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Tuberculosis, Pulmonary Cochrane Pediatric Emergency Medicine Reviews

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Cochrane Systematic Review: Xpert MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults

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Steingart KR, Schiller I, Horne DJ, Pai M, Boehme CC, Dendukuri N

OBJECTIVES: To assess the diagnostic accuracy of Xpert(R) MTB/RIF for pulmonary TB (TB detection), where Xpert(R) MTB/RIF was used as both an initial test replacing microscopy and an add-on test following a negative smear microscopy result.To assess the diagnostic accuracy of Xpert(R) MTB/RIF for rifampicin resistance detection, where Xpert(R) MTB/RIF was used as the initial test replacing culture-based drug susceptibility testing (DST).The populations of interest were adults presumed to have pulmonary, rifampicin-resistant or multidrug-resistant TB (MDR-TB), with or without HIV infection. The settings of interest were intermediate- and peripheral-level laboratories. The latter may be associated with primary health care facilities.