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Cystic Fibrosis Cochrane Pediatric Emergency Medicine Reviews

Browse Cochrane Pediatric Emergency Medicine Reviews

 


Cochrane Systematic Review: Oral calorie supplements for cystic fibrosis

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Smyth RL, Walters S

OBJECTIVES: To establish whether in people with CF, oral calorie supplements: increase daily calorie intake; and improve overall nutritional intake, nutritional indices, lung function, survival and quality of life. To assess adverse effects associated with using these supplements.

Cochrane Systematic Review: Newborn screening for cystic fibrosis

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Southern KW, Mrelle MM, Dankert-Roelse JE, Nagelkerke AD

OBJECTIVES: To examine whether newborn screening for CF prevents or reduces irreversible organ damage and improves clinical outcomes, quality of life and survival in people with CF without unacceptable adverse effects.

Cochrane Systematic Review: Oral non-steroidal anti-inflammatory drug therapy for lung disease in cystic fibrosis

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Lands LC, Stanojevic S

OBJECTIVES: To assess the effectiveness of treatment with NSAIDs in CF.

Cochrane Systematic Review: Nebulised hypertonic saline for cystic fibrosis

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Wark P, McDonald VM

OBJECTIVES: To investigate the effects of nebulised HS in CF compared to placebo or other treatments for mucociliary clearance.

Cochrane Systematic Review: Inhaled corticosteroids for cystic fibrosis

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Balfour-Lynn IM, Welch K

OBJECTIVES: To assess the effectiveness of taking regular ICS, compared to not taking them, in children and adults with CF.

Cochrane Systematic Review: Home versus hospital intravenous antibiotic therapy for cystic fibrosis

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Balaguer A, Gonzlez de Dios J

OBJECTIVES: To determine whether home intravenous antibiotic therapy in cystic fibrosis is as effective as inpatient intravenous antibiotic therapy and if it is preferred by individuals or families or both.

Cochrane Systematic Review: Once-daily versus multiple-daily dosing with intravenous aminoglycosides for cystic fibrosis

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Smyth AR, Bhatt J

OBJECTIVES: To assess the effectiveness and safety of once-daily versus multiple-daily dosing of intravenous aminoglycoside antibiotics for the management of pulmonary exacerbations in cystic fibrosis.

Cochrane Systematic Review: Omega-3 fatty acids for cystic fibrosis

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Oliver C, Watson H

OBJECTIVES: To determine whether there is evidence that omega-3 polyunsaturated fatty acid supplementation reduces morbidity and mortality and to identify any adverse events associated with supplementation.

Cochrane Systematic Review: Macrolide antibiotics for cystic fibrosis

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Southern KW, Barker PM, Solis-Moya A, Patel L

OBJECTIVES: To test the hypotheses that, in people with cystic fibrosis, macrolide antibiotics: 1. improve clinical status compared to placebo or another antibiotic; 2. do not have unacceptable adverse effects. If benefit was demonstrated, we aimed to assess the optimal type, dose and duration of macrolide therapy.

Cochrane Systematic Review: Non-invasive ventilation for cystic fibrosis

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Moran F, Bradley JM, Piper AJ

OBJECTIVES: To compare the effect of non-invasive ventilation versus no non-invasive ventilation in people with cystic fibrosis.

Cochrane Systematic Review: Inhaled bronchodilators for cystic fibrosis

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Halfhide C1, Evans HJ, Couriel J.

OBJECTIVES: To evaluate the effectiveness of inhaled bronchodilators in children and adults with cystic fibrosis.

Cochrane Systematic Review: Insulin and oral agents for managing cystic fibrosis-related diabetes

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Onady GM, Stolfi A

OBJECTIVES: To establish the effectiveness of agents for managing diabetes in people with cystic fibrosis in relation to blood sugar levels, lung function and weight management.

Cochrane Systematic Review: Oral anti-pseudomonal antibiotics for cystic fibrosis

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Remmington T, Jahnke N, Harkensee C

OBJECTIVES: To determine the benefit or harm of oral anti-pseudomonal antibiotic therapy for people with CF, colonised with Pseudomonas aeruginosa, in the:1. treatment of a pulmonary exacerbation; and 2. long-term treatment of chronic infection.

Cochrane Systematic Review: Inspiratory muscle training for cystic fibrosis

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Houston BW, Mills N, Solis-Moya A

OBJECTIVES: To determine the effect of inspiratory muscle training on health-related quality of life, pulmonary function and exercise tolerance.

Cochrane Systematic Review: Vitamin A supplementation for cystic fibrosis

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Bonifant CM, Shevill E, Chang AB

OBJECTIVES: To determine if vitamin A supplementation in children and adults with cystic fibrosis:1. reduces the frequency of vitamin A deficiency disorders;2. improves general and respiratory health;3. increases the frequency of vitamin A toxicity.

Cochrane Systematic Review: Anti-inflammatory drugs and analgesics for managing symptoms in people with cystic fibrosis-related arthritis

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Thornton J, Rangaraj S

OBJECTIVES: To review the effectiveness and safety of pharmacological agents for the symptomatic management of cystic fibrosis-related arthritis in adults and children with cystic fibrosis.

Cochrane Systematic Review: Vitamin D supplementation for cystic fibrosis

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Ferguson JH, Chang AB

OBJECTIVES: To assess the effects of vitamin D supplementation on the frequency of vitamin D deficiency, respiratory outcomes and vitamin D toxicity in the cystic fibrosis population.

Cochrane Systematic Review: Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis

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Hurley MN, Forrester DL, Smyth AR

OBJECTIVES: To determine if antibiotic adjuvants improve clinical and microbiological outcome of pulmonary infection in people with cystic fibrosis.

Cochrane Systematic Review: Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis

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Jagannath VA, Asokan GV, Fedorowicz Z, Lee TW

OBJECTIVES: To assess the effects of neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis.

Cochrane Systematic Review: Inhaled antibiotics for pulmonary exacerbations in cystic fibrosis

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Ryan G, Jahnke N, Remmington T

OBJECTIVES: To determine if treatment of pulmonary exacerbations with inhaled antibiotics in people with cystic fibrosis improves their quality of life, reduces time off school or work and improves their long-term survival.

Cochrane Systematic Review: Vitamin K supplementation for cystic fibrosis

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Jagannath VA, Fedorowicz Z, Thaker V, Chang AB

OBJECTIVES: To assess the effects of vitamin K supplementation in people with cystic fibrosis and to determine the optimal dose and route of administration of vitamin K for both routine and therapeutic use.

Cochrane Systematic Review: Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation

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Horsley A, Jones AM

OBJECTIVES: To assess the effectiveness and safety of different antibiotic regimens in people with cystic fibrosis experiencing an exacerbation, who are chronically infected with organisms of the Burkholderia cepacia complex.

Cochrane Systematic Review: Interventions for the eradication of methicillin-resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis

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Lo DK, Hurley MN, Muhlebach MS, Smyth AR

OBJECTIVES: To evaluate the effectiveness of treatment regimens designed to eradicate MRSA and to determine whether the eradication of MRSA confers better clinical and microbiological outcomes for people with cystic fibrosis.