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Croup is a common respiratory illness caused by a viral infection in the airway. Accompanied by a barky cough and respiratory distress, this illness is most common in children aged birth to 6 years, peaking at 2 years of age.

BROWSE EVIDENCE REPOSITORY

 

En bref

Recommendations de Base: Laryngite Aigu

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Johnson, DW. & TREKK Network

Bottom line recommendations for the treatment and management of croup- French. Published online: October 2014.

Bottom Line Recommendations: Croup

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Johnson, DW. & TREKK Network

Bottom line recommendations for the treatment and management of croup. Published online: September 2014.

directive clinique

Clinical Practice Guideline: Guideline for the Diagnosis and Management of Croup

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Alberta Medical Association,

Developed by Alberta Clinical Practice Guideline Working Group. Published: 2003; Last revised: 2008.

Clinical Practice Guideline: Summary: Diagnosis and Management of Croup

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Albera Medical Association,

Summary of Alberta Clinical Practice Guideline document. Published: 2003; Last revised; 2008.

Résumé de l'examen systématique

Cochrane Summary: Nebulized epinephrine for croup in children

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Bjornson, C, Russell, K, Vandermeer, B, Klassen, TP, Johnson, DW,

Objective: To assess the efficacy (measured by croup scores, rate of intubation and health care utilization such as rate of hospitalization) and safety (frequency and severity of side effects) of nebulized epinephrine versus placebo in children with croup, evaluated in an emergency department (ED) or hospital setting. Published online: October 2013; Evidence current to: July 2013.

Cochrane Summary: Glucocorticoids for croup

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Russell, K, Liang, Y, O'Gorman, K, Johnson, DW, Klassen, TP,

Objective: To provide evidence to guide clinicians in their treatment of patients with croup by determining the effectiveness of glucocorticoids and to identify areas requiring future research. Published online: January 2012; Evidence current to: July 2010.

Vue d'ensemble de l'examen systématique

Cochrane Overview: The Cochrane Library and the treatment of croup in children: an overview of reviews (2010)

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Bjornson, C, Russell, K, Foisy, M, Johnson, D,

Objective: To synthesize the evidence currently in the Cochrane Database of Systematic Reviews (CDSR) related to the clinical effectiveness and applicability of four treatments for croup - glucocorticoids, epinephrine, heliox and humidified air. Published: December 2010.

Cochrane Overview: Evidence Summary: Croup

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Alberta Research Centre for Health Evidence (ARCHE),

The purpose of this document is to describe the effectiveness of four treatment options, based on a 2012 Overview of Reviews. Published online: 2014.

examen systématique

Cochrane Systematic Review: Nebulized epinephrine for croup in children (2013)

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Bjornson, C, Russell, K, Vandermeer, B, Klassen, TP, Johnson, DW,

Objective: To assess the efficacy (measured by croup scores, rate of intubation and health care utilization such as rate of hospitalization) and safety (frequency and severity of side effects) of nebulized epinephrine versus placebo in children with croup, evaluated in an emergency department (ED) or hospital setting. Published: October 2013; Evidence current to: July 2013.

Cochrane Systematic Review: Glucocorticoids for croup (2011)

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Russell, K, Liang, Y, O'Gorman, K, Johnson, DW, Klassen, TP,

Objective: To provide evidence to guide clinicians in their treatment of patients with croup by determining the effectiveness of glucocorticoids and to identify areas requiring future research. Published: January 2011; Evidence current to: July 2010.

Cochrane Systematic Review: Humidified air inhalation for treating croup (2006)

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Moore, M, Little, P,

Objective: To assess the efficacy of humidified air in the treatment of croup. Published: January 2006; Evidence current to: January 2006.

Cochrane Systematic Review: Heliox for croup in children (2010)

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Vorwerk, C, Coats, T,

Objective: To examine the effect of heliox on relieving symptoms and distress, determined by a croup score (a tool for measuring the severity of croup) or clinical assessment variables, through comparisons with placebo or active treatment(s) in children with croup. Published: February 2010; Evidence current to: June 2009.

Review: Croup in children

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Candice L. Bjornson, David W. Johnson

Objective: This review will address the diagnosis and management of croup in children, specifically focusing on clinical assessment of disease severity to guide management decisions.

étude clé

Key Study: Controlled delivery of high vs low humidity vs mist therapy for croup in emergency departments: a randomized controlled trial (2006)

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Scolnik, D, Coates, AL, Stephens, D, Da Silva, Z, Lavine, E, Schuh, S,

Objective: To determine whether a significant difference in the clinical Westley croup score exists in children with moderate to severe croup who were admitted to the emergency department and who received either 100% humidity or 40% humidity via nebulizer or blow-by humidity. Published: 2006.

Key Study: A randomized trial of a single dose of oral dexamethasone for mild croup (2004)

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Bjornson, CL, Klassen, TP, Williamson, J, Brant, R, Mitton, C, Plint, A, Bull...

Objective: The primary outcome was a return to a medical care provider for croup within seven days after treatment. The secondary outcome was the presence of ongoing symptoms of croup on days 1, 2, and 3 after treatment. Other outcomes included economic costs, hours of sleep lost by the child, and stress on the part of the parent in relation to the child's illness. Published: 2004.

Key Study: Outpatient treatment of moderate croup with dexamethasone: intramuscular versus oral dosing (2000)

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Rittichier, KK, Ledwith, CA,

Objective: Steroid use for the treatment of croup has been supported by several studies, although few have addressed the use of oral dexamethasone for outpatient management. The efficacy of oral (PO) versus intramuscular (IM) dosing of dexamethasone in the outpatient treatment of moderate croup are compared in this study. Published: 2000.

Key Study: A comparison of nebulized budesonide, intramuscular dexamethasone, and placebo for moderately severe croup (1998)

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Johnson, DW, Jacobson, S, Edney, PC, Hadfield, P, Mundy, ME, Schuh, S,

Objective: To study how budesonide compares with dexamethasone, the conventional therapy for croup, and whether either reduces the rate of hospitalization. Published: 1998.

Key Study: Nebulized budesonide and oral dexamethasone for treatment of croup: a randomized controlled trial (1998)

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Klassen, TP, Craig, WR, Moher, D, Osmond, MH, Pasterkamp, H, Sutcliffe, T, Wa...

Objective: To determine the effectiveness of 3 glucocorticoid regimens in patients with croup. Published: 1998.

Key Study: Oral and inhaled steroids in croup - A randomized, placebo-controlled trial (1995)

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Geelhoed, GC, Macdonald, WB,

Objective: To compare the efficacy of oral dexamethasone and inhaled budesonide in children hospitalized with croup, using a three-way, double blind, randomized, placebo-controlled clinical trial design. Published: 1995.

Key Study: Placebo-controlled trial of prednisolone in children intubated for croup (1992)

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Tibballs, J, Shann, FA, Landau, LI,

Objective: To study the effect of prednisolone on two clinical endpoints--the duration of intubation and the need for reintubation. Published: 1992.

Key Study: Nebulized racemic epinephrine by IPPB for the treatment of croup: a double-blind study (1978)

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Westley, CR, Cotton, EK, Brooks, JG,

Objective: To test the effectiveness of racemic epinephrine for the treatment of croup in comparison to saline. Published: 1978.