Cochrane Systematic Review: Oral calorie supplements for cystic fibrosis
Smyth RL, Walters S
Smyth RL, Walters S
OBJECTIVES: To establish whether in people with CF, oral calorie supplements: increase daily calorie intake; and improve overall nutritional intake, nutritional indices, lung function, survival and quality of life. To assess adverse effects associated with using these supplements.
OBJECTIVES: To establish whether in people with CF, oral calorie supplements: increase daily calorie intake; and improve overall nutritional intake, nutritional indices, lung function, survival and quality of life. To assess adverse effects associated with using these supplements.
Cochrane Systematic Review: Newborn screening for cystic fibrosis
Southern KW, Mrelle MM, Dankert-Roelse JE, Nagelkerke AD
Southern KW, Mrelle MM, Dankert-Roelse JE, Nagelkerke AD
OBJECTIVES: To examine whether newborn screening for CF prevents or reduces irreversible organ damage and improves clinical outcomes, quality of life and survival in people with CF without unacceptable adverse effects.
OBJECTIVES: To examine whether newborn screening for CF prevents or reduces irreversible organ damage and improves clinical outcomes, quality of life and survival in people with CF without unacceptable adverse effects.
Cochrane Systematic Review: Oral non-steroidal anti-inflammatory drug therapy for lung disease in cystic fibrosis
Lands LC, Stanojevic S
Lands LC, Stanojevic S
OBJECTIVES: To assess the effectiveness of treatment with NSAIDs in CF.
OBJECTIVES: To assess the effectiveness of treatment with NSAIDs in CF.
Cochrane Systematic Review: Nebulised hypertonic saline for cystic fibrosis
Wark P, McDonald VM
Wark P, McDonald VM
OBJECTIVES: To investigate the effects of nebulised HS in CF compared to placebo or other treatments for mucociliary clearance.
OBJECTIVES: To investigate the effects of nebulised HS in CF compared to placebo or other treatments for mucociliary clearance.
Cochrane Systematic Review: Inhaled corticosteroids for cystic fibrosis
Balfour-Lynn IM, Welch K
Balfour-Lynn IM, Welch K
OBJECTIVES: To assess the effectiveness of taking regular ICS, compared to not taking them, in children and adults with CF.
OBJECTIVES: To assess the effectiveness of taking regular ICS, compared to not taking them, in children and adults with CF.
Cochrane Systematic Review: Home versus hospital intravenous antibiotic therapy for cystic fibrosis
Balaguer A, Gonzlez de Dios J
Balaguer A, Gonzlez de Dios J
OBJECTIVES: To determine whether home intravenous antibiotic therapy in cystic fibrosis is as effective as inpatient intravenous antibiotic therapy and if it is preferred by individuals or families or both.
OBJECTIVES: To determine whether home intravenous antibiotic therapy in cystic fibrosis is as effective as inpatient intravenous antibiotic therapy and if it is preferred by individuals or families or both.
Cochrane Systematic Review: Once-daily versus multiple-daily dosing with intravenous aminoglycosides for cystic fibrosis
Smyth AR, Bhatt J
Smyth AR, Bhatt J
OBJECTIVES: To assess the effectiveness and safety of once-daily versus multiple-daily dosing of intravenous aminoglycoside antibiotics for the management of pulmonary exacerbations in cystic fibrosis.
OBJECTIVES: To assess the effectiveness and safety of once-daily versus multiple-daily dosing of intravenous aminoglycoside antibiotics for the management of pulmonary exacerbations in cystic fibrosis.
Cochrane Systematic Review: Omega-3 fatty acids for cystic fibrosis
Oliver C, Watson H
Oliver C, Watson H
OBJECTIVES: To determine whether there is evidence that omega-3 polyunsaturated fatty acid supplementation reduces morbidity and mortality and to identify any adverse events associated with supplementation.
OBJECTIVES: To determine whether there is evidence that omega-3 polyunsaturated fatty acid supplementation reduces morbidity and mortality and to identify any adverse events associated with supplementation.
Cochrane Systematic Review: Macrolide antibiotics for cystic fibrosis
Southern KW, Barker PM, Solis-Moya A, Patel L
Southern KW, Barker PM, Solis-Moya A, Patel L
OBJECTIVES: To test the hypotheses that, in people with cystic fibrosis, macrolide antibiotics: 1. improve clinical status compared to placebo or another antibiotic; 2. do not have unacceptable adverse effects. If benefit was demonstrated, we aimed to assess the optimal type, dose and duration of macrolide therapy.
OBJECTIVES: To test the hypotheses that, in people with cystic fibrosis, macrolide antibiotics: 1. improve clinical status compared to placebo or another antibiotic; 2. do not have unacceptable adverse effects. If benefit was demonstrated, we aimed to assess the optimal type, dose and duration of macrolide therapy.
Cochrane Systematic Review: Non-invasive ventilation for cystic fibrosis
Moran F, Bradley JM, Piper AJ
Moran F, Bradley JM, Piper AJ
OBJECTIVES: To compare the effect of non-invasive ventilation versus no non-invasive ventilation in people with cystic fibrosis.
OBJECTIVES: To compare the effect of non-invasive ventilation versus no non-invasive ventilation in people with cystic fibrosis.
Cochrane Systematic Review: Inhaled bronchodilators for cystic fibrosis
Halfhide C1, Evans HJ, Couriel J.
Halfhide C1, Evans HJ, Couriel J.
OBJECTIVES: To evaluate the effectiveness of inhaled bronchodilators in children and adults with cystic fibrosis.
OBJECTIVES: To evaluate the effectiveness of inhaled bronchodilators in children and adults with cystic fibrosis.
Cochrane Systematic Review: Insulin and oral agents for managing cystic fibrosis-related diabetes
Onady GM, Stolfi A
Onady GM, Stolfi A
OBJECTIVES: To establish the effectiveness of agents for managing diabetes in people with cystic fibrosis in relation to blood sugar levels, lung function and weight management.
OBJECTIVES: To establish the effectiveness of agents for managing diabetes in people with cystic fibrosis in relation to blood sugar levels, lung function and weight management.
Cochrane Systematic Review: Oral anti-pseudomonal antibiotics for cystic fibrosis
Remmington T, Jahnke N, Harkensee C
Remmington T, Jahnke N, Harkensee C
OBJECTIVES: To determine the benefit or harm of oral anti-pseudomonal antibiotic therapy for people with CF, colonised with Pseudomonas aeruginosa, in the:1. treatment of a pulmonary exacerbation; and 2. long-term treatment of chronic infection.
OBJECTIVES: To determine the benefit or harm of oral anti-pseudomonal antibiotic therapy for people with CF, colonised with Pseudomonas aeruginosa, in the:1. treatment of a pulmonary exacerbation; and 2. long-term treatment of chronic infection.
Cochrane Systematic Review: Inspiratory muscle training for cystic fibrosis
Houston BW, Mills N, Solis-Moya A
Houston BW, Mills N, Solis-Moya A
OBJECTIVES: To determine the effect of inspiratory muscle training on health-related quality of life, pulmonary function and exercise tolerance.
OBJECTIVES: To determine the effect of inspiratory muscle training on health-related quality of life, pulmonary function and exercise tolerance.
Cochrane Systematic Review: Vitamin A supplementation for cystic fibrosis
Bonifant CM, Shevill E, Chang AB
Bonifant CM, Shevill E, Chang AB
OBJECTIVES: To determine if vitamin A supplementation in children and adults with cystic fibrosis:1. reduces the frequency of vitamin A deficiency disorders;2. improves general and respiratory health;3. increases the frequency of vitamin A toxicity.
OBJECTIVES: To determine if vitamin A supplementation in children and adults with cystic fibrosis:1. reduces the frequency of vitamin A deficiency disorders;2. improves general and respiratory health;3. increases the frequency of vitamin A toxicity.
Cochrane Systematic Review: Anti-inflammatory drugs and analgesics for managing symptoms in people with cystic fibrosis-related arthritis
Thornton J, Rangaraj S
Thornton J, Rangaraj S
OBJECTIVES: To review the effectiveness and safety of pharmacological agents for the symptomatic management of cystic fibrosis-related arthritis in adults and children with cystic fibrosis.
OBJECTIVES: To review the effectiveness and safety of pharmacological agents for the symptomatic management of cystic fibrosis-related arthritis in adults and children with cystic fibrosis.
Cochrane Systematic Review: Vitamin D supplementation for cystic fibrosis
Ferguson JH, Chang AB
Ferguson JH, Chang AB
OBJECTIVES: To assess the effects of vitamin D supplementation on the frequency of vitamin D deficiency, respiratory outcomes and vitamin D toxicity in the cystic fibrosis population.
OBJECTIVES: To assess the effects of vitamin D supplementation on the frequency of vitamin D deficiency, respiratory outcomes and vitamin D toxicity in the cystic fibrosis population.
Cochrane Systematic Review: Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis
Hurley MN, Forrester DL, Smyth AR
Hurley MN, Forrester DL, Smyth AR
OBJECTIVES: To determine if antibiotic adjuvants improve clinical and microbiological outcome of pulmonary infection in people with cystic fibrosis.
OBJECTIVES: To determine if antibiotic adjuvants improve clinical and microbiological outcome of pulmonary infection in people with cystic fibrosis.
Cochrane Systematic Review: Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis
Jagannath VA, Asokan GV, Fedorowicz Z, Lee TW
Jagannath VA, Asokan GV, Fedorowicz Z, Lee TW
OBJECTIVES: To assess the effects of neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis.
OBJECTIVES: To assess the effects of neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis.
Cochrane Systematic Review: Inhaled antibiotics for pulmonary exacerbations in cystic fibrosis
Ryan G, Jahnke N, Remmington T
Ryan G, Jahnke N, Remmington T
OBJECTIVES: To determine if treatment of pulmonary exacerbations with inhaled antibiotics in people with cystic fibrosis improves their quality of life, reduces time off school or work and improves their long-term survival.
OBJECTIVES: To determine if treatment of pulmonary exacerbations with inhaled antibiotics in people with cystic fibrosis improves their quality of life, reduces time off school or work and improves their long-term survival.
Cochrane Systematic Review: Vitamin K supplementation for cystic fibrosis
Jagannath VA, Fedorowicz Z, Thaker V, Chang AB
Jagannath VA, Fedorowicz Z, Thaker V, Chang AB
OBJECTIVES: To assess the effects of vitamin K supplementation in people with cystic fibrosis and to determine the optimal dose and route of administration of vitamin K for both routine and therapeutic use.
OBJECTIVES: To assess the effects of vitamin K supplementation in people with cystic fibrosis and to determine the optimal dose and route of administration of vitamin K for both routine and therapeutic use.
Cochrane Systematic Review: Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation
Horsley A, Jones AM
Horsley A, Jones AM
OBJECTIVES: To assess the effectiveness and safety of different antibiotic regimens in people with cystic fibrosis experiencing an exacerbation, who are chronically infected with organisms of the Burkholderia cepacia complex.
OBJECTIVES: To assess the effectiveness and safety of different antibiotic regimens in people with cystic fibrosis experiencing an exacerbation, who are chronically infected with organisms of the Burkholderia cepacia complex.
Cochrane Systematic Review: Interventions for the eradication of methicillin-resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis
Lo DK, Hurley MN, Muhlebach MS, Smyth AR
Lo DK, Hurley MN, Muhlebach MS, Smyth AR
OBJECTIVES: To evaluate the effectiveness of treatment regimens designed to eradicate MRSA and to determine whether the eradication of MRSA confers better clinical and microbiological outcomes for people with cystic fibrosis.
OBJECTIVES: To evaluate the effectiveness of treatment regimens designed to eradicate MRSA and to determine whether the eradication of MRSA confers better clinical and microbiological outcomes for people with cystic fibrosis.
Cochrane Systematic Review: Oral calorie supplements for cystic fibrosis
Smyth RL, Walters S
Smyth RL, Walters S
OBJECTIVES: To establish whether in people with CF, oral calorie supplements: increase daily calorie intake; and improve overall nutritional intake, nutritional indices, lung function, survival and quality of life. To assess adverse effects associated with using these supplements.
OBJECTIVES: To establish whether in people with CF, oral calorie supplements: increase daily calorie intake; and improve overall nutritional intake, nutritional indices, lung function, survival and quality of life. To assess adverse effects associated with using these supplements.
Cochrane Systematic Review: Newborn screening for cystic fibrosis
Southern KW, Mrelle MM, Dankert-Roelse JE, Nagelkerke AD
Southern KW, Mrelle MM, Dankert-Roelse JE, Nagelkerke AD
OBJECTIVES: To examine whether newborn screening for CF prevents or reduces irreversible organ damage and improves clinical outcomes, quality of life and survival in people with CF without unacceptable adverse effects.
OBJECTIVES: To examine whether newborn screening for CF prevents or reduces irreversible organ damage and improves clinical outcomes, quality of life and survival in people with CF without unacceptable adverse effects.
Cochrane Systematic Review: Oral non-steroidal anti-inflammatory drug therapy for lung disease in cystic fibrosis
Lands LC, Stanojevic S
Lands LC, Stanojevic S
OBJECTIVES: To assess the effectiveness of treatment with NSAIDs in CF.
OBJECTIVES: To assess the effectiveness of treatment with NSAIDs in CF.
Cochrane Systematic Review: Nebulised hypertonic saline for cystic fibrosis
Wark P, McDonald VM
Wark P, McDonald VM
OBJECTIVES: To investigate the effects of nebulised HS in CF compared to placebo or other treatments for mucociliary clearance.
OBJECTIVES: To investigate the effects of nebulised HS in CF compared to placebo or other treatments for mucociliary clearance.
Cochrane Systematic Review: Inhaled corticosteroids for cystic fibrosis
Balfour-Lynn IM, Welch K
Balfour-Lynn IM, Welch K
OBJECTIVES: To assess the effectiveness of taking regular ICS, compared to not taking them, in children and adults with CF.
OBJECTIVES: To assess the effectiveness of taking regular ICS, compared to not taking them, in children and adults with CF.
Cochrane Systematic Review: Home versus hospital intravenous antibiotic therapy for cystic fibrosis
Balaguer A, Gonzlez de Dios J
Balaguer A, Gonzlez de Dios J
OBJECTIVES: To determine whether home intravenous antibiotic therapy in cystic fibrosis is as effective as inpatient intravenous antibiotic therapy and if it is preferred by individuals or families or both.
OBJECTIVES: To determine whether home intravenous antibiotic therapy in cystic fibrosis is as effective as inpatient intravenous antibiotic therapy and if it is preferred by individuals or families or both.
Cochrane Systematic Review: Once-daily versus multiple-daily dosing with intravenous aminoglycosides for cystic fibrosis
Smyth AR, Bhatt J
Smyth AR, Bhatt J
OBJECTIVES: To assess the effectiveness and safety of once-daily versus multiple-daily dosing of intravenous aminoglycoside antibiotics for the management of pulmonary exacerbations in cystic fibrosis.
OBJECTIVES: To assess the effectiveness and safety of once-daily versus multiple-daily dosing of intravenous aminoglycoside antibiotics for the management of pulmonary exacerbations in cystic fibrosis.
Cochrane Systematic Review: Omega-3 fatty acids for cystic fibrosis
Oliver C, Watson H
Oliver C, Watson H
OBJECTIVES: To determine whether there is evidence that omega-3 polyunsaturated fatty acid supplementation reduces morbidity and mortality and to identify any adverse events associated with supplementation.
OBJECTIVES: To determine whether there is evidence that omega-3 polyunsaturated fatty acid supplementation reduces morbidity and mortality and to identify any adverse events associated with supplementation.
Cochrane Systematic Review: Macrolide antibiotics for cystic fibrosis
Southern KW, Barker PM, Solis-Moya A, Patel L
Southern KW, Barker PM, Solis-Moya A, Patel L
OBJECTIVES: To test the hypotheses that, in people with cystic fibrosis, macrolide antibiotics: 1. improve clinical status compared to placebo or another antibiotic; 2. do not have unacceptable adverse effects. If benefit was demonstrated, we aimed to assess the optimal type, dose and duration of macrolide therapy.
OBJECTIVES: To test the hypotheses that, in people with cystic fibrosis, macrolide antibiotics: 1. improve clinical status compared to placebo or another antibiotic; 2. do not have unacceptable adverse effects. If benefit was demonstrated, we aimed to assess the optimal type, dose and duration of macrolide therapy.
Cochrane Systematic Review: Non-invasive ventilation for cystic fibrosis
Moran F, Bradley JM, Piper AJ
Moran F, Bradley JM, Piper AJ
OBJECTIVES: To compare the effect of non-invasive ventilation versus no non-invasive ventilation in people with cystic fibrosis.
OBJECTIVES: To compare the effect of non-invasive ventilation versus no non-invasive ventilation in people with cystic fibrosis.
Cochrane Systematic Review: Inhaled bronchodilators for cystic fibrosis
Halfhide C1, Evans HJ, Couriel J.
Halfhide C1, Evans HJ, Couriel J.
OBJECTIVES: To evaluate the effectiveness of inhaled bronchodilators in children and adults with cystic fibrosis.
OBJECTIVES: To evaluate the effectiveness of inhaled bronchodilators in children and adults with cystic fibrosis.
Cochrane Systematic Review: Insulin and oral agents for managing cystic fibrosis-related diabetes
Onady GM, Stolfi A
Onady GM, Stolfi A
OBJECTIVES: To establish the effectiveness of agents for managing diabetes in people with cystic fibrosis in relation to blood sugar levels, lung function and weight management.
OBJECTIVES: To establish the effectiveness of agents for managing diabetes in people with cystic fibrosis in relation to blood sugar levels, lung function and weight management.
Cochrane Systematic Review: Oral anti-pseudomonal antibiotics for cystic fibrosis
Remmington T, Jahnke N, Harkensee C
Remmington T, Jahnke N, Harkensee C
OBJECTIVES: To determine the benefit or harm of oral anti-pseudomonal antibiotic therapy for people with CF, colonised with Pseudomonas aeruginosa, in the:1. treatment of a pulmonary exacerbation; and 2. long-term treatment of chronic infection.
OBJECTIVES: To determine the benefit or harm of oral anti-pseudomonal antibiotic therapy for people with CF, colonised with Pseudomonas aeruginosa, in the:1. treatment of a pulmonary exacerbation; and 2. long-term treatment of chronic infection.
Cochrane Systematic Review: Inspiratory muscle training for cystic fibrosis
Houston BW, Mills N, Solis-Moya A
Houston BW, Mills N, Solis-Moya A
OBJECTIVES: To determine the effect of inspiratory muscle training on health-related quality of life, pulmonary function and exercise tolerance.
OBJECTIVES: To determine the effect of inspiratory muscle training on health-related quality of life, pulmonary function and exercise tolerance.
Cochrane Systematic Review: Vitamin A supplementation for cystic fibrosis
Bonifant CM, Shevill E, Chang AB
Bonifant CM, Shevill E, Chang AB
OBJECTIVES: To determine if vitamin A supplementation in children and adults with cystic fibrosis:1. reduces the frequency of vitamin A deficiency disorders;2. improves general and respiratory health;3. increases the frequency of vitamin A toxicity.
OBJECTIVES: To determine if vitamin A supplementation in children and adults with cystic fibrosis:1. reduces the frequency of vitamin A deficiency disorders;2. improves general and respiratory health;3. increases the frequency of vitamin A toxicity.
Cochrane Systematic Review: Anti-inflammatory drugs and analgesics for managing symptoms in people with cystic fibrosis-related arthritis
Thornton J, Rangaraj S
Thornton J, Rangaraj S
OBJECTIVES: To review the effectiveness and safety of pharmacological agents for the symptomatic management of cystic fibrosis-related arthritis in adults and children with cystic fibrosis.
OBJECTIVES: To review the effectiveness and safety of pharmacological agents for the symptomatic management of cystic fibrosis-related arthritis in adults and children with cystic fibrosis.
Cochrane Systematic Review: Vitamin D supplementation for cystic fibrosis
Ferguson JH, Chang AB
Ferguson JH, Chang AB
OBJECTIVES: To assess the effects of vitamin D supplementation on the frequency of vitamin D deficiency, respiratory outcomes and vitamin D toxicity in the cystic fibrosis population.
OBJECTIVES: To assess the effects of vitamin D supplementation on the frequency of vitamin D deficiency, respiratory outcomes and vitamin D toxicity in the cystic fibrosis population.
Cochrane Systematic Review: Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis
Hurley MN, Forrester DL, Smyth AR
Hurley MN, Forrester DL, Smyth AR
OBJECTIVES: To determine if antibiotic adjuvants improve clinical and microbiological outcome of pulmonary infection in people with cystic fibrosis.
OBJECTIVES: To determine if antibiotic adjuvants improve clinical and microbiological outcome of pulmonary infection in people with cystic fibrosis.
Cochrane Systematic Review: Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis
Jagannath VA, Asokan GV, Fedorowicz Z, Lee TW
Jagannath VA, Asokan GV, Fedorowicz Z, Lee TW
OBJECTIVES: To assess the effects of neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis.
OBJECTIVES: To assess the effects of neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis.
Cochrane Systematic Review: Inhaled antibiotics for pulmonary exacerbations in cystic fibrosis
Ryan G, Jahnke N, Remmington T
Ryan G, Jahnke N, Remmington T
OBJECTIVES: To determine if treatment of pulmonary exacerbations with inhaled antibiotics in people with cystic fibrosis improves their quality of life, reduces time off school or work and improves their long-term survival.
OBJECTIVES: To determine if treatment of pulmonary exacerbations with inhaled antibiotics in people with cystic fibrosis improves their quality of life, reduces time off school or work and improves their long-term survival.
Cochrane Systematic Review: Vitamin K supplementation for cystic fibrosis
Jagannath VA, Fedorowicz Z, Thaker V, Chang AB
Jagannath VA, Fedorowicz Z, Thaker V, Chang AB
OBJECTIVES: To assess the effects of vitamin K supplementation in people with cystic fibrosis and to determine the optimal dose and route of administration of vitamin K for both routine and therapeutic use.
OBJECTIVES: To assess the effects of vitamin K supplementation in people with cystic fibrosis and to determine the optimal dose and route of administration of vitamin K for both routine and therapeutic use.
Cochrane Systematic Review: Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation
Horsley A, Jones AM
Horsley A, Jones AM
OBJECTIVES: To assess the effectiveness and safety of different antibiotic regimens in people with cystic fibrosis experiencing an exacerbation, who are chronically infected with organisms of the Burkholderia cepacia complex.
OBJECTIVES: To assess the effectiveness and safety of different antibiotic regimens in people with cystic fibrosis experiencing an exacerbation, who are chronically infected with organisms of the Burkholderia cepacia complex.
Cochrane Systematic Review: Interventions for the eradication of methicillin-resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis
Lo DK, Hurley MN, Muhlebach MS, Smyth AR
Lo DK, Hurley MN, Muhlebach MS, Smyth AR
OBJECTIVES: To evaluate the effectiveness of treatment regimens designed to eradicate MRSA and to determine whether the eradication of MRSA confers better clinical and microbiological outcomes for people with cystic fibrosis.
OBJECTIVES: To evaluate the effectiveness of treatment regimens designed to eradicate MRSA and to determine whether the eradication of MRSA confers better clinical and microbiological outcomes for people with cystic fibrosis.