Severe Head Injury Cochrane Pediatric Emergency Medicine Reviews

Pediatric head trauma is one of the most common reasons for consultation in the ED, and can be mild, moderate or severe. The most common causes of head trauma in children and youth presenting to Canadian EDs include falls, sports-related injuries, being hit on the head by an object or by colliding with an obstacle, or injuries involving bicycles and motor vehicles. Annual rates range from 130 to 200 cases per 100,000 population, leading to at least 20,000 emergency department visits in Canadian pediatric hospitals per year.

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Cochrane Systematic Review: Hyperventilation therapy for acute traumatic brain injury


Schierhout G, Roberts I

OBJECTIVES: To quantify the effect of hyperventilation on death and neurological disability following head injury.

Cochrane Systematic Review: Decompressive craniectomy for the treatment of refractory high intracranial pressure in traumatic brain injury


Sahuquillo J, Arikan F

OBJECTIVES: To assess the effects of secondary decompressive craniectomy (DC) on outcome and quality of life in patients with severe TBI in whom conventional medical therapeutic measures have failed to control raised ICP.

Cochrane Systematic Review: Excitatory amino acid inhibitors for traumatic brain injury


Willis C, Lybrand S, Bellamy N

OBJECTIVES: To assess systematically the efficacy of excitatory amino acid inhibitors on improving patient outcome following traumatic brain injury.

Cochrane Systematic Review: Bradykinin beta-2 receptor antagonists for acute traumatic brain injury


Ker K, Blackhall K

OBJECTIVES: The objective was to assess the safety and effectiveness of beta-2 receptor antagonists for TBI.

Cochrane Systematic Review: Progesterone for acute traumatic brain injury


Ma J, Huang S, Qin S, You C

OBJECTIVES: To assess the effectiveness and safety of progesterone in people with acute TBI.

Cochrane Systematic Review: Hypothermia for neuroprotection in children after cardiopulmonary arrest


Scholefield B, Duncan H, Davies P, Gao Smith F, Khan K, Perkins GD, Morris K

OBJECTIVES: To assess the clinical effectiveness of therapeutic hypothermia after paediatric cardiopulmonary arrest.

Systematic Review: Haemostatic drugs for traumatic brain injury


Perel P, Roberts I, Shakur H, Thinkhamrop B, Phuenpathom N, Yutthakasemsunt S

To assess the effects of haemostatic drugs on mortality, disability and thrombotic complications inpatientswith traumatic brain injury.

Systematic Review: Corticosteroids for acute traumatic brain injury


Alderson P, Roberts I

To quantify the effectiveness and safety of corticosteroids in the treatment ofacutetraumatic brain injury.