA) to identify discernible phenotypes among children with acute concussion and examine the association between phenotypes and persistent post-concussive symptoms (PPCS) at 4 and 12 weeks post-injury. We conducted LCA of variables representing pre-injury history, clinical presentation, and parent symptom ratings, derived from a prospective cohort, observational study that recruited participants from August 2013 until June 2015 at nine pediatric emergency departments within the Pediatric Emergency Research Canada network.

Key study: Early subthreshold aerobic exercise for sport-related concussion: a randomized clinical trial

Visit

Leddy JJ, Haider MN, Ellis MJ, et al.

To assess the effectiveness of subsymptom threshold aerobic exercise vs a placebo-like stretching program prescribed to adolescents in the acute phase of recovery from SRC.

Key study: Insomnia in adolescents with slow recovery from concussion

Visit

Brooks BL, Sayers PQ, Virani S, Rajaram AA, Tomfohr-Madsen L.

This study examined: 1) some of the psychometric properties of the Insomnia Severity Index (ISI), 2) the prevalence and severity of insomnia symptoms, and 3) associations between insomnia symptoms and clinical measures of post-concussion symptoms, mental health symptoms, and cognitive tests in adolescents with slow recovery from concussion.

Key study: Low-value diagnostic imaging use in the pediatric emergency department in the United States and Canada

Visit

Cohen E, Rodean J, Diong C, et al.

Objective To compare overall and low-value use of diagnostic imaging across pediatric ED visits in Ontario, Canada, and the United States.

Key study: Natural progression of symptom change and recovery from concussion in a pediatric population

Visit

Ledoux AA, Tang K, Yeates KO, et al.

Objectives: To describe the natural progression of symptom change by age group (5-7, 8-12, and 13-18 years) and sex, as well as to develop centile curves to inform families about children after injury recovery.

Key study: Persistent vestibular-ocular impairment following concussion in adolescents

Visit

Sinnott AM, Elbin RJ, Collins MW, Reeves VL, Holland CL, Kontos AP.

Objectives: The current study investigated the role of persistent vestibular-ocular symptoms and impairment following sport-related concussion on recovery time and clinical outcomes among adolescents.

Key study: Physical activity after mild traumatic brain injury: what are the relationships with fatigue and sleep quality?

Visit

van Markus-Doornbosch F, Peeters E, van der Pas S, Vlieland TV, Meesters J.

To determine self-reported physical activity (PA) levels and relationships with fatigue and sleep quality in adolescents and young adults after mild traumatic brain injury (mTBI).

Key study: Practice patterns in pharmacological and non-pharmacological therapies for children with mild traumatic brain injury: a survey of 15 canadian and United States centers

Visit

Mannix R, Zemek R, Yeates KO, et al.

Given the lack of evidence regarding effective pharmacological and non-pharmacological interventions for pediatric mild traumatic brain injury (mTBI) and the resultant lack of treatment recommendations reflected in consensus guidelines, variation in the management of pediatric mTBI is to be expected. We therefore surveyed practitioners across 15 centers in the United States and Canada who care for children with pediatric mTBI to evaluate common-practice variation in the management of pediatric mTBI.

Key study: Quality of life and symptom burden 1 month after concussion in children and adolescents

Visit

Howell DR, Wilson JC, Kirkwood MW, Grubenhoff JA.

We conducted a prospective study of children and adolescents (n = 176; mean age = 13.0 2.7 years; 38% female) assessed acutely post-concussion and again 30 days later. We investigated the association between symptom burden and quality of life (QOL) outcomes, as well as the effect of age on QOL.

Key study: Reduction of computed tomography use for pediatric closed head injury evaluation at a nonpediatric community emergency department

Visit

Puffenbarger MS, Ahmad FA, Argent M, Gu H, Samson C, Quayle KS, Saito JM.

The purpose of this study was to determine if implementation of a Pediatric Emergency Care Applied Research Network (PECARN)-based Closed Head Injury Assessment Tool could safely decrease computed tomography (CT) use for pediatric head injury evaluation at a nonpediatric community emergency department (ED).

Key study: Risk factors for prolonged symptoms of mild traumatic brain injury: a pediatric sports concussion clinic cohort

Visit

Fehr SD, Nelson LD, Scharer KR, et al.

To examine predictors of prolonged symptom duration from mild traumatic brain injury (mTBI) in a pediatric sports medicine specialty clinic cohort as these predictors may be distinct in this population.

Key study: Trouble falling asleep after concussion is associated with higher symptom burden among children and adolescents

Visit

Howell DR, Oldham JR, Brilliant AN, Meehan WP.

Our objective was to identify factors associated with trouble falling asleep postconcussion.

Key study: Use of the vestibular and oculomotor examination for concussion in a pediatric emergency department

Visit

Corwin DJ, Propert KJ, Zorc JJ, Zonfrillo MR, Wiebe DJ.

We aimed to measure rates of exam performance after implementation of training and support tools in a pediatric emergency department.

Key study: What comes first: return to school or return to activity for youth after concussion? Maybe we dont have to choose.

Visit

DeMatteo CA, Randall S, Lin CA, Claridge EA.

This study investigates recovery trajectories of children/youth while following RTA and RTS protocols simultaneously, with the following objectives: (1) to compare rates and patterns of progression through the stages of both protocols; (2) to evaluate symptom trajectories of youth post-concussion while progressing through stages of RTS and RTA; and (3) to propose a new model for concussion management in youth that involves the integration of Return to Activity and Return to School protocols.

Key study: Characterizing hospitalizations for pediatric concussion and trends in care

Visit

Rhine T, Byczkowski T, Altaye M, Wade SL, Babcock L.

Objective: Delineate a cohort of children admitted for concussion, describe care practices received, examine factors associated with prolonged length of stay (LOS) or emergency department (ED) readmission, and investigate changes in care over time.

Key study: Identifying persistent postconcussion symptom risk in a pediatric sports medicine clinic

Visit

Howell DR, Zemek R, Brilliant AN, Mannix RC, Master CL, Meehan WP.

To determine if the Predicting Persistent Post-concussive Problems in Pediatrics (5P) clinical risk score, an emergency department (ED)derived and validated tool, is associated with developing PPCS when obtained in a primary care sports concussion setting.

Key study: MRI in mild pediatric traumatic brain injury: diagnostic overkill or useful tool?

Visit

Cohrs, G., Huhndorf, M., Niemczyk, N. et al.

Magnetic resonance imaging (MRI) is a sensitive imaging tool which lacks the burden of ionizing radiation. It is not established as primary diagnostic tool in traumatic brain injury (TBI). The purpose of this study was to evaluate the usefulness of MRI as initial imaging modality in the emergency management of mild pediatric TBI.

Key study: No association between metoclopramide treatment in ED and reduced risk of post-concussion headache

Visit

Bresee N, Aglipay M, Dubrovsky AS, et al.

There is a lack of definitive pediatric literature on effective pharmacotherapy for persistent post-concussion headache symptoms. This study assessed whether acute metoclopramide treatment in the Emergency Department (ED) was associated with a reduction in persistent headache in children at 1- and 4-weeks post-concussion.

Key study: Resumption of physical activity within 7 days of a concussion was associated with lower rates of persistent postconcussive symptoms (PPCS)

Visit

Kanani AN, Hartshorn S.

A planned secondary analysis of nine pediatric emergency departments of return to physical activity within 7 days postinjury (ranging from light exercise to a full return to competitive sports).

Key study: The diagnosis of concussion in pediatric emergency departments: a prospective multicenter study

Visit

Boutis K, Gravel J, Freedman SB, et al.

Objectives: We compared the frequency of persistent concussion symptoms in children who were provided the diagnosis of concussion by an emergency physician versus those who met Berlin/Zurich international criteria for this diagnosis. We also determined the clinical variables independently associated with a physician-diagnosed concussion.

Key study: Vision and vestibular system dysfunction predicts prolonged concussion recovery in children

Visit

Master CL, Master SR, Wiebe DJ, et al.

Objective: Up to one-third of children with concussion have prolonged symptoms lasting beyond 4 weeks. Vision and vestibular dysfunction is common after concussion. It is unknown whether such dysfunction predicts prolonged recovery. We sought to determine which vision or vestibular problems predict prolonged recovery in children.

Key study: Symptom-guided emergency department discharge instructions for children with concussion

Visit

Brooks TM, Smith MM, Silvis RM, et al.

Objectives: The objective was to evaluate the use and utility of a novel set of emergency department discharge instructions (DIs) for concussion based on a child's ongoing symptoms: symptom-guided DIs (symptom DIs). Differences in clinical outcomes were also assessed.

Key study: The Child Sport Concussion Assessment Tool 5th Edition (Child SCAT5): Background and rationale

Visit

Davis GA, Purcell L, Schneider KJ, et al.

This article presents the Child Sport Concussion Assessment Tool 5th Edition (Child SCAT5). The Sport Concussion Assessment Tool was introduced in 2004, following the 2nd International Conference on Concussion in Sport in Prague, Czech Republic.

Key Study: Clinical risk score for persistent postconcussion symptoms among children with acute concussion in the ED

Visit

Zemek R, Barrowman N, Freedman SB, Gravel J, Gagnon I, McGahern C, Aglipay M,...

Objective: To derive and validate a clinical risk score for persistent postconcussion symptoms among children presenting to the emergency department.

Key study: Association between early participation in physical activity following acute concussion and persistent postconcussive symptoms in children and adolescents

Visit

Grool AM, Aglipay M, Momoli F, et al.

To investigate the association between participation in physical activity within 7 days postinjury and incidence of persistent postconcussive symptoms (PPCS).

Key Study: Comparison of PECARN, CATCH, and CHALICE rules for children with minor head injury: a prospective cohort study

Visit

Easter JS, Bakes K, Dhaliwal J, Miller M, Caruso E, Haukoos JS

Objective: To evaluate the diagnostic accuracy of clinical decision rules and physician judgment for identifying clinically important traumatic brain injuries in children with minor head injuries presenting to the emergency department.

Congenital Heart Defect English (17) French All (17)

Overview of studies: Congenital Heart Disease In Pediatric Patients: Recognizing The Undiagnosed And Managing Complications In The Emergency Department

Visit

Judge P, Meckler G

Objective: This review focuses on the recognition and initial management of patients with undiagnosed congenital heart disease presenting to the ED and touches on considerations for postoperative infants and children with complex congenital heart disease.

Key Study: The Critically Ill Infant with Congenital Heart Disease

Visit

Strobel, AM & Lu, N.

Objective: This article presents an approach for identification of infants with congenital heart disorders.

Key Study: Reappraisal of the prostaglandin E1 dose for early newborns with patent ductus arteriosus-dependent pulmonary circulation

Visit

Huang FK, Lin CC, Huang TC, Weng KP, Liu PY, Chen YY, Wang HP, Ger LP, Hsieh KS

Objective: To review our experience of a low initial dose of PGE1 treatment in early newborns with congenital heart disease and patent ductus arteriosus (PDA)-dependent pulmonary flow.

Key Study: Congenital heart disease

Visit

Dolbec K, Mick NW

This publication provides an overview of the presentations of congenital heart defects, and makes diagnosis and management recommendations for emergency physicians.

Key Study: Impact of oxygen saturation targets and oxygen therapy during the transport of neonates with clinically suspected congenital heart disease

Visit

Shivananda S, Kirsh J, Whyte HE, Muthalally K, McNamara PJ

Objective: To determine the effect of average SpO(2) range and oxygen administration during neonatal transport on clinical markers of cardiovascular instability.

Key Study: Approach to diagnosing congenital cardiac disorders

Visit

Hartas GA, Tsounias E, Gupta-Malhotra M

Objective: To give a general picture of the diagnostic approach to a multitude of heart defects.

Key Study: To intubate or not to intubate? Transporting infants on prostaglandin E1

Visit

Meckler GD, Lowe C

This document describes the pretransport and transport management of infants receiving prostaglandin E(1) infusion for congenital heart disease and compares transport complications among unintubated and electively intubated infants.

Overview of studies: Emergency presentation of congenital heart disease in children

Visit

EB Medicine

Objective: To address the evaluation and management of pediatric patients with congenital heart defects in the context of the evidence available from the medical literature.

Key Study: Lessons from transporting newborn infants with known or suspected congenital heart disease

Visit

Bouchut JC, Teyssedre S

This study presents the results of an evaluation of transporting, by a nonspecialized emergency medical service, neonates with known or suspected cardiac abnormalities.

Key Study: Evaluation and management of the cyanotic neonate

Visit

Steinhorn RH

This document discusses the potential challenges in recognizing cyanosis, including the presence of higher concentrations of fetal hemoglobin, and its oxygen binding characteristics.

Key Study: Transporting newborn infants with suspected duct dependent congenital heart disease on low-dose prostaglandin E1 without routine mechanical ventilation

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Browning Carmo KA, Barr P, West M, Hopper NW, White JP, Badawi N

Objective: To evaluate the safety of transporting newborn infants with suspected duct dependent congenital heart disease (CHD) treated with prostaglandin E1 (PGE1) without routine mechanical ventilation.

Key Study: Cardiac emergencies in the first year of life

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Yee L

This document discusses the most common causes of cyanotic and acyanotic heart disease in infants.

Key Study: ABC of clinical electrocardiography: Paediatric electrocardiography

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Goodacre S, McLeod K

General clinicians and junior paediatricians may have little experience of interpreting paediatric electrocardiograms. Although the basic principles of cardiac conduction and depolarisation are the same as for adults, age related changes in the anatomy and physiology of infants and children produce normal ranges for electrocardiographic features that differ from adults and vary with age. Awareness of these differences is the key to correct interpretation of paediatric electrocardiograms.

Key Study: Management of the neonate with symptomatic congenital heart disease

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Penny DJ, Shekerdemian LS

This document addresses some of the principles on which resuscitation and stabilisation of the symptomatic neonate with congenital heart disease may be based.

Key Study: Prevalence and clinical significance of cardiac murmurs in neonates

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Ainsworth S, Wyllie JP, Wren C