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Acute otitis media (AOM) is a common, symptomatic infection of the middle ear. Nasopharyngeal secretions that contain viruses and bacteria can enter the middle ear via the eustachian tube. Usually the middle ear drains well but if there is eustachian tube swelling, fluid from the middle ear may not drain properly. Under these conditions bacteria and viruses present in the middle ear can multiply, creating clinical AOM.

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Key studies

Key Study: Symptomatic and asymptomatic respiratory viral infections in the first year of life: association with acute otitis media development

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Chonmaitree T, Alvarez-Fernandez P, Jennings K, Trujillo R, Marom T, Loeffelh...

The purpose of this study was to determine the clinical significance of asymptomatic respiratory viral infection in infants.

Key Study: Treatment of acute otitis media in children under 2 years of age

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Hoberman A, Paradise JL, Rockette HE, Shaikh N, Wald ER, Kearney DH, Colborn ...

The purpose of this clinical trial was to determine the extent to which antimicrobial treatment affects the course of both symptoms and signs of acute otitis media, irrespective of the apparent severity of the disease, among children 6 to 23 months of age who have been diagnosed with acute otitis media.

Key Study: A placebo-controlled trial of antimicrobial treatment for acute otitis media

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Thtinen PA, Laine MK, Huovinen P, Jalava J, Ruuskanen O, Ruohola A

This randomized, double-blind, placebo-controlled study assessed the efficacy of antimicrobial treatment for acute otitis media.