Hartling L, Milne A, Foisy M, Lang E, Sinclair D, Klassen TP, Evered L.

 

This overview of systematic reviews (SR) examines the safety and efficacy of sedative agents commonly used for procedural sedation in children in the ED or similar settings, finding consistent safety and efficacy for nitrous oxide and ketamine, with very rare significant adverse events for propofol. Considerable heterogeneity in outcomes and reporting across studies and previous reviews indicates a need for standardized outcome sets and reporting to facilitate evidence-based recommendations for care.