Procedural Sedation Cochrane Pediatric Emergency Medicine Reviews

Procedural sedation and analgesia, commonly referred to as “sedation,” is a treatment strategy to relieve pain, anxiety and suppress patient movements during diagnostic and therapeutic procedures by administering anxiolytic, sedative, analgesic, and/or dissociative drugs. The goal is to minimize patient awareness and discomfort while maintaining patient safety. Sedation depth should vary in accordance with the specific needs of the patient and procedure.

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Cochrane Systematic Review: EMLA and Amethocaine for reduction of children's pain associated with needle insertion


Lander JA, Weltman BJ, So SS

OBJECTIVES: To compare the topical anaesthetics amethocaine and an eutectic mixture of local anaesthetics (EMLA) in terms of anaesthetic efficacy, ease of needle insertion and adverse events when used for intravenous cannulation and venipuncture in children.

Cochrane Systematic Review: Local anaesthetic sympathetic blockade for complex regional pain syndrome


Stanton TR, Wand BM, Carr DB, Birklein F, Wasner GL, O'Connell NE

OBJECTIVES: To assess the efficacy of LASB for the treatment of pain in CRPS and to evaluate the incidence of adverse effects of the procedure.

Cochrane Systematic Review: Topical anaesthetics for repair of dermal laceration


Eidelman A, Weiss JM, Baldwin CL, Enu IK, McNicol ED, Carr DB

OBJECTIVES: To compare the efficacy and safety of infiltrated local anaesthetics with those of topical local anaesthetics for repair of dermal lacerations and to evaluate the efficacy and safety of various single or multi-component topical anaesthetics to identify cocaine-free topically applied local anaesthetics that may provide equivalent analgesia to those containing cocaine.

Cochrane Systematic Review: Local anaesthetics and regional anaesthesia for preventing chronic pain after surgery


Andreae MH, Andreae DA

OBJECTIVES: To compare local anaesthetics and regional anaesthesia versus conventional analgesia for the prevention of persistent pain six or 12 months after surgery.

Cochrane Systematic Review: Sweet-tasting solutions for needle-related procedural pain in infants one month to one year of age


Kassab M, Foster JP, Foureur M, Fowler C

OBJECTIVES: To determine the effectiveness of sweet-tasting solutions for needle-related procedural pain in infants one month to one year of age compared with no treatment, placebo, other sweet-tasting solutions, or pharmacological or other non-pharmacological pain-relieving methods.