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Asthma Cochrane Pediatric Emergency Medicine Reviews

Asthma is the most common chronic disease in children, and acute exacerbations of asthma are one of the most common reasons for children to seek emergency care and require urgent hospitalization. Approximately half to two-thirds of children with asthma who seek emergency care can be classified as having mild respiratory distress, and between 2 and 5% have severe respiratory distress; the remainder has moderate respiratory distress.

Browse Cochrane Pediatric Emergency Medicine Reviews

 


Cochrane Systematic Review: Addition of intravenous beta2-agonists to inhaled beta2-agonists for acute asthma

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Travers AH, Milan SJ, Jones AP, Camargo CA Jr, Rowe BH.

Objectives: To determine the benefit of adding intravenous (IV) beta(2)-agonists to inhaled beta(2)-agonist therapy for acute asthma treated in the emergency department.

Cochrane Systematic Review: Antibiotics for acute asthma

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Graham V, Lasserson T, Rowe BH.

Objectives: To determine the efficacy of antibiotics prescribed in the treatment of acute asthma

Cochrane Systematic Review: Anticholinergic drugs for wheeze in children under the age of two years

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Everard ML, Bara A, Kurian M, Elliott TM, Ducharme F, Mayowe V.

Objectives: Wheeze in infancy and early childhood is common and appears to be increasing. Most wheezing episodes in infancy are a result of viral infection. Bronchodilator medications such as beta2-agonists and anti-cholinergic agents are often used to relieve symptoms, but patterns of use vary. The objective of this review was to assess the effects of anti-cholinergic therapy in the treatment of wheezing infants. This is a second update of this review.

Cochrane Systematic Review: Anticholinergic therapy for acute asthma in children

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Teoh L, Cates CJ, Hurwitz M, Acworth JP, van Asperen P, Chang AB.

Objectives: To determine the effectiveness of only inhaled anticholinergic drugs (i.e. administered alone), compared to a control in children over the age of two years with acute asthma.

Cochrane Systematic Review: Anti-leukotriene agents compared to inhaled corticosteroids in the management of recurrent and/or chronic asthma in adults and children

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Chauhan BF, Ducharme FM.

Objectives: To determine the safety and efficacy of anti-leukotrienes compared to inhaled corticosteroids as monotherapy in adults and children with asthma and to provide better insight into the influence of patient and treatment characteristics on the magnitude of effects.

Cochrane Systematic Review: Combined inhaled anticholinergics and beta2-agonists for initial treatment of acute asthma in children

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Griffiths B, Ducharme FM.

Objectives: To determine whether the addition of inhaled anticholinergics to SABAs provides clinical improvement and affects the incidence of adverse effects in children with acute asthma exacerbations.

Cochrane Systematic Review: Commercial versus home-made spacers in delivering bronchodilator therapy for acute therapy in children

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Rodriguez C, Sossa M, Lozano JM.

Objectives: The aim of this review was to compare the response to inhaled beta-2 agonists delivered through metered-dose inhaler using home-made spacers, to the use of commercially produced spacers, in children with acute exacerbations of wheezing or asthma.

Cochrane Systematic Review: Corticosteroids for hospitalised children with acute asthma

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Smith M, Iqbal S, Elliott TM, Everard M, Rowe BH.

Objectives: To determine the benefit of systemic corticosteroids (oral, intravenous, or intramuscular) compared to placebo and inhaled steroids in acute paediatric asthma.

Cochrane Systematic Review: Corticosteroids for preventing relapse following acute exacerbations of asthma

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Rowe BH, Spooner CH, Ducharme FM, Bretzlaff JA, Bota GW.

Objectives: To determine the benefit of corticosteroids (oral, intramuscular, or intravenous) for the treatment of asthmatic patients discharged from an acute care setting (i.e. usually the emergency department) after assessment and treatment of an acute asthmatic exacerbation.

Cochrane Systematic Review: Dietary marine fatty acids (fish oil) for asthma in adults and children

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Woods RK, Thien FC, Abramson MJ.

Objectives: 1. To determine the effect of marine n-3 fatty acid (fish oil) supplementation in asthma. 2. To determine the effect of a diet high in fish oil in asthma.

Cochrane Systematic Review: Early emergency department treatment of acute asthma with systemic corticosteroids

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Rowe BH, Spooner C, Ducharme FM, Bretzlaff JA, Bota GW.

Objectives: To determine the benefit of treating patients with acute asthma with systemic corticosteroids within an hour of presenting to the emergency department (ED).

Cochrane Systematic Review: Early use of inhaled corticosteroids in the emergency department treatment of acute asthma

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Edmonds ML, Milan SJ, Camargo CA Jr, Pollack CV, Rowe BH.

Objectives: To determine the benefit of ICS for the treatment of patients with acute asthma managed in the emergency department (ED).

Cochrane Systematic Review: Formoterol versus short-acting beta-agonists as relief medication for adults and children with asthma

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Welsh EJ, Cates CJ.

Objectives: To asses the efficacy and safety of formoterol as reliever therapy in comparison to short-acting beta(2)-agonists in adults and children with asthma.

Cochrane Systematic Review: gastroesophageal reflux treatment for asthma in adults and children

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Gibson PG, Henry RL, Coughlan JL.

Objectives: The objective of this review was to evaluate the effectiveness of treatments for gastroesophageal reflux in terms of their benefit on asthma.

Cochrane Systematic Review: Heliox for non-intubated acute asthma patients

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Rodrigo G, Pollack C, Rodrigo C, Rowe BH.

Objectives: To determine the effect of the addition of heliox to standard medical care on the course of acute asthma, as measured by pulmonary function testing and clinical endpoints.

Cochrane Systematic Review: High dose versus low dose inhaled corticosteroid as initial starting dose for asthma in adults and children

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Powell H, Gibson PG.

Objectives: To establish the optimal starting dose of ICS by evaluating the efficacy of initial high dose ICS with low dose ICS in subjects with asthma, not currently on ICS.

Cochrane Systematic Review: Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma

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Cates CJ, Welsh EJ, Rowe BH.

Objectives: To assess the effects of holding chambers (spacers) compared to nebulisers for the delivery of beta(2)-agonists for acute asthma.

Cochrane Systematic Review: Inhaled corticosteroids compared to placebo for prevention of exercise induced bronchoconstriction

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Koh MS, Tee A, Lasserson TJ, Irving LB.

Objectives: The objectives of this review were to evaluate the use of inhaled corticosteroids in the treatment of exercise induced bronchoconstriction in a systematic way. Specifically, the review was designed to: determine whether inhaled corticosteroids (compared to placebo) has an attenuating effect on exercise induced bronchoconstriction in adult and pediatric asthmatic patients; estimate the magnitude of the attenuating effect.

Cochrane Systematic Review: Inhaled corticosteroids versus sodium cromoglycate in children and adults with asthma

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Guevara JP, Ducharme FM, Keren R, Nihtianova S, Zorc J.

Objectives: To compare the relative effectiveness and adverse effects of ICS and SCG among children and adults with chronic asthma.

Cochrane Systematic Review: Inhaled magnesium sulfate in the treatment of acute asthma

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Powell C, Dwan K, Milan SJ, Beasley R, Hughes R, Knopp-Sihota JA, Rowe BH.

Objectives: To determine the efficacy of inhaled MgSO(4) administered in acute asthma on pulmonary functions and admission rates.Specific aims: To quantify the effects of inhaled MgSO(4) i) in addition to inhaled (2)-agonist, ii) in comparison to inhaled (2)-agonist alone or iii) in addition to combination treatment with inhaled (2) -agonist and ipratropium bromide.

Cochrane Systematic Review: Inhaled sodium cromoglycate for asthma in children

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van der Wouden JC, Uijen JH, Bernsen RM, Tasche MJ, de Jongste JC, Ducharme F.

Objectives: To determine the efficacy of sodium cromoglycate compared to placebo in the prophylactic treatment of children with asthma.

Cochrane Systematic Review: Inhaled steroids for acute asthma following emergency department discharge

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Edmonds ML, Milan SJ, Brenner BE, Camargo CA Jr, Rowe BH.

Objectives: To determine the effectiveness of ICS on outcomes in the treatment of acute asthma following discharge from the ED. To quantify the effectiveness of ICS therapy on acute asthma following ED discharge, when used in addition to, or as a substitute for, systemic corticosteroids.

Cochrane Systematic Review: Inhaled steroids for episodic viral wheeze of childhood

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McKean M, Ducharme F.

Objectives: The objective of this review was to identify whether corticosteroid treatment, given episodically or daily, is beneficial to children with viral episodic wheeze.

Cochrane Systematic Review: Interventions for educating children who are at risk of asthma-related emergency department attendance

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Boyd M, Lasserson TJ, McKean MC, Gibson PG, Ducharme FM, Haby M.

Objectives: To conduct a systematic review of the literature and update the previous review as to whether asthma education leads to improved health outcomes in children who have attended the emergency room for asthma.

Cochrane Systematic Review: Intranasal corticosteroids for asthma control in people with coexisting asthma and rhinitis

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Taramarcaz P, Gibson PG.

Objectives: To assess the efficacy of intranasal corticosteroids on asthma outcomes in people with rhinitis and asthma.

Cochrane Systematic Review: Intravenous aminophylline for acute severe asthma in children over two years receiving inhaled bronchodilators

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Mitra A, Bassler D, Goodman K, Lasserson TJ, Ducharme FM.

Objectives: To determine if the addition of intravenous aminophylline produces a beneficial effect in children with acute severe asthma receiving conventional therapy.

Cochrane Systematic Review: Intravenous beta2-agonists for acute asthma in the emergency department

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Travers A, Jones AP, Kelly K, Barker SJ, Camargo CA, Rowe BH.

Objectives: To determine the benefit of intravenous (IV) beta2-agonists for severe acute asthma treated in the emergency department.

Cochrane Systematic Review: Intravenous beta2-agonists versus intravenous aminophylline for acute asthma

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Travers AH, Jones AP, Camargo CA Jr, Milan SJ, Rowe BH.

Objectives: To compare the benefit of IV beta(2)-agonists versus IV aminophylline for acute asthma treated in the emergency department and in patients admitted to hospital with acute severe asthma.

Cochrane Systematic Review: Ketamine for management of acute exacerbations of asthma in children

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Jat KR, Chawla D.

Objectives: To evaluate the efficacy of ketamine compared to placebo, no intervention or standard care for management of severe acute asthma in children who had not responded to standard therapy.

Cochrane Systematic Review: Ketotifen alone or as additional medication for long-term control of asthma and wheeze in children

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Schwarzer G, Bassler D, Mitra A, Ducharme FM, Forster J.

Objectives: The objective of this review is to determine, whether ketotifen alone or in combination with other co-interventions results in better control of asthma in children with asthma and/or wheezing and examine its safety profile.

Cochrane Systematic Review: Leukotriene receptor antagonists in addition to usual care for acute asthma in adults and children

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Watts K, Chavasse RJ.

Objectives: To determine if the addition of a leukotriene receptor antagonist (LTRA) produces a beneficial effect in children and adults with acute asthma who are currently receiving inhaled bronchodilators and systemic corticosteroids.

Cochrane Systematic Review: Magnesium sulfate for treating exacerbations of acute asthma in the emergency department

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Rowe BH, Bretzlaff JA, Bourdon C, Bota GW, Camargo CA Jr.

Objectives: To examine the effect of additional intravenous magnesium sulfate in patients with acute asthma managed in the emergency department.

Cochrane Systematic Review: Parent-initiated oral corticosteroid therapy for intermittent wheezing illnesses in children

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Vuillermin P, South M, Robertson C.

Objectives: The objectives were to assess the benefits and harmful effects of parent-initiated OCS, in the management of intermittent wheezing illnesses in children, based on the results of randomised clinical trials.

Cochrane Systematic Review: Safety of regular formoterol or salmeterol in children with asthma: an overview of Cochrane reviews

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Cates CJ, Oleszczuk M, Stovold E, Wieland LS.

Objectives: We have used the paediatric trial results from Cochrane systematic reviews to assess the safety of regular formoterol or salmeterol, either as monotherapy or as combination therapy, in children with asthma.

Cochrane Systematic Review: Selenium supplementation for asthma

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Allam MF, Lucane RA.

Objectives: Recognition that chronic asthma can be associated with selenium deficiency has led to the investigation of the role of selenium supplementation in reducing the symptoms and impact of chronic asthma. The objective of this review was to assess the efficacy of selenium supplementation as an adjunct to medication for the treatment of chronic asthma.

Cochrane Systematic Review: Short acting beta2-agonists for recurrent wheeze in children under two years of age

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Chavasse R, Seddon P, Bara A, McKean M.

Objectives: To determine the effectiveness of b2-agonist for the treatment of infants with recurrent and persistent wheeze.

Cochrane Systematic Review: Vitamin C supplementation for asthma

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Kaur B, Rowe BH, Arnold E.

Objectives: To evaluate the evidence for the efficacy of vitamin C in the treatment of asthma.

Cochrane Systematic Review: Written action plans for asthma in children

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Bhogal S, Zemek R, Ducharme FM.

Objectives: The objectives of this review were firstly to evaluate the independent effect of providing versus not providing a written action plan in children and adolescents with asthma, and secondly to compare the effect of different written action plans.

Cochrane Systematic Review: Written individualised management plans for asthma in children and adults

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Toelle B, Ram FS.

Objectives: To determine whether the provision of a written asthma self-management plan increases adherence and improves outcome.