Systematic Review: Early goal-directed therapy in severe sepsis and septic shock: a contemporary review of the literature (2008)

Systematic Review: Early goal-directed therapy in severe sepsis and septic shock: a contemporary review of the literature (2008)

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Objective: Aggressive approaches to acute diseases such as acute myocardial infarction, trauma, and stroke have improved outcomes. Early goal-directed therapy for severe sepsis and septic shock represents a similar approach. An analysis of the literature assessing external validity and generalizability of this intervention is lacking. Published: 2008.