Cochrane Systematic Review: Adjusting the pH of lidocaine for reducing pain on injection

Cochrane Systematic Review: Adjusting the pH of lidocaine for reducing pain on injection

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OBJECTIVES: The objective of this review was to determine if adjusting the pH of lidocaine had any effect on pain resulting from non-intravascular injections in adults and children. We tested the hypothesis that adjusting the pH of lidocaine solution to a level closer to the physiologic pH reduces this pain.